ES2156135T3 - Derivados de 3-(fenilalquilaminoalquiloxi)-5-fenilpirazol, procedimiento y productos intermedios para su preparacion y su empleo como agentes reductores de la frecuencia cardiaca. - Google Patents

Derivados de 3-(fenilalquilaminoalquiloxi)-5-fenilpirazol, procedimiento y productos intermedios para su preparacion y su empleo como agentes reductores de la frecuencia cardiaca.

Info

Publication number
ES2156135T3
ES2156135T3 ES94119149T ES94119149T ES2156135T3 ES 2156135 T3 ES2156135 T3 ES 2156135T3 ES 94119149 T ES94119149 T ES 94119149T ES 94119149 T ES94119149 T ES 94119149T ES 2156135 T3 ES2156135 T3 ES 2156135T3
Authority
ES
Spain
Prior art keywords
group
rent
hydrogen
means hydrogen
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94119149T
Other languages
English (en)
Inventor
Wolfgang Dr Kehrbach
Michael Dr Mlinaric
Dieter Dr Ziegler
Reinhard Dr Bruckner
Willi Dr Bielenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Solvay Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals GmbH filed Critical Solvay Pharmaceuticals GmbH
Application granted granted Critical
Publication of ES2156135T3 publication Critical patent/ES2156135T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBEN COMPUESTOS 3 - (FENILALQUIL AMINOALQUILOXI) - 5 FENILPIRAZOL CON EFECTO REDUCTOR DE LA FRECUENCIA CARDIACA Y SU ELABORACION. LOS COMPUESTOS POSEE LA FORMULA GENERAL I DONDE N SIGNIFICA UNA CIFRA COMPLETA DEL 1 AL 5, A SIGNIFICA UN GRUPO DE LA FORMULA GENERAL A DONDE R1 SIGNIFICA HIDROGENO O UN GRUPO ALQUIL INFERIOR Y Q UN GRUPO (CH2)M DONDE M SIGNIFICA 2 HASTA 8 Y QUE PUEDE SER SUSTITUIDO EVENTUALMENTE EN LA POSICION ALFA CON RESPECTO AL ATOMO DE OXIGENO POR 1 HASTA 2 GRUPOS ALQUIL INFERIOR O REPRESENTA LA CADENA 2 - HIDROXIPROPILENO, O A ES UN GRUPO DE LA FORMULA GENERAL B DONDE P SIGNIFICA 4 HASTA 6 Y B ES UN GRUPO (CH2)R, DONDE R ES DESDE 1 HASTA 3 Y DE FORMA QUE PUEDEN SER SUSTITUIDOS EVENTUALMENTE EN LA POSICION ALFA CON RESPECTO AL ATOMO DE OXIGENO POR 1 HASTA 2 GRUPOS DE ALQUIL INFERIOR, R2 SIGNIFICA HIDROGENO, HALOGENO, ALQUIL INFERIOR, ALCOXI, INFERIOR, HIDROXI, TRIFLUORMETIL O NITRO O, EN EL CASO DE QUE A NO CONTENGA NINGUN GRUPO OH Y R3, R6 Y R7 NO SEAN NINGUN GRUPOHIDROXI, SIGNIFICA TAMBIEN ALCANOILOXI INFERIOR Y R3 SIGNIFICA HIDROGENO, HALOGENO, ALQUIL INFERIOR, ALCOXI INFERIOR, HIDROXI O, EN EL CASO DE QUE A NO CONTENGA NINGUN GRUPO OH Y R2, R6 Y R7 NO SEAN NINGUN GRUPO HIDROXI, SIGNIFICA TAMBIEN ALCANOILOXI INFERIOR O R2 Y R3 ESTAN LIGADOS EN DOS ATOMOS DE CARBONO VECINOS Y REPRESENTAN CONJUNTAMENTE UN GRUPO ALQUILENDIOXI CON 1 HASTA 2 ATOMOS DE CARBONO, R4 SIGNIFICA HIDROGENO O ALQUIL INFERIOR, R5 ESTA DISPUESTA EN LA POSICION 1 O 2 Y SIGNIFICA HIDROGENO, ALQUIL INFERIOR O UN GRUPO FENIL ALQUIL INFERIOR, R6 SIGNIFICA HIDROGENO, ALQUIL INFERIR, ALCOXI INFERIOR, HIDROXI, HALOGENO, TRIFLUORMETIL O NITRO O, EN EL CASO DE QUE A NO CONTENGA NINGUN GRUPO OH Y R2, R3 Y R7 NO SEAN NINGUN GRUPO HIDROXI, SIGNIFICA TAMBIEN ALCANOILOXI INFERIOR Y R7 SIGNIFICA HIDROGENO, ALQUIL INFERIR, ALCOXI INFERIOR, HIDROXI O HALOGENO O, EN EL CASO DE QUE A NO CONTENGA NINGUN OH Y R2, R3 Y R6 NO SEAN HIDROXI, SIGNIFICA TAMBIEN ALCANOILOXI INFERIOR O R6 Y R7 ESTAN LIGADOS EN DOS ATOMOS DE CARBONO VECINOS Y FORMAN CONJUNTAMENTE UN GRUPO ALQUILENDIOXI CON 1 HASTA 2 ATOMOS DE CARBONO, ASI COMO SUS SALES DE ADICION ACIDA TOLERABLES FISIOLOGICAMENTE Y ASI COMO PRODUCTOS INTERMEDIOS DE LA FORMULA GENERAL XI DONDE R1'' SIGNIFICA UN GRUPO ALQUIL INFERIOR O UN GRUPO DE PROTECCION AMINO, R2'' SIGNIFICA HIDROGENO, HALOGENO, ALQUIL INFERIOR, TRIFLUORMETILO ALCOXI INFERIOR Y R3'' SIGNIFICA HIDROGENO, HALOGENO, ALQUIL INFERIOR O ALCOXI INFERIOR O R2'' Y R3'' ESTAN LIGADOS EN 2 ATOMOS DE CARBONO VECINOS Y REPRESENTAN CONJUNTAMENTE UN GRUPO ALQUILENDIOXI CON 1 HASTA 2 ATOMOS DE CARBONO, N SIGNIFICA UNA CIFRA COMPLETA DEL 1 HASTA 5, Q ES UN GRUPO (CH2)M'', DONDE M'' SIGNIFICA 1 HASTA 7 Y QUE ES SUSTITUIDO EVENTUALMENTE EL LA POSICION ALFA CON RESPECTO AL ATOMO DE OXIGENO POR 1 HASTA 2 GRUPOS ALQUIL INFERIOR, R4 SIGNIFICA HIDROGENO O ALQUIL INFERIOR, R5 ESTA DISPUESTA EN LA POSICION 1 O 2 Y SIGNIFICA HIDROGENO, ALQUIL INFERIOR O UN GRUPO FENIL ALQUIL INFERIOR, R6'''' SIGNIFICA HIDROGENO, ALQUIL INFERIOR, ALCOXI INFERIOR, HALOGENO O TRIFLUORMETIL Y R7'' SIGNIFICA HIDROGENO, ALQUIL INFERIOR, ALCOXI INFERIOR O HALOGENO.
ES94119149T 1993-12-08 1994-12-05 Derivados de 3-(fenilalquilaminoalquiloxi)-5-fenilpirazol, procedimiento y productos intermedios para su preparacion y su empleo como agentes reductores de la frecuencia cardiaca. Expired - Lifetime ES2156135T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4341749A DE4341749A1 (de) 1993-12-08 1993-12-08 3-(Phenylalkylaminoalkyloxy)-5-phenylpyrazol- Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES2156135T3 true ES2156135T3 (es) 2001-06-16

