ES2159714T3 - Hidroximetil-imidazodiazepinas y sus esteres. - Google Patents

Hidroximetil-imidazodiazepinas y sus esteres.

Info

Publication number
ES2159714T3
ES2159714T3 ES96900024T ES96900024T ES2159714T3 ES 2159714 T3 ES2159714 T3 ES 2159714T3 ES 96900024 T ES96900024 T ES 96900024T ES 96900024 T ES96900024 T ES 96900024T ES 2159714 T3 ES2159714 T3 ES 2159714T3
Authority
ES
Spain
Prior art keywords
sup
hydroximethyl
esters
imidazodiazepinas
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96900024T
Other languages
English (en)
Inventor
Rene Borer
Bernd Buttelmann
Max Gerecke
Andre Szente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2159714T3 publication Critical patent/ES2159714T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A LAS HIDROXIMETIL IMIDAZODIAZEPINAS Y SUS ESTERES DE FORMULA GENERAL (I). ESTOS COMPUESTOS PUEDEN UTILIZARSE COMO AGENTES ANSIOLITICOS Y/O ANTICONVULSIVANTES Y/O RELAJANTES MUSCULARES Y/O HIPNOTICOS SEDANTES. EN LA FORMULA (I), A JUNTO CON LOS ATOMOS DE CARBONO DESIGNADOS COMO {AL} Y {BE} ES UNO DE LOS RADICALES (A{SUP,1}), (A{SUP,2}) O (A{SUP,3}); R{SUP,1} ES HIDROGENO O ALCANOILO INFERIOR; R{SUP,2} ES FENILO O HALOFENILO O 2 UILO INFERIOR, METILAMINOMETILO, ALILAMINOMETILO O DIETILAMINOMETILO; R{SUP,4} ES HALOGENO, CF{SUB,3} O NITRO; R{SUP,5} ES HIDROGENO O HALOGENO.
ES96900024T 1995-01-06 1996-01-03 Hidroximetil-imidazodiazepinas y sus esteres. Expired - Lifetime ES2159714T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2895 1995-01-06

Publications (1)

Publication Number Publication Date
ES2159714T3 true ES2159714T3 (es) 2001-10-16

Family

ID=4177731

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96900024T Expired - Lifetime ES2159714T3 (es) 1995-01-06 1996-01-03 Hidroximetil-imidazodiazepinas y sus esteres.

Country Status (16)

Country Link
US (1) US6174881B1 (es)
EP (1) EP0801651B1 (es)
JP (1) JP3001979B2 (es)
CN (1) CN1168140A (es)
AT (1) ATE203026T1 (es)
AU (1) AU4296196A (es)
BR (1) BR9606823A (es)
CA (1) CA2209424A1 (es)
DE (1) DE59607274D1 (es)
DK (1) DK0801651T3 (es)
ES (1) ES2159714T3 (es)
FI (1) FI972865L (es)
GR (1) GR3036867T3 (es)
PT (1) PT801651E (es)
TR (1) TR199700587T1 (es)
WO (1) WO1996020941A1 (es)

