ES2132872T3 - Procedimiento de purificacion de diacetilreina. - Google Patents

Procedimiento de purificacion de diacetilreina.

Info

Publication number
ES2132872T3
ES2132872T3 ES96900687T ES96900687T ES2132872T3 ES 2132872 T3 ES2132872 T3 ES 2132872T3 ES 96900687 T ES96900687 T ES 96900687T ES 96900687 T ES96900687 T ES 96900687T ES 2132872 T3 ES2132872 T3 ES 2132872T3
Authority
ES
Spain
Prior art keywords
diacetilreine
purification procedure
diacetilrhein
add
hydrolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96900687T
Other languages
English (en)
Inventor
Avraham Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Steba Beheer BV
Original Assignee
Steba Beheer BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4184836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2132872(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Steba Beheer BV filed Critical Steba Beheer BV
Application granted granted Critical
Publication of ES2132872T3 publication Critical patent/ES2132872T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

EL PRESENTE PROCEDIMIENTO COMPRENDE LAS ETAPAS QUE CONSISTEN EN: A) PONER LA DIACETILRHEINA EN SUSPENSION EN UNA MEZCLA SOLVENTE ORGANICA-AGUA; B) AÑADIR UNA AMINA TERCIARIA; C) AÑADIR A LA SOLUCION OBTENIDA UNA SAL DE ACIDO DE METAL ALCALINO O ALCALINOTERREO, D) EFECTUAR UNA HIDROLISIS EN MEDIO POCO ACIDO; RECOGER LA DIACETILRHEINA PURIFICADA, POR FILTRACION.
ES96900687T 1995-02-07 1996-02-07 Procedimiento de purificacion de diacetilreina. Expired - Lifetime ES2132872T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH00342/95A CH689279A5 (fr) 1995-02-07 1995-02-07 Procédé de purification de la diacétylrhéine.

Publications (1)

Publication Number Publication Date
ES2132872T3 true ES2132872T3 (es) 1999-08-16

Family

ID=4184836

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96900687T Expired - Lifetime ES2132872T3 (es) 1995-02-07 1996-02-07 Procedimiento de purificacion de diacetilreina.

Country Status (11)

Country Link
US (1) US5756782A (es)
EP (1) EP0754173B1 (es)
JP (2) JP3782109B2 (es)
AT (1) ATE178882T1 (es)
CA (1) CA2187210C (es)
CH (1) CH689279A5 (es)
DE (1) DE69602062T2 (es)
ES (1) ES2132872T3 (es)
GR (1) GR3030759T3 (es)
IL (1) IL117047A (es)
WO (1) WO1996024572A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292132B1 (it) * 1997-06-11 1999-01-25 Synteco S R L Procedimento per la preparazione di diacereina
IT1312309B1 (it) * 1999-05-07 2002-04-15 Synteco Spa Procedimento per la purificazione di diacereina
ITMI20022535A1 (it) * 2002-11-29 2004-05-30 Synteco Spa Procedimento per la purificazione della diacereina.
MXPA03008622A (es) * 2003-09-23 2005-03-30 Interquim S A De C V Metodo de purificacion de diacereina cruda por la via del tolueno.
KR100885677B1 (ko) 2007-05-22 2009-02-25 주식회사 엔지켐 디아세레인의 정제 방법
ITMI20080011A1 (it) * 2008-01-04 2009-07-05 Chimico Internaz S P A Procedimento per la preparazione di diacereina
EP2218707A1 (en) * 2009-02-16 2010-08-18 Evultis S.A. Process for the preparation of non-genotoxic Diacetylrhein (Diacerein)
BRPI0917627A2 (pt) * 2008-12-09 2015-11-17 Evultis Sa "processo para produzir diacereína não genotóxica, diacereína não genotíxica, cápsulas e formulações farmacêuticas"
EP2196450A1 (en) 2008-12-09 2010-06-16 Evultis S.A. Process for the preparation of pure diacetylrhein (diacerein)
WO2011099834A2 (es) * 2010-02-15 2011-08-18 Interquim, S.A. De C.V. Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida
CN115521205B (zh) * 2022-09-22 2023-11-10 北京百奥药业有限责任公司 双醋瑞因钠盐的晶型及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
IT1189097B (it) * 1986-05-02 1988-01-28 Proter Spa Sali di diacetilreina e loro impiego terapeutico nel trattamento dell'artrosi
DE4120990C2 (de) * 1991-06-25 1995-07-27 Madaus Ag Verfahren zur Herstellung von Diacetylrhein
US5393898A (en) * 1991-06-25 1995-02-28 Madaus Ag Method of preparing diacetyl rhein
DE4120989C2 (de) * 1991-06-25 1995-07-27 Madaus Ag Verfahren zur Herstellung von Diacetylrhein
IT1264545B1 (it) * 1993-07-30 1996-10-02 Medidom Lab Procedimento per la preparazione della diacereina

Also Published As

Publication number Publication date
JP3782109B2 (ja) 2006-06-07
JP2004244424A (ja) 2004-09-02
IL117047A (en) 1998-12-06
EP0754173A1 (fr) 1997-01-22
DE69602062D1 (de) 1999-05-20
JP4104576B2 (ja) 2008-06-18
GR3030759T3 (en) 1999-11-30
WO1996024572A1 (fr) 1996-08-15
US5756782A (en) 1998-05-26
ATE178882T1 (de) 1999-04-15
DE69602062T2 (de) 1999-12-16
IL117047A0 (en) 1996-06-18
CA2187210C (en) 2007-09-11
JPH09511766A (ja) 1997-11-25
CH689279A5 (fr) 1999-01-29
CA2187210A1 (en) 1996-08-15
EP0754173B1 (fr) 1999-04-14

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