ES2140027T3 - P-isopropilbenceno-sulfonato de valina y un procedimiento para purificar valina. - Google Patents
P-isopropilbenceno-sulfonato de valina y un procedimiento para purificar valina.Info
- Publication number
- ES2140027T3 ES2140027T3 ES96304313T ES96304313T ES2140027T3 ES 2140027 T3 ES2140027 T3 ES 2140027T3 ES 96304313 T ES96304313 T ES 96304313T ES 96304313 T ES96304313 T ES 96304313T ES 2140027 T3 ES2140027 T3 ES 2140027T3
- Authority
- ES
- Spain
- Prior art keywords
- valine
- acid
- salt
- isopropylbenzene
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 title abstract 3
- 239000004474 valine Substances 0.000 title abstract 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 title abstract 2
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 2
- QJVOZXGJOGJKPT-IGHBBLSQSA-N (1r,2r,5s,11ar)-2-(prop-2-en-1-yl)-1,2,3,4,5,6,11,11a-octahydro-10h-1,5-methanopyrido[1,2-a][1,5]diazocin-10-one Chemical compound C([C@@H]12)C(=O)C=CN1C[C@@H]1CN[C@H](CC=C)[C@H]2C1 QJVOZXGJOGJKPT-IGHBBLSQSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- QJVOZXGJOGJKPT-UHFFFAOYSA-N albine Natural products C12CC(=O)C=CN2CC2CNC(CC=C)C1C2 QJVOZXGJOGJKPT-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA PRESENTE INVENCION SE DIRIGE A LA NECESIDAD DE SUMINISTRAR UN PROCESO PARA PURIFICAR VALINA QUE TENGA UNA ALTA PUREZA DE ALTA PRODUCCION POR UN METODO SENCILLO Y USANDO UN PRECIPITANTE BARATO. UNA DISOLUCION ACUOSA QUE CONTIENE VALINA ES REACCIONADA CON ACIDO P-ISOPROPILBENCENOSULFONICO O SU SAL SOLUBLE EN AGUA PARA FORMAR UN CRISTAL DE P-ISOPROPILBENCENOSULFONATO DE VALINA. EL P-ISOPROPILBENCENOSULFONATO DE VALINA ES SEPARADO Y DESPUES DISOCIADO PARA PURIFICAR Y OBTENER VALINA. EL ACIDO PISOPROPILBENCENOSULFONICO USADO PUEDE ESTAR EN FORMA DE ACIDO LIBRE, O UNA SAL COMO POR EJEMPLO UNA SAL DE METALICA ALCALINA O UNA SAL AMONICA. EL PROCEDIMIENTO PARA LA FORMACION DE UN ADUCTO COMPRENDE 1 MOL DE VALINA Y 1 MOL DE ACIDO P-ISOPROPILBENCENOSULFONICO Y LA PURIFICACION DE VALINA PRODUCE LOS EFECTOS DE QUE COMO LA SOLUBILIDAD DEL P-ISOPROPILBENCENOSULFONATO DE VALINA ES BAJA, LA VALINA PUEDE SER OBTENIDA EN ALTA EFICACIA, Y DE QUE LA VALINA PUEDE SER SEPARADA EN ALTA VELOCIDAD DE LA LEUCINA YDE LA ISOLEUCINA LAS CUALES SON EN GENERAL DIFICILES DE SEPARAR DE LA VALINA, A CAUSA DE LA ESPECIFIDAD DEL ADUCTO. EL ACIDO PISOPROPILBENCENOSULFONICO PUEDE SER FACILMENTE PRODUCIDO SULFONANDO ISOPROPILBENCENO BARATO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14484395A JP3694921B2 (ja) | 1995-06-12 | 1995-06-12 | バリンの精製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2140027T3 true ES2140027T3 (es) | 2000-02-16 |
Family
ID=15371723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96304313T Expired - Lifetime ES2140027T3 (es) | 1995-06-12 | 1996-06-07 | P-isopropilbenceno-sulfonato de valina y un procedimiento para purificar valina. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5689001A (es) |
| EP (1) | EP0748791B1 (es) |
| JP (1) | JP3694921B2 (es) |
| KR (1) | KR100399509B1 (es) |
| CN (1) | CN1069308C (es) |
| CA (1) | CA2178879C (es) |
| DE (1) | DE69605152T2 (es) |
| ES (1) | ES2140027T3 (es) |
| MY (1) | MY112976A (es) |
| TW (1) | TW336927B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10237030A (ja) * | 1997-02-26 | 1998-09-08 | Ajinomoto Co Inc | 分岐鎖アミノ酸の精製法 |
