ES2150739T3 - Compuestos triciclicos de piperidinilamino como antagonistas de sustancia p. - Google Patents

Compuestos triciclicos de piperidinilamino como antagonistas de sustancia p.

Info

Publication number
ES2150739T3
ES2150739T3 ES97306054T ES97306054T ES2150739T3 ES 2150739 T3 ES2150739 T3 ES 2150739T3 ES 97306054 T ES97306054 T ES 97306054T ES 97306054 T ES97306054 T ES 97306054T ES 2150739 T3 ES2150739 T3 ES 2150739T3
Authority
ES
Spain
Prior art keywords
sup
sub
piperidinylamine
antagonists
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97306054T
Other languages
English (en)
Inventor
Hiroki Koike
Hiroaki Wakabayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2150739T3 publication Critical patent/ES2150739T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

ESTA INVENCION PROPORCIONA COMPUESTOS DE LA FORMULA: Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN LOS QUE AR SUP,1} SE SELECCIONA DE GRUPOS CON LA SIGUIENTE FORMULA: EN LOS QUE R SUP,1} Y R SUP,2} SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO C SUB,1} O -CH=CH-; X ES ALCOXI C SUB,1} ,1} C SUB,6}; Y AR SUP,2} ES UN FENILO OPCIONALMENTE SUSTITUIDO CON UN ATOMO DE HALOGENO. ESTOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS GASTROINTESTINALES, TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL (SNC), ENFERMEDAD INFLAMATORIA, EMESIS, INCONTINENCIA URINARIA, DOLOR, MIGRAÑA, INSOLACION, ANGIOGENESIS, ENFERMEDADES, TRASTORNOS Y ESTADOS ADVERSOS CAUSADOS POR HELICOBACTER PYLORI O SIMILARES EN UN MAMIFERO, EN ESPECIAL EN HUMANOS.
ES97306054T 1996-08-14 1997-08-08 Compuestos triciclicos de piperidinilamino como antagonistas de sustancia p. Expired - Lifetime ES2150739T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9600798 1996-08-14

Publications (1)

Publication Number Publication Date
ES2150739T3 true ES2150739T3 (es) 2000-12-01

Family

ID=11004463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97306054T Expired - Lifetime ES2150739T3 (es) 1996-08-14 1997-08-08 Compuestos triciclicos de piperidinilamino como antagonistas de sustancia p.

Country Status (10)

Country Link
US (2) US5972930A (es)
EP (1) EP0824100B1 (es)
AT (1) ATE196470T1 (es)
BR (1) BR9704352A (es)
CA (1) CA2212784C (es)
DE (1) DE69703143T2 (es)
DK (1) DK0824100T3 (es)
ES (1) ES2150739T3 (es)
GR (1) GR3034775T3 (es)
MX (1) MX9706196A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20060653A1 (es) * 2004-08-31 2006-09-27 Glaxo Group Ltd Derivados triciclicos condensados como moduladores del receptor 5-ht1
RU2409582C2 (ru) * 2004-08-31 2011-01-20 Глэксо Груп Лимитед Конденсированные трициклические производные для лечения психотических расстройств
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232929A (en) * 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
DE69213451T2 (de) * 1991-06-20 1997-01-09 Pfizer Inc., New York Fluoralkoxybenzylaminoderivate stickstoffhaltiger heterocyclen
WO1994004496A1 (en) * 1992-08-19 1994-03-03 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
IL111002A (en) * 1993-09-22 1998-09-24 Glaxo Group Ltd Piperidine derivatives their preparation and pharmaceutical compositions containing them
US6180647B1 (en) * 1995-07-07 2001-01-30 Pfizer Inc. Substituted benzolactam compounds as substance P antagonists
TW340842B (en) * 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds

Also Published As

Publication number Publication date
GR3034775T3 (en) 2001-02-28
MX9706196A (es) 1998-02-28
US5972930A (en) 1999-10-26
CA2212784C (en) 2001-02-27
DK0824100T3 (da) 2000-11-20
EP0824100B1 (en) 2000-09-20
DE69703143T2 (de) 2001-03-22
ATE196470T1 (de) 2000-10-15
US6143767A (en) 2000-11-07
CA2212784A1 (en) 1998-02-14
BR9704352A (pt) 1999-01-05
DE69703143D1 (de) 2000-10-26
EP0824100A1 (en) 1998-02-18

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