ES2156204T3 - Fenilimidazolidinas sustituidas con actividad antiandrogena. - Google Patents

Fenilimidazolidinas sustituidas con actividad antiandrogena.

Info

Publication number
ES2156204T3
ES2156204T3 ES95906361T ES95906361T ES2156204T3 ES 2156204 T3 ES2156204 T3 ES 2156204T3 ES 95906361 T ES95906361 T ES 95906361T ES 95906361 T ES95906361 T ES 95906361T ES 2156204 T3 ES2156204 T3 ES 2156204T3
Authority
ES
Spain
Prior art keywords
sub
represent
rent
radical
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95906361T
Other languages
English (en)
Inventor
Andre Claussner
Francois Goubet
Jean-Georges Teutsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9400042A external-priority patent/FR2715402B1/fr
Priority claimed from FR9410660A external-priority patent/FR2724169B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2156204T3 publication Critical patent/ES2156204T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LOS PRODUCTOS DE FORMULA GENERAL (I), EN LA QUE Z{SUB,1} Y Z{SUB,2} IDENTICOS O DIFERENTES REPRESENTAN CIANO, NITRO, HALOGENO, TRIFLUORMETILO O CARBOXI LIBRE ESTERIFICADO, EL GRUPO -A-B ES ELEGIDO ENTRE LOS RADICALES (A) Y (B) EN LOS QUE X REPRESENTA OXIGENO O AZUFRE, R{SUB,3J} REPRESENTA R{SUB,3} CON LA EXCEPCION DEL VALOR DEL HIDROGENO, R{SUB,3} ES ELEGIDO ENTRE LOS SIGUIENTES RADICALES: HIDROGENO; ALQUILO, ALCENILO, ALQUINILO, ARILO O ARILALQUILO, EVENTUALMENTE SUSTITUIDOS, Y REPRESENTA OXIGENO O AZUFRE O NH, R{SUB,4} Y R{SUB,5} IDENTICOS O DIFERENTES, REPRESENTAN PARTICULARMENTE ALQUILO SUSTITUIDO POR HIDROXILO, CON LA EXCEPCION DE LOS PRODUCTOS EN LOS QUE R{SUB,4} Y R{SUB,5} IDENTICOS O DIFERENTES REPRESENTAN HIDROGENO O UN RADICAL ALQUILO (C{SUB,1-12}) EVENTUALMENTE SUSTITUIDO POR UNO O VARIOS ATOMOS DE HALOGENO O R{SUB,4} Y R{SUB,5} REPRESENTAN UN RADICAL CICLOALQUILO (C{SUB,1-17}) O UNO DE R{SUB,4} O R{SUB,5} REPRESENTA METILO, EL OTRO HIDROXIMETILO, Y REPRESENTA OXIGENO O NH, -A-B- REPRESENTA (C), Z{SUB,1} ES UN RADICAL 4-NITRO Y Z{SUB,2} UN RADICAL 3CF{SUB,3}.
ES95906361T 1994-01-05 1995-01-04 Fenilimidazolidinas sustituidas con actividad antiandrogena. Expired - Lifetime ES2156204T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9400042A FR2715402B1 (fr) 1994-01-05 1994-01-05 Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR9410660A FR2724169B1 (fr) 1994-09-06 1994-09-06 Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ES2156204T3 true ES2156204T3 (es) 2001-06-16

Family

ID=26230882

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95906361T Expired - Lifetime ES2156204T3 (es) 1994-01-05 1995-01-04 Fenilimidazolidinas sustituidas con actividad antiandrogena.

Country Status (20)

