ES2145881T3 - Peptidos derivados de trifluoro-metil-cetonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents
Peptidos derivados de trifluoro-metil-cetonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2145881T3 ES2145881T3 ES95401043T ES95401043T ES2145881T3 ES 2145881 T3 ES2145881 T3 ES 2145881T3 ES 95401043 T ES95401043 T ES 95401043T ES 95401043 T ES95401043 T ES 95401043T ES 2145881 T3 ES2145881 T3 ES 2145881T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- group
- alkilo
- trifluoro
- ketones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPUESTO DE FORMULA (I) EN LA QUE: R 1 REPRESENTA UN GRUPO ALKILO O CICLOALKILO C{SUB,3-7), R{SUB,2} REPRESENTA UN GRUPO ALKILO O CICLOALKILO C{SUB,3-7}, R{SUB,3} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALKILO, R{SUB,4} REPRESENTA UN ATOMO DE HALOGENO O UN GRUPO ALKILO O ALCOXI, R{SUB,5} REPRESENTA UN GRUPO ALKILO, X, Y REPRESENTA UN GRUPO ALKILO, X, Y DIFERENTE REPRESENTAN CO O SO {SUB,2}, N REPRESENTA 1,2, O 3, P REPRESENTA 0 O 1, Z REPRESENTA UN ATOMO DE AZUFRE O DE OXIGENO, A REPRESENTA CUALQUIERA DE LOS SIGUIENTES GRUPOS, EN EL QUE: A{SUB, 1} REPRESENTA CON EL ATOMO DE NITROGENO Y E DE CARBONO AL QUE ESTA SUJETO UN HETEROCICLICO MONO O BICICLICO, . O EN EL QUE R{SUB,6} REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALKILO, CICLOALKILO O UN GRUPO INDAN-2-ILO. R{SUB,7} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALKILO, COMPUESTOS DE FORMULA (I) QUE COMPRENDEN LOS HIDRATOS DE LA FUNCION CETONA COCF{SUB,3} CORRESPONDIENTES, SUS ENANTIOMEROS, DIASTEREOISOMEROS Y EPIMEROS ASI COMO SUS SALES DE ADICION A UNA BASE FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9405494A FR2719589B1 (fr) | 1994-05-05 | 1994-05-05 | Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2145881T3 true ES2145881T3 (es) | 2000-07-16 |
Family
ID=9462887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95401043T Expired - Lifetime ES2145881T3 (es) | 1994-05-05 | 1995-05-05 | Peptidos derivados de trifluoro-metil-cetonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5567804A (es) |
| EP (1) | EP0680972B1 (es) |
| JP (1) | JP2887271B2 (es) |
| CN (1) | CN1058021C (es) |
| AT (1) | ATE190317T1 (es) |
| AU (1) | AU683147B2 (es) |
| CA (1) | CA2148650A1 (es) |
| DE (1) | DE69515361T2 (es) |
| DK (1) | DK0680972T3 (es) |
| ES (1) | ES2145881T3 (es) |
| FI (1) | FI952111A7 (es) |
| FR (1) | FR2719589B1 (es) |
| GR (1) | GR3033511T3 (es) |
| NO (1) | NO951746L (es) |
| NZ (1) | NZ272066A (es) |
| PT (1) | PT680972E (es) |
| ZA (1) | ZA953639B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999043352A1 (en) * | 1998-02-24 | 1999-09-02 | Fujisawa Pharmaceutical Co., Ltd. | Preventives/remedies for skin aging |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| US5296591A (en) * | 1990-12-31 | 1994-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Trifluoromethylketone derivatives, processes for preparation thereof and use thereof |
| FR2694295B1 (fr) * | 1992-07-28 | 1994-09-02 | Adir | Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent. |
-
1994
- 1994-05-05 FR FR9405494A patent/FR2719589B1/fr not_active Expired - Lifetime
-
1995
- 1995-05-03 AU AU17862/95A patent/AU683147B2/en not_active Ceased
- 1995-05-03 FI FI952111A patent/FI952111A7/fi unknown
- 1995-05-04 CN CN95104794A patent/CN1058021C/zh not_active Expired - Fee Related
- 1995-05-04 CA CA002148650A patent/CA2148650A1/fr not_active Abandoned
- 1995-05-04 NZ NZ272066A patent/NZ272066A/en unknown
- 1995-05-04 NO NO951746A patent/NO951746L/no not_active Application Discontinuation
- 1995-05-05 DE DE69515361T patent/DE69515361T2/de not_active Expired - Fee Related
- 1995-05-05 PT PT95401043T patent/PT680972E/pt unknown
- 1995-05-05 AT AT95401043T patent/ATE190317T1/de not_active IP Right Cessation
- 1995-05-05 US US08/437,433 patent/US5567804A/en not_active Expired - Fee Related
- 1995-05-05 DK DK95401043T patent/DK0680972T3/da active
- 1995-05-05 ES ES95401043T patent/ES2145881T3/es not_active Expired - Lifetime
- 1995-05-05 EP EP95401043A patent/EP0680972B1/fr not_active Expired - Lifetime
- 1995-05-05 ZA ZA953639A patent/ZA953639B/xx unknown
- 1995-05-08 JP JP7109361A patent/JP2887271B2/ja not_active Expired - Lifetime
-
2000
- 2000-05-25 GR GR20000401202T patent/GR3033511T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA953639B (en) | 1996-01-03 |
| NO951746L (no) | 1995-11-06 |
| FI952111A0 (fi) | 1995-05-03 |
| DE69515361T2 (de) | 2000-10-19 |
| NO951746D0 (no) | 1995-05-04 |
| CN1116627A (zh) | 1996-02-14 |
| JP2887271B2 (ja) | 1999-04-26 |
| US5567804A (en) | 1996-10-22 |
| PT680972E (pt) | 2000-06-30 |
| CN1058021C (zh) | 2000-11-01 |
| FR2719589B1 (fr) | 1996-06-14 |
| AU683147B2 (en) | 1997-10-30 |
| JPH07309892A (ja) | 1995-11-28 |
| DE69515361D1 (de) | 2000-04-13 |
| AU1786295A (en) | 1995-11-16 |
| DK0680972T3 (da) | 2000-07-31 |
| FI952111A7 (fi) | 1995-11-06 |
| EP0680972A1 (fr) | 1995-11-08 |
| CA2148650A1 (fr) | 1995-11-06 |
| NZ272066A (en) | 1997-02-24 |
| FR2719589A1 (fr) | 1995-11-10 |
| ATE190317T1 (de) | 2000-03-15 |
| GR3033511T3 (en) | 2000-09-29 |
| EP0680972B1 (fr) | 2000-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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