DK0690867T3 - Taxaner med furyl- eller thienylsubstitueret sidekæde - Google Patents

Taxaner med furyl- eller thienylsubstitueret sidekæde

Info

Publication number: DK0690867T3
Authority: DK; Denmark
Prior art keywords: furyl; side chain; thienyl substituted; substituted side; taxanes
Prior art date: 1993-03-22

Application number

DK94911675T

Other languages

English (en)

Inventor

Robert A East Paul Dira Holton

Hossain East Paul Di Nadizadeh

Ronald J East Paul Di Biediger

Kasthuri - Vietor Avenu Rengan

Yukio East Paul Dirac D Suzuki

Chunlin East Paul Dirac Dr Tao

Ki-Byung East Paul Dirac Chai

Hamid East Paul Dirac Idmoumaz

Original Assignee

Univ Florida State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-22

Filing date

1994-03-21

Publication date

2003-06-10

1994-03-21 Application filed by Univ Florida State filed Critical Univ Florida State

2003-06-10 Application granted granted Critical

2003-06-10 Publication of DK0690867T3 publication Critical patent/DK0690867T3/da

Links

125000002541 furyl group Chemical group 0.000 title abstract 2
229940123237 Taxane Drugs 0.000 title 1
125000001544 thienyl group Chemical group 0.000 title 1
239000002671 adjuvant Substances 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)

DK94911675T 1993-03-22 1994-03-21 Taxaner med furyl- eller thienylsubstitueret sidekæde DK0690867T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US3485293A	1993-03-22	1993-03-22
US9471793A	1993-07-20	1993-07-20
PCT/US1994/003097 WO1994021651A1 (en)	1993-03-22	1994-03-21	Taxanes having furyl or thienyl substituted side-chain

Publications (1)

Publication Number	Publication Date
DK0690867T3 true DK0690867T3 (da)	2003-06-10

Family

ID=26711460

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
DK94911675T DK0690867T3 (da)	1993-03-22	1994-03-21	Taxaner med furyl- eller thienylsubstitueret sidekæde
DK02009839T DK1228759T3 (da)	1993-03-22	1994-03-21	Farmaceutiske præparater indeholdende en taxan med en furyl- eller thienylsubstitueret sidekæde
DK94910982T DK0689436T3 (da)	1993-03-22	1994-03-21	Texaner, der ikke har en oxogruppe ved C-9, og farmaceutiske præparater, der indeholder disse
DK02019282T DK1260223T3 (da)	1993-03-22	1994-03-21	Taxaner med furyl- eller thienylsubstituerede sidekæde
DK02009840T DK1227093T3 (da)	1993-03-22	1994-03-21	Beta-lactamer, der kan anvendes til fremstilling af taxaner med en furyl- eller thienylsubstitueret sidekæde

Family Applications After (4)

Application Number	Title	Priority Date	Filing Date
DK02009839T DK1228759T3 (da)	1993-03-22	1994-03-21	Farmaceutiske præparater indeholdende en taxan med en furyl- eller thienylsubstitueret sidekæde
DK94910982T DK0689436T3 (da)	1993-03-22	1994-03-21	Texaner, der ikke har en oxogruppe ved C-9, og farmaceutiske præparater, der indeholder disse
DK02019282T DK1260223T3 (da)	1993-03-22	1994-03-21	Taxaner med furyl- eller thienylsubstituerede sidekæde
DK02009840T DK1227093T3 (da)	1993-03-22	1994-03-21	Beta-lactamer, der kan anvendes til fremstilling af taxaner med en furyl- eller thienylsubstitueret sidekæde

Country Status (12)