Country Link
US (1) US5750553A (es)
EP (1) EP0738263B1 (es)
JP (1) JPH09507241A (es)
KR (1) KR100372065B1 (es)
CN (1) CN1113873C (es)
AT (1) ATE200281T1 (es)
AU (1) AU687152B2 (es)
BR (1) BR9506457A (es)
CA (1) CA2180379A1 (es)
DE (1) DE69520560T2 (es)
DK (1) DK0738263T3 (es)
ES (1) ES2156204T3 (es)
FI (1) FI112475B (es)
GR (1) GR3035853T3 (es)
HU (1) HUT76299A (es)
IL (1) IL111908A (es)
MA (1) MA23423A1 (es)
PT (1) PT738263E (es)
TW (1) TW521073B (es)
WO (1) WO1995018794A1 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
FR2742749B1 (fr) * 1995-12-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
SK117499A3 (en) * 1997-03-03 2000-05-16 Boehringer Ingelheim Pharma Small molecules useful in the treatment of inflammatory and immune cell-mediated diseases, small molecules and pharmaceutical composition with their content
USRE38132E1 (en) 1997-03-03 2003-06-03 Boehringer Ingelheim Pharmaceuticals, Inc. Phenylpyrrolidines, phenylimidazolidines,3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease
US6355664B1 (en) 1997-03-03 2002-03-12 Boehringer Ingelheim Pharmaceuticals, Inc. Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease
DE59913181D1 (de) * 1998-10-23 2006-04-27 Aventis Pharma Sa Zubereitungen zur topischen applikation von antiandrogen wirksamen substanzen
US6184249B1 (en) * 1998-12-18 2001-02-06 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
WO2001007052A1 (en) 1999-07-21 2001-02-01 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
WO2001007044A1 (en) 1999-07-21 2001-02-01 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
US6492408B1 (en) * 1999-07-21 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
JP3833532B2 (ja) 1999-07-21 2006-10-11 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 炎症性疾患の治療において有用な小分子
US6828458B2 (en) 2000-05-25 2004-12-07 Biophysica, Inc. Topical antiandrogen for hair loss and other hyperandrogenic conditions
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
JP2004509072A (ja) * 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
EP1854798A3 (en) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
DE10141443B4 (de) * 2001-08-23 2007-02-01 Christos C. Prof. Dr. Zouboulis Verwendung von molekularbiologisch hergestellten, nicht-viralen Wirkstoffen zur Behandlung der Akne
IL160990A0 (en) * 2001-10-01 2004-08-31 Bristol Myers Squibb Co Spiro-hydantoin compounds useful as anti-inflammatory agents
AU2002364082A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
US6875438B2 (en) * 2002-04-27 2005-04-05 Aventis Pharma Deutschland Gmbh Preparations for topical administration of substances having antiandrogenic activity
EP1709193B1 (en) * 2003-12-19 2011-03-16 The Regents of The University of California Methods and materials for assessing prostate cancer therapies
AU2011202578B2 (en) * 2004-02-24 2012-03-22 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
WO2005099693A2 (en) * 2004-02-24 2005-10-27 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
KR20070106969A (ko) * 2004-09-09 2007-11-06 추가이 세이야쿠 가부시키가이샤 신규 이미다졸리딘 유도체 및 그 용도
AU2005285035B2 (en) * 2004-09-10 2012-03-22 Janssen Pharmaceutica N.V. Novel imidazolidin-2-one derivatives as selective androgen receptor modulators (SARMS)
TW200616634A (en) * 2004-10-01 2006-06-01 Bristol Myers Squibb Co Crystalline forms and process for preparing spiro-hydantoin compounds
US20060142319A1 (en) * 2004-12-14 2006-06-29 Bang-Chi Chen Pyridyl-substituted spiro-hydantoin crystalline forms and process
US7186727B2 (en) * 2004-12-14 2007-03-06 Bristol-Myers Squibb Company Pyridyl-substituted spiro-hydantoin compounds and use thereof
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
ES2689292T3 (es) 2006-03-27 2018-11-13 The Regents Of The University Of California Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos
NZ572374A (en) 2006-03-29 2011-12-22 Univ California Diarylthiohydantoin compounds
US8168667B2 (en) * 2006-05-31 2012-05-01 Galapagos Nv Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
GB0610765D0 (en) * 2006-05-31 2006-07-12 Proskelia Sas Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
US9284345B2 (en) 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
EP2220050A2 (en) 2007-10-26 2010-08-25 The Regents Of The University Of California Diarylhydantoin compounds as androgen receptor modulators
PT2225238E (pt) * 2007-11-29 2014-12-18 Boehringer Ingelheim Int Derivados de amidas do ácido 6,7-di-hidro-5h-imidazo[1,2- a]imidazol-3-carboxílico
GB2463514C (en) 2008-09-11 2018-09-26 Galapagos Nv Imidazolidine compounds and uses therefor
FR2944524B1 (fr) * 2009-04-17 2012-11-30 Ipsen Pharma Sas Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament
