ES2154302T3 - Preparacion de dispositivos de uso medico mediante procedimientos de fabricacion por modelizacion de solidos con estructura no impuesta. - Google Patents

Preparacion de dispositivos de uso medico mediante procedimientos de fabricacion por modelizacion de solidos con estructura no impuesta.

Info

Publication number
ES2154302T3
ES2154302T3 ES94930822T ES94930822T ES2154302T3 ES 2154302 T3 ES2154302 T3 ES 2154302T3 ES 94930822 T ES94930822 T ES 94930822T ES 94930822 T ES94930822 T ES 94930822T ES 2154302 T3 ES2154302 T3 ES 2154302T3
Authority
ES
Spain
Prior art keywords
taxed
preparation
medical use
manufacturing procedures
use devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94930822T
Other languages
English (en)
Inventor
Linda G Cima
Michael J Cima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/200,636 external-priority patent/US5518680A/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of ES2154302T3 publication Critical patent/ES2154302T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A61F2/105—Skin implants, e.g. artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/165—Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B33Y70/10—Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/0086—Special surfaces of prostheses, e.g. for improving ingrowth for preferentially controlling or promoting the growth of specific types of cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30032—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in absorbability or resorbability, i.e. in absorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/3028—Three-dimensional shapes polyhedral different from parallelepipedal and pyramidal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3093—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30932—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for retarding or preventing ingrowth of bone tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30962—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using stereolithography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A61F2250/0031—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00359—Bone or bony tissue
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0063—Density
    • B29K2995/0064—Non-uniform density
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/901—Method of manufacturing prosthetic device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249954—With chemically effective material or specified gas other than air, N, or carbon dioxide in void-containing component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249961—With gradual property change within a component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249978—Voids specified as micro
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249986—Void-containing component contains also a solid fiber or solid particle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249994—Composite having a component wherein a constituent is liquid or is contained within preformed walls [e.g., impregnant-filled, previously void containing component, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249994—Composite having a component wherein a constituent is liquid or is contained within preformed walls [e.g., impregnant-filled, previously void containing component, etc.]
    • Y10T428/249999—Differentially filled foam, filled plural layers, or filled layer with coat of filling material

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Composite Materials (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Ceramic Engineering (AREA)
  • Civil Engineering (AREA)
  • Structural Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN TECNICAS DE SOLIDOS DE FORMA LIBRE PARA FABRICACION DE DISPOSITIVOS MEDICOS PARA LIBERACION CONTROLADA DE UN AGENTE BIOACTIVO E IMPLANTACION Y CRECIMIENTO DE CELULAS UTILIZANDO DISEÑO ASISTIDO POR ORDENADOR. EJEMPLOS DE METODOS DE SFF INCLUYEN ESTEREOLITOGRAFIA (SLA), SINTERIZACION SELECTIVA DE LASER (SLS), FABRICACION DE PARTICULAS BALISTICAS (BPM), MODELADO DE DEPOSICION DE FUSION (FDM), E IMPRESION TRIDIMENSIONAL (3DP). LA MACROESTRUCTURA Y POROSIDAD DEL DISPOSITIVO PUEDE SER MANIPULADA MEDIANTE EL CONTROL DE LOS PARAMETROS DE IMPRESION. LO MAS IMPORTANTE ES QUE ESTAS CARACTERISTICAS PUEDEN DISEÑARSE Y ADAPTARSE UTILIZANDO DISEÑO ASISTIDO POR ORDENADOR (CAD) PARA PACIENTES INDIVIDUALES PARA OPTIMIZAR LA TERAPIA.
ES94930822T 1993-10-18 1994-10-18 Preparacion de dispositivos de uso medico mediante procedimientos de fabricacion por modelizacion de solidos con estructura no impuesta. Expired - Lifetime ES2154302T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/138,345 US5490962A (en) 1993-10-18 1993-10-18 Preparation of medical devices by solid free-form fabrication methods
US08/200,636 US5518680A (en) 1993-10-18 1994-02-23 Tissue regeneration matrices by solid free form fabrication techniques

Publications (1)

Publication Number Publication Date
ES2154302T3 true ES2154302T3 (es) 2001-04-01

Family

ID=22481617

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94930822T Expired - Lifetime ES2154302T3 (es) 1993-10-18 1994-10-18 Preparacion de dispositivos de uso medico mediante procedimientos de fabricacion por modelizacion de solidos con estructura no impuesta.

Country Status (11)

Country Link
US (3) US5490962A (es)
EP (1) EP0724428B1 (es)
JP (1) JP2930420B2 (es)
AT (1) ATE198146T1 (es)
CA (1) CA2173318C (es)
DE (1) DE69426457T2 (es)
DK (1) DK0724428T3 (es)
ES (1) ES2154302T3 (es)
GR (1) GR3035455T3 (es)
PT (1) PT724428E (es)
WO (1) WO1995011007A1 (es)

