ES2143301T3 - Composiciones biocompatibles. - Google Patents

Composiciones biocompatibles.

Info

Publication number
ES2143301T3
ES2143301T3 ES97913308T ES97913308T ES2143301T3 ES 2143301 T3 ES2143301 T3 ES 2143301T3 ES 97913308 T ES97913308 T ES 97913308T ES 97913308 T ES97913308 T ES 97913308T ES 2143301 T3 ES2143301 T3 ES 2143301T3
Authority
ES
Spain
Prior art keywords
heparin
polymer
methacrylate
monomer
metacriloiloxietil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97913308T
Other languages
English (en)
Inventor
Manuchehr Porssa
Paul Mathew Mcneillis
Richard Neil Templar Freeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Vascular Devices Ltd
Original Assignee
Biocompatibles Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Ltd filed Critical Biocompatibles Ltd
Application granted granted Critical
Publication of ES2143301T3 publication Critical patent/ES2143301T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)

Abstract

SE FORMA UN POLIMERO A PARTIR DE MONOMEROS INCLUYENDO UN MONOMERO CON UN ION ANFOTERO, UN MONOMERO CATIONICO Y UN TERMONOMERO HIDROFOBICO. EL POLIMERO PUEDE SER RETICULABLE. EL POLIMERO PUEDE SER APLICADO SOBRE UNA SUPERFICIE A PARTIR DE UNA COMPOSICION LIQUIDA DE RECUBRIMIENTO SEGUIDO DE PONER EN CONTACTO LA SUPERFICIE RECUBIERTA CON HEPARINA. LOS SUSTRATOS DOBLEMENTE RECUBIERTOS PRESENTAN UNA ACTIVIDAD MEJORADA DE LA HEPARINA EN PERIODOS EXTENSOS SI SE COMPARAN CON LAS SUPERFICIES HEPARINIZADAS QUE ESTAN COMERCIALMENTE DISPONIBLES. SE PUEDEN UTILIZAR OTROS MUCOPOLISACARIDOS CARGADOS ANIONICAMENTE. LOS POLIMEROS TAMBIEN PUEDEN ELIMINAR HEPARINA A PARTIR DE SANGRE TRATADA PARA EVITAR LA UTILIZACION DE INHIBIDORES POTENCIALMENTE TOXICOS DE LA HEPARINA. PREFERIBLEMENTE SE FORMA EL TERPOLIMERO A PARTIR DE LA SAL INTERNA DE 2 METACRILOILOXIETIL 2 (TRIMETILAMONIO)FOSFATO, METACRILATO DE COLINA Y METACRILATO DE N DODECILO.
ES97913308T 1996-11-20 1997-11-20 Composiciones biocompatibles. Expired - Lifetime ES2143301T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9624130.2A GB9624130D0 (en) 1996-11-20 1996-11-20 Biocompatible compositions

Publications (1)

Publication Number Publication Date
ES2143301T3 true ES2143301T3 (es) 2000-05-01

Family

ID=10803229

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97913308T Expired - Lifetime ES2143301T3 (es) 1996-11-20 1997-11-20 Composiciones biocompatibles.

Country Status (11)

Country Link
US (2) US6432314B1 (es)
EP (2) EP0866815B1 (es)
JP (2) JP4051414B2 (es)
AT (2) ATE215971T1 (es)
AU (3) AU5061198A (es)
CA (1) CA2271132C (es)
DE (2) DE69711913T2 (es)
ES (1) ES2143301T3 (es)
GB (1) GB9624130D0 (es)
WO (3) WO1998022516A1 (es)
ZA (3) ZA9710466B (es)