US8575360B2 (en) 2009-06-02 2013-11-05 Boehringer Ingelheim International Gmbh Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amides
EP2445914B1 (en) 2009-06-02 2015-07-22 Boehringer Ingelheim International GmbH DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES
CA2773038A1 (en) 2009-09-04 2011-03-10 P. Jeffrey Conn Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
KR101456994B1 (ko) 2009-09-10 2014-11-04 통유지 안드로겐 수용체 길항제 및 그의 용도
TW201111378A (en) 2009-09-11 2011-04-01 Bayer Schering Pharma Ag Substituted (heteroarylmethyl) thiohydantoins
SG10201907588XA (en) 2010-02-16 2019-09-27 Aragon Pharmaceuticals Inc Androgen Receptor Modulators And Uses Thereof
RU2434851C1 (ru) * 2010-07-22 2011-11-27 Александр Васильевич Иващенко Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
CN103608333B (zh) 2011-03-10 2016-01-06 苏州开拓药业有限公司 雄激素受体拮抗剂及其用途
UY34646A (es) 2012-03-02 2013-10-31 Novartis Ag Compuestos de espirohidantoína y su uso como moduladores selectivos del receptor de andrógenos
CN115737643A (zh) 2012-09-26 2023-03-07 阿拉贡药品公司 用于治疗非转移性去势抵抗性前列腺癌的抗雄激素
DK2945628T3 (da) 2013-01-15 2020-05-04 Aragon Pharmaceuticals Inc Androgen receptormodulator i kombination med abirateronacetat og prednison til behandling af prostatacancer
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
MX2020003845A (es) 2017-10-16 2020-11-06 Aragon Pharmaceuticals Inc Antiandrógenos para el tratamiento de cáncer de próstata no metastásico resistente a la castración.
WO2019183369A1 (en) * 2018-03-21 2019-09-26 University Of Miami Neurite outgrowth promoters and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1032258B (de) * 1956-12-20 1958-06-19 Kali Chemie Ag Verfahren zur Herstellung von in 5-Stellung mono- und disubstituierten 1-Aryl-hydantoinen
GB997037A (en) * 1962-03-19 1965-06-30 Ici Ltd New hydrantoin derivatives
DK123717B (da) * 1968-11-25 1972-07-24 Sumitomo Chemical Co 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning.
JPS5136332B1 (es) * 1970-12-09 1976-10-07
US4093444A (en) * 1973-05-22 1978-06-06 Pepro, Societe Pour Le Developpement Et La Vente De Specialites Chimiques Hydantoin derivatives and methods for regulating plant-growth
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
DE2540872A1 (de) * 1975-09-13 1977-03-24 Basf Ag Hydantoin-derivate
JPS52113965A (en) * 1976-03-22 1977-09-24 Nippon Soda Co Ltd Hydantoin derivatives, their preparation, fungicides for agriculture a nd gardening use containing the same
JPS53112875A (en) * 1977-03-15 1978-10-02 Sumitomo Chem Co Ltd 1-chlorocarbonylmethyl-3-(3,5-dichlorophenyl)hydantoin, its preparation and industrial bactericide containing the same
JPS53124267A (en) * 1977-04-06 1978-10-30 Sumitomo Chem Co Ltd 1-alkoxyacyl-3-(3,5-dihalogenophenyl)hydantoin derivatives, their preparation and bactericides for agricultural and horticultural uses containing the same as active agent
JPS5427564A (en) * 1977-08-02 1979-03-01 Sumitomo Chem Co Ltd 1-branched alkylcarbonyl-3-(3,5-dihalogenophenyl) hydantoins, their preparation, and bactericides for pomicultural and horticultural uses containing the same as active agent.
MC1220A1 (fr) * 1977-10-28 1979-07-20 Hoffmann La Roche Nouveaux derives d'imidazolidine
FI801184A7 (fi) * 1979-04-24 1981-01-01 F Hoffmann La Roche & Co Menetelmä imidatsolidiini-johdannaisten valmistamiseksi.
BE884897R (fr) * 1980-08-22 1981-02-23 Hoffmann La Roche Preparations pharmaceutiques
US4753957A (en) * 1981-09-28 1988-06-28 Rohm And Haas Company Substituted 2,4-imidazolidinediones and fungicidal compositions
DE3382406D1 (de) * 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.
FR2619381B1 (fr) * 1987-08-13 1989-12-08 Roussel Uclaf Nouvelles imidazolidines substituees par un radical hydroxymethyle et un radical phenyl substitue, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant et un intermediaire pour leur preparation
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2671348B1 (fr) * 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
WO1995018794A1 (fr) 1995-07-13
EP0738263A1 (fr) 1996-10-23
CA2180379A1 (fr) 1995-07-13
PT738263E (pt) 2001-08-30
JPH09507241A (ja) 1997-07-22
US5750553A (en) 1998-05-12
DE69520560D1 (de) 2001-05-10
HU9601836D0 (en) 1996-09-30
DE69520560T2 (de) 2001-09-13
TW521073B (en) 2003-02-21
FI962754L (fi) 1996-07-04
KR100372065B1 (ko) 2003-05-12
GR3035853T3 (en) 2001-08-31
FI962754A0 (fi) 1996-07-04
MA23423A1 (fr) 1995-10-01
CN1141631A (zh) 1997-01-29
IL111908A0 (en) 1995-03-15
ATE200281T1 (de) 2001-04-15
HUT76299A (en) 1997-07-28
DK0738263T3 (da) 2001-06-18
EP0738263B1 (fr) 2001-04-04
CN1113873C (zh) 2003-07-09
IL111908A (en) 2003-05-29
AU1457395A (en) 1995-08-01
FI112475B (fi) 2003-12-15
BR9506457A (pt) 1997-10-07
AU687152B2 (en) 1998-02-19