Families Citing this family (501)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5740051A (en) * 1991-01-25 1998-04-14 Sanders Prototypes, Inc. 3-D model making
EP0641196B1 (en) * 1992-05-29 2001-08-22 Vivorx, Incorporated Microencapsulation of cells
DE69315003T2 (de) * 1992-07-17 1998-03-12 Ethicon Inc Strahlenhärtbare Urethan-Acrylatprepolymere und vernetzte Polymere
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US6176874B1 (en) * 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US6280771B1 (en) * 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
US7963997B2 (en) * 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US8795242B2 (en) * 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US5590454A (en) * 1994-12-21 1997-01-07 Richardson; Kendrick E. Method and apparatus for producing parts by layered subtractive machine tool techniques
US5653925A (en) * 1995-09-26 1997-08-05 Stratasys, Inc. Method for controlled porosity three-dimensional modeling
US5817206A (en) * 1996-02-07 1998-10-06 Dtm Corporation Selective laser sintering of polymer powder of controlled particle size distribution
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7332537B2 (en) * 1996-09-04 2008-02-19 Z Corporation Three dimensional printing material system and method
US5902441A (en) * 1996-09-04 1999-05-11 Z Corporation Method of three dimensional printing
US7037382B2 (en) * 1996-12-20 2006-05-02 Z Corporation Three-dimensional printer
US6007318A (en) * 1996-12-20 1999-12-28 Z Corporation Method and apparatus for prototyping a three-dimensional object
AU736912B2 (en) * 1997-02-20 2001-08-02 Therics, Inc. Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same
US6341952B2 (en) 1997-03-20 2002-01-29 Therics, Inc. Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods
AU6868598A (en) * 1997-03-20 1998-10-12 Therics, Inc. Fabrication of tissue products using a mold formed by solid free-form methods
US6213168B1 (en) 1997-03-31 2001-04-10 Therics, Inc. Apparatus and method for dispensing of powders
US20030008396A1 (en) * 1999-03-17 2003-01-09 Ku David N. Poly(vinyl alcohol) hydrogel
US7147666B1 (en) * 1997-11-26 2006-12-12 Bernard Francis Grisoni Monolithic implants with openings
US20030036746A1 (en) * 2001-08-16 2003-02-20 Avi Penner Devices for intrabody delivery of molecules and systems and methods utilizing same
US20070142901A1 (en) * 1998-02-17 2007-06-21 Steinke Thomas A Expandable stent with sliding and locking radial elements
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US7658727B1 (en) * 1998-04-20 2010-02-09 Medtronic, Inc Implantable medical device with enhanced biocompatibility and biostability
US6086942A (en) 1998-05-27 2000-07-11 International Brachytherapy S.A. Fluid-jet deposition of radioactive material for brachytherapy devices
US5960609A (en) * 1998-06-12 1999-10-05 Microdose Technologies, Inc. Metering and packaging method and device for pharmaceuticals and drugs
US6821462B2 (en) * 1998-07-10 2004-11-23 Jeneric/Pentron, Inc. Mass production of shells and models for dental restorations produced by solid free-form fabrication methods
US6808659B2 (en) * 1998-07-10 2004-10-26 Jeneric/Pentron Incorporated Solid free-form fabrication methods for the production of dental restorations
US6322728B1 (en) * 1998-07-10 2001-11-27 Jeneric/Pentron, Inc. Mass production of dental restorations by solid free-form fabrication methods
US20050023710A1 (en) * 1998-07-10 2005-02-03 Dmitri Brodkin Solid free-form fabrication methods for the production of dental restorations
MXPA01002609A (es) * 1998-09-10 2002-04-08 Sumitomo Pharma Preparacion de farmaco de liberacion sostenida a largo plazo.
WO2000021470A1 (en) * 1998-10-12 2000-04-20 Therics, Inc. Composites for tissue regeneration and methods of manufacture thereof
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US6471520B1 (en) * 1998-11-13 2002-10-29 Milwaukee School Of Engineering Model of complex structure and method of making the same
US6547994B1 (en) 1998-11-13 2003-04-15 Therics, Inc. Rapid prototyping and manufacturing process
US6228437B1 (en) 1998-12-24 2001-05-08 United Technologies Corporation Method for modifying the properties of a freeform fabricated part
US6147135A (en) 1998-12-31 2000-11-14 Ethicon, Inc. Fabrication of biocompatible polymeric composites
JP2002534139A (ja) * 1999-01-05 2002-10-15 マサチューセッツ・アイ・アンド・イア・インファーマリー 網膜と脈絡膜への経強膜徐放性薬剤標的送達
US6923979B2 (en) * 1999-04-27 2005-08-02 Microdose Technologies, Inc. Method for depositing particles onto a substrate using an alternating electric field
US6368346B1 (en) 1999-06-03 2002-04-09 American Medical Systems, Inc. Bioresorbable stent
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
EP1210064B1 (en) * 1999-08-18 2005-03-09 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
IT1311576B1 (it) * 1999-10-25 2002-03-13 Ghimas Spa Dispositivo medico invasivo, in particolare per la rigenerazionetissutale guidata.
WO2001034371A2 (en) * 1999-11-05 2001-05-17 Z Corporation Material systems and methods of three-dimensional printing
US6793497B2 (en) 1999-11-12 2004-09-21 Milwaukee School Of Engineering Molecular models
AU770395B2 (en) * 1999-11-17 2004-02-19 Boston Scientific Limited Microfabricated devices for the delivery of molecules into a carrier fluid
DE60027458T2 (de) * 1999-12-10 2007-07-05 Massachusetts Institute Of Technology, Cambridge Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
AU2624801A (en) * 1999-12-30 2001-07-16 Osteotech, Inc. Intervertebral implants
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6551838B2 (en) * 2000-03-02 2003-04-22 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
US20030207959A1 (en) * 2000-03-13 2003-11-06 Eduardo Napadensky Compositions and methods for use in three dimensional model printing
US7300619B2 (en) * 2000-03-13 2007-11-27 Objet Geometries Ltd. Compositions and methods for use in three dimensional model printing
US8481241B2 (en) 2000-03-13 2013-07-09 Stratasys Ltd. Compositions and methods for use in three dimensional model printing
AU2001249935A1 (en) * 2000-04-05 2001-10-23 Therics, Inc. System and method for rapidly customizing a design and remotely manufacturing biomedical devices using a computer system
US6772026B2 (en) * 2000-04-05 2004-08-03 Therics, Inc. System and method for rapidly customizing design, manufacture and/or selection of biomedical devices
US20010050031A1 (en) * 2000-04-14 2001-12-13 Z Corporation Compositions for three-dimensional printing of solid objects
DE10018987A1 (de) 2000-04-17 2001-10-31 Envision Technologies Gmbh Vorrichtung und Verfahren zum Herstellen von dreidimensionalen Objekten
AU2001265128A1 (en) 2000-05-30 2001-12-11 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
AU2001273687A1 (en) * 2000-07-10 2002-01-21 Massachusetts Institute Of Technology Method and materials for controlling migration of binder liquid in a powder
US9387094B2 (en) * 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US6432752B1 (en) * 2000-08-17 2002-08-13 Micron Technology, Inc. Stereolithographic methods for fabricating hermetic semiconductor device packages and semiconductor devices including stereolithographically fabricated hermetic packages
EP1324842B1 (de) 2000-09-25 2007-12-19 Voxeljet Technology GmbH Verfahren zum herstellen eines bauteils in ablagerungstechnik
DE10047614C2 (de) * 2000-09-26 2003-03-27 Generis Gmbh Vorrichtung zum schichtweisen Aufbau von Modellen
DE10047615A1 (de) * 2000-09-26 2002-04-25 Generis Gmbh Wechselbehälter
CN1119231C (zh) * 2000-09-29 2003-08-27 清华大学 无加热液化过程的挤压、喷射成形工艺方法
DE10049043A1 (de) * 2000-10-04 2002-05-02 Generis Gmbh Verfahren zum Entpacken von in ungebundenem Partikelmaterial eingebetteten Formkörpern
US7226442B2 (en) * 2000-10-10 2007-06-05 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US7024248B2 (en) * 2000-10-16 2006-04-04 Remon Medical Technologies Ltd Systems and methods for communicating with implantable devices
US20030120274A1 (en) * 2000-10-20 2003-06-26 Morris John W. Implant retaining device
US7666445B2 (en) 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
US6641776B1 (en) * 2000-11-15 2003-11-04 Scimed Life Systems, Inc. Method for preparing radiopaque surgical implement
US7323193B2 (en) * 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US8123814B2 (en) 2001-02-23 2012-02-28 Biomet Manufacturing Corp. Method and appartus for acetabular reconstruction
US7597715B2 (en) * 2005-04-21 2009-10-06 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
JP2004522546A (ja) * 2001-03-16 2004-07-29 ビボキシド オサケユイチア 生体活性ガラスの局所化した電磁エネルギーおよび／または音響エネルギーによる焼結
FI110481B (fi) * 2001-03-16 2003-02-14 Vivoxid Oy Bioaktiivisten lasien ja niiden komposiittien sintraus
FI20010523A0 (fi) * 2001-03-16 2001-03-16 Yli Urpo Antti Soolien, geelien ja niiden seosten käsittely
DE10114290B4 (de) * 2001-03-23 2004-08-12 Ivoclar Vivadent Ag Desktop-Verfahren zur Herstellung von Dentalprodukten unter Verwendung des 3D-Plottings
US6660208B2 (en) * 2001-03-30 2003-12-09 3D Systems, Inc. Detoxification of solid freeform fabrication materials
DE10117875C1 (de) * 2001-04-10 2003-01-30 Generis Gmbh Verfahren, Vorrichtung zum Auftragen von Fluiden sowie Verwendung einer solchen Vorrichtung
CA2442855A1 (en) * 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
WO2002089767A1 (en) 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US20070087048A1 (en) * 2001-05-31 2007-04-19 Abrams Andrew L Oral dosage combination pharmaceutical packaging
US20020188342A1 (en) * 2001-06-01 2002-12-12 Rykhus Robert L. Short-term bioresorbable stents
US20030069629A1 (en) * 2001-06-01 2003-04-10 Jadhav Balkrishna S. Bioresorbable medical devices
US20040173146A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
US20040173147A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
US6962715B2 (en) * 2001-10-24 2005-11-08 Hewlett-Packard Development Company, L.P. Method and dosage form for dispensing a bioactive substance
US6827250B2 (en) 2001-06-28 2004-12-07 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
JP2003052804A (ja) * 2001-08-09 2003-02-25 Ichiro Ono インプラントの製造方法およびインプラント
JP2003070816A (ja) * 2001-08-30 2003-03-11 Pentax Corp インプラントの設計方法およびインプラント
GB0121985D0 (en) * 2001-09-11 2001-10-31 Isis Innovation Tissue engineering scaffolds
EP2295088B1 (en) 2001-10-12 2016-12-07 Warsaw Orthopedic, Inc. Improved bone graft
US7509240B2 (en) * 2001-10-15 2009-03-24 The Regents Of The University Of Michigan Solid freeform fabrication of structurally engineered multifunctional devices
US7300668B2 (en) 2001-10-29 2007-11-27 Massachusetts Institute Of Technology System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