Family

ID=6504420

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94119149T Expired - Lifetime ES2156135T3 (es) 1993-12-08 1994-12-05 Derivados de 3-(fenilalquilaminoalquiloxi)-5-fenilpirazol, procedimiento y productos intermedios para su preparacion y su empleo como agentes reductores de la frecuencia cardiaca.

Country Status (19)

Country Link
EP (1) EP0663395B1 (es)
JP (1) JP3492433B2 (es)
KR (1) KR950017965A (es)
CN (1) CN1109051A (es)
AT (1) ATE201200T1 (es)
AU (1) AU7769494A (es)
CA (1) CA2137446A1 (es)
CZ (1) CZ303194A3 (es)
DE (2) DE4341749A1 (es)
ES (1) ES2156135T3 (es)
FI (1) FI945750L (es)
HU (1) HUT68518A (es)
IL (1) IL111539A0 (es)
NO (1) NO944722L (es)
NZ (1) NZ264883A (es)
PL (1) PL306155A1 (es)
RU (1) RU94045839A (es)
SK (1) SK150694A3 (es)
ZA (1) ZA949537B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9422708D0 (en) * 1994-11-10 1995-01-04 Zeneca Ltd Herbicides
FR2773153A1 (fr) * 1997-12-29 1999-07-02 Rhone Poulenc Agrochimie Nouveaux composes fongicides
EP1829873A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrrazole derivatives as sigma receptors antagonists
EP1829866A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1001161A (en) * 1972-05-05 1976-12-07 Burton K. Wasson 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation
DE2828529A1 (de) * 1978-06-29 1980-01-17 Kali Chemie Pharma Gmbh Neue 5-phenylpyrazol-derivate, verfahren zu deren herstellung und arzneimittel
FR2479219A1 (fr) * 1980-04-01 1981-10-02 Nativelle Sa Ets Amino-alcoxy pyrazoles, procede pour leur preparation, et medicaments les contenant
FR2513996A1 (fr) * 1981-10-02 1983-04-08 Nativelle Sa Ets Derives du pyrazole, procede pour leur preparation et application en therapeutique
DE3424586A1 (de) * 1984-07-04 1986-01-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-aminocarbonylmethoxy-5-phenyl-pyrazol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4040632A1 (de) * 1990-12-19 1992-06-25 Kali Chemie Pharma Gmbh Phenylalkylaminoalkyl-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
CN1109051A (zh) 1995-09-27
CZ303194A3 (en) 1995-08-16
ATE201200T1 (de) 2001-06-15
HU9403458D0 (en) 1995-02-28
ZA949537B (en) 1995-08-11
FI945750A7 (fi) 1995-06-09
SK150694A3 (en) 1995-07-11
NO944722L (no) 1995-06-09
FI945750A0 (fi) 1994-12-07
PL306155A1 (en) 1995-06-12
JP3492433B2 (ja) 2004-02-03
NO944722D0 (no) 1994-12-07
CA2137446A1 (en) 1995-06-09
EP0663395B1 (de) 2001-05-16
RU94045839A (ru) 1996-09-27
NZ264883A (en) 1995-12-21
DE4341749A1 (de) 1995-06-14
EP0663395A1 (de) 1995-07-19
IL111539A0 (en) 1995-01-24
FI945750L (fi) 1995-06-09
JPH07196622A (ja) 1995-08-01
KR950017965A (ko) 1995-07-22
HUT68518A (en) 1995-06-28
AU7769494A (en) 1995-06-15
DE59409756D1 (de) 2001-06-21

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