ES2139923T3 - Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas. - Google Patents

Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas.

Info

Publication number
ES2139923T3
ES2139923T3 ES95927686T ES95927686T ES2139923T3 ES 2139923 T3 ES2139923 T3 ES 2139923T3 ES 95927686 T ES95927686 T ES 95927686T ES 95927686 T ES95927686 T ES 95927686T ES 2139923 T3 ES2139923 T3 ES 2139923T3
Authority
ES
Spain
Prior art keywords
pct
breastfeeders
procedure
reagent concentrations
constantly high
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95927686T
Other languages
English (en)
Inventor
Kim Clausen
Rocus Marinus Dekkers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of ES2139923T3 publication Critical patent/ES2139923T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADOS DE BE -LACTAMA PUEDEN SER VENTAJOSAMENTE SINTETIZADOS MEDIANTE UNA REACCION ENZIMATICA DE LA AMINA {BE}LACTAMA PADRE CON EL AGENTE DE ACILACION CORRESPONDIENTE A CONCENTRACIONES CONSTANTEMENTE ALTAS DE DICHOS REACTIVOS.
ES95927686T 1994-07-18 1995-07-18 Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas. Expired - Lifetime ES2139923T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK85394 1994-07-18

Publications (1)

Publication Number Publication Date
ES2139923T3 true ES2139923T3 (es) 2000-02-16

Family

ID=8098286

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95927686T Expired - Lifetime ES2139923T3 (es) 1994-07-18 1995-07-18 Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas.

Country Status (9)

Country Link
US (1) US6048708A (es)
EP (1) EP0771357B1 (es)
CN (1) CN1095875C (es)
AT (1) ATE185842T1 (es)
AU (1) AU3163295A (es)
DE (1) DE69512917D1 (es)
ES (1) ES2139923T3 (es)
MX (1) MX9700565A (es)
WO (1) WO1996002663A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
AU8799498A (en) * 1997-06-10 1998-12-30 Gist-Brocades B.V. Process for enzymatically preparing a beta-lactam antibiotic and this antibiotic
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
DE19823332C2 (de) * 1998-05-26 2000-09-07 Unifar Kimya Sanayii Ve Ticare Verfahren zur enzymatischen Herstellung von Betalactam-Antibiotika
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
US7588913B2 (en) 2003-07-03 2009-09-15 Dsm Ip Assets B.V. Process for the preparation of cephradine
US20080249329A1 (en) * 2005-09-29 2008-10-09 Dsm Ip Assets B.V. Process For Esterification Of An Organic Acid
KR101420451B1 (ko) 2006-05-19 2014-07-16 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 세파드록실의 결정화 방법
WO2009016642A1 (en) * 2007-07-27 2009-02-05 Fermenta Biotech Limited Process for the preparation of immobilized recombinant penicillin acylase catalyst from achromobacter sp. ccm 4824 expressed in e. coli bl 21 ccm 7394 and its use for the synthesis of beta-lactam antibiotics
CN101525603B (zh) * 2008-03-04 2013-12-25 中国医药集团总公司四川抗菌素工业研究所 固定化α-氨基酸酯水解酶及其制备与应用
EP3069612A3 (en) 2009-06-15 2016-10-19 Encore Health, LLC Dithiol compounds, derivatives, and uses therefor
WO2011113486A1 (en) 2010-03-17 2011-09-22 Deretil, S.A. Process for the synthesis of hydroxyphenylglycine esters
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
EP2723882B1 (en) 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase
WO2013181575A2 (en) 2012-06-01 2013-12-05 Momenta Pharmaceuticals, Inc. Methods related to denosumab
CN105153197B (zh) * 2015-07-28 2017-05-31 齐鲁安替制药有限公司 一种头孢中间体的制备方法
CN115710595B (zh) * 2022-09-29 2025-07-08 国药集团威奇达药业有限公司 从头孢羟氨苄结晶母液中回收7-氨基去乙酰氧基头孢烷酸和d-对羟基苯甘氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5231436B2 (es) * 1971-08-20 1977-08-15
ATE138690T1 (de) * 1988-04-26 1996-06-15 Gist Brocades Nv Verfahren zur enzymatischen herstellung von beta- lactamen
US5334497A (en) * 1988-12-13 1994-08-02 Hideki Inaba Method of feeding a substrate into tubular bioreactor
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.
EP0537255B1 (en) * 1990-07-04 2006-02-15 DSM IP Assets B.V. Process for preparation of beta-lactams

Also Published As

Publication number Publication date
US6048708A (en) 2000-04-11
AU3163295A (en) 1996-02-16
CN1095875C (zh) 2002-12-11
EP0771357A1 (en) 1997-05-07
MX9700565A (es) 1997-05-31
EP0771357B1 (en) 1999-10-20
CN1152945A (zh) 1997-06-25
WO1996002663A1 (en) 1996-02-01
ATE185842T1 (de) 1999-11-15
DE69512917D1 (de) 1999-11-25

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