US7931914B2 (en) * 2001-10-29 2011-04-26 Massachusetts Institute Of Technology System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
JP2005509001A (ja) * 2001-10-29 2005-04-07 セリクス， インコーポレイテッド 投薬形態の三次元懸濁液プリンティング
US20050121411A1 (en) * 2002-10-29 2005-06-09 Microfabrica Inc. Medical devices and EFAB methods and apparatus for producing them
US6855167B2 (en) * 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
WO2003079985A2 (en) * 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US8293530B2 (en) 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
WO2003092665A2 (en) * 2002-05-02 2003-11-13 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
DE60323482D1 (de) * 2002-05-06 2008-10-23 Massachusetts Inst Technology Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken
DE10222167A1 (de) 2002-05-20 2003-12-04 Generis Gmbh Vorrichtung zum Zuführen von Fluiden
DE10224981B4 (de) * 2002-06-05 2004-08-19 Generis Gmbh Verfahren zum schichtweisen Aufbau von Modellen
WO2004017915A2 (en) * 2002-08-20 2004-03-04 Exactech, Inc. Composition for the carrying and delivery of bone growth inducing material and methods for producing and applying the composition
WO2004021923A2 (en) * 2002-09-04 2004-03-18 Reva Medical, Inc. A slide and lock stent and method of manufacture from a single piece shape
US7235195B2 (en) * 2002-09-06 2007-06-26 Novartis Ag Method for making opthalmic devices
US7087109B2 (en) * 2002-09-25 2006-08-08 Z Corporation Three dimensional printing material system and method
AU2003275326A1 (en) * 2002-09-30 2004-04-23 Massachussetts Eye And Ear Infirmary In vitro culture of tissue structures
US20040152800A1 (en) * 2002-10-09 2004-08-05 Shalaby Shalaby W. Photo-crosslinkable, crystalline, polyaxial, absorbable polyester for rapid prototyping
US20040086674A1 (en) * 2002-11-01 2004-05-06 Holman Thomas J. Laser sintering process and devices made therefrom
US6796770B2 (en) 2002-11-06 2004-09-28 Spx Corporation Impeller and method using solid free form fabrication
US20060147332A1 (en) 2004-12-30 2006-07-06 Howmedica Osteonics Corp. Laser-produced porous structure
ATE287307T1 (de) 2002-11-08 2005-02-15 Howmedica Osteonics Corp Lasererzeugte poröse oberfläche
JP3927487B2 (ja) * 2002-12-02 2007-06-06 株式会社大野興業 人工骨モデルの製造方法
US7589868B2 (en) * 2002-12-11 2009-09-15 Agfa Graphics Nv Method and apparatus for creating 3D-prints and a 3-D printing system
WO2004057064A1 (ja) * 2002-12-21 2004-07-08 Juridical Foundation Osaka Industrial Promotion Organization 酸化物ナノ構造体及びそれらの製造方法並びに用途
AU2003900180A0 (en) * 2003-01-16 2003-01-30 Silverbrook Research Pty Ltd Method and apparatus (dam001)
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US6993406B1 (en) 2003-04-24 2006-01-31 Sandia Corporation Method for making a bio-compatible scaffold
DE602004031011D1 (de) * 2003-04-25 2011-02-24 Boston Scient Scimed Inc Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe
EP1628823B8 (en) * 2003-05-21 2012-06-27 3D Systems Incorporated Thermoplastic powder material system for appearance models from 3d printing systems
WO2004106041A2 (en) * 2003-05-23 2004-12-09 Z Corporation Apparatus and methods for 3d printing
US7051654B2 (en) * 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
US7067169B2 (en) * 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
KR20060031808A (ko) * 2003-06-11 2006-04-13 오스테오테크, 인코포레이티드 뼈 임플란트 및 그의 제조 방법
US7807077B2 (en) * 2003-06-16 2010-10-05 Voxeljet Technology Gmbh Methods and systems for the manufacture of layered three-dimensional forms
DE10327272A1 (de) * 2003-06-17 2005-03-03 Generis Gmbh Verfahren zum schichtweisen Aufbau von Modellen
AU2004258953B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2005009365A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2533358C (en) * 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US8758820B2 (en) * 2003-08-11 2014-06-24 Shionogi Inc. Robust pellet
JP2007502294A (ja) * 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
US20050059757A1 (en) * 2003-08-29 2005-03-17 Z Corporation Absorbent fillers for three-dimensional printing
US8246996B2 (en) * 2003-08-29 2012-08-21 Shionogi Inc. Antibiotic product, use and formulation thereof
JP2007513869A (ja) * 2003-09-15 2007-05-31 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
WO2005037137A2 (en) * 2003-10-17 2005-04-28 Therics, Inc. Spinal cage insert, filler piece and method of manufacturing
US20050085922A1 (en) * 2003-10-17 2005-04-21 Shappley Ben R. Shaped filler for implantation into a bone void and methods of manufacture and use thereof
EP1689321B1 (en) 2003-11-07 2017-01-04 The University of Connecticut Artificial tissue systems and uses thereof
JP2007517039A (ja) * 2003-12-24 2007-06-28 アドバンシス ファーマスーティカル コーポレイション 変性放出製剤の吸収増強
CA2535169A1 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
CA2553254C (en) * 2004-01-12 2013-12-17 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
NZ579516A (en) 2004-01-27 2011-01-28 Osteotech Inc Stabilized bone graft
US7910124B2 (en) * 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
US8002830B2 (en) 2004-02-06 2011-08-23 Georgia Tech Research Corporation Surface directed cellular attachment
DE102004008168B4 (de) 2004-02-19 2015-12-10 Voxeljet Ag Verfahren und Vorrichtung zum Auftragen von Fluiden und Verwendung der Vorrichtung
US7645475B2 (en) 2004-03-03 2010-01-12 Mentor Corporation Devices having a textured surface
US7329377B2 (en) * 2004-03-12 2008-02-12 Massachusetts Institute Of Technology Cyclic shrinkage of a templated 3D network material
US20050203482A1 (en) * 2004-03-15 2005-09-15 Chinea Vanessa I. Pharmaceutical dispensing apparatus and method
US20050202051A1 (en) * 2004-03-15 2005-09-15 Chinea Vanessa I. Pharmaceutical vehicle
US7261542B2 (en) * 2004-03-18 2007-08-28 Desktop Factory, Inc. Apparatus for three dimensional printing using image layers
ATE339163T1 (de) * 2004-03-30 2006-10-15 Fin Ceramica Faenza Spa Verfahren zur herstellung von einer biologisch aktiven prothesenvorrichtung zur wiederherstellung von knochengewebe und die prothesenvorrichtung
DE102004022961B4 (de) 2004-05-10 2008-11-20 Envisiontec Gmbh Verfahren zur Herstellung eines dreidimensionalen Objekts mit Auflösungsverbesserung mittels Pixel-Shift
EP1744871B1 (de) 2004-05-10 2008-05-07 Envisiontec GmbH Verfahren zur herstellung eines dreidimensionalen objekts mit auflösungsverbesserung mittels pixel-shift
JP2007537007A (ja) * 2004-05-12 2007-12-20 マサチューセッツ インスティテュート オブ テクノロジー 溶剤蒸気膜形成を含んだ立体印刷法等の製法
DE102004025374A1 (de) * 2004-05-24 2006-02-09 Technische Universität Berlin Verfahren und Vorrichtung zum Herstellen eines dreidimensionalen Artikels
US8012501B2 (en) * 2004-06-10 2011-09-06 Synthes Usa, Llc Flexible bone composite
AU2011213897B2 (en) * 2004-06-10 2013-05-16 Synthes (Usa) Flexible bone composite
US20050278025A1 (en) * 2004-06-10 2005-12-15 Salumedica Llc Meniscus prosthesis
US8715727B2 (en) * 2004-07-02 2014-05-06 Shionogi Inc. Tablet for pulsed delivery
US7763065B2 (en) * 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
US7556490B2 (en) * 2004-07-30 2009-07-07 Board Of Regents, The University Of Texas System Multi-material stereolithography
US7537590B2 (en) * 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
AU2005279729B2 (en) * 2004-09-01 2010-12-02 Microchips, Inc. Multi-cap reservoir devices for controlled release or exposure of reservoir contents
US8271093B2 (en) 2004-09-17 2012-09-18 Cardiac Pacemakers, Inc. Systems and methods for deriving relative physiologic measurements using a backend computing system
US7387359B2 (en) * 2004-09-21 2008-06-17 Z Corporation Apparatus and methods for servicing 3D printers
US7389154B2 (en) * 2004-09-29 2008-06-17 Hewlett-Packard Development Company, L.P. Fabricating a three-dimensional object
AU2005302484A1 (en) * 2004-10-28 2006-05-11 Microchips, Inc. Orthopedic and dental implant devices providing controlled drug delivery
WO2006053031A2 (en) * 2004-11-12 2006-05-18 Mayo Foundation For Medical Education And Research Photocrosslinkable poly(caprolactone fumarate)
US7413846B2 (en) * 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
JP4897699B2 (ja) * 2004-11-18 2012-03-14 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ ポリカプロラクトンとポリ（プロピレンフマレート）とのブロックコポリマー
US7813808B1 (en) 2004-11-24 2010-10-12 Remon Medical Technologies Ltd Implanted sensor system with optimized operational and sensing parameters
US7879109B2 (en) * 2004-12-08 2011-02-01 Biomet Manufacturing Corp. Continuous phase composite for musculoskeletal repair
US8535357B2 (en) 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
US8292944B2 (en) * 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
CA2595457A1 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US7509738B2 (en) * 2005-01-26 2009-03-31 Honeywell International, Inc. Solid-free-form fabrication of hot gas valve discs
WO2006088946A2 (en) * 2005-02-14 2006-08-24 Mayo Medical Ventures Tissue support structure
US20100168890A1 (en) * 2005-03-24 2010-07-01 Ex One Corporation Three-Dimensional Data Extraction Using Ray Casting
US7658603B2 (en) * 2005-03-31 2010-02-09 Board Of Regents, The University Of Texas System Methods and systems for integrating fluid dispensing technology with stereolithography
US8266780B2 (en) 2005-04-21 2012-09-18 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8292967B2 (en) 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8066778B2 (en) 2005-04-21 2011-11-29 Biomet Manufacturing Corp. Porous metal cup with cobalt bearing surface
US8021432B2 (en) 2005-12-05 2011-09-20 Biomet Manufacturing Corp. Apparatus for use of porous implants
US7780897B2 (en) 2005-04-22 2010-08-24 Board Of Regents, The University Of Texas System Hydrogel constructs using stereolithography
ATE511439T1 (de) * 2005-04-29 2011-06-15 Mayo Foundation Hydrophile/hydrophobe polymernetze auf der basis von poly(caprolactonfumarat), poly(ethylenglycolfumarat) und copolymere davon
JP2006318835A (ja) * 2005-05-16 2006-11-24 Seiko Epson Corp 多層化膜の形成方法および多層化膜、並びに電気光学装置、電子機器
DE202005009755U1 (de) * 2005-06-21 2005-09-08 Cervitech, Inc. Halter für Zwischenwirbelprothesen
WO2007001624A2 (en) * 2005-06-28 2007-01-04 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
US7914574B2 (en) * 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US20070042491A1 (en) * 2005-08-18 2007-02-22 Karp Jeffrey M Amplification of cell populations from embryonic stem cells
US7742815B2 (en) * 2005-09-09 2010-06-22 Cardiac Pacemakers, Inc. Using implanted sensors for feedback control of implanted medical devices
WO2007047556A2 (en) * 2005-10-14 2007-04-26 Microchips, Inc. Passive wear-indicating sensor for implantable prosthetic device
CA2627907C (en) * 2005-11-01 2014-06-17 Osteotech, Inc. Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier
