ES2137175T3 - Antagonistas del receptor fibrinogeno. - Google Patents

Antagonistas del receptor fibrinogeno.

Info

Publication number
ES2137175T3
ES2137175T3 ES92304113T ES92304113T ES2137175T3 ES 2137175 T3 ES2137175 T3 ES 2137175T3 ES 92304113 T ES92304113 T ES 92304113T ES 92304113 T ES92304113 T ES 92304113T ES 2137175 T3 ES2137175 T3 ES 2137175T3
Authority
ES
Spain
Prior art keywords
antagonists
fibrinogen receptor
fibrinogen
inhibition
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92304113T
Other languages
English (en)
Inventor
Mark E Duggan
Nathan Ihle
George Hartman
Laura M Turchi
Melissa S Egbertson
William F Hoffman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2137175T3 publication Critical patent/ES2137175T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Materials For Medical Uses (AREA)

Abstract

SE PRESENTAN ANTAGONISTAS DE LOS RECEPTORES DEL FIBRINOGENO DE LA FORMULA: PARA SU USO EN LA INHIBICION DE LA UNION DEL FIBRINOGENO A LAS PLAQUETAS DE LA SANGRE Y PARA LA INHIBICION DE LA AGREGACION DE LAS PLAQUETAS SANGUINEAS.
ES92304113T 1991-05-07 1992-05-07 Antagonistas del receptor fibrinogeno. Expired - Lifetime ES2137175T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69689391A 1991-05-07 1991-05-07
US72035791A 1991-06-25 1991-06-25
US87126292A 1992-04-23 1992-04-23

Publications (1)

Publication Number Publication Date
ES2137175T3 true ES2137175T3 (es) 1999-12-16

Family

ID=27418643

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92304113T Expired - Lifetime ES2137175T3 (es) 1991-05-07 1992-05-07 Antagonistas del receptor fibrinogeno.

Country Status (20)

Country Link
US (2) US5281585A (es)
EP (1) EP0512831B1 (es)
JP (1) JP2531562B2 (es)
KR (1) KR920021531A (es)
CN (1) CN1067883A (es)
AT (1) ATE184874T1 (es)
AU (1) AU647618B2 (es)
BG (1) BG98194A (es)
CA (1) CA2068064C (es)
DE (1) DE69230013T2 (es)
ES (1) ES2137175T3 (es)
FI (1) FI934894L (es)
HU (1) HUT68769A (es)
IE (1) IE921463A1 (es)
IL (1) IL101779A0 (es)
MX (1) MXPA92002103A (es)
NO (1) NO933999L (es)
NZ (1) NZ242609A (es)
WO (1) WO1992019595A1 (es)
YU (1) YU47992A (es)

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US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
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Also Published As

Publication number Publication date
JP2531562B2 (ja) 1996-09-04
WO1992019595A1 (en) 1992-11-12
HUT68769A (en) 1995-07-28
ATE184874T1 (de) 1999-10-15
NZ242609A (en) 1995-04-27
FI934894A7 (fi) 1993-11-05
CA2068064A1 (en) 1992-11-08
FI934894A0 (fi) 1993-11-05
DE69230013T2 (de) 2000-04-27
AU1611192A (en) 1992-11-12
HU9303145D0 (en) 1994-01-28
CA2068064C (en) 2001-01-02
US5455243A (en) 1995-10-03
EP0512831A1 (en) 1992-11-11
KR920021531A (ko) 1992-12-18
AU647618B2 (en) 1994-03-24
MXPA92002103A (es) 2005-08-25
JPH069525A (ja) 1994-01-18
FI934894L (fi) 1993-11-05
NO933999D0 (no) 1993-11-05
IE921463A1 (en) 1992-11-18
NO933999L (no) 1993-11-05
CN1067883A (zh) 1993-01-13
YU47992A (sh) 1995-03-27
DE69230013D1 (de) 1999-10-28
EP0512831B1 (en) 1999-09-22
IL101779A0 (en) 1992-12-30
US5281585A (en) 1994-01-25
BG98194A (bg) 1994-09-30

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