ES2146580T3 - Agente tensioactivo sintetico para los pulmones. - Google Patents

Agente tensioactivo sintetico para los pulmones.

Info

Publication number
ES2146580T3
ES2146580T3 ES91920210T ES91920210T ES2146580T3 ES 2146580 T3 ES2146580 T3 ES 2146580T3 ES 91920210 T ES91920210 T ES 91920210T ES 91920210 T ES91920210 T ES 91920210T ES 2146580 T3 ES2146580 T3 ES 2146580T3
Authority
ES
Spain
Prior art keywords
lung surfactant
temperature
composition
phosphatidylcholine
lamellar form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91920210T
Other languages
English (en)
Inventor
Andrew S Janoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ES2146580T3 publication Critical patent/ES2146580T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA COMPOSICION ACTIVA SUPERFICIALMENTE SINTETICA PARA PULMON Y PROCESO PARA EL DEPOSITO DE UNA MONOCAPA DE COLINA FOSFATIDIL DE ACCION SUPERFICIAL EN LOS ALVEOLOS DEL PULMON DE UN MAMIFERO. LA COMPOSICION COMPRENDE UN AGENTE ACTIVO SUPERFICIALMENTE EN EL PULMON A BASE DE COLINA FOSFATIDIL, UNA AMINA FOSFATILETANOL, Y COLESTEROL EN PROPORCIONES TALES QUE LA COMPOSICION ES EN FORMA LAMINAR O POR DEBAJO DE LA PRIMERA TEMPERATURA Y EN FORMA NO LAMINAR EN UNA SEGUNDA TEMPERATURA QUE ES MAS ALTA QUE LA PRIMERA. EL AGENTE ACTIVO SUPERFICIAL DE PULMON COLINA FOSFATIDIL REFERIDA PARA SU USO EN ESTA INVENCION ES COLINA FOSFATIDIL (DPPC) DIPALMITOIL, QUE ES CONOCIDA POR MAYOR CONSTITUYENTE LIPIDO DE AGENTE SUPERFICIAL ACTIVO DE PULMON NATURAL MAMIFERO, Y UNA AMINA FOSFATIDILETANOL REFERIDA QUE ES DIOLEOIL AMINA FOSFATIDILETANOL (DOPE). EN UNA INCORPORACION PARTICULAR, LA COMPOSICION ESTA EN FORMA LAMINAR A UNA TEMPERATURA APROXIMADAMENTE A LA DE LA HABITACION (25 MINAR A UNA TEMPERATURA EN LA ZONA DEAPROXIMADAMENTE 30 HASTA 37 EN CONDICIONES NORMALES (37 INCLUIR UNO O MAS PEPTIDOS TERAPEUTICOS U OTROS AGENTES FARMACEUTICOS. EL AGENTE ACTIVO SUPERFICIAL SINTETICO DE PULMON PUEDE SER UTILIZADO EN EL TRATAMIENTO DE MAMIFEROS EN SINDROMES DE AGOTAMIENTO RESPIRATORIO ORIGINADO POR UNA INSUFICIENCIA DEL AGENTE SUPERFICIAL ACTIVO DE PULMON NATURAL.
ES91920210T 1990-10-17 1991-10-17 Agente tensioactivo sintetico para los pulmones. Expired - Lifetime ES2146580T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59949390A 1990-10-17 1990-10-17

Publications (1)

Publication Number Publication Date
ES2146580T3 true ES2146580T3 (es) 2000-08-16

Family

ID=24399851

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91920210T Expired - Lifetime ES2146580T3 (es) 1990-10-17 1991-10-17 Agente tensioactivo sintetico para los pulmones.

