ES2141727T3 - Derivados de 10-desacetoxitaxol. - Google Patents

Derivados de 10-desacetoxitaxol.

Info

Publication number
ES2141727T3
ES2141727T3 ES92920702T ES92920702T ES2141727T3 ES 2141727 T3 ES2141727 T3 ES 2141727T3 ES 92920702 T ES92920702 T ES 92920702T ES 92920702 T ES92920702 T ES 92920702T ES 2141727 T3 ES2141727 T3 ES 2141727T3
Authority
ES
Spain
Prior art keywords
alkynyl
aryl
alkyl
derivatives
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92920702T
Other languages
English (en)
Inventor
Robert A Holton
Shu-Hui Chen
Vittorio Farina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Florida State University
Original Assignee
Bristol Myers Squibb Co
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Florida State University filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2141727T3 publication Critical patent/ES2141727T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A 10 Y SUS DERIVADOS, QUE SON UTILES COMO AGENTES TUMORALES. ESTOS COMPUESTOS TIENEN LA FORMULA (I), EN LA QUE R2 ES HIDROGENO, HIDROXI O GRUPO HIDROXI PROTEGIDO; R3 Y R4 SON INDEPENDIENTEMENTE HIDROGENO, HIDROXI, UN GRUPO HIDROXI PROTEGIDO, METILO, H, IENTEMENTE HIDROGENO, ALQUILO O ARILO; Y R8 Y R9 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO, ALQUENILO, ALQUINILO, O ARILO; Y R10 ES ALCOXI, ALQUILO, ALQUENILO, ALQUINILO O ARILO.
ES92920702T 1991-09-23 1992-09-22 Derivados de 10-desacetoxitaxol. Expired - Lifetime ES2141727T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US90040892A 1992-06-18 1992-06-18

Publications (1)

Publication Number Publication Date
ES2141727T3 true ES2141727T3 (es) 2000-04-01

Family

ID=27117344

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92920702T Expired - Lifetime ES2141727T3 (es) 1991-09-23 1992-09-22 Derivados de 10-desacetoxitaxol.

Country Status (15)

Country Link
EP (1) EP0642503B1 (es)
JP (1) JP3304088B2 (es)
KR (1) KR100239201B1 (es)
AT (1) ATE187170T1 (es)
AU (1) AU663732B2 (es)
CA (1) CA2119363C (es)
CZ (1) CZ287609B6 (es)
DE (1) DE69230379T2 (es)
DK (1) DK0642503T3 (es)
ES (1) ES2141727T3 (es)
FI (1) FI112479B (es)
HU (1) HU225474B1 (es)
NO (1) NO304740B1 (es)
UA (1) UA39860C2 (es)
WO (1) WO1993006093A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998656A (en) 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
PL174374B1 (pl) * 1992-07-01 1998-07-31 Bristol Myers Squibb Co Fluorotaksole
US5681714A (en) * 1992-07-30 1997-10-28 Mount Sinai Hospital Corporation Nucleic acid encoding tek receptor tyrosine kinase
EP0582469A2 (en) * 1992-08-06 1994-02-09 Wisconsin Alumni Research Foundation Process for preparing taxol-type compound from beta-lactam precursors
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
DK0690867T3 (da) * 1993-03-22 2003-06-10 Univ Florida State Taxaner med furyl- eller thienylsubstitueret sidekæde
CN1502331A (zh) 1993-07-19 2004-06-09 Ѫ�ܼ���ҩ�﹫˾ 抗血管生长组合物及使用方法
FR2711369B1 (fr) * 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
FR2721024B1 (fr) * 1994-06-09 1996-07-12 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
WO1995033740A1 (en) * 1994-06-09 1995-12-14 Daiichi Pharmaceutical Co., Ltd. Deacetoxytaxol derivative
FR2723094A1 (fr) * 1994-07-26 1996-02-02 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5840929A (en) * 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
AU728057B2 (en) * 1995-09-13 2001-01-04 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
DE19621311A1 (de) 1996-05-28 1997-12-04 Bayer Ag Substituierte Phenyluracile
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
KR101096282B1 (ko) * 2009-04-24 2011-12-20 주식회사 삼양제넥스 탁산 유도체를 제조하는 방법
JP5847942B2 (ja) 2012-07-19 2016-01-27 富士フイルム株式会社 タキサン系活性成分含有液体組成物、その製造方法及び液体製剤

Also Published As

Publication number Publication date
AU663732B2 (en) 1995-10-19
EP0642503B1 (en) 1999-12-01
FI941324A0 (fi) 1994-03-22
UA39860C2 (uk) 2001-07-16
HU225474B1 (en) 2006-12-28
NO304740B1 (no) 1999-02-08
CA2119363A1 (en) 1993-04-01
DK0642503T3 (da) 2000-05-22
CZ66194A3 (en) 1995-07-12
KR100239201B1 (ko) 2000-02-01
AU2692692A (en) 1993-04-27
NO941021L (no) 1994-05-20
EP0642503A1 (en) 1995-03-15
CA2119363C (en) 2001-07-17
FI941324L (fi) 1994-03-22
DE69230379T2 (de) 2000-05-25
EP0642503A4 (en) 1994-07-07
JP3304088B2 (ja) 2002-07-22
NO941021D0 (no) 1994-03-22
FI112479B (fi) 2003-12-15
JPH07502981A (ja) 1995-03-30
CZ287609B6 (cs) 2001-01-17
DE69230379D1 (de) 2000-01-05
ATE187170T1 (de) 1999-12-15
WO1993006093A1 (en) 1993-04-01
HUT68422A (en) 1995-04-26
HU9400832D0 (en) 1994-06-28

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