ES2147725T3 - Moleculas de adn recombinantes que codifican una cadena del receptor del antigeno de celulas t, procedimiento de preparacion, anticuerpos y medicamentos que las contienen. - Google Patents

Moleculas de adn recombinantes que codifican una cadena del receptor del antigeno de celulas t, procedimiento de preparacion, anticuerpos y medicamentos que las contienen.

Info

Publication number
ES2147725T3
ES2147725T3 ES92430003T ES92430003T ES2147725T3 ES 2147725 T3 ES2147725 T3 ES 2147725T3 ES 92430003 T ES92430003 T ES 92430003T ES 92430003 T ES92430003 T ES 92430003T ES 2147725 T3 ES2147725 T3 ES 2147725T3
Authority
ES
Spain
Prior art keywords
sequence
recombinant dna
antigen receptor
cell antigen
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92430003T
Other languages
English (en)
Inventor
Francois Romagne
Agthoven Andre Van
Bernard Malissen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMMUNOTECH SA
Original Assignee
IMMUNOTECH SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IMMUNOTECH SA filed Critical IMMUNOTECH SA
Application granted granted Critical
Publication of ES2147725T3 publication Critical patent/ES2147725T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

ADN RECOMBINANTE QUE COMPRENDE UNA SECUENCIA NUCLEOTIDICA QUIMERICA QUE CODIFICA UNA CADENA DEL RECEPTOR PARA EL ANTIGENO DE LAS CELULAS T, COMPONIENDOSE DICHA SECUENCIA: UENCIA PROCEDENTE DE UN MAMIFERO Y QUE CODIFICA LA TOTALIDAD DE LA PARTE VARIABLE (V), DIVERSIDAD (D) Y DE UNION (J), -Y DE UNA SECUENCIA DE ORIGEN MURINO QUE CODIFICA LA PARTE COMPLEMENTARIA CONSTANTE (C) AUSENTE DE LA SECUENCIA DE MAMIFERO ANTERIOR, ESTANDO UNIDAS AMBAS SECUENCIAS EN UN SITIO DE RESTRICCION NATURAL O CREADO ARTIFICIALMENTE, ANTICUERPOS OBTENIDOS POR LA UTILIZACION DE DICHOS ADN, COMPOSICION FARMACEUTICAS Y PRODUCTOS DE DIAGNOSTICOS QUE LOS CONTIENEN, Y PROCESO DE PREPARACION.
ES92430003T 1991-02-15 1992-02-12 Moleculas de adn recombinantes que codifican una cadena del receptor del antigeno de celulas t, procedimiento de preparacion, anticuerpos y medicamentos que las contienen. Expired - Lifetime ES2147725T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR919102189A FR2672901B1 (fr) 1991-02-15 1991-02-15 Nouvelles molecules de dna recombinants codant pour une chaine du recepteur pour l'antigene des cellules t, procede de preparation, anticorps et medicaments les renfermant.

Publications (1)

Publication Number Publication Date
ES2147725T3 true ES2147725T3 (es) 2000-10-01

Family

ID=9410030

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92430003T Expired - Lifetime ES2147725T3 (es) 1991-02-15 1992-02-12 Moleculas de adn recombinantes que codifican una cadena del receptor del antigeno de celulas t, procedimiento de preparacion, anticuerpos y medicamentos que las contienen.

Country Status (10)

Country Link
EP (1) EP0499555B1 (es)
JP (1) JPH0591881A (es)
AT (1) ATE193058T1 (es)
CA (1) CA2061266A1 (es)
DE (1) DE69231046T2 (es)
DK (1) DK0499555T3 (es)
ES (1) ES2147725T3 (es)
FR (1) FR2672901B1 (es)
GR (1) GR3034176T3 (es)
PT (1) PT499555E (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69528894T2 (de) 1994-05-02 2003-03-27 Bernd Groner Bifunktionelles protein, herstellung und verwendung
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
WO2013033626A2 (en) 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
WO2013169691A1 (en) 2012-05-07 2013-11-14 Trustees Of Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86278A (en) * 1988-05-04 2003-06-24 Yeda Res & Dev Endowing cells with antibody specificity using chimeric t cell receptor
CA2018248A1 (en) * 1989-06-07 1990-12-07 Clyde W. Shearman Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use

Also Published As

Publication number Publication date
DE69231046T2 (de) 2001-01-11
CA2061266A1 (fr) 1992-08-16
FR2672901A1 (fr) 1992-08-21
ATE193058T1 (de) 2000-06-15
EP0499555B1 (fr) 2000-05-17
DE69231046D1 (de) 2000-06-21
EP0499555A1 (fr) 1992-08-19
GR3034176T3 (en) 2000-11-30
JPH0591881A (ja) 1993-04-16
PT499555E (pt) 2000-10-31
FR2672901B1 (fr) 1994-09-30
DK0499555T3 (da) 2000-10-09

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