ES2149281T3 - Derivado opticamente activo de imidazolidinona y su proceso de fabricacion. - Google Patents

Derivado opticamente activo de imidazolidinona y su proceso de fabricacion.

Info

Publication number
ES2149281T3
ES2149281T3 ES94926387T ES94926387T ES2149281T3 ES 2149281 T3 ES2149281 T3 ES 2149281T3 ES 94926387 T ES94926387 T ES 94926387T ES 94926387 T ES94926387 T ES 94926387T ES 2149281 T3 ES2149281 T3 ES 2149281T3
Authority
ES
Spain
Prior art keywords
imidazolidinone
same
manufacturing process
optically active
active derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94926387T
Other languages
English (en)
Inventor
Yasuo Takano
Kei Okazaki
Takashi - - - Sakurad Hirayama
Tsuyoshi Aza-Unoki Tomo Anraku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2149281T3 publication Critical patent/ES2149281T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE PRESENTA UN DERIVADO DE LA IMIDAZOLIDINONA OPTICAMENTE ACTIVO REPRESENTADO POR LA FORMULA GENERAL (I) QUE TIENE ACTIVIDAD COLINERGICA (UNA ACTIVIDAD DE LA MUSCARINA M{SUB,1}) Y QUE ES UTIL PARA EL TRATAMIENTO DE LA DEMENCIA SENIL, UNA SAL FARMACOLOGICAMENTE ACEPTABLE DE ADICION ACIDA DEL MISMO, Y UN PROCESO PARA PRODUCIR EL MISMO, Y EN DONDE R Y R1 PUEDEN SER IGUALES O DIFERENTES Y CADA UNA REPRESENTA HIDROGENO, HALOGENO, ALQUILO INFERIOR OPCIONALMENTE HALOGENADO, ALCOXIDO INFERIOR, ALQUILTIO INFERIOR, ALCOXICARBONILO INFERIOR, NITRO, AMINO O CIANO Y N REPRESENTA 1 A 4.
ES94926387T 1993-09-17 1994-09-12 Derivado opticamente activo de imidazolidinona y su proceso de fabricacion. Expired - Lifetime ES2149281T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25498393 1993-09-17
JP24226494A JP3916093B2 (ja) 1993-09-17 1994-09-09 光学活性イミダゾリジノン誘導体とその製造方法

Publications (1)

Publication Number Publication Date
ES2149281T3 true ES2149281T3 (es) 2000-11-01

Family

ID=26535688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94926387T Expired - Lifetime ES2149281T3 (es) 1993-09-17 1994-09-12 Derivado opticamente activo de imidazolidinona y su proceso de fabricacion.

Country Status (15)

Country Link
US (1) US5726188A (es)
EP (1) EP0719772B1 (es)
JP (1) JP3916093B2 (es)
KR (1) KR100323930B1 (es)
CN (1) CN1041088C (es)
AT (1) ATE194611T1 (es)
AU (1) AU679259B2 (es)
CA (1) CA2172162C (es)
DE (1) DE69425266T2 (es)
DK (1) DK0719772T3 (es)
ES (1) ES2149281T3 (es)
GR (1) GR3034499T3 (es)
HU (1) HU217668B (es)
PT (1) PT719772E (es)
WO (1) WO1995007905A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504272A (ja) * 1993-09-15 1997-04-28 メルク シヤープ エンド ドーム リミテツド ドーパミンアンタゴニストとしてのイミダゾロン及びオキサゾロン誘導体
US6159990A (en) * 1997-06-18 2000-12-12 Synaptic Pharmaceutical Corporation Oxazolidinones as α1A receptor antagonists
US6316623B1 (en) * 1998-08-21 2001-11-13 Isis Pharmaceuticals, Inc. Ethylenediamine compound libraries
BR0213611A (pt) * 2001-10-02 2005-12-20 Acadia Pharm Inc Composto, composição farmacêutica, seus usos, método para aumentar a atividade de um receptor colinérgico, métodos para tratamento ou prevenção de distúrbio mental, dor, pressão intraocular aumentada e progressão ou formação de placas amilóides
US6951849B2 (en) * 2001-10-02 2005-10-04 Acadia Pharmaceuticals Inc. Benzimidazolidinone derivatives as muscarinic agents
WO2007036718A2 (en) * 2005-09-30 2007-04-05 Glaxo Group Limited Compounds which have activity at m1 receptor and their uses in medicine
WO2007036711A1 (en) * 2005-09-30 2007-04-05 Glaxo Group Limited BENZIMIDAZOLONES WHICH HAVE ACTIVITY AT Ml RECEPTOR
US8283364B2 (en) * 2005-09-30 2012-10-09 Glaxo Group Limited Compounds which have activity at M1 receptor and their uses in medicine
EP2123769B1 (en) 2007-02-19 2016-05-18 Kaneka Corporation Method for producing optically active 3-aminopiperidine or salt thereof
EP2457899A4 (en) * 2009-07-21 2015-06-03 Sumitomo Chemical Co METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE NIPECOTAMIDE