WO2007056671A1 (en) * 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
US9440003B2 (en) * 2005-11-04 2016-09-13 Boston Scientific Scimed, Inc. Medical devices having particle-containing regions with diamond-like coatings
CA2629600C (en) 2005-11-14 2011-11-01 Biomet 3I, Inc. Deposition of discrete nanoparticles on an implant surface
US20070136092A1 (en) * 2005-11-30 2007-06-14 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
US8340944B2 (en) * 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US20070174128A1 (en) * 2005-11-30 2007-07-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
US20080114577A1 (en) * 2005-11-30 2008-05-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems associated with nutraceutical related assays
US20070289258A1 (en) * 2006-06-14 2007-12-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Individualized pharmaceutical selection and packaging
US20080033763A1 (en) * 2005-11-30 2008-02-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems related to receiving nutraceutical associated information
US20080052114A1 (en) * 2005-11-30 2008-02-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems and methods related to nutraceuticals
US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US20110145009A1 (en) * 2005-11-30 2011-06-16 Jung Edward K Y Methods and systems related to transmission of nutraceutical associatd information
US20080103746A1 (en) * 2005-11-30 2008-05-01 Searete Llc, A Limited Liability Corporation Systems and methods for pathogen detection and response
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US7827042B2 (en) * 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US20080004905A1 (en) * 2006-06-28 2008-01-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for analysis of nutraceutical associated components
US20070124219A1 (en) * 2005-11-30 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized nutraceutical selection and packaging
US7927787B2 (en) * 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US20070124176A1 (en) * 2005-11-30 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US20070126157A1 (en) * 2005-12-02 2007-06-07 Z Corporation Apparatus and methods for removing printed articles from a 3-D printer
US8728387B2 (en) * 2005-12-06 2014-05-20 Howmedica Osteonics Corp. Laser-produced porous surface
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
CA2572095C (en) 2005-12-30 2009-12-08 Howmedica Osteonics Corp. Laser-produced implants
US20070292822A1 (en) * 2006-02-01 2007-12-20 Micro Dental Laboratories, Inc. Method for Production of Dental Prosthetics
US7635447B2 (en) * 2006-02-17 2009-12-22 Biomet Manufacturing Corp. Method and apparatus for forming porous metal implants
WO2007114895A2 (en) * 2006-04-06 2007-10-11 Z Corporation Production of three-dimensional objects by use of electromagnetic radiation
WO2007119214A2 (en) * 2006-04-13 2007-10-25 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
DE102006019963B4 (de) 2006-04-28 2023-12-07 Envisiontec Gmbh Vorrichtung und Verfahren zur Herstellung eines dreidimensionalen Objekts durch schichtweises Verfestigen eines unter Einwirkung von elektromagnetischer Strahlung verfestigbaren Materials mittels Maskenbelichtung
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
ITMO20060159A1 (it) * 2006-05-18 2007-11-19 Marcello Marchesi "metodo per la rigenerazione guidata di tessuti ossei e/o parodontali in ambito medico chirurgico ed odontoiatrico e dispositivo cosi' ottenibile."
US20070275035A1 (en) * 2006-05-24 2007-11-29 Microchips, Inc. Minimally Invasive Medical Implant Devices for Controlled Drug Delivery
JP5243413B2 (ja) * 2006-05-26 2013-07-24 スリーディー システムズ インコーポレーテッド ３次元プリンターで材料を処理する装置と方法
US20070288021A1 (en) * 2006-06-07 2007-12-13 Howmedica Osteonics Corp. Flexible joint implant
DE102006030350A1 (de) * 2006-06-30 2008-01-03 Voxeljet Technology Gmbh Verfahren zum Aufbauen eines Schichtenkörpers
WO2008005035A1 (en) * 2006-07-05 2008-01-10 Agency For Science, Technology And Research Porous polymeric articles
WO2008008845A2 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
US7955268B2 (en) * 2006-07-21 2011-06-07 Cardiac Pacemakers, Inc. Multiple sensor deployment
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
DE102006038858A1 (de) * 2006-08-20 2008-02-21 Voxeljet Technology Gmbh Selbstaushärtendes Material und Verfahren zum schichtweisen Aufbau von Modellen
US8147861B2 (en) 2006-08-15 2012-04-03 Howmedica Osteonics Corp. Antimicrobial implant
CN101528158B (zh) 2006-08-21 2011-10-05 21世纪国际新技术株式会社 骨模型、骨填充材以及骨填充材的制造方法
US20080077440A1 (en) * 2006-09-26 2008-03-27 Remon Medical Technologies, Ltd Drug dispenser responsive to physiological parameters
EP2079491B1 (en) 2006-10-17 2013-02-27 Reva Medical, Inc. N-substituted monomers and polymers
US8529958B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20080111282A1 (en) * 2006-11-10 2008-05-15 Baojun Xie Process for Making Three Dimensional Objects From Dispersions of Polymer Colloidal Particles
US7931651B2 (en) 2006-11-17 2011-04-26 Wake Lake University Health Sciences External fixation assembly and method of use
WO2008073297A2 (en) * 2006-12-08 2008-06-19 Z Corporation Three dimensional printing material system and method using peroxide cure
CN101616785B (zh) * 2007-01-10 2014-01-08 3D系统公司 具有改进的颜色、制品性能和易用性的三维印刷材料体系
US8377016B2 (en) 2007-01-10 2013-02-19 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US7704275B2 (en) 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
AU2008216371B2 (en) * 2007-02-12 2014-04-10 Warsaw Orthopedic, Inc. Joint revision implant
JP4972725B2 (ja) * 2007-02-14 2012-07-11 国立大学法人京都大学 高分子材料の直接造形法および直接造形装置
US7968626B2 (en) * 2007-02-22 2011-06-28 Z Corporation Three dimensional printing material system and method using plasticizer-assisted sintering
US8568649B1 (en) * 2007-03-20 2013-10-29 Bowling Green State University Three-dimensional printer, ceramic article and method of manufacture
US8475946B1 (en) 2007-03-20 2013-07-02 Bowling Green State University Ceramic article and method of manufacture
JP2010530769A (ja) * 2007-06-14 2010-09-16 カーディアック ペースメイカーズ， インコーポレイテッド 体内圧力測定装置および方法
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
WO2008157492A2 (en) * 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
CA3062443C (en) * 2007-06-15 2022-03-15 Warsaw Orthopedic, Inc. Method of treating tissue
EP2011631B1 (en) 2007-07-04 2012-04-18 Envisiontec GmbH Process and device for producing a three-dimensional object
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
US9358113B2 (en) * 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
DE102007033434A1 (de) 2007-07-18 2009-01-22 Voxeljet Technology Gmbh Verfahren zum Herstellen dreidimensionaler Bauteile
US10226919B2 (en) 2007-07-18 2019-03-12 Voxeljet Ag Articles and structures prepared by three-dimensional printing method
US8142886B2 (en) * 2007-07-24 2012-03-27 Howmedica Osteonics Corp. Porous laser sintered articles
WO2009020607A2 (en) * 2007-08-07 2009-02-12 Arsenal Medical, Inc. Method and apparatus for composite drug delivery medical devices
US20100279007A1 (en) * 2007-08-14 2010-11-04 The Penn State Research Foundation 3-D Printing of near net shape products
WO2009040352A1 (fr) * 2007-09-24 2009-04-02 Berner Fachhochschule für Technik und Informatik HTI Dispositif pour le dépôt de couches
JP5209725B2 (ja) 2007-09-27 2013-06-12 スリーエム イノベイティブ プロパティズ カンパニー 歯科矯正技工器具を製造するための歯科模型のデジタル形成方法
US20090087483A1 (en) * 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US8265949B2 (en) 2007-09-27 2012-09-11 Depuy Products, Inc. Customized patient surgical plan
US9138239B2 (en) 2007-09-30 2015-09-22 DePuy Synthes Products, Inc. Customized patient-specific tibial cutting blocks
ES2802126T3 (es) * 2007-09-30 2021-01-15 Depuy Products Inc Instrumento quirúrgico ortopédico personalizado específico de un paciente
US8979855B2 (en) 2007-09-30 2015-03-17 DePuy Synthes Products, Inc. Customized patient-specific bone cutting blocks
US8357111B2 (en) 2007-09-30 2013-01-22 Depuy Products, Inc. Method and system for designing patient-specific orthopaedic surgical instruments
US9173662B2 (en) 2007-09-30 2015-11-03 DePuy Synthes Products, Inc. Customized patient-specific tibial cutting blocks
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
EP2205189B1 (en) 2007-10-10 2017-12-06 Wake Forest University Health Sciences Devices for treating spinal cord tissue
DE102007049058A1 (de) * 2007-10-11 2009-04-16 Voxeljet Technology Gmbh Materialsystem und Verfahren zum Verändern von Eigenschaften eines Kunststoffbauteils
EP2211921B1 (en) * 2007-10-19 2013-12-25 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
DE102007050679A1 (de) 2007-10-21 2009-04-23 Voxeljet Technology Gmbh Verfahren und Vorrichtung zum Fördern von Partikelmaterial beim schichtweisen Aufbau von Modellen
DE102007050953A1 (de) * 2007-10-23 2009-04-30 Voxeljet Technology Gmbh Vorrichtung zum schichtweisen Aufbau von Modellen
EP2052693B2 (en) 2007-10-26 2021-02-17 Envisiontec GmbH Process and freeform fabrication system for producing a three-dimensional object
WO2009070180A1 (en) 2007-11-30 2009-06-04 Reva Medical, Inc. Axially-radially nested expandable device
WO2009085781A1 (en) * 2007-12-21 2009-07-09 3M Innovative Properties Company Methods of preparing a virtual dentition model and fabricating a dental retainer therefrom
CN103990184A (zh) * 2008-01-09 2014-08-20 韦克福里斯特大学健康科学院 用于治疗中枢神经系统病理的装置和方法
EP2240116B1 (en) 2008-01-28 2015-07-01 Biomet 3I, LLC Implant surface with increased hydrophilicity
JP5211177B2 (ja) * 2008-02-11 2013-06-12 カーディアック ペースメイカーズ， インコーポレイテッド 心臓内の調律識別のための血行動態の監視方法
WO2009102640A1 (en) * 2008-02-12 2009-08-20 Cardiac Pacemakers, Inc. Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices
GB0809721D0 (en) * 2008-05-28 2008-07-02 Univ Bath Improvements in or relating to joints and/or implants
JP2011525849A (ja) 2008-06-25 2011-09-29 ボストン サイエンティフィック サイムド，インコーポレイテッド 治療剤を含む医療機器
EP2299926B1 (en) 2008-06-26 2019-12-18 3M Innovative Properties Company Method for making a transfer tray for orthodontic appliances
CA2730362C (en) 2008-07-18 2018-07-10 Wake Forest University Health Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
US20100042213A1 (en) * 2008-08-13 2010-02-18 Nebosky Paul S Drug delivery implants
CA2734183C (en) * 2008-08-13 2016-11-01 Smed-Ta/Td, Llc Orthopaedic implant with spatially varying porosity
US8475505B2 (en) * 2008-08-13 2013-07-02 Smed-Ta/Td, Llc Orthopaedic screws
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
ES2686906T3 (es) * 2008-08-29 2018-10-22 Smed-Ta/Td, Llc Implante ortopédico
JP2012501806A (ja) * 2008-09-12 2012-01-26 ボストン サイエンティフィック サイムド，インコーポレイテッド ステントの層単位製造
