ES2155073T3 - Matriz de dos fases para un dispositivo de aporte de farmacos de liberacion sostenida. - Google Patents

Matriz de dos fases para un dispositivo de aporte de farmacos de liberacion sostenida.

Info

Publication number
ES2155073T3
ES2155073T3 ES93923258T ES93923258T ES2155073T3 ES 2155073 T3 ES2155073 T3 ES 2155073T3 ES 93923258 T ES93923258 T ES 93923258T ES 93923258 T ES93923258 T ES 93923258T ES 2155073 T3 ES2155073 T3 ES 2155073T3
Authority
ES
Spain
Prior art keywords
phase
drug
support
phase matrix
support device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93923258T
Other languages
English (en)
Inventor
Tsung-Min Hsu
Tung Fen Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Application granted granted Critical
Publication of ES2155073T3 publication Critical patent/ES2155073T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UNA MATRIZ QUE CONTIENE FARMACO HIDROFILICO DE DOS FASES PARA USAR UN PARCHES (10) TRANSDERMICOS DE DISTRIBUCION DE FARMACO EN LA QUE UNA FASE ES UNA FASE DE POLIMERO HIDROFOBICO CONTINUA QUE OPCIONALMENTE INCLUYE UN SOLVENTE HIDROFOBICO QUE ACTUA COMO UNA REALZADOR DE LA PERMEACION DE LA PIEL Y LA OTRA FASE ES UN SILICATO INORGANICO HIDRATADO PARTICULADO DISPERSADO EN CUYA FASE ACUOSA ABSORBIDA SE DISUELVE EL FARMACO. UN ESTRUCTURA DE PARCHE (10) TRANSDERMICO SIMPLE CONTIENE COMO COMPONENTES UNA CAPA AUXILIAR (11), UNA CAPA DE MATRIZ (12) Y UNA CAPA DE ENVUELTA DE LIBERACION (13).
ES93923258T 1992-10-05 1993-10-05 Matriz de dos fases para un dispositivo de aporte de farmacos de liberacion sostenida. Expired - Lifetime ES2155073T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95663592A 1992-10-05 1992-10-05
US08/056,076 US5989586A (en) 1992-10-05 1993-04-30 Two-phase matrix for sustained release drug delivery device

Publications (1)

Publication Number Publication Date
ES2155073T3 true ES2155073T3 (es) 2001-05-01

Family

ID=26734946

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93923258T Expired - Lifetime ES2155073T3 (es) 1992-10-05 1993-10-05 Matriz de dos fases para un dispositivo de aporte de farmacos de liberacion sostenida.

Country Status (14)

Country Link
US (2) US5989586A (es)
EP (1) EP0662822B1 (es)
JP (1) JPH08504757A (es)
CN (1) CN1089469A (es)
AT (1) ATE198420T1 (es)
AU (1) AU5321194A (es)
CA (1) CA2145631C (es)
DE (1) DE69329825T2 (es)
DK (1) DK0662822T3 (es)
ES (1) ES2155073T3 (es)
GR (1) GR3035626T3 (es)
PT (1) PT662822E (es)
TW (1) TW252919B (es)
WO (1) WO1994007468A1 (es)

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WO1994007468A1 (en) 1994-04-14
EP0662822B1 (en) 2001-01-03
CA2145631A1 (en) 1994-04-14
GR3035626T3 (en) 2001-06-29
TW252919B (es) 1995-08-01
DE69329825D1 (de) 2001-02-08
CA2145631C (en) 2004-02-10
ATE198420T1 (de) 2001-01-15
EP0662822A1 (en) 1995-07-19
AU5321194A (en) 1994-04-26
PT662822E (pt) 2001-04-30
DE69329825T2 (de) 2001-06-13
JPH08504757A (ja) 1996-05-21
EP0662822A4 (en) 1996-08-07
US5840336A (en) 1998-11-24
DK0662822T3 (da) 2001-01-29
US5989586A (en) 1999-11-23
CN1089469A (zh) 1994-07-20

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