ES2152320T3 - Conjugados hepatotropicos de farmacos antivirales, vehiculos para dichos conjugados y composiciones farmaceuticas que los contienen. - Google Patents

Conjugados hepatotropicos de farmacos antivirales, vehiculos para dichos conjugados y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2152320T3
ES2152320T3 ES94918793T ES94918793T ES2152320T3 ES 2152320 T3 ES2152320 T3 ES 2152320T3 ES 94918793 T ES94918793 T ES 94918793T ES 94918793 T ES94918793 T ES 94918793T ES 2152320 T3 ES2152320 T3 ES 2152320T3
Authority
ES
Spain
Prior art keywords
conjugates
pharmaces
antiviral
hepatotropic
vehicles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918793T
Other languages
English (en)
Inventor
Luigi Fiume
Corrado Busi
Stefano Giuseppina Di
Alessandro Mattioli
Massimo Baldacci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratori Baldacci SpA
Original Assignee
Laboratori Baldacci SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratori Baldacci SpA filed Critical Laboratori Baldacci SpA
Application granted granted Critical
Publication of ES2152320T3 publication Critical patent/ES2152320T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

MEDIANTE LA CONJUGACION DE LOS FARMACOS ANTIVIRALES TALES COMO PARA NADO DE ENTRE LOS POLIAMINOACIDOS BASICOS Y EN PARTICULAR DE POLI-L-LISINA O POLIL-ORNITINA EN DONDE LA MAYOR PARTE DE LOS GRUPOS AMINO, QUE NO SON SUSTITUIDOS POR FARMACOS ANTIVIRALES, SON SUSTITUIDOS POR MOLECULAS DE GALACTOSA, ES POSIBLE LA ADMINISTRACION INTRAMUSCULAR DEL FARMACO SIN FORMACION DE ANTICUERPOS, SIN UNA TOXICIDAD AGUDA Y CON UN OBJETIVO HEPATICO.
ES94918793T 1993-05-26 1994-05-24 Conjugados hepatotropicos de farmacos antivirales, vehiculos para dichos conjugados y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2152320T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI931082A IT1270817B (it) 1993-05-26 1993-05-26 Coniugati di farmaci antivirali ad attivita' epatotropica, relativi veicolanti e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
ES2152320T3 true ES2152320T3 (es) 2001-02-01

Family

ID=11366263

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918793T Expired - Lifetime ES2152320T3 (es) 1993-05-26 1994-05-24 Conjugados hepatotropicos de farmacos antivirales, vehiculos para dichos conjugados y composiciones farmaceuticas que los contienen.

Country Status (15)

Country Link
EP (1) EP0652776B1 (es)
JP (1) JPH07509495A (es)
KR (1) KR100295579B1 (es)
AT (1) ATE196256T1 (es)
AU (1) AU6997094A (es)
BR (1) BR9405378A (es)
CA (1) CA2141028A1 (es)
DE (1) DE69425860T2 (es)
ES (1) ES2152320T3 (es)
HU (1) HU221306B1 (es)
IT (1) IT1270817B (es)
PT (1) PT652776E (es)
RU (1) RU2140292C1 (es)
UA (1) UA47386C2 (es)
WO (1) WO1994027642A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2192250C2 (ru) * 2000-07-11 2002-11-10 Нижегородский научно-исследовательский кожно-венерологический институт Способ лечения больных красным плоским лишаем
CN103202804A (zh) * 2013-02-22 2013-07-17 广东先强药业股份有限公司 一种单磷酸阿糖腺苷注射液及其制备方法
WO2018185321A1 (en) * 2017-04-07 2018-10-11 Thomas Crouzier Reinforcement of mucus barrier properties

Also Published As

Publication number Publication date
PT652776E (pt) 2001-03-30
HU9500585D0 (en) 1995-04-28
JPH07509495A (ja) 1995-10-19
KR950702438A (ko) 1995-07-29
WO1994027642A1 (en) 1994-12-08
RU2140292C1 (ru) 1999-10-27
ATE196256T1 (de) 2000-09-15
AU6997094A (en) 1994-12-20
RU95105590A (ru) 1997-02-27
UA47386C2 (uk) 2002-07-15
DE69425860D1 (de) 2000-10-19
ITMI931082A0 (it) 1993-05-26
HUT70481A (en) 1995-10-30
EP0652776B1 (en) 2000-09-13
ITMI931082A1 (it) 1994-11-26
CA2141028A1 (en) 1994-12-08
BR9405378A (pt) 1999-09-08
KR100295579B1 (ko) 2001-11-22
DE69425860T2 (de) 2001-04-12
HU221306B1 (en) 2002-09-28
IT1270817B (it) 1997-05-09
EP0652776A1 (en) 1995-05-17

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