US20110212501A1 (en) * 2008-09-12 2011-09-01 The Brigham And Women's Hospital, Inc. 3-dimensional multi-layered hydrogels and methods of making the same
US10188103B2 (en) * 2008-09-15 2019-01-29 The Boeing Company Antimicrobial coating fabrication method and structure
US10537915B2 (en) 2008-09-15 2020-01-21 The Boeing Company Contaminant resistant coating fabrication structure and method
US7947071B2 (en) 2008-10-10 2011-05-24 Reva Medical, Inc. Expandable slide and lock stent
EP2334230A1 (en) * 2008-10-10 2011-06-22 Cardiac Pacemakers, Inc. Systems and methods for determining cardiac output using pulmonary artery pressure measurements
KR20110086045A (ko) * 2008-10-24 2011-07-27 오스테오테크, 인코포레이티드 뼈 형성 촉진용 조성물 및 뼈 형성 촉진방법
WO2010059291A1 (en) 2008-11-19 2010-05-27 Cardiac Pacemakers, Inc. Assessment of pulmonary vascular resistance via pulmonary artery pressure
DE102008058378A1 (de) 2008-11-20 2010-05-27 Voxeljet Technology Gmbh Verfahren zum schichtweisen Aufbau von Kunststoffmodellen
US10610364B2 (en) 2008-12-04 2020-04-07 Subchondral Solutions, Inc. Method for ameliorating joint conditions and diseases and preventing bone hypertrophy
WO2010093955A1 (en) * 2009-02-12 2010-08-19 Osteotech,Inc. Segmented delivery system
US20100324378A1 (en) * 2009-06-17 2010-12-23 Tran Binh C Physiologic signal monitoring using ultrasound signals from implanted devices
WO2011005493A2 (en) * 2009-06-22 2011-01-13 Mayo Foundation For Medical Education And Research Methods and materials for tissue repair
US20100331998A1 (en) * 2009-06-30 2010-12-30 Ringeisen Timothy A Electrokinetic device for tissue repair
US10016278B2 (en) * 2009-06-30 2018-07-10 Dsm Ip Assets B.V. Biphasic implant device providing joint fluid therapy
US9744123B2 (en) * 2009-06-30 2017-08-29 Kensey Nash Corporation Biphasic implant device providing gradient
US8888828B2 (en) * 2009-07-16 2014-11-18 Covidien Lp Composite fixation device
US8323429B2 (en) * 2009-07-31 2012-12-04 United States Gypsum Company Method for preparing three-dimensional plaster objects
US9668863B2 (en) 2009-08-19 2017-06-06 Smith & Nephew, Inc. Porous implant structures
US8349239B2 (en) 2009-09-23 2013-01-08 Stratasys, Inc. Seam concealment for three-dimensional models
US8372330B2 (en) 2009-10-19 2013-02-12 Global Filtration Systems Resin solidification substrate and assembly
AU2010319306B2 (en) * 2009-11-12 2015-08-27 Smith & Nephew, Inc. Controlled randomized porous structures and methods for making same
ES2702753T3 (es) * 2010-01-05 2019-03-05 Microdose Therapeutx Inc Dispositivo de inhalación
DE102010006939A1 (de) 2010-02-04 2011-08-04 Voxeljet Technology GmbH, 86167 Vorrichtung zum Herstellen dreidimensionaler Modelle
US8673018B2 (en) * 2010-02-05 2014-03-18 AMx Tek LLC Methods of using water-soluble inorganic compounds for implants
US10149722B2 (en) 2010-02-25 2018-12-11 DePuy Synthes Products, Inc. Method of fabricating customized patient-specific bone cutting blocks
EP2538864B1 (en) 2010-02-25 2018-10-31 DePuy Products, Inc. Customized patient-specific bone cutting blocks
IT1398443B1 (it) * 2010-02-26 2013-02-22 Lima Lto S P A Ora Limacorporate Spa Elemento protesico integrato
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
DE102010013733A1 (de) 2010-03-31 2011-10-06 Voxeljet Technology Gmbh Vorrichtung zum Herstellen dreidimensionaler Modelle
DE102010013732A1 (de) 2010-03-31 2011-10-06 Voxeljet Technology Gmbh Vorrichtung zum Herstellen dreidimensionaler Modelle
CN102843997B (zh) 2010-04-10 2015-02-25 雷瓦医药公司 可膨胀滑动锁紧支架
DE102010014969A1 (de) 2010-04-14 2011-10-20 Voxeljet Technology Gmbh Vorrichtung zum Herstellen dreidimensionaler Modelle
DE102010015451A1 (de) 2010-04-17 2011-10-20 Voxeljet Technology Gmbh Verfahren und Vorrichtung zum Herstellen dreidimensionaler Objekte
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525168B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US20120101593A1 (en) * 2010-10-20 2012-04-26 BIOS2 Medical, Inc. Implantable polymer for bone and vascular lesions
DE102010056346A1 (de) 2010-12-29 2012-07-05 Technische Universität München Verfahren zum schichtweisen Aufbau von Modellen
DE102011007957A1 (de) 2011-01-05 2012-07-05 Voxeljet Technology Gmbh Vorrichtung und Verfahren zum Aufbauen eines Schichtenkörpers mit wenigstens einem das Baufeld begrenzenden und hinsichtlich seiner Lage einstellbaren Körper
EP2757964B1 (en) 2011-05-26 2016-05-04 Cartiva, Inc. Tapered joint implant and related tools
US9381154B2 (en) * 2011-06-09 2016-07-05 Xerox Corporation Direct inkjet fabrication of drug delivery devices
US8641721B2 (en) 2011-06-30 2014-02-04 DePuy Synthes Products, LLC Customized patient-specific orthopaedic pin guides
AU2012286817A1 (en) 2011-07-26 2014-02-13 The Curators Of The University Of Missouri Engineered comestible meat
US8414654B1 (en) * 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
US9364896B2 (en) 2012-02-07 2016-06-14 Medical Modeling Inc. Fabrication of hybrid solid-porous medical implantable devices with electron beam melting technology
EP2819620A4 (en) 2012-02-29 2015-11-04 206 Ortho Inc METHOD AND APPARATUS FOR TREATING BONE FRACTURES, INCLUDING THE USE OF COMPOSITE IMPLANTS
DE102012004213A1 (de) 2012-03-06 2013-09-12 Voxeljet Technology Gmbh Verfahren und Vorrichtung zum Herstellen dreidimensionaler Modelle
US9131995B2 (en) 2012-03-20 2015-09-15 Biomet 3I, Llc Surface treatment for an implant surface
US9135374B2 (en) 2012-04-06 2015-09-15 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
US9180010B2 (en) 2012-04-06 2015-11-10 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
DE102012010272A1 (de) 2012-05-25 2013-11-28 Voxeljet Technology Gmbh Verfahren zum Herstellen dreidimensionaler Modelle mit speziellen Bauplattformen und Antriebssystemen
DE102012012363A1 (de) 2012-06-22 2013-12-24 Voxeljet Technology Gmbh Vorrichtung zum Aufbauen eines Schichtenkörpers mit entlang des Austragbehälters bewegbarem Vorrats- oder Befüllbehälter
CN102716512A (zh) * 2012-06-29 2012-10-10 上海大学 药物分级缓释型骨修复体制备方法
BR112015004530A8 (pt) 2012-09-05 2019-08-27 Aprecia Pharmaceuticals Co montagem de equipamento de impressão tridimensional e método para preparação de artigos impressos tridimensionalmente
US8888480B2 (en) 2012-09-05 2014-11-18 Aprecia Pharmaceuticals Company Three-dimensional printing system and equipment assembly
AU2013317842A1 (en) * 2012-09-20 2015-04-30 Ohr Pharma, Llc Multilayer biodegradable microparticles for sustained release of therapeutic agents
US20140099351A1 (en) 2012-10-04 2014-04-10 Axxia Pharmaceuticals, Llc Process for making controlled release medical implant products
DE102012020000A1 (de) 2012-10-12 2014-04-17 Voxeljet Ag 3D-Mehrstufenverfahren
DE102013004940A1 (de) 2012-10-15 2014-04-17 Voxeljet Ag Verfahren und Vorrichtung zum Herstellen von dreidimensionalen Modellen mit temperiertem Druckkopf
WO2014066724A1 (en) 2012-10-26 2014-05-01 Wake Forest University Health Sciences Novel nanofiber-based graft for heart valve replacement and methods of using the same
JP6071420B2 (ja) * 2012-10-26 2017-02-01 京セラメディカル株式会社 生体用ネジ部材
EP2919823B1 (en) * 2012-11-14 2019-07-03 Orthopaedic Innovation Centre Inc. Antimicrobial articles produced by additive manufacturing
DE102012022859A1 (de) 2012-11-25 2014-05-28 Voxeljet Ag Aufbau eines 3D-Druckgerätes zur Herstellung von Bauteilen
WO2014089711A1 (de) * 2012-12-11 2014-06-19 Dr.H.C. Robert Mathys Stiftung Knochenersatz und verfahren zu dessen herstellung
CA2936015C (en) 2013-01-17 2021-05-25 Ehsan Toyserkani Systems and methods for additive manufacturing of heterogeneous porous structures and structures made therefrom
DE102013003303A1 (de) 2013-02-28 2014-08-28 FluidSolids AG Verfahren zum Herstellen eines Formteils mit einer wasserlöslichen Gussform sowie Materialsystem zu deren Herstellung
US9408732B2 (en) 2013-03-14 2016-08-09 Reva Medical, Inc. Reduced-profile slide and lock stent
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
JP6466399B2 (ja) * 2013-03-15 2019-02-06 アプレシア・ファーマスーティカルズ・カンパニー トピラマートの急速分散性の剤形
US9408699B2 (en) 2013-03-15 2016-08-09 Smed-Ta/Td, Llc Removable augment for medical implant
MX365513B (es) 2013-03-15 2019-06-06 Aprecia Pharmaceuticals LLC Forma de dosificacion de dispersion rapida que contiene levetiracetam.
US20140261430A1 (en) 2013-03-15 2014-09-18 Lucy Carol Davis Facial Mask Apparatus and Method of Making
ES2761265T3 (es) * 2013-03-15 2020-05-19 Aprecia Pharmaceuticals LLC Forma de dosificación de oxcarbazepina rápidamente dispersable
US9724203B2 (en) 2013-03-15 2017-08-08 Smed-Ta/Td, Llc Porous tissue ingrowth structure
US9241881B2 (en) * 2013-03-15 2016-01-26 Stewart J. Lustgarten Dental material and method
US9681966B2 (en) 2013-03-15 2017-06-20 Smed-Ta/Td, Llc Method of manufacturing a tubular medical implant
EP2999747B1 (en) 2013-05-23 2020-08-12 206 ORTHO, Inc. Apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone
US20190060529A9 (en) * 2013-05-28 2019-02-28 The Johns Hopkins University Oxygen-charged implantable medical devices for and methods of local delivery of oxygen via outgassing
US20150037385A1 (en) 2013-08-02 2015-02-05 Northwestern University Ceramic-containing bioactive inks and printing methods for tissue engineering applications
KR102171123B1 (ko) 2013-08-16 2020-10-29 더 엑스원 컴퍼니 ３차원 인쇄된 금속 주조용 몰드 및 그를 제조하기 위한 방법
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
WO2015057761A1 (en) 2013-10-17 2015-04-23 The Exone Company Three-dimensional printed hot isostatic pressing containers and processes for making same
DE102013018182A1 (de) 2013-10-30 2015-04-30 Voxeljet Ag Verfahren und Vorrichtung zum Herstellen von dreidimensionalen Modellen mit Bindersystem
US10730232B2 (en) * 2013-11-19 2020-08-04 Guill Tool & Engineering Co, Inc. Coextruded, multilayer and multicomponent 3D printing inputs
DE102013018031A1 (de) 2013-12-02 2015-06-03 Voxeljet Ag Wechselbehälter mit verfahrbarer Seitenwand
DE102013020491A1 (de) 2013-12-11 2015-06-11 Voxeljet Ag 3D-Infiltrationsverfahren
MX2016007786A (es) 2013-12-16 2017-03-03 Massachusetts Inst Technology Formulaciones de sal de micronutrientes fortificadas.
AU2014364930B2 (en) 2013-12-16 2017-06-15 Massachusetts Institute Of Technology Micromolded or 3-D printed pulsatile release vaccine formulations
EP2886307A1 (de) 2013-12-20 2015-06-24 Voxeljet AG Vorrichtung, Spezialpapier und Verfahren zum Herstellen von Formteilen
US11001048B2 (en) 2013-12-23 2021-05-11 The Exone Company Method of three-dimensional printing using a multi-component build powder
WO2015100086A1 (en) 2013-12-23 2015-07-02 The Exone Company Methods and systems for three-dimensional printing utilizing multiple binder fluids