Country	Link
EP (6)	EP0689436B1 (da)
JP (2)	JPH08508255A (da)
AT (5)	ATE295363T1 (da)
AU (3)	AU6367994A (da)
CA (2)	CA2158454C (da)
DE (5)	DE69434374T2 (da)
DK (5)	DK0690867T3 (da)
ES (5)	ES2211879T3 (da)
IL (4)	IL180090A0 (da)
PT (5)	PT1260223E (da)
SG (3)	SG68049A1 (da)
WO (2)	WO1994021250A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2712289B1 (fr) *	1993-11-08	1996-01-05	Rhone Poulenc Rorer Sa	Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
US6500858B2 (en)	1994-10-28	2002-12-31	The Research Foundation Of The State University Of New York	Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6458976B1 (en)	1994-10-28	2002-10-01	The Research Foundation Of State University Of New York	Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
WO1996013495A1 (en) *	1994-10-28	1996-05-09	The Research Foundation Of State University Of New York	Taxoid derivatives, their preparation and their use as antitumor agents
JP2964475B2 (ja)	1994-11-17	1999-10-18	田辺製薬株式会社	バッカチン誘導体及びその製法
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
KR100380875B1 (ko)	1995-04-28	2003-10-10	다이이찌 세이야꾸 가부시기가이샤	펜타사이클릭화합물
AU728057B2 (en) *	1995-09-13	2001-01-04	Florida State University	Radiosensitizing taxanes and their pharmaceutical preparations
FR2745814B1 (fr) *	1996-03-06	1998-04-03	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2746797B1 (fr) *	1996-03-27	1998-06-19	Centre Nat Rech Scient	Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation
AU724499B2 (en) *	1996-05-06	2000-09-21	Florida State University	1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
AU4768797A (en) *	1996-10-24	1998-05-15	Institute Armand-Frappier	A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
HK1047935A1 (zh) *	2000-02-02	2003-03-14	佛罗里达州立大学研究基金有限公司	作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷
CO5280224A1 (es) *	2000-02-02	2003-05-30	Univ Florida State Res Found	Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
RO121270B1 (ro) *	2000-02-02	2007-02-28	Florida State University Research Foundation, Inc.	Taxani substituiţi cu esteri în poziţia c10, ca agenţi antitumorali
EP1894921A3 (en) *	2003-09-25	2008-03-12	Tapestry Pharmaceuticals, Inc.	9, 10-Alpha, Alpha-Oh-Taxane analogs and methods for production thereof
EP1785416A3 (en)	2003-09-25	2007-05-30	Tapestry Pharmaceuticals, Inc.	9, 10-alpha, alpha-OH-Taxane Analogs and methods for production thereof
PA8625301A1 (es) *	2004-03-05	2006-06-02	Univ Florida State Res Found	Taxanos con sustituyente lactiloxilo en el c7
BRPI0611959A2 (pt) *	2005-06-10	2011-12-20	Univ Florida State Res Found	resolução de misturas enantioméricas de beta-lactamas
US11786504B2 (en)	2006-09-28	2023-10-17	Tapestry Pharmaceuticals, Inc.	Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en)	2007-03-28	2008-10-09	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en)	2006-11-06	2024-01-16	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
WO2008109360A1 (en)	2007-02-28	2008-09-12	Tapestry Pharmaceuticals, Inc	Taxane analogs for the treatment of brain cancer

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6075458A (ja) *	1983-06-17	1985-04-27	Osaka Soda Co Ltd	３，４−ジフエニル−１−（４−置換）アリ−ルメチルアゼチジン−２−オンの製法
US4751299A (en) *	1983-11-18	1988-06-14	Takeda Chemical Industries, Ltd.	Optically active β-lactams and method of their production
JPS61243079A (ja) *	1985-04-01	1986-10-29	Mect Corp	１−（アルコキシカルボニルアルキル）−４−（２−フリル）−３−置換−２−アゼチジノン及びその製造方法
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5006650A (en) *	1987-02-11	1991-04-09	The Upjohn Company	Novel N-1 substituted beta-lactams as antibiotics
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
AU637109B2 (en) *	1989-06-22	1993-05-20	Rijksuniversiteit Utrecht	Improved synthesis of beta-lactams using a metal compound
US5136060A (en) *	1989-11-14	1992-08-04	Florida State University	Method for preparation of taxol using an oxazinone
US5283253A (en) *	1991-09-23	1994-02-01	Florida State University	Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
JP3304088B2 (ja) *	1991-09-23	2002-07-22	フロリダ・ステイト・ユニバーシティ	１０−デスアセトキシタキソール誘導体
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) *	1991-09-23	1994-02-08	Florida State University	Butenyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) *	1991-09-23	1993-10-05	Florida State University	Certain substituted taxanes and pharmaceutical compositions containing them
CA2254273C (en) *	1991-09-23	2003-03-25	Florida State University	Preparation of substituted isoserine esters using metal alkoxides and .beta.-lactams
US5243045A (en) *	1991-09-23	1993-09-07	Florida State University	Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides
FR2688518B1 (fr) *	1992-03-13	1994-05-06	Rhone Poulenc Rorer Sa	Procede de preparation de derives du taxane.
DE69325454T2 (de) *	1992-04-17	2000-01-20	Abbott Laboratories, Abbott Park	Taxol-derivate
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.

