ATE267012T1 - Tetrahydro-beta carbolinverbindungen - Google Patents

Tetrahydro-beta carbolinverbindungen

Info

Publication number: ATE267012T1
Authority: AT; Austria
Prior art keywords: tetrahydro; compounds; beta; carboline compounds; beta carboline
Prior art date: 1996-03-25

Application number

AT97916854T

Other languages

English (en)

Inventor

James E Audia

David L G Nelson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-25

Filing date

1997-03-24

Publication date

2004-06-15

1997-03-24 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2004-06-15 Application granted granted Critical

2004-06-15 Publication of ATE267012T1 publication Critical patent/ATE267012T1/de

Links

CFTOTSJVQRFXOF-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Chemical class N1C2=CC=CC=C2C2=C1CNCC2 CFTOTSJVQRFXOF-UHFFFAOYSA-N 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
102000006969 5-HT2B Serotonin Receptor Human genes 0.000 abstract 1
108010072584 5-HT2B Serotonin Receptor Proteins 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
ZXLDQJLIBNPEFJ-UHFFFAOYSA-N tetrahydro-beta-carboline Natural products C1CNC(C)C2=C1C1=CC=C(OC)C=C1N2 ZXLDQJLIBNPEFJ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT97916854T 1996-03-25 1997-03-24 Tetrahydro-beta carbolinverbindungen ATE267012T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1411996P	1996-03-25	1996-03-25
PCT/US1997/004473 WO1997035578A1 (en)	1996-03-25	1997-03-24	Tetrahydro-beta-carboline compounds

Publications (1)

Publication Number	Publication Date
ATE267012T1 true ATE267012T1 (de)	2004-06-15

Family

ID=21763645

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97916854T ATE267012T1 (de)	1996-03-25	1997-03-24	Tetrahydro-beta carbolinverbindungen

Country Status (20)

Country	Link
US (1)	US5886004A (de)
EP (1)	EP0942722B1 (de)
JP (1)	JP2001509130A (de)
KR (1)	KR20000004963A (de)
CN (1)	CN1225584A (de)
AT (1)	ATE267012T1 (de)
AU (1)	AU714024B2 (de)
BR (1)	BR9708347A (de)
CA (1)	CA2248874A1 (de)
CZ (1)	CZ298098A3 (de)
DE (1)	DE69729211T2 (de)
EA (1)	EA199800867A1 (de)
ES (1)	ES2221049T3 (de)
IL (1)	IL126062A0 (de)
NO (1)	NO984445L (de)
NZ (1)	NZ331827A (de)
PL (1)	PL329212A1 (de)
TR (1)	TR199801910T2 (de)
WO (1)	WO1997035578A1 (de)
YU (1)	YU41998A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5886003A (en) *	1996-03-25	1999-03-23	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of venomous bites and stings
ES2152860B1 (es) *	1998-10-23	2001-08-16	Finaf 92 Sa	Forma cristalina de la nefazodona y procedimiento para su preparacion.
AU4856600A (en)	1999-05-18	2000-12-05	Synaptic Pharmaceutical Corporation	Use of agonists or antagonists of the 5-ht7 receptor to treat disorders of the bladder
US6444477B1 (en) *	2000-11-28	2002-09-03	Pharmagene Laboratories Limited	Assay method for detecting 5-HT2B antagonists
DE10252667A1 (de) *	2002-11-11	2004-05-27	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
CA2557158A1 (en) *	2004-02-20	2005-09-01	Astellas Pharma Inc.	Prophylactic antimigraine agents
US7550499B2 (en) *	2004-05-12	2009-06-23	Bristol-Myers Squibb Company	Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
MX2007008434A (es) *	2005-01-19	2007-07-25	Squibb Bristol Myers Co	Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos.
US20080171788A1 (en) *	2005-02-08	2008-07-17	Shinobu Akuzawa	Medicament For Irritable Bowel Syndrome
ATE485269T1 (de) *	2005-06-27	2010-11-15	Bristol Myers Squibb Co	C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden
WO2007002584A1 (en)	2005-06-27	2007-01-04	Bristol-Myers Squibb Company	Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
AR056867A1 (es) *	2005-06-27	2007-10-31	Bristol Myers Squibb Co	Antagonistas heterociclicos n- enlazados del receptor de p2y1 utiles en el tratamiento de condiciones tromboticas. composiciones farmaceuticas.
WO2007002634A1 (en) *	2005-06-27	2007-01-04	Bristol-Myers Squibb Company	Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
EP1923387B1 (de) *	2005-08-08	2011-10-19	Astellas Pharma Inc.	Acylguanidinderivat oder salz davon
US7960569B2 (en) *	2006-10-17	2011-06-14	Bristol-Myers Squibb Company	Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2012051502A1 (en)	2010-10-14	2012-04-19	University Of Utah Research Foundation	Methods and compositions related to neuroactive thiazoline compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5500431A (en) *	1993-04-14	1996-03-19	Eli Lilly And Company	Tetrahydro-β-carbolines
US5663178A (en) *	1995-02-06	1997-09-02	Eli Lilly And Company	Tetrahydro-beta carbolines
JPH09510216A (ja) *	1994-03-11	1997-10-14	イーライ・リリー・アンド・カンパニー	５−ｈｔ▲下２ｂ▼受容体に関連する病態を治療するための方法
JP2000507269A (ja) *	1996-03-15	2000-06-13	イーライ・リリー・アンド・カンパニー	一般かぜまたはアレルギー性鼻炎の処置方法
US5886003A (en) *	1996-03-25	1999-03-23	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of venomous bites and stings