US9415546B2 (en) * 2014-01-29 2016-08-16 Xerox Corporation System and method for controlling material drop volume in three dimensional object printing
CN113575862A (zh) 2014-02-05 2021-11-02 福克和谷德公司 由培养的肌肉细胞制成的干燥的食物制品
US9527244B2 (en) 2014-02-10 2016-12-27 Global Filtration Systems Apparatus and method for forming three-dimensional objects from solidifiable paste
CA2943416C (en) 2014-03-25 2019-10-29 Orthopaedic Innovation Centre Inc. Antimicrobial articles produced by additive manufacturing
DE102014004692A1 (de) 2014-03-31 2015-10-15 Voxeljet Ag Verfahren und Vorrichtung für den 3D-Druck mit klimatisierter Verfahrensführung
KR101641252B1 (ko) * 2014-04-08 2016-07-29 엘지전자 주식회사 3d 프린터의 제어장치
EP3143090B1 (en) 2014-05-15 2020-10-07 Northwestern University Ink compositions for three-dimensional printing and methods of forming objects using the ink compositions
DE102014007584A1 (de) 2014-05-26 2015-11-26 Voxeljet Ag 3D-Umkehrdruckverfahren und Vorrichtung
US20170120329A1 (en) 2014-05-29 2017-05-04 The Exone Company Process for Making Nickel-Based Superalloy Articles by Three-Dimensional Printing
US9327537B2 (en) 2014-06-06 2016-05-03 Xerox Corporation System for adjusting operation of a printer during three-dimensional object printing using an optical sensor
US9446556B2 (en) 2014-06-06 2016-09-20 Xerox Corporation System for compensating for drop volume variation during three-dimensional printing of an object
US9738032B2 (en) 2014-06-06 2017-08-22 Xerox Corporation System for controlling operation of a printer during three-dimensional object printing with reference to a distance from the surface of object
US9675478B2 (en) 2014-06-11 2017-06-13 Abbott Cardiovascular Systems Inc. Solvent method for forming a polymer scaffolding
US9381280B2 (en) 2014-06-13 2016-07-05 Abbott Cardiovascular Systems Inc. Plasticizers for a biodegradable scaffolding and methods of forming same
US10314942B2 (en) * 2014-06-30 2019-06-11 Bacterin International, Inc. Manufacture of biomaterial implants via three-dimensional printing technology
US20170203514A1 (en) 2014-07-17 2017-07-20 The Exone Company Methods and Apparatuses for Curing Three-Dimensional Printed Articles
WO2016019937A1 (de) 2014-08-02 2016-02-11 Voxeljet Ag Verfahren und gussform, insbesondere zur verwendung in kaltgussverfahren
CN107107463B (zh) * 2014-09-08 2019-10-25 中央兰开夏大学 固体剂型生产
US10350329B2 (en) 2014-10-15 2019-07-16 Northwestern University Graphene-based ink compositions for three-dimensional printing applications
US9844930B2 (en) * 2014-11-05 2017-12-19 Xerox Corporation 3D printing of digestible shells for medicaments
US9771487B2 (en) * 2014-11-10 2017-09-26 Xerox Corporation Method of three-dimensional printing
US20180001551A1 (en) 2014-12-03 2018-01-04 The Exone Company Process for Making Densified Carbon Articles by Three Dimensional Printing
US10449692B2 (en) 2014-12-08 2019-10-22 Tethon Corporation Three-dimensional (3D) printing
DE102015006533A1 (de) 2014-12-22 2016-06-23 Voxeljet Ag Verfahren und Vorrichtung zum Herstellen von 3D-Formteilen mit Schichtaufbautechnik
US10279078B2 (en) 2014-12-31 2019-05-07 Bacterin International, Inc. Crosslinkable 3D printed biomaterial-based implants and methods of manufacture thereof
EP3277228B1 (en) 2015-03-31 2020-01-15 Cartiva, Inc. Carpometacarpal (cmc) implants
WO2016161025A1 (en) 2015-03-31 2016-10-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
WO2016168363A1 (en) 2015-04-14 2016-10-20 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
DE102015006363A1 (de) 2015-05-20 2016-12-15 Voxeljet Ag Phenolharzverfahren
CA3254279A1 (en) 2015-06-03 2025-03-18 Triastek, Inc. PHARMACEUTICAL FORMS AND RELATED USES
US11014306B2 (en) * 2015-07-09 2021-05-25 Hewlett-Packard Development Company, L.P. Generating three-dimensional objects with target surface roughness
CN116423825A (zh) 2015-08-21 2023-07-14 阿普雷奇亚制药有限责任公司 三维打印系统和设备组件
DE102015011503A1 (de) 2015-09-09 2017-03-09 Voxeljet Ag Verfahren zum Auftragen von Fluiden
DE102015011790A1 (de) 2015-09-16 2017-03-16 Voxeljet Ag Vorrichtung und Verfahren zum Herstellen dreidimensionaler Formteile
WO2017053433A1 (en) 2015-09-21 2017-03-30 Modern Meadow, Inc. Fiber reinforced tissue composites
US11298210B2 (en) 2015-10-09 2022-04-12 John H. Khouri Orthodontic assembly
EP3380025B1 (en) * 2015-11-25 2021-01-27 Subchondral Solutions, Inc. Devices for repairing anatomical joint conditions
DE102015015353A1 (de) 2015-12-01 2017-06-01 Voxeljet Ag Verfahren und Vorrichtung zur Herstellung von dreidimensionalen Bauteilen mittels Überschussmengensensor
WO2017096068A1 (en) * 2015-12-01 2017-06-08 The Trustees Of Columbia University In The City Of New York Vapor pressure solid articles and methods for making and using the same
EP3389570B1 (en) 2015-12-16 2024-04-17 Nuvasive, Inc. Porous spinal fusion implant
DE102015016464B4 (de) 2015-12-21 2024-04-25 Voxeljet Ag Verfahren und Vorrichtung zum Herstellen von 3D-Formteilen
KR101837652B1 (ko) 2016-01-04 2018-03-12 (주)퓨레코 코어-쉘 구조를 갖는 3d 프린터용 기능성 필라멘트 및 그 제조방법
WO2017143356A1 (en) * 2016-01-25 2017-08-24 Sunp Biotech, Llc High temperature module for a 3d biological printer deposition system
WO2017143357A1 (en) * 2016-01-25 2017-08-24 Sunp Biotech, Llc Low temperature module for a 3d biological printer deposition system and build platform
EP3205666B1 (en) 2016-02-15 2020-04-22 Modern Meadow, Inc. Method for making a biofabricated material containing collagen fibrils
JP6878417B2 (ja) * 2016-02-17 2021-05-26 トリアステック インコーポレイテッド 剤形およびそれらの使用
DE102016002777A1 (de) 2016-03-09 2017-09-14 Voxeljet Ag Verfahren und Vorrichtung zum Herstellen von 3D-Formteilen mit Baufeldwerkzeugen
US11013827B2 (en) 2016-04-30 2021-05-25 Bvw Holding Ag Microstructured haptotaxic implant
TWI731967B (zh) * 2016-04-30 2021-07-01 瑞士商Ｂｖｗ控股公司 微結構化趨觸植入物
CA3023278C (en) 2016-05-05 2019-04-30 Triastek, Inc. Controlled release dosage form
US10765658B2 (en) 2016-06-22 2020-09-08 Mastix LLC Oral compositions delivering therapeutically effective amounts of cannabinoids
US10022231B2 (en) * 2016-07-22 2018-07-17 Cytex Therapeutics, Inc. Articular cartilage repair
GB201612853D0 (en) 2016-07-25 2016-09-07 Univ Central Lancashire Solid dosage form production
GB201620066D0 (en) * 2016-11-28 2017-01-11 Ucl Business Plc Solid Pharmaceutical dosage formulations and processes
KR20190107712A (ko) 2017-01-26 2019-09-20 트리아스텍 인코포레이티드 특정 위장 부위에서의 제어 방출의 투여 형태
EP3614972A4 (en) * 2017-04-27 2021-01-13 Indian Institute of Technology, Delhi 3D PRINTING CONSTRUCTIONS FOR CORRECTION OF BONE DEFECTS AND STEM CELL RELEASE
WO2018199993A1 (en) * 2017-04-28 2018-11-01 Hewlett-Packard Development Company, L.P. Producing ingredient delivery devices for release control
US11298747B2 (en) 2017-05-18 2022-04-12 Howmedica Osteonics Corp. High fatigue strength porous structure
KR102626745B1 (ko) 2017-05-26 2024-01-17 인피니트 머티리얼 솔루션즈, 엘엘씨 수용성 중합체 조성물
US11628517B2 (en) * 2017-06-15 2023-04-18 Howmedica Osteonics Corp. Porous structures produced by additive layer manufacturing
EP3470097B1 (en) * 2017-10-16 2021-03-31 Arctic Biomaterials Oy Orthopedic bioabsorbable implants
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
WO2019129558A1 (en) * 2017-12-29 2019-07-04 Exentis Knowledge Gmbh Method for producing a nutraceutical delivery system
EP3731656A1 (en) * 2017-12-29 2020-11-04 Exentis Knowledge GmbH Nutraceutical delivery system
CN116270513A (zh) 2018-01-09 2023-06-23 南京三迭纪医药科技有限公司 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型
US10350822B1 (en) 2018-01-09 2019-07-16 Triastek Inc. Dosage forms with desired release profiles and methods of designing and making thereof
US12060657B2 (en) * 2018-03-06 2024-08-13 Basf Se Filaments based on a core material comprising a fibrous filler
DE102018107585B3 (de) * 2018-03-29 2019-03-28 Universität Rostock Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen
US11051829B2 (en) 2018-06-26 2021-07-06 DePuy Synthes Products, Inc. Customized patient-specific orthopaedic surgical instrument
GB201813186D0 (en) 2018-08-13 2018-09-26 Univ Central Lancashire Solid dosage from production
AU2020209847B2 (en) 2019-01-17 2024-10-17 Modern Meadow, Inc. Layered collagen materials and methods of making the same
US20200367477A1 (en) * 2019-05-24 2020-11-26 Alexander SCHOFIELD Artificial coral articles and preparation methods thereof
US12227659B2 (en) 2019-06-10 2025-02-18 Hewlett-Packard Development Company, L.P. Three-dimensional printing with pore-promoting agents
US11724486B2 (en) 2019-07-09 2023-08-15 Kyndryl, Inc. Printing customized medication based on current user data and medical records of the user
GB201910233D0 (en) * 2019-07-17 2019-08-28 Univ Oxford Innovation Ltd Scaffold for bone ingrowth
WO2021016288A1 (en) 2019-07-25 2021-01-28 D2 Medical Llc Bone-derived thermoplastic filament and method of manufacture
EP4013602A1 (en) * 2019-08-14 2022-06-22 Merck Patent GmbH Method for additive manufacture of a product, manufacturing device and solid pharmaceutical dosage form
US11851641B2 (en) * 2019-08-30 2023-12-26 Han Bio Usa Method for producing stem cell culture plate available for tissue engineering using 3D printing for human organoid generation
DE202019106375U1 (de) * 2019-11-15 2019-11-25 Kumovis GmbH Orthopädisches Implantat
WO2021105878A1 (en) 2019-11-26 2021-06-03 3M Innovative Properties Company A dental template for direct bonding orthodontic appliances and methods of making and using the same
US12371581B2 (en) 2020-03-25 2025-07-29 Infinite Material Solutions, Llc High performance water soluble polymer compositions
US11504879B2 (en) 2020-04-17 2022-11-22 Beehive Industries, LLC Powder spreading apparatus and system
WO2021214613A1 (en) 2020-04-24 2021-10-28 3M Innovative Properties Company An indirect bonding tray for bonding orthodontic appliances and methods of making and using the same
US20210355326A1 (en) 2020-05-01 2021-11-18 Modern Meadow, Inc. Protein polyurethane alloys and layered materials including the same
WO2022089588A1 (zh) 2020-10-30 2022-05-05 南京三迭纪医药科技有限公司 胃滞留药物剂型
EP4304837A4 (en) 2021-03-12 2024-11-20 Hewlett-Packard Development Company, L.P. THREE-DIMENSIONAL PRINTING WITH PORE-PROMOTING AGENTS
CN113244181B (zh) * 2021-04-28 2023-05-26 浙江工业大学 一种采用大光斑加热熔融配方粉末快速制备片剂的方法
EP4159202A1 (en) 2021-09-29 2023-04-05 Biomind Labs Inc Pharmaceutical formulation containing a psychedelic substance obtained by 3d printing by selective laser sintering (sls)
US11771528B1 (en) 2022-09-12 2023-10-03 Spectrum Spine Ip Holdings, Llc Implant with enhanced osteoinductivity
US20240075683A1 (en) 2022-09-01 2024-03-07 Illinois Tool Works Inc. Method for manufacture of custom object complementary to vehicle exterior surface defect