1994
- 1994-03-21 DK DK94911675T patent/DK0690867T3/da active
- 1994-03-21 EP EP94910982A patent/EP0689436B1/en not_active Expired - Lifetime
- 1994-03-21 PT PT02019282T patent/PT1260223E/pt unknown
- 1994-03-21 WO PCT/US1994/003053 patent/WO1994021250A1/en not_active Ceased
- 1994-03-21 ES ES94910982T patent/ES2211879T3/es not_active Expired - Lifetime
- 1994-03-21 CA CA002158454A patent/CA2158454C/en not_active Expired - Fee Related
- 1994-03-21 CA CA002158862A patent/CA2158862C/en not_active Expired - Fee Related
- 1994-03-21 AT AT02009840T patent/ATE295363T1/de not_active IP Right Cessation
- 1994-03-21 ES ES02019282T patent/ES2242807T3/es not_active Expired - Lifetime
- 1994-03-21 DE DE69434374T patent/DE69434374T2/de not_active Expired - Fee Related
- 1994-03-21 ES ES94911675T patent/ES2193155T3/es not_active Expired - Lifetime
- 1994-03-21 JP JP6521330A patent/JPH08508255A/ja active Pending
- 1994-03-21 EP EP03027078A patent/EP1398028A3/en not_active Withdrawn
- 1994-03-21 DK DK02009839T patent/DK1228759T3/da active
- 1994-03-21 PT PT94910982T patent/PT689436E/pt unknown
- 1994-03-21 ES ES02009839T patent/ES2232694T3/es not_active Expired - Lifetime
- 1994-03-21 SG SG9801036A patent/SG68049A1/en unknown
- 1994-03-21 WO PCT/US1994/003097 patent/WO1994021651A1/en not_active Ceased
- 1994-03-21 AT AT02019282T patent/ATE295164T1/de not_active IP Right Cessation
- 1994-03-21 DE DE69434373T patent/DE69434373T2/de not_active Expired - Fee Related
- 1994-03-21 DE DE69434190T patent/DE69434190T2/de not_active Expired - Fee Related
- 1994-03-21 IL IL180090A patent/IL180090A0/en unknown
- 1994-03-21 AU AU63679/94A patent/AU6367994A/en not_active Abandoned
- 1994-03-21 SG SG1996006328A patent/SG73401A1/en unknown
- 1994-03-21 AT AT02009839T patent/ATE284689T1/de not_active IP Right Cessation
- 1994-03-21 AT AT94910982T patent/ATE254914T1/de not_active IP Right Cessation
- 1994-03-21 PT PT02009840T patent/PT1227093E/pt unknown
- 1994-03-21 SG SG9904638A patent/SG89298A1/en unknown
- 1994-03-21 PT PT94911675T patent/PT690867E/pt unknown
- 1994-03-21 DK DK94910982T patent/DK0689436T3/da active
- 1994-03-21 PT PT02009839T patent/PT1228759E/pt unknown
- 1994-03-21 EP EP02019282A patent/EP1260223B1/en not_active Expired - Lifetime
- 1994-03-21 DE DE69433355T patent/DE69433355T2/de not_active Expired - Fee Related
- 1994-03-21 DK DK02019282T patent/DK1260223T3/da active
- 1994-03-21 DK DK02009840T patent/DK1227093T3/da active
- 1994-03-21 JP JP6521307A patent/JPH08508469A/ja active Pending
- 1994-03-21 AT AT94911675T patent/ATE232871T1/de not_active IP Right Cessation
- 1994-03-21 IL IL10905094A patent/IL109050A0/xx unknown
- 1994-03-21 EP EP94911675A patent/EP0690867B1/en not_active Expired - Lifetime
- 1994-03-21 EP EP02009840A patent/EP1227093B1/en not_active Expired - Lifetime
- 1994-03-21 IL IL109052A patent/IL109052A/en not_active IP Right Cessation
- 1994-03-21 DE DE69432141T patent/DE69432141T2/de not_active Expired - Fee Related
- 1994-03-21 AU AU64138/94A patent/AU691804B2/en not_active Ceased
- 1994-03-21 ES ES02009840T patent/ES2241923T3/es not_active Expired - Lifetime
- 1994-03-21 EP EP02009839A patent/EP1228759B1/en not_active Expired - Lifetime
1998
- 1998-08-03 AU AU78636/98A patent/AU714180B2/en not_active Ceased
2008
- 2008-04-17 IL IL190945A patent/IL190945A0/en unknown