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GB9522332D0 (en) 1995-11-01 1996-01-03 Biocompatibles Ltd Braided stent
US6258371B1 (en) * 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
US6706260B1 (en) 1998-07-07 2004-03-16 Nof Corporation Wound-covering preparation, wound-covering material, and method of wound healing
EP1141054B1 (en) * 1998-12-11 2004-02-25 Biocompatibles UK Limited Crosslinked polymers and refractive devices formed therefrom
ATE245667T1 (de) * 1999-05-27 2003-08-15 Biocompatibles Uk Ltd Lösungen von polymeren
AU4941400A (en) * 1999-05-27 2001-01-22 Biocompatibles Limited Local drug delivery
WO2001052915A1 (en) * 2000-01-24 2001-07-26 Biocompatibles Limited Coated implants
DE60129148T2 (de) 2000-10-06 2008-02-28 Biocompatibles Uk Ltd., Farnham Zwitterionische polymere
GB0100761D0 (en) 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
US8252531B2 (en) 2001-04-26 2012-08-28 Nof Corporation Nonspecific hybridization inhibitors, clinical examination reagents and clinical examination method
US6844028B2 (en) 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
DE60334779D1 (en) 2002-03-07 2010-12-16 Biocompatibles Uk Ltd Mit nucleinsäure complexierte block-copolymere
WO2005027991A1 (en) * 2003-09-19 2005-03-31 Cambridge University Technical Services Ltd Orthopaedic devices
US20050208093A1 (en) * 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions
US7892284B2 (en) * 2005-02-28 2011-02-22 Hoya Corporation Intraocular lens and process for producing the same
WO2008006912A2 (en) * 2006-07-14 2008-01-17 Biocompatibles Uk Limited Polymer
JP5557373B2 (ja) 2006-11-21 2014-07-23 アボット ラボラトリーズ 薬剤溶出性コーティングにおけるテトラフルオロエチレン、ヘキサフルオロプロピレン、及びフッ化ビニリデンのターポリマーの使用
US20080286332A1 (en) 2007-05-14 2008-11-20 Pacetti Stephen D Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties
JP5019524B2 (ja) * 2007-06-01 2012-09-05 国立大学法人 東京大学 新規ポリ（メタ）アクリレート共重合体ならびに小胞体及びゴルジ体への送達方法
WO2010065958A1 (en) * 2008-12-05 2010-06-10 Semprus Biosciences Corp. Layered non-fouling, antimicrobial, antithrombogenic coatings
EP2579908A4 (en) 2010-06-09 2016-03-23 Arrow Int Inc ANTITHROMBOGENIC, ANTIMICROBIAL AND ANTIFOULING COMPOSITIONS WITH GRAFT FORM
EP2579904A4 (en) 2010-06-09 2015-12-02 Semprus Biosciences Corp NON-CROPPED ANTIMICROBIAL ANTITHROMBOGENIC GRAFT COMPOSITIONS
WO2012162789A1 (en) * 2011-06-01 2012-12-06 University Of British Columbia Polymers for reversing heparin-based anticoagulation
MX2014007202A (es) 2011-12-14 2015-03-09 Semprus Biosciences Corp Lentes de contacto modificadas en la superficie.
EP2791213A4 (en) 2011-12-14 2015-10-28 Semprus Biosciences Corp SILICONE HYDROGEN CONTACT LENS MODIFIED WITH LANTHANIDE OR TRANSITION METAL OXIDANTS
EP2791215A4 (en) 2011-12-14 2015-07-22 Semprus Biosciences Corp SURGICAL PROCESS FOR SURFACE MODIFICATION OF CONTACT LENSES
WO2013090813A1 (en) 2011-12-14 2013-06-20 Semprus Biosciences Corp. Redox processes for contact lens modification
AU2012351991B2 (en) 2011-12-14 2015-09-24 Semprus Biosciences Corp. Multistep UV process to create surface modified contact lenses
CN103193927B (zh) * 2013-04-27 2016-01-20 南京构友生物材料有限公司 可键合的血液友好聚合物及其制法与用途
CN105283521B (zh) * 2013-05-27 2018-05-11 Jsr株式会社 由无机材料构成的表面用的表面处理剂、表面被改性的器具和装置、该器具和装置的制造方法
US10384167B2 (en) 2013-11-21 2019-08-20 Oasys Water LLC Systems and methods for improving performance of osmotically driven membrane systems
WO2016052618A1 (ja) 2014-10-02 2016-04-07 旭化成メディカル株式会社 生体由来液処理フィルター及びフィルターデバイス
KR20180076552A (ko) * 2016-12-28 2018-07-06 주식회사 엘지화학 친수성 코팅 조성물
WO2020231797A1 (en) * 2019-05-10 2020-11-19 Trustees Of Tufts College Zwitterionic charged copolymer membranes
MX2023013903A (es) 2021-05-27 2023-12-11 Metro Int Biotech Llc Solidos cristalinos de mononucleotido de acido nicotinico y esteres de estos y metodos de elaboracion y uso.
CN113476661B (zh) * 2021-07-05 2022-08-05 中国医学科学院生物医学工程研究所 一种三层结构复合型自愈合人造血管及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE306597B (es) 1964-12-17 1968-12-02 Incentive Ab
US3861948A (en) * 1972-05-22 1975-01-21 Kendall & Co Pressure sensitive adhesive tape
ZA733409B (en) * 1972-05-31 1974-05-29 Commw Scient Ind Res Org A process of manufacturing ion-exchange resins
SE456347B (sv) 1982-02-09 1988-09-26 Ird Biomaterial Ab Ytmodifierat fast substrat samt forfarande for framstellning derav
SE8200751L (sv) 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
US4517241A (en) * 1982-12-02 1985-05-14 Alpert Andrew J Chromatographic support material
US4704324A (en) * 1985-04-03 1987-11-03 The Dow Chemical Company Semi-permeable membranes prepared via reaction of cationic groups with nucleophilic groups
US4865870A (en) 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
JP2890316B2 (ja) * 1989-07-07 1999-05-10 科学技術振興事業団 生体適合性医療デバイス用材料
GB9023498D0 (en) 1990-10-29 1990-12-12 Biocompatibles Ltd Soft contact lens material
US5075399A (en) * 1990-11-15 1991-12-24 Phillips Petroleum Company Superabsorbent crosslinked ampholytic ion pair copolymers
RU2167886C2 (ru) * 1991-07-05 2001-05-27 Биокомпэтиблз Лимитед. Полимер, способ получения полимера, поверхность с покрытием, способ покрытия поверхности
AU3592693A (en) * 1992-01-21 1993-08-03 University Of Utah, The Method and composition for heparin binding using polyaminocations covalently immobilised on polymeric surfaces with polyethylene oxide spacers
ES2157924T3 (es) 1992-04-24 2001-09-01 Biocompatibles Ltd Procedimiento para la reduccion de la adherencia de microorganismos.
US5342621A (en) 1992-09-15 1994-08-30 Advanced Cardiovascular Systems, Inc. Antithrombogenic surface
GB9226791D0 (en) * 1992-12-23 1993-02-17 Biocompatibles Ltd New materials
JPH07184989A (ja) 1993-12-28 1995-07-25 Kuraray Co Ltd 血液適合性医療用高分子材料および医療材料
JPH07285831A (ja) * 1994-04-18 1995-10-31 Mitsubishi Chem Corp 毛髪化粧料組成物