| AU2003211310A1 (en) * | 2002-03-06 | 2003-09-16 | Ajinomoto Co., Inc. | PROCESS FOR PRODUCING tert-LEUCINE |
| EP1618097A1 (en) | 2003-04-21 | 2006-01-25 | Teva Pharmaceutical Industries Ltd | Process for the preparation of valsartan |
| US7161029B2 (en) * | 2003-12-17 | 2007-01-09 | Ajinomoto Co., Inc. | DiL-lysine monosulfate trihydrate crystal and method of making |
| CN1300102C (zh) * | 2005-11-07 | 2007-02-14 | 河南省德利科技发展公司 | 缬氨酸结晶剂的合成方法 |
| CN101434553B (zh) * | 2008-11-12 | 2011-10-19 | 江苏神华药业有限公司 | 全膜提取缬氨酸的方法 |
| CN101580475B (zh) * | 2009-03-30 | 2013-01-09 | 江苏神华药业有限公司 | 一种生产缬氨酸的新工艺 |
| BR112014005784B1 (pt) * | 2011-09-12 | 2019-07-16 | Kyowa Hakko Bio Co., Ltd. | Processo para a produção de aminoácidos |
| KR101449808B1 (ko) | 2012-02-06 | 2014-10-14 | 씨제이제일제당 (주) | 발린의 연속적 분리를 위한 장치 및 이를 이용한 발린의 연속적 분리 방법 |
| US9120722B1 (en) | 2014-08-14 | 2015-09-01 | Wellman Biosciences Co. Ltd. | Optically active valine complex and a method for producing the same |
| US10239823B2 (en) * | 2017-08-25 | 2019-03-26 | Vitaworks Ip, Llc | Process for purifying long chain amino acids |
| JP7525254B2 (ja) * | 2019-11-14 | 2024-07-30 | ミヨシ油脂株式会社 | 有機アンモニウム塩とそれを用いた生体試料処理剤 |
| CN113773215B (zh) * | 2020-06-10 | 2024-02-02 | 安徽华恒生物科技股份有限公司 | 一种高堆积密度的l-缬氨酸及其制备方法和其应用 |
| EP4711468A1 (en) * | 2023-06-28 | 2026-03-18 | CJ Cheiljedang Corporation | Method for preparing l-valine crystals and/or granules by using ph control |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2894954A (en) * | 1957-04-25 | 1959-07-14 | Eagle Ottawa Leather Company | Method of selectively extracting amino acids |
| JPS523016A (en) * | 1975-06-24 | 1977-01-11 | Tanabe Seiyaku Co Ltd | Preparation of high-purity leucine |
| JPS6296454A (ja) * | 1985-10-22 | 1987-05-02 | Hiroyuki Nohira | Ｄｌ−バリンの光学分割法 |
-
1995
- 1995-06-12 JP JP14484395A patent/JP3694921B2/ja not_active Expired - Lifetime
-
1996
- 1996-06-07 ES ES96304313T patent/ES2140027T3/es not_active Expired - Lifetime
- 1996-06-07 DE DE69605152T patent/DE69605152T2/de not_active Expired - Lifetime
- 1996-06-07 EP EP96304313A patent/EP0748791B1/en not_active Expired - Lifetime
- 1996-06-10 US US08/661,117 patent/US5689001A/en not_active Expired - Lifetime
- 1996-06-11 KR KR1019960020696A patent/KR100399509B1/ko not_active Expired - Lifetime
- 1996-06-12 MY MYPI96002373A patent/MY112976A/en unknown
- 1996-06-12 TW TW085107064A patent/TW336927B/zh not_active IP Right Cessation
- 1996-06-12 CN CN96108814A patent/CN1069308C/zh not_active Expired - Lifetime
- 1996-06-12 CA CA002178879A patent/CA2178879C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08333312A (ja) | 1996-12-17 |
| KR100399509B1 (ko) | 2003-12-24 |
| KR970001305A (ko) | 1997-01-24 |
| MY112976A (en) | 2001-10-31 |
| CN1069308C (zh) | 2001-08-08 |
| DE69605152D1 (de) | 1999-12-23 |
| US5689001A (en) | 1997-11-18 |
| TW336927B (en) | 1998-07-21 |
| JP3694921B2 (ja) | 2005-09-14 |
| EP0748791A2 (en) | 1996-12-18 |
| DE69605152T2 (de) | 2000-07-06 |
| CA2178879A1 (en) | 1996-12-13 |
| CA2178879C (en) | 2007-01-30 |
| EP0748791A3 (en) | 1997-11-19 |
| CN1142488A (zh) | 1997-02-12 |
| EP0748791B1 (en) | 1999-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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