ES2146580T3 - Agente tensioactivo sintetico para los pulmones. - Google Patents

Agente tensioactivo sintetico para los pulmones.

Info

Publication number
ES2146580T3
ES2146580T3 ES91920210T ES91920210T ES2146580T3 ES 2146580 T3 ES2146580 T3 ES 2146580T3 ES 91920210 T ES91920210 T ES 91920210T ES 91920210 T ES91920210 T ES 91920210T ES 2146580 T3 ES2146580 T3 ES 2146580T3
Authority
ES
Spain
Prior art keywords
lung surfactant
temperature
composition
phosphatidylcholine
lamellar form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91920210T
Other languages
English (en)
Inventor
Andrew S Janoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ES2146580T3 publication Critical patent/ES2146580T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA COMPOSICION ACTIVA SUPERFICIALMENTE SINTETICA PARA PULMON Y PROCESO PARA EL DEPOSITO DE UNA MONOCAPA DE COLINA FOSFATIDIL DE ACCION SUPERFICIAL EN LOS ALVEOLOS DEL PULMON DE UN MAMIFERO. LA COMPOSICION COMPRENDE UN AGENTE ACTIVO SUPERFICIALMENTE EN EL PULMON A BASE DE COLINA FOSFATIDIL, UNA AMINA FOSFATILETANOL, Y COLESTEROL EN PROPORCIONES TALES QUE LA COMPOSICION ES EN FORMA LAMINAR O POR DEBAJO DE LA PRIMERA TEMPERATURA Y EN FORMA NO LAMINAR EN UNA SEGUNDA TEMPERATURA QUE ES MAS ALTA QUE LA PRIMERA. EL AGENTE ACTIVO SUPERFICIAL DE PULMON COLINA FOSFATIDIL REFERIDA PARA SU USO EN ESTA INVENCION ES COLINA FOSFATIDIL (DPPC) DIPALMITOIL, QUE ES CONOCIDA POR MAYOR CONSTITUYENTE LIPIDO DE AGENTE SUPERFICIAL ACTIVO DE PULMON NATURAL MAMIFERO, Y UNA AMINA FOSFATIDILETANOL REFERIDA QUE ES DIOLEOIL AMINA FOSFATIDILETANOL (DOPE). EN UNA INCORPORACION PARTICULAR, LA COMPOSICION ESTA EN FORMA LAMINAR A UNA TEMPERATURA APROXIMADAMENTE A LA DE LA HABITACION (25 MINAR A UNA TEMPERATURA EN LA ZONA DEAPROXIMADAMENTE 30 HASTA 37 EN CONDICIONES NORMALES (37 INCLUIR UNO O MAS PEPTIDOS TERAPEUTICOS U OTROS AGENTES FARMACEUTICOS. EL AGENTE ACTIVO SUPERFICIAL SINTETICO DE PULMON PUEDE SER UTILIZADO EN EL TRATAMIENTO DE MAMIFEROS EN SINDROMES DE AGOTAMIENTO RESPIRATORIO ORIGINADO POR UNA INSUFICIENCIA DEL AGENTE SUPERFICIAL ACTIVO DE PULMON NATURAL.
ES91920210T 1990-10-17 1991-10-17 Agente tensioactivo sintetico para los pulmones. Expired - Lifetime ES2146580T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59949390A 1990-10-17 1990-10-17

Publications (1)

Publication Number Publication Date
ES2146580T3 true ES2146580T3 (es) 2000-08-16

Family

ID=24399851

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91920210T Expired - Lifetime ES2146580T3 (es) 1990-10-17 1991-10-17 Agente tensioactivo sintetico para los pulmones.

Country Status (11)

Country Link
EP (1) EP0553272B1 (es)
JP (1) JP3171445B2 (es)
KR (1) KR0181309B1 (es)
AT (1) ATE192930T1 (es)
AU (1) AU650303B2 (es)
CA (1) CA2093133C (es)
DE (1) DE69132211T2 (es)
DK (1) DK0553272T3 (es)
ES (1) ES2146580T3 (es)
GR (1) GR3034211T3 (es)
WO (1) WO1992006703A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
CZ292186B6 (cs) 1996-01-24 2003-08-13 Altana Pharma Ag Způsob výroby práškového prostředku s obsahem plicní povrchově aktivní látky, práškový prostředek a jeho použití
WO1997035559A2 (en) * 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
CN1642533A (zh) * 2002-03-18 2005-07-20 山之内制药株式会社 吸入用粉末医药组合物及其制备方法
NZ607358A (en) 2010-08-23 2015-04-24 Takeda Gmbh Humidified particles comprising a therapeutically active substance
AU2015226287B2 (en) 2014-03-05 2019-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Humidifier for humidifying an aerosol
US10737088B2 (en) 2014-03-05 2020-08-11 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Device for providing a constant amount of aerosol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795920A (en) * 1980-12-04 1982-06-15 Teijin Ltd Remedy for respiratory disease
US4915951A (en) * 1987-12-03 1990-04-10 California Institute Of Technology Cryoprotective reagent

Also Published As

Publication number Publication date
CA2093133A1 (en) 1992-04-18
JPH06502427A (ja) 1994-03-17
EP0553272B1 (en) 2000-05-17
GR3034211T3 (en) 2000-12-29
AU8929191A (en) 1992-05-20
DE69132211T2 (de) 2000-11-23
WO1992006703A1 (en) 1992-04-30
EP0553272A4 (en) 1994-09-07
KR0181309B1 (ko) 1999-03-20
JP3171445B2 (ja) 2001-05-28
AU650303B2 (en) 1994-06-16
ATE192930T1 (de) 2000-06-15
DE69132211D1 (de) 2000-06-21
CA2093133C (en) 1999-03-30
EP0553272A1 (en) 1993-08-04
DK0553272T3 (da) 2000-09-04

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