ES2154725T3 - Nuevos compuestos de sililo y su utilizacion. - Google Patents

Nuevos compuestos de sililo y su utilizacion.

Info

Publication number
ES2154725T3
ES2154725T3 ES95912217T ES95912217T ES2154725T3 ES 2154725 T3 ES2154725 T3 ES 2154725T3 ES 95912217 T ES95912217 T ES 95912217T ES 95912217 T ES95912217 T ES 95912217T ES 2154725 T3 ES2154725 T3 ES 2154725T3
Authority
ES
Spain
Prior art keywords
sililo
compounds
new
epimers
enrichment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95912217T
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Beate Gutterer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Application granted granted Critical
Publication of ES2154725T3 publication Critical patent/ES2154725T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION DESCRIBE UN PROCEDIMIENTO PARA EL ENRIQUECIMIENTO EN EPIMEROS DE COMPUESTOS DE FORMULA (I) POR SILILACION, CRISTALIZACION FRACCIONADA E HIDROLISIS ACIDA.
ES95912217T 1994-03-09 1995-03-07 Nuevos compuestos de sililo y su utilizacion. Expired - Lifetime ES2154725T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH70194 1994-03-09

Publications (1)

Publication Number Publication Date
ES2154725T3 true ES2154725T3 (es) 2001-04-16

Family

ID=4193160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95912217T Expired - Lifetime ES2154725T3 (es) 1994-03-09 1995-03-07 Nuevos compuestos de sililo y su utilizacion.

Country Status (13)

Country Link
US (1) US5728826A (es)
EP (1) EP0749438B1 (es)
JP (1) JP3734090B2 (es)
AT (1) ATE198074T1 (es)
AU (1) AU697541B2 (es)
CA (1) CA2185015C (es)
DE (1) DE59508898D1 (es)
DK (1) DK0749438T3 (es)
ES (1) ES2154725T3 (es)
GR (1) GR3035449T3 (es)
NZ (1) NZ282402A (es)
PT (1) PT749438E (es)
WO (1) WO1995024416A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19635498A1 (de) * 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
US20070135398A1 (en) * 2005-11-02 2007-06-14 Pierluigi Rossetto Process for the preparation of ciclesonide
US20070232578A1 (en) * 2006-02-15 2007-10-04 Pierluigi Rossetto Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
CA2663737A1 (en) * 2006-09-19 2008-03-27 Cipla Limited Processes for the preparation of ciclesonide and its crystal form
EP2262823B1 (en) * 2008-03-13 2013-01-23 Farmabios S.p.A. Process for the preparation of pregnane derivatives
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
PE20190622A1 (es) 2016-06-02 2019-04-26 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados del mismo
MA49796A (fr) 2017-12-01 2020-06-03 Abbvie Inc Agoniste du récepteur des glucocorticoïdes et immunoconjugués de celui-ci

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3513163A (en) * 1968-02-12 1970-05-19 Searle & Co 21-tri(lower alkyl)-siloxypregnane-3,20-diones
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL

Also Published As

Publication number Publication date
EP0749438A1 (de) 1996-12-27
NZ282402A (en) 1998-02-26
GR3035449T3 (en) 2001-05-31
CA2185015A1 (en) 1995-09-14
AU697541B2 (en) 1998-10-08
DK0749438T3 (da) 2001-04-02
CA2185015C (en) 2007-05-08
DE59508898D1 (de) 2001-01-18
JP3734090B2 (ja) 2006-01-11
AU1949195A (en) 1995-09-25
US5728826A (en) 1998-03-17
JPH09509952A (ja) 1997-10-07
PT749438E (pt) 2001-05-31
EP0749438B1 (de) 2000-12-13
WO1995024416A1 (de) 1995-09-14
ATE198074T1 (de) 2000-12-15

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