Also Published As

Publication number	Publication date
EP0690867A1 (en)	1996-01-10
CA2158454A1 (en)	1994-09-29
CA2158862A1 (en)	1994-09-29
DE69434374T2 (de)	2005-11-24
IL180090A0 (en)	2007-05-15
DK1260223T3 (da)	2005-09-05
SG89298A1 (en)	2002-06-18
EP1227093A3 (en)	2002-08-07
ATE232871T1 (de)	2003-03-15
DE69433355D1 (de)	2004-01-08
WO1994021651A1 (en)	1994-09-29
EP1228759B1 (en)	2004-12-15
EP1228759A2 (en)	2002-08-07
EP1227093B1 (en)	2005-05-11
EP1398028A3 (en)	2004-03-24
ES2193155T3 (es)	2003-11-01
IL190945A0 (en)	2009-02-11
IL109050A0 (en)	1994-06-24
DK0689436T3 (da)	2004-03-29
DE69432141D1 (de)	2003-03-27
ES2241923T3 (es)	2005-11-01
EP0689436A4 (da)	1996-02-07
WO1994021250A1 (en)	1994-09-29
DE69432141T2 (de)	2003-07-31
EP1398028A2 (en)	2004-03-17
IL109052A0 (en)	1994-06-24
DE69434373T2 (de)	2006-03-09
PT1260223E (pt)	2005-09-30
DE69433355T2 (de)	2004-05-27
AU714180B2 (en)	1999-12-23
PT1227093E (pt)	2005-09-30
EP1227093A2 (en)	2002-07-31
EP0690867B1 (en)	2003-02-19
PT689436E (pt)	2004-04-30
CA2158454C (en)	2006-05-23
SG73401A1 (en)	2000-06-20
SG68049A1 (en)	2001-08-21
ATE284689T1 (de)	2005-01-15
ATE295363T1 (de)	2005-05-15
AU6367994A (en)	1994-10-11
JPH08508469A (ja)	1996-09-10
EP0690867A4 (en)	1996-03-20
AU7863698A (en)	1998-10-01
PT1228759E (pt)	2005-04-29
EP0689436B1 (en)	2003-11-26
ES2232694T3 (es)	2005-06-01
DE69434373D1 (de)	2005-06-16
AU691804B2 (en)	1998-05-28
ES2211879T3 (es)	2004-07-16
EP1260223B1 (en)	2005-05-11
JPH08508255A (ja)	1996-09-03
EP1260223A1 (en)	2002-11-27
ATE254914T1 (de)	2003-12-15
PT690867E (pt)	2003-06-30
DK1227093T3 (da)	2005-08-29
EP0689436A1 (en)	1996-01-03
IL109052A (en)	2009-07-20
DE69434190D1 (de)	2005-01-20
CA2158862C (en)	2006-10-10
ES2242807T3 (es)	2005-11-16
EP1228759A3 (en)	2002-09-25
DK1228759T3 (da)	2005-04-18
DE69434190T2 (de)	2005-05-25
DE69434374D1 (de)	2005-06-16
AU6413894A (en)	1994-10-11
ATE295164T1 (de)	2005-05-15

Publication	Publication Date	Title
IL190945A0 (en)	2009-02-11	??- lactam, compounds
ES2126919T3 (es)	1999-04-01	Taxanos semisinteticos con actividad antitumoral.
ATE442129T1 (de)	2009-09-15	Camptothecin-carboxylat-formulierungen
PL344183A1 (en)	2001-10-08	Metabolites of ecteinascidin 743
CO5190674A1 (es)	2002-08-29	Tratamiento de desordenes neuroticos desordenes neuroticos
ATE208774T1 (de)	2001-11-15	Arylsulfonylimidazolon-derivate als antitumormittel
DK1423109T3 (da)	2005-12-27	Præparater som omfatter pektin og ascorbinsyre
ATE350064T1 (de)	2007-01-15	Pharmazeutische zusammensetzungen von rapamycines
UY27628A1 (es)	2003-08-29	"2'-halo -3',5'-dialcoxi-fen-1'il-2-imidazolidinas y su uso como un fármaco"
ATE401325T1 (de)	2008-08-15	C10-carbamoyloxysubstituierte taxane als antitumormittel
ATE392422T1 (de)	2008-05-15	C7-carbamoyloxysubstituierte taxane als antitumormittel
MXPA04006675A (es)	2004-10-04	Composicion farmaceutica que comprende glitazona y acido 4-oxobutanoico y uso de la misma para tratamiento de diabetes.
ECSP972024A (es)	1999-01-12	Mezclas de dos componentes fungicidas basadas en metalaxilo