Country Status (11)

Country Link
EP (1) EP0553272B1 (es)
JP (1) JP3171445B2 (es)
KR (1) KR0181309B1 (es)
AT (1) ATE192930T1 (es)
AU (1) AU650303B2 (es)
CA (1) CA2093133C (es)
DE (1) DE69132211T2 (es)
DK (1) DK0553272T3 (es)
ES (1) ES2146580T3 (es)
GR (1) GR3034211T3 (es)
WO (1) WO1992006703A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
PT877602E (pt) 1996-01-24 2002-07-31 Byk Gulden Lomberg Chem Fab Processo para o fabrico de composicoes de surfactantes pulmonares em po
US6120795A (en) * 1996-03-27 2000-09-19 Ortho Pharmaceutical Corp. Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
AU2003213402A1 (en) * 2002-03-18 2003-09-29 Yamanouchi Pharmaceutical Co., Ltd. Powdery medicinal compositions for inhalation and process for producing the same
EA201300255A1 (ru) 2010-08-23 2013-06-28 Такеда Гмбх Увлажненные частицы, содержащие терапевтически активное вещество
AU2015226287B2 (en) 2014-03-05 2019-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Humidifier for humidifying an aerosol
AU2015226289B8 (en) 2014-03-05 2019-10-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for providing a constant amount of aerosol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795920A (en) * 1980-12-04 1982-06-15 Teijin Ltd Remedy for respiratory disease
US4915951A (en) * 1987-12-03 1990-04-10 California Institute Of Technology Cryoprotective reagent

Also Published As

Publication number Publication date
AU650303B2 (en) 1994-06-16
DK0553272T3 (da) 2000-09-04
EP0553272B1 (en) 2000-05-17
CA2093133A1 (en) 1992-04-18
JPH06502427A (ja) 1994-03-17
EP0553272A1 (en) 1993-08-04
JP3171445B2 (ja) 2001-05-28
DE69132211T2 (de) 2000-11-23
CA2093133C (en) 1999-03-30
GR3034211T3 (en) 2000-12-29
EP0553272A4 (en) 1994-09-07
KR0181309B1 (ko) 1999-03-20
AU8929191A (en) 1992-05-20
ATE192930T1 (de) 2000-06-15
WO1992006703A1 (en) 1992-04-30
DE69132211D1 (de) 2000-06-21

Similar Documents

Publication Publication Date Title
US5614216A (en) Synthetic lung surfactant
Taeusch et al. Characterization of bovine surfactant for infants with respiratory distress syndrome
CA2096537C (en) Method of administering dipalmitoylphosphatidylcholine dispersions
JP5065047B2 (ja) 肺表面活性物質の配合物
KR101516443B1 (ko) 개선된 특성을 가지는 재구성된 계면활성제
AU2007297691B2 (en) Pulmonary surfactant formulations and methods for promoting mucus clearance
DE3378353D1 (en) Lung surfactant
ES2004856T3 (es) Agente tensioactivo pulmonar natural, procedimiento de preparacion y composiciones farmaceuticas.
EP0092121B1 (en) Methods and compositions for treating gastro-intestinal ulcer diesease
ES2146580T3 (es) Agente tensioactivo sintetico para los pulmones.
EP0528034B1 (en) Remedy for asthma
PT1841458E (pt) Regime de tratamento com surfactante para tratar ou prevenir displasia broncopulmonar
Obladen et al. Surfactant substitution
EP2538960B1 (en) Surfactant compositions comprising polypeptide complexes
UA26313A (uk) Засіб для замісhої терапії захворюваhь дихальhих шляхів, переважhо при сиhдромі задухи
DeAngelis et al. Metabolism of synthetic surfactants
McLean et al. Biomimetic pulmonary surfactants
ES2092969A1 (es) Surfactante pulmonar natural de origen porcino.
US20130323318A1 (en) Protein free surfactant composition for pulmonary diseases and a process for preparing the same
KR970074792A (ko) 합성 펩타이드를 이용한 폐 계면활성제
Wuthe et al. Mechanical properties of fetal minipig lungs after substitution of surfactant with fluorocarbon and dipalmitoylphosphatidylcholine
JP2001089391A (ja) Ｉｒｄｓおよびａｌｉの治療用の製薬的組成物、その使用、およびそれを有する製品
IT8948659A1 (it) Preparazioni farmaceutiche per uso topico a base di liposomi di eparina, eparinoidi e frazioni, lmw eparina e vlmw eparina dotate, di elevato assorbimento e controllata clearance epidermica.
ITMI960665A1 (it) Uso della lisofosfatidilcolina nel campo della riproduzione umana

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 553272

Country of ref document: ES