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US459757A (en) * 1891-09-22 Electric-arc lamp
US3196152A (en) * 1965-07-20 Phenyl and alkyleneamino substituted imidazolidinones and salts thereof
US3355457A (en) * 1965-05-21 1967-11-28 American Cyanamid Co Substituted 2-imidazolinones
US3459757A (en) * 1965-10-22 1969-08-05 American Cyanamid Co Imidazolidines
US4011238A (en) * 1972-07-26 1977-03-08 Gruppo Lepetit S.P.A. 2-imidazolidione derivatives
GB9106571D0 (en) * 1991-03-27 1991-05-15 Erba Carlo Spa Derivatives of substituted imidazol-2-one and process for their preparation
US5300515A (en) * 1991-01-31 1994-04-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
JPH09504272A (ja) * 1993-09-15 1997-04-28 メルク シヤープ エンド ドーム リミテツド ドーパミンアンタゴニストとしてのイミダゾロン及びオキサゾロン誘導体

Also Published As

Publication number Publication date
CA2172162A1 (en) 1995-03-23
AU7624394A (en) 1995-04-03
WO1995007905A1 (en) 1995-03-23
CA2172162C (en) 2005-04-19
DE69425266D1 (de) 2000-08-17
DK0719772T3 (da) 2000-11-06
KR960704878A (ko) 1996-10-09
EP0719772B1 (en) 2000-07-12
CN1041088C (zh) 1998-12-09
DE69425266T2 (de) 2001-02-22
AU679259B2 (en) 1997-06-26
CN1135216A (zh) 1996-11-06
EP0719772A1 (en) 1996-07-03
ATE194611T1 (de) 2000-07-15
JP3916093B2 (ja) 2007-05-16
HU9600622D0 (en) 1996-05-28
HUT75649A (en) 1997-05-28
JPH07133273A (ja) 1995-05-23
EP0719772A4 (en) 1996-09-04
PT719772E (pt) 2000-11-30
KR100323930B1 (ko) 2004-05-06
HU217668B (hu) 2000-03-28
GR3034499T3 (en) 2000-12-29
US5726188A (en) 1998-03-10

Similar Documents

Publication Publication Date Title
NO20000841L (no) N-Aroylfenylalanin-derivater
ES2149281T3 (es) Derivado opticamente activo de imidazolidinona y su proceso de fabricacion.
TR199800849T2 (xx) Siklikle heterosiklik N-ikame edilmi� alfa-iminohidroksamla karbon asitleri
BR0009167A (pt) Inibidores de enzima impdh
SV1999000102A (es) Compuestos heterociclicos como inhibidores de enzimas de rotamasa. ref. pcs 9475 afae/bb.
NO980313L (no) N-(aroyl)glysin-hydroksaminsyre-derivater og beslektete forbindelser
DE69717474D1 (de) Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien
DK0779291T3 (da) Med heterocyclylcarbonyl substituerede benzofuranyl-urinstoffer
ATE182333T1 (de) Heterocyclische verbindungen, ihre herstellung und verwendung
SE8804570D0 (sv) New ciclosporin crystal form process for its produktion pharmaceutical compositions containing it and its use
DE122011000008I1 (de) Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen.
SE8107273L (sv) 2-oxoazetidinderivat, sett att framstella democh anvendning derav
BG48336A3 (bg) Метод за получаване на заместени хетероциклични бензамиди
EP1589018A4 (en) METHOD OF PREPARING HEXAHYDROFUROFURANOL DERIVATIVES, INTERMEDIATE PRODUCTS AND MANUFACTURING METHOD THEREFOR
AR027578A1 (es) Derivados de indano
FI891822A0 (fi) Foerfarande foer framstaellning av organiska kemikalier.
ES541780A0 (es) Tetrahidrotienopiridinas
ES2178121T3 (es) Derivado de 2-fenil-2-(2-piperidiniliden) acetato y un procedimiento para fabricar el mismo, y procedimiento para fabricar un derivado de 2-fenil-2-(2-piperidinil) acetato opticamente activo para la hidrogenacion asimetrica.
ES2118842T3 (es) Derivados del acido aminobenzoico.
ES2059396T3 (es) Derivados de indeno y metodos.
DK0767783T3 (da) Substituerede alkyldiaminderivater og deres anvendelse som tachykinin-antagonister
ES2122941B1 (es) Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
UA26443A (uk) Похідhі 20,21-диhоребурhамеhіhу, їх рацемати або оптичhі ізомери, або їх адитивhі солі з оргаhічhими кислотами, що мають hоотропhі та аhтидепресивhі властивості
NO20030021L (no) Heterosykliske forbindelser som er inhibitorer for enzymet DPP-IV
DK0446798T3 (da) 1-Alkyl-, 1-alkenyl- og 1-alkynylaryl-2-amino-1,3-propandioler og beslægtede forbindelser, en fremgangsmåde og mellemprodukter til deres fremstilling samt deres anvendelse som lægemidler

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 719772

Country of ref document: ES