1997
- 1997-03-24 IL IL12606297A patent/IL126062A0/xx unknown
- 1997-03-24 KR KR1019980707567A patent/KR20000004963A/ko not_active Withdrawn
- 1997-03-24 US US08/823,456 patent/US5886004A/en not_active Expired - Fee Related
- 1997-03-24 JP JP53449297A patent/JP2001509130A/ja not_active Ceased
- 1997-03-24 BR BR9708347A patent/BR9708347A/pt not_active Application Discontinuation
- 1997-03-24 CZ CZ982980A patent/CZ298098A3/cs unknown
- 1997-03-24 CA CA002248874A patent/CA2248874A1/en not_active Abandoned
- 1997-03-24 AT AT97916854T patent/ATE267012T1/de not_active IP Right Cessation
- 1997-03-24 CN CN97194732A patent/CN1225584A/zh active Pending
- 1997-03-24 EP EP97916854A patent/EP0942722B1/de not_active Expired - Lifetime
- 1997-03-24 WO PCT/US1997/004473 patent/WO1997035578A1/en not_active Ceased
- 1997-03-24 DE DE69729211T patent/DE69729211T2/de not_active Expired - Fee Related
- 1997-03-24 EA EA199800867A patent/EA199800867A1/ru unknown
- 1997-03-24 ES ES97916854T patent/ES2221049T3/es not_active Expired - Lifetime
- 1997-03-24 AU AU25361/97A patent/AU714024B2/en not_active Ceased
- 1997-03-24 TR TR1998/01910T patent/TR199801910T2/xx unknown
- 1997-03-24 PL PL97329212A patent/PL329212A1/xx unknown
- 1997-03-24 NZ NZ331827A patent/NZ331827A/en unknown
1998
- 1998-09-24 NO NO984445A patent/NO984445L/no unknown
- 1998-09-25 YU YU41998A patent/YU41998A/sh unknown

Also Published As

Publication number	Publication date
WO1997035578A1 (en)	1997-10-02
YU41998A (sh)	1999-07-28
EP0942722A4 (de)	2002-06-05
PL329212A1 (en)	1999-03-15
EA199800867A1 (ru)	1999-02-25
DE69729211D1 (en)	2004-06-24
EP0942722A1 (de)	1999-09-22
BR9708347A (pt)	1999-08-03
JP2001509130A (ja)	2001-07-10
ES2221049T3 (es)	2004-12-16
CA2248874A1 (en)	1997-10-02
NO984445L (no)	1998-11-20
CZ298098A3 (cs)	1999-02-17
DE69729211T2 (de)	2005-05-04
NZ331827A (en)	2000-02-28
US5886004A (en)	1999-03-23
CN1225584A (zh)	1999-08-11
AU2536197A (en)	1997-10-17
TR199801910T2 (xx)	1998-12-21
AU714024B2 (en)	1999-12-16
IL126062A0 (en)	1999-05-09
NO984445D0 (no)	1998-09-24
KR20000004963A (ko)	2000-01-25
EP0942722B1 (de)	2004-05-19

Legal Events

Date	Code	Title	Description
2004-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
BR9708347A (pt)	1999-08-03	Compostos de tetrahidorbeta-carbonila
IL128003A0 (en)	1999-11-30	Therapeutic multispecific compounds comprised of anti-fcalpha receptor antibodies
DK0841928T3 (da)	2003-01-27	Sustained release-formulering af d-threo-methylphenidat
ES2168650T3 (es)	2002-06-16	Compuestos y metodos moduladores de receptores de androgenos.
NO990985D0 (no)	1999-03-01	Katalytisk blanding egnet for Fischer-Tropsch-prosessen
PL339860A1 (en)	2001-01-15	Methods of modulating the action of serine/threonine protein kinase by means of compounds based on 5-azaquinoxaline
HU9801711D0 (en)	1998-09-28	Use of substituted imidazolidin-2,4-dion compounds as analgetic
EP1083903A4 (de)	2001-10-04	Überbrückte indenopyrrolocarbazole
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MY127474A (en)	2006-12-29	Naphthyl compounds, intermediates, compositions, and methods of use
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IL121352A0 (en)	1998-01-04	Intermediates for the preparation of 2-imidazolin-5-ones
EP0971885A4 (de)	2001-03-07	Verfahren zur herstellung von indan-ähnlichen verbindungen
WO2001012838A3 (en)	2001-10-04	Compounds which modulate the activity of an lpa receptor
DK0593285T3 (da)	2002-02-11	Mellemprodukter og fremgangsmåder dertil til fremstilling af 5,6-dihydropyrrolo-(2,3-d)pyrimidiner
TR200001329T2 (tr)	2001-01-22	Pirrolo (3,2-b) piridin için yöntemler ve ara bileşikler
MY127539A (en)	2006-12-29	Bridged indenopyrrolocarbazoles
UY24621A1 (es)	2001-08-27	Nuevos compuestos
MX9703752A (es)	1998-06-30	Proceso y compuestos intermedios para la preparacion de compuestos pesticidas de fluoroolefinas.