ES2151079T3 - Preparacion de liberacion sostenida que contiene una sal metalica de un peptido. - Google Patents

Preparacion de liberacion sostenida que contiene una sal metalica de un peptido.

Info

Publication number
ES2151079T3
ES2151079T3 ES95930707T ES95930707T ES2151079T3 ES 2151079 T3 ES2151079 T3 ES 2151079T3 ES 95930707 T ES95930707 T ES 95930707T ES 95930707 T ES95930707 T ES 95930707T ES 2151079 T3 ES2151079 T3 ES 2151079T3
Authority
ES
Spain
Prior art keywords
water
except
peptide
endotheline
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95930707T
Other languages
English (en)
Inventor
Yasutaka Igari
Yutaka Yamagata
Satoshi Iinuma
Hiroaki Okada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26521438&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2151079(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2151079T3 publication Critical patent/ES2151079T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PREPARACION DE LIBERACION CONSTANTE QUE CONTIENE UNA SAL METALICA POLIVALENTE INSOLUBLE EN AGUA O DEBILMENTE SOLUBLE EN AGUA DE UN TIPO DE PEPTIDO SOLUBLE EN AGUA DE UNA SUSTANCIA ACTIVA FISIOLOGICAMENTE EXCEPTO PARA UN ANTAGONISTA DE ENDOTELINA Y UN POLIMERO BIODEGRADABLE. LA PRESENTE INVENCION ES DE LIBERACION MANTENIDA Y ALTAMENTE EFICAZ PARA INCORPORAR UN TIPO PEPTIDO SOLUBLE EN AGUA DE LA SUSTANCIA ACTIVA FISIOLOGICAMENTE EXCEPTO PARA UN ANTAGONISTA DE ENDOTELINA Y EVITA LA RUPTURA INICIAL DEL TIPO PEPTIDO SOLUBLE EN AGUA DE LA SUSTANCIA ACTIVA FISIOLOGICA SALVO PARA EL ANTAGONISTA DE ENDOTELINA. LA PREPARACION DE LIBERACION MANTENIDA DE LA PRESENTE INVENCION ES CAPAZ DE LIBERAR EL TIPO PEPTIDO SOLUBLE EN AGUA DE LA SUSTANCIA ACTIVA FISIOLOGICAMENTE EXCEPTO EN EL CASO DE UN ANTAGONISTA DE ENDOTELINA MIENTRAS SE MANTIENE SU BIOACTIVIDAD DESPUES DE LA ADMINISTRACION IN VIVO. ADEMAS EL TIPO PEPTIDO SOLUBLE EN AGUA DE UNA SUSTANCIA ACTIVA FISIOLOGICAMENTE SALVO PARA UN ANTAGONISTA DE ENDOTELINA EL LA PREPARACION DE LIBERACION MANTENIDA SE CONSERVA ESTABLE POR UN LARGO PERIODO DE TIEMPO, CON UNA PEQUEÑA PERDIDA DE BIOACTIVIDAD.
ES95930707T 1994-09-09 1995-09-06 Preparacion de liberacion sostenida que contiene una sal metalica de un peptido. Expired - Lifetime ES2151079T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21644994 1994-09-09
JP31029194 1994-12-14

Publications (1)

Publication Number Publication Date
ES2151079T3 true ES2151079T3 (es) 2000-12-16

Family

ID=26521438

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95930707T Expired - Lifetime ES2151079T3 (es) 1994-09-09 1995-09-06 Preparacion de liberacion sostenida que contiene una sal metalica de un peptido.

Country Status (15)

Country Link
EP (2) EP1002529A1 (es)
KR (1) KR100356550B1 (es)
CN (1) CN1157562A (es)
AT (1) ATE197398T1 (es)
AU (1) AU695323B2 (es)
BR (1) BR9509201A (es)
CA (1) CA2196184C (es)
DE (1) DE69519382T3 (es)
DK (1) DK0779806T3 (es)
ES (1) ES2151079T3 (es)
FI (1) FI970952A0 (es)
GR (1) GR3035171T3 (es)
NZ (1) NZ292263A (es)
PT (1) PT779806E (es)
WO (1) WO1996007399A1 (es)

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EP0779806B1 (en) 2000-11-08
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WO1996007399A1 (en) 1996-03-14
CA2196184A1 (en) 1996-03-14
GR3035171T3 (en) 2001-04-30
KR970705379A (ko) 1997-10-09
DE69519382T3 (de) 2008-09-18
EP0779806B2 (en) 2008-04-16
EP1002529A1 (en) 2000-05-24
AU695323B2 (en) 1998-08-13
FI970952A7 (fi) 1997-03-06
DK0779806T3 (da) 2000-11-27
NZ292263A (en) 1998-12-23
EP0779806A1 (en) 1997-06-25
PT779806E (pt) 2001-02-28
DE69519382D1 (de) 2000-12-14
AU3399095A (en) 1996-03-27
CN1157562A (zh) 1997-08-20
DE69519382T2 (de) 2001-05-17
FI970952A0 (fi) 1997-03-06
CA2196184C (en) 2009-06-09
BR9509201A (pt) 1997-12-30
ATE197398T1 (de) 2000-11-11

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