DK0712387T3 - 2-Aminoindaner som selektive dopamin-D3-ligander - Google Patents

2-Aminoindaner som selektive dopamin-D3-ligander

Info

Publication number: DK0712387T3
Authority: DK; Denmark
Prior art keywords: alkyl; hydrogen; pct; cycloalkyl; alkenyl
Prior art date: 1993-08-06

Application number

DK94925094T

Other languages

English (en)

Inventor

Susanne R Haadsma-Svensson

Clas A Sonesson

Chiu-Hong Lin

R Nicholas Waters

Kjell A I Svensson

Per A E Carlsson

Lars Olov Hansson

Nils Peter Stjernlof

Bengt R Andersson

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-06

Filing date

1994-07-21

Publication date

2000-05-29

1994-07-21 Application filed by Upjohn Co filed Critical Upjohn Co

2000-05-29 Application granted granted Critical

2000-05-29 Publication of DK0712387T3 publication Critical patent/DK0712387T3/da

Links

VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
LMHHFZAXSANGGM-UHFFFAOYSA-N 2-aminoindane Chemical class C1=CC=C2CC(N)CC2=C1 LMHHFZAXSANGGM-UHFFFAOYSA-N 0.000 title 1
229960003638 dopamine Drugs 0.000 title 1
239000003446 ligand Substances 0.000 title 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 3
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
102000004073 Dopamine D3 Receptors Human genes 0.000 abstract 1
108090000525 Dopamine D3 Receptors Proteins 0.000 abstract 1
101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
101100533874 Hypocrea jecorina (strain QM6a) sor5 gene Proteins 0.000 abstract 1
229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 abstract 1
125000001422 pyrrolinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000565 sulfonamide group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 abstract 1

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- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK94925094T 1993-08-06 1994-07-21 2-Aminoindaner som selektive dopamin-D3-ligander DK0712387T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10327093A	1993-08-06	1993-08-06
PCT/US1994/008046 WO1995004713A1 (en)	1993-08-06	1994-07-21	2-aminoindans as selective dopamine d3 ligands

Publications (1)

Publication Number	Publication Date
DK0712387T3 true DK0712387T3 (da)	2000-05-29

Family

ID=22294299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94925094T DK0712387T3 (da)	1993-08-06	1994-07-21	2-Aminoindaner som selektive dopamin-D3-ligander

Country Status (11)

Country	Link
US (1)	US5708018A (da)
EP (1)	EP0712387B1 (da)
JP (1)	JP3342491B2 (da)
AT (1)	ATE187436T1 (da)
AU (1)	AU7513494A (da)
DE (1)	DE69422044T2 (da)
DK (1)	DK0712387T3 (da)
ES (1)	ES2139750T3 (da)
GR (1)	GR3032508T3 (da)
LV (1)	LV12630B (da)
WO (1)	WO1995004713A1 (da)

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JP5701213B2 (ja)	2008-10-10	2015-04-15	インスティチュートオブファーマコロジーアンドトキシコロジーアカデミーオブミリタリーメディカルサイエンシズピー．エル．エー．チャイナ	新規なドーパミンｄ３受容体リガンド、その調製及び使用
US9227944B2 (en)	2008-10-10	2016-01-05	Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China	Dopamine D3 receptor ligands and preparation and medical uses of the same
US9549909B2 (en)	2013-05-03	2017-01-24	The Katholieke Universiteit Leuven	Method for the treatment of dravet syndrome
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1994
- 1994-07-21 WO PCT/US1994/008046 patent/WO1995004713A1/en not_active Ceased
- 1994-07-21 US US08/592,318 patent/US5708018A/en not_active Expired - Fee Related
- 1994-07-21 EP EP94925094A patent/EP0712387B1/en not_active Expired - Lifetime
- 1994-07-21 AT AT94925094T patent/ATE187436T1/de not_active IP Right Cessation
- 1994-07-21 DK DK94925094T patent/DK0712387T3/da active
- 1994-07-21 ES ES94925094T patent/ES2139750T3/es not_active Expired - Lifetime
- 1994-07-21 AU AU75134/94A patent/AU7513494A/en not_active Abandoned
- 1994-07-21 DE DE69422044T patent/DE69422044T2/de not_active Expired - Fee Related
- 1994-07-21 JP JP50642195A patent/JP3342491B2/ja not_active Expired - Fee Related
2000
- 2000-01-27 GR GR20000400202T patent/GR3032508T3/el not_active IP Right Cessation
- 2000-12-08 LV LVP-00-170A patent/LV12630B/en unknown

Also Published As

Publication number	Publication date
JPH09501429A (ja)	1997-02-10
ES2139750T3 (es)	2000-02-16
US5708018A (en)	1998-01-13
GR3032508T3 (en)	2000-05-31
EP0712387A1 (en)	1996-05-22
JP3342491B2 (ja)	2002-11-11
DE69422044T2 (de)	2000-05-31
ATE187436T1 (de)	1999-12-15
LV12630A (lv)	2001-03-20
DE69422044D1 (de)	2000-01-13
WO1995004713A1 (en)	1995-02-16
LV12630B (en)	2001-08-20
AU7513494A (en)	1995-02-28
EP0712387B1 (en)	1999-12-08

Publication	Publication Date	Title
DE69422044D1 (de)	2000-01-13	2-aminoindane als selektive dopamin-d3-liganden
ATE96775T1 (de)	1993-11-15	N-phenylalkylsubstituierte alphaaminocarboxamidderivate und verfahren zu deren herstellung.
PL321634A1 (en)	1997-12-08	2-aminoindanes as selective ligands of dopamine receptor d3
BG102634A (en)	1999-08-31	New condensated pyrolocarboxamides, a new class gaba receptor ligands in the brain
ATE206110T1 (de)	2001-10-15	Zns-aktive semicarbazone und diese enthaltende pharmazeutische zubereitungen
ES2130135T3 (es)	1999-07-01	Nuevos compuestos heterociclicos de 6,7,8,9-tetrahidro-3h-benz(e)indol con actividad terapeutica sobre el sistema nervioso central.
MY101352A (en)	1991-09-05	New benzamides.
AU3386299A (en)	1999-10-25	N-aryloxyethylamine derivatives for the treatment of depression
DE69110124D1 (de)	1995-07-06	Indolderivate, herstellung und verwendung.
ATE161533T1 (de)	1998-01-15	Imidanolon- und oxanolonderivate als dopaminantagonisten
CA2130678A1 (en)	1993-08-25	2,3,4,5-tetrahydro-1h-3-benzazepines and pharmaceutically acceptable acid addition salts thereof
TW223631B (da)	1994-05-11
CA2225382A1 (en)	1997-01-09	Sialic acid derivatives
PL309189A1 (en)	1995-09-18	Novel phenylethyl and phenylpropyl amines
ATE112256T1 (de)	1994-10-15	9-amino-2-phenylbicyclo(3.3.1>nonane und 9-amino- 2-phenylbicyclo(3.3.1>-non-2-ene und diese enthaltende therapeutische mittel.