Also Published As

Publication number Publication date
EP0866815B1 (en) 2000-02-23
JP2001504877A (ja) 2001-04-10
DE69701319D1 (de) 2000-03-30
WO1998022516A1 (en) 1998-05-28
WO1998022517A1 (en) 1998-05-28
JP2001506915A (ja) 2001-05-29
DE69711913T2 (de) 2002-10-10
EP0939779B1 (en) 2002-04-10
DE69701319T2 (de) 2000-07-13
EP0866815A3 (en) 1998-10-21
AU5061198A (en) 1998-06-10
CA2271132C (en) 2007-04-17
EP0866815A2 (en) 1998-09-30
CA2271132A1 (en) 1998-05-28
ATE189899T1 (de) 2000-03-15
JP4051414B2 (ja) 2008-02-27
EP0939779A1 (en) 1999-09-08
AU5061098A (en) 1998-06-10
DE69711913D1 (de) 2002-05-16
WO1998022162A1 (en) 1998-05-28
ZA9710466B (en) 1998-11-20
ATE215971T1 (de) 2002-04-15
US6432314B1 (en) 2002-08-13
AU728887B2 (en) 2001-01-18
ZA9710467B (en) 1998-11-20
AU5060898A (en) 1998-06-10
GB9624130D0 (en) 1997-01-08
JP4295359B2 (ja) 2009-07-15
ZA9710468B (en) 1998-11-20
US6251964B1 (en) 2001-06-26

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