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4046513A (en) * 1976-06-30 1977-09-06 Miles Laboratories, Inc. Printed reagent test devices and method of making same
US4787900A (en) * 1982-04-19 1988-11-29 Massachusetts Institute Of Technology Process for forming multilayer bioreplaceable blood vessel prosthesis
US4520821A (en) * 1982-04-30 1985-06-04 The Regents Of The University Of California Growing of long-term biological tissue correction structures in vivo
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
JPS6021763A (ja) * 1983-07-15 1985-02-04 ティーディーケイ株式会社 人工骨材料
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4620327A (en) * 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
US5011692A (en) 1985-12-28 1991-04-30 Sumitomo Pharmaceuticals Company, Limited Sustained pulsewise release pharmaceutical preparation
US4927632A (en) 1986-06-26 1990-05-22 Alza Corporation Selective pulsed drug delivery system
NL8801741A (nl) * 1988-07-08 1990-02-01 Utermoehlen Nv Kunsthuid.
JP2678945B2 (ja) * 1989-04-17 1997-11-19 有限会社ナイセム 人工血管とその製造方法及び人工血管用基質
US5204055A (en) * 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5059123A (en) 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
WO1991017724A1 (en) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5460758A (en) * 1990-12-21 1995-10-24 Eos Gmbh Electro Optical Systems Method and apparatus for production of a three-dimensional object
DE4102259A1 (de) * 1991-01-23 1992-07-30 Artos Med Produkte Verfahren zur herstellung beliebig geformter koerper
US5348788A (en) * 1991-01-30 1994-09-20 Interpore Orthopaedics, Inc. Mesh sheet with microscopic projections and holes
ES2081564T3 (es) * 1991-01-31 1996-03-16 Texas Instruments Inc Metodo y sistema para la fabricacion, controlada por ordenador, de objetos tridimensionales a partir de datos de ordenador.
DE4120325A1 (de) * 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
GB9206509D0 (en) 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges containing active agents
US5496372A (en) * 1992-04-17 1996-03-05 Kyocera Corporation Hard tissue prosthesis including porous thin metal sheets
US5370692A (en) * 1992-08-14 1994-12-06 Guild Associates, Inc. Rapid, customized bone prosthesis
US5510066A (en) * 1992-08-14 1996-04-23 Guild Associates, Inc. Method for free-formation of a free-standing, three-dimensional body
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques

