ES2139923T3 - Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas. - Google Patents

Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas.

Info

Publication number
ES2139923T3
ES2139923T3 ES95927686T ES95927686T ES2139923T3 ES 2139923 T3 ES2139923 T3 ES 2139923T3 ES 95927686 T ES95927686 T ES 95927686T ES 95927686 T ES95927686 T ES 95927686T ES 2139923 T3 ES2139923 T3 ES 2139923T3
Authority
ES
Spain
Prior art keywords
pct
breastfeeders
procedure
reagent concentrations
constantly high
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95927686T
Other languages
English (en)
Inventor
Kim Clausen
Rocus Marinus Dekkers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of ES2139923T3 publication Critical patent/ES2139923T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADOS DE BE -LACTAMA PUEDEN SER VENTAJOSAMENTE SINTETIZADOS MEDIANTE UNA REACCION ENZIMATICA DE LA AMINA {BE}LACTAMA PADRE CON EL AGENTE DE ACILACION CORRESPONDIENTE A CONCENTRACIONES CONSTANTEMENTE ALTAS DE DICHOS REACTIVOS.
ES95927686T 1994-07-18 1995-07-18 Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas. Expired - Lifetime ES2139923T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK85394 1994-07-18

Publications (1)

Publication Number Publication Date
ES2139923T3 true ES2139923T3 (es) 2000-02-16

Family

ID=8098286

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95927686T Expired - Lifetime ES2139923T3 (es) 1994-07-18 1995-07-18 Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas.

Country Status (9)

Country Link
US (1) US6048708A (es)
EP (1) EP0771357B1 (es)
CN (1) CN1095875C (es)
AT (1) ATE185842T1 (es)
AU (1) AU3163295A (es)
DE (1) DE69512917D1 (es)
ES (1) ES2139923T3 (es)
MX (1) MX9700565A (es)
WO (1) WO1996002663A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
NL1006266C2 (nl) * 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
WO1998056945A1 (en) * 1997-06-10 1998-12-17 Dsm N.V. PROCESS FOR ENZYMATICALLY PREPARING A β-LACTAM ANTIBIOTIC AND THIS ANTIBIOTIC
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
DE19823332C2 (de) * 1998-05-26 2000-09-07 Unifar Kimya Sanayii Ve Ticare Verfahren zur enzymatischen Herstellung von Betalactam-Antibiotika
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
HUE036242T2 (hu) 2003-07-03 2018-06-28 Dsm Sinochem Pharm Nl Bv Eljárás cefradin elõállítására
EP1931619B1 (en) * 2005-09-29 2015-06-24 DSM Sinochem Pharmaceuticals Netherlands B.V. Methanesulphonic acid salt of dihydrophenylglycine methyl ester or of phenylglycine methyl ester
WO2007134987A1 (en) 2006-05-19 2007-11-29 Dsm Ip Assets B.V. Process for the crystallisation of cefadroxil
CN101802212B (zh) * 2007-07-27 2013-08-28 酵素生物技术有限公司 从大肠杆菌BL21CCM7394中无色菌CCM4824制备固定重组青霉素酰化酶催化剂的方法及其在合成β-内酰胺抗生素中的应用
CN101525603B (zh) * 2008-03-04 2013-12-25 中国医药集团总公司四川抗菌素工业研究所 固定化α-氨基酸酯水解酶及其制备与应用
EP3069612A3 (en) 2009-06-15 2016-10-19 Encore Health, LLC Dithiol compounds, derivatives, and uses therefor
WO2011113486A1 (en) 2010-03-17 2011-09-22 Deretil, S.A. Process for the synthesis of hydroxyphenylglycine esters
EP2723881A2 (en) 2011-06-23 2014-04-30 DSM Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
EP2723882B1 (en) 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase
EP2856159A4 (en) 2012-06-01 2016-04-13 Momenta Pharmaceuticals Inc METHODS RELATING TO DENOSUMAB
CN105153197B (zh) * 2015-07-28 2017-05-31 齐鲁安替制药有限公司 一种头孢中间体的制备方法
CN115710595B (zh) * 2022-09-29 2025-07-08 国药集团威奇达药业有限公司 从头孢羟氨苄结晶母液中回收7-氨基去乙酰氧基头孢烷酸和d-对羟基苯甘氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5231436B2 (es) * 1971-08-20 1977-08-15
ES2090031T3 (es) * 1988-04-26 1996-10-16 Gist Brocades Nv Proceso para la preparacion enzimatica de beta-lactamas.
US5334497A (en) * 1988-12-13 1994-08-02 Hideki Inaba Method of feeding a substrate into tubular bioreactor
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.
EP0537255B1 (en) * 1990-07-04 2006-02-15 DSM IP Assets B.V. Process for preparation of beta-lactams

Also Published As

Publication number Publication date
ATE185842T1 (de) 1999-11-15
DE69512917D1 (de) 1999-11-25
MX9700565A (es) 1997-05-31
EP0771357B1 (en) 1999-10-20
AU3163295A (en) 1996-02-16
CN1152945A (zh) 1997-06-25
WO1996002663A1 (en) 1996-02-01
EP0771357A1 (en) 1997-05-07
CN1095875C (zh) 2002-12-11
US6048708A (en) 2000-04-11

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