ES2154637T3 - Aportacion de genes dirigidos que codifican proteinas inmunogenicas. - Google Patents

Aportacion de genes dirigidos que codifican proteinas inmunogenicas.

Info

Publication number
ES2154637T3
ES2154637T3 ES92913964T ES92913964T ES2154637T3 ES 2154637 T3 ES2154637 T3 ES 2154637T3 ES 92913964 T ES92913964 T ES 92913964T ES 92913964 T ES92913964 T ES 92913964T ES 2154637 T3 ES2154637 T3 ES 2154637T3
Authority
ES
Spain
Prior art keywords
gen
cell
specific
immunogenic
link agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92913964T
Other languages
English (en)
Inventor
George Y Wu
George L Spitalny
Mark A Findeis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Immune Response Corp
Original Assignee
University of Connecticut
Immune Response Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut, Immune Response Corp filed Critical University of Connecticut
Application granted granted Critical
Publication of ES2154637T3 publication Critical patent/ES2154637T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PUEDEN USAR COMPLEJOS MOLECULARES PARA OBTENER UN GEN QUE CODIFICA UNA PROTEINA INMUNOGENICA O POLIPEPTIDO A UNA CELULA ESPECIFICA IN VIVO. EL GEN SE INCORPORA DENTRO DE LA CELULA OBJETIVO, EXPRESADA Y EL PRODUCTO CODIFICADO DE GEN SE SEGREGA Y SE OBTIENE UNA RESPUESTA INMUNOLOGICA CONTRA LA PROTEINA INMUNOGENICA O POLIPETIDO. EL COMPLEJO MOLECULAR COMPRENDE UN GEN EXPRESABLE QUE CODIFICA UNA PROTEINA INMUNOGENICA DESEADA O COLIPETIDO COMPLEJADO CON UN PORTADOR DE UN AGENTE DE ENLACE DE CELULA ESPECIFICA Y UN AGENTE DE ENLACE DE GEN. EL AGENTE DE ENLACE DE CELULA ESPECIFICA ES ESPECIFICO PARA UNA ESTRUCTURA DE SUPERFICIE CELULAR QUE MEDIA EN LA INTERNALIZACION DE LIGANDOS POR ENDOCITOSIS. UN EJEMPLO ES EL RECEPTOR DE ASIALOGLICOPROTEINA DE HEPATOCITOS. EL AGENTE DE ENLACE DE GEN ES UN COMPUESTO TAL COMO UN POLICATION QUE COMPLEJA ESTABLEMENTE EL GEN BAJO CONDICIONES EXTRACELULARES Y LIBERA EL GEN BAJO CONDICIONES INTRACELULARES DE MANERA QUE PUEDE FUNCIONAR DENTRO DE UNA CELULA. EL COMPLEJO MOLECULAR ES ESTABLE Y SOLUBLE IN FLUIDOS FISIOLOGICOS Y PUEDE SER USADO PARA OBTENER UNA RESPUESTA INMUNOLOGICA CONTRA UNA VARIEDAD DE INMUNOGENES EN UN ORGANISMO PARA LA VACUAN O LA PRODUCCION DE ANTICUERPOS.
ES92913964T 1991-05-14 1992-05-14 Aportacion de genes dirigidos que codifican proteinas inmunogenicas. Expired - Lifetime ES2154637T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69989191A 1991-05-14 1991-05-14

Publications (1)

Publication Number Publication Date
ES2154637T3 true ES2154637T3 (es) 2001-04-16

Family

ID=24811356

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92913964T Expired - Lifetime ES2154637T3 (es) 1991-05-14 1992-05-14 Aportacion de genes dirigidos que codifican proteinas inmunogenicas.

Country Status (9)

Country Link
EP (1) EP0584279B1 (es)
JP (1) JPH06510524A (es)
AT (1) ATE199647T1 (es)
AU (1) AU668870B2 (es)
CA (1) CA2103064A1 (es)
DE (1) DE69231736T2 (es)
DK (1) DK0584279T3 (es)
ES (1) ES2154637T3 (es)
WO (1) WO1992020316A2 (es)

Families Citing this family (154)

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WO1992020316A2 (en) 1992-11-26
AU668870B2 (en) 1996-05-23
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ATE199647T1 (de) 2001-03-15
CA2103064A1 (en) 1992-11-15

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