Also Published As

Publication number Publication date
US5869170A (en) 1999-02-09
US5490962A (en) 1996-02-13
PT724428E (pt) 2001-04-30
CA2173318A1 (en) 1995-04-27
JP2930420B2 (ja) 1999-08-03
DE69426457D1 (de) 2001-01-25
JPH09502999A (ja) 1997-03-25
EP0724428B1 (en) 2000-12-20
WO1995011007A1 (en) 1995-04-27
US6530958B1 (en) 2003-03-11
CA2173318C (en) 2002-01-01
DE69426457T2 (de) 2001-05-23
EP0724428A1 (en) 1996-08-07
ATE198146T1 (de) 2001-01-15
GR3035455T3 (en) 2001-05-31
DK0724428T3 (da) 2001-02-05

Similar Documents

Publication Publication Date Title
ES2154302T3 (es) Preparacion de dispositivos de uso medico mediante procedimientos de fabricacion por modelizacion de solidos con estructura no impuesta.
Velásquez-García et al. Biomedical applications of metal 3D printing
US10881486B2 (en) Three-dimensional printed dental appliances using lattices
ES2908182T3 (es) Método de planificación ortodóntica
DE69624241D1 (de) Mittels eines herstellungsverfahrens für frei gestaltete feste strukturen hergestellte matritzen für vaskularisierte geweberegeneration
US10548690B2 (en) Orthodontic planning systems
León et al. 3D metal printing-additive manufacturing technologies for frameworks of implant-borne fixed dental prosthesis
Sun et al. The application of rapid prototyping in prosthodontics
Cesarano III et al. Customization of load‐bearing hydroxyapatite lattice scaffolds
JP2018038848A (ja) 制御された無作為性の多孔性構造
CN103917215A (zh) 通过增材制造制备的网状结构
Cima et al. Preparation of medical devices by solid free-form fabrication methods
JP2007236926A (ja) レーザによって作製されるインプラント
US20240299134A1 (en) Orthodontic planning systems
Qiu et al. Nasal prosthesis rehabilitation using CAD-CAM technology after total rhinectomy: a pilot study
CN105930615A (zh) Cad-cam-3d打印系统的流动交通工作站及自动加工口腔修复体
JP2014500747A (ja) 義歯用の枠組みおよびその製造方法
CN113017874A (zh) 基于梁基结构的复杂多孔种植体设计及制造方法
CN202724045U (zh) 寰椎融合假体
Bhatnagar et al. Additive Manufacturing: A 3-Dimensional Approach in Periodontics
Rathee et al. 3D Printing: An Upcoming Technology in Prosthodontics
Mazzoli et al. Preliminary Considerations on the Design of Multi-layered Bone Scaffold for Laser-Based Printing
Eggbeer et al. The appropriate application of computer aided design and manufacture techniques in silicone facial prosthetics
Akhila et al. Rapid prototyping: An innovative technique in prosthodontics
Ergun et al. Customized Scaffold Fabrication with Solid Free Form Technique

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 724428

Country of ref document: ES