Similar Documents

Publication Publication Date Title
ES2169112T3 (es) Nuevas imidazolidinas sustituidas con un heterociclo, su procedimiento de preparacion, y sus productos intermedios, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
ES2044187T3 (es) Mercapto-4 butiramidas n-mono o n,n-disubstituidas por un radical mono o polihidroxialquilo, y su utilizacion como agentes reductores en un procedimiento para la deformacion permanente del cabello.
ES8401017A1 (es) Un procedimiento para la produccion de un n-fenicarbamato.
IL135333A0 (en) Acylsulfamoyl benzoic acid amides, plant protection agents containing said acylsulfamoyl benzoic acid amides, and method for producing the same
DK51986D0 (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
ES2065133T3 (es) Derivados de piperazina.
AR000119A1 (es) Compuesto de piridacinona composición fungicida que la comprende y método para controlar hongos fitopatogenos con el mismo
MY101176A (en) Heterocyclic compounds as fungicides
ES2046271T3 (es) Empleo de derivados de 4-formilaminopiperidina como estabilizantes y material organico estabilizado con ellos.
ECSP920893A (es) Derivados de 2-imidazolin - 5 onas y 2-imidazolin -5-tionas con propiedades fungicidas
ES2143487T3 (es) 1,2,4-oxadiazolil-fenoxialquilisoxazoles y su empleo como agentes antivirales.
ES8206438A1 (es) Procedimiento para la obtencion de fenileteres sustituidos
DE3579883D1 (de) 1-((aminoalkyl und aminoalkylamino)carbonyl und thiocarbonyl) alpha,alpha-diarylpyrrolidin, piperidin und homopiperidinacetamide und acetonitrile.
ES2052539T3 (es) Procedimiento para preparar isoxazolidinas 2,3-disustituidas.
ES351866A1 (es) Procedimiento para mejorar las propiedades de utilizacion de vulcanizados.
BRPI0113837B8 (pt) compostos mutilinas com atividade antimicrobiana e composição farmacêutica que os compreende
BR9500031A (pt) Peróxido etilenicamente insaturado, peróxidos poliméricos derivados das composições de peróxido etilenicamente insaturado, e, processo para o uso dos mesmos
ES2073258T3 (es) Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
ES2089736T3 (es) Derivados de bencilideno.
ES2044970T3 (es) Procedimiento para la obtencion de compuestos hidrogenados del acido 1-benzooxacicloalquil-piridincarboxilico.
ES8402563A1 (es) Procedimiento para preparar derivados de guanidina.
ES2037011T3 (es) Procedimiento para la preparacion de nuevos derivados de benzofuran-2-il-imidazol.
PE60096A1 (es) Inhibidor de la escualeno sintetasa
ES2175556T3 (es) Procedimiento para la obtencion de monoeteres de pirocatequina y pirocatequinas.
ES2103144T3 (es) 2-nitro p-fenilendiaminas azufradas en posicion 5, su procedimiento de preparacion, composiciones tintoriales que las contienen y su utilizacion en el tinte de las fibras queratinicas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 738263

Country of ref document: ES