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US6444664B1 (en) 1997-04-18 2002-09-03 Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) Method for controlling the plasma level of lipoproteins to treat alzheimeris disease
EP0875247B1 (en) * 1997-04-18 2003-05-28 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Method for controlling the plasma level of lipoproteins
WO2000069858A1 (en) * 1999-05-12 2000-11-23 F. Hoffmann-La Roche Ag Imidazodiazepine derivative
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
TWI232863B (en) * 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
KR100864267B1 (ko) * 2001-06-14 2008-10-20 엔.브이.오가논 ＡＭＰＡ 수용체의 양성 조절제로서의(피리도/티에노)-[ｆ]-옥사제핀-5-온 유도체
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
BRPI0714886B8 (pt) 2006-07-10 2021-05-25 Paion Uk Ltd sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
KR101589314B1 (ko) 2007-08-20 2016-01-28 에보텍 인터내셔널 게엠베하 수면 장애의 치료
MX354217B (es) 2010-05-14 2018-02-19 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
PL2902030T3 (pl) 2010-05-14 2017-07-31 Dana-Farber Cancer Institute, Inc. Związki tienotriazolodiazepinowe do leczenia nowotworu
EP2571875A4 (en) 2010-05-14 2013-10-30 Dana Farber Cancer Inst Inc CONTRACEPTIVE COMPOSITIONS FOR MEN AND METHODS OF USE THEREOF
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
PE20150683A1 (es) 2012-05-22 2015-06-03 Paion Uk Ltd Composiciones que comprenden benzodiazepinas de accion corta
CN103012408B (zh) * 2012-11-28 2015-02-04 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
US9975896B2 (en) 2013-07-25 2018-05-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
RU2016122654A (ru) 2013-11-08 2017-12-14 Дана-Фарбер Кэнсер Инститьют, Инк. Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка
US10793571B2 (en) 2014-01-31 2020-10-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
EP3099677A4 (en) 2014-01-31 2017-07-26 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
JP2017506666A (ja) 2014-02-28 2017-03-09 テンシャ セラピューティクス，インコーポレイテッド 高インスリン血症に関連した症状の処置
WO2015200766A2 (en) 2014-06-26 2015-12-30 The Johns Hopkins University Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
CN106793775B (zh) 2014-08-08 2020-06-02 达纳-法伯癌症研究所股份有限公司 二氢碟啶酮衍生物及其用途
CN106715437A (zh) 2014-08-08 2017-05-24 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
KR20170068597A (ko) 2014-10-27 2017-06-19 텐샤 세러퓨틱스 인코포레이티드 브로모도메인 저해제
WO2016201370A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
RU2018112953A (ru) 2015-09-11 2019-10-14 Дана-Фарбер Кэнсер Инститьют, Инк. Ацетамидтиенотриазолодиазепины и пути их применения
EP3347021A4 (en) 2015-09-11 2019-07-24 Dana-Farber Cancer Institute, Inc. CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF
MX2018006499A (es) 2015-11-25 2018-08-01 Dana Farber Cancer Inst Inc Inhibidores de bromodominio bivalentes y usos de los mismos.
US20190175613A1 (en) 2016-04-14 2019-06-13 Paion Uk Limited Orally inhaled and nasal benzodiazepines
CN107325101B (zh) * 2017-06-29 2019-03-26 上海合全药物研发有限公司 6-羟甲基-6,7-二氢-5h,9h-咪唑并二氮杂卓-8-羧酸叔丁酯的合成方法
CN113087713B (zh) * 2021-03-29 2022-10-04 中国人民解放军军事科学院军事医学研究院 一类苯并二氮䓬衍生物及其制备方法和用途
USD1017893S1 (en) * 2022-03-03 2024-03-12 Elc Management Llc Cosmetic applicator
USD1023445S1 (en) * 2022-03-03 2024-04-16 Elc Management Llc Cosmetic applicator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902794A (en) 1971-04-28 1990-02-20 The Upjohn Company Triazolo-benzodiazepines
US3763179A (en) * 1972-05-05 1973-10-02 Upjohn Co 2-imidazol-1-yl benzophenones
US4280957A (en) * 1974-09-11 1981-07-28 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
DE2547652A1 (de) * 1974-11-15 1976-05-20 Upjohn Co Pharmazeutische zubereitung
DE3432974A1 (de) 1983-09-12 1985-04-04 The Upjohn Co., Kalamazoo, Mich. Arzneimittel zur prophylaxe oder therapie der negativen shizophreniesymtome bei menschen
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
EP0730596A4 (en) 1993-11-22 1997-07-30 Merck & Co Inc BENZODIAZEPINE
US5439906A (en) 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines

Also Published As

Publication number Publication date
FI972865A7 (fi) 1997-09-03
US6174881B1 (en) 2001-01-16
MX9705061A (es) 1997-10-31
ATE203026T1 (de) 2001-07-15
BR9606823A (pt) 1997-12-30
FI972865A0 (fi) 1997-07-04
TR199700587T1 (xx) 1998-02-21
CA2209424A1 (en) 1996-07-11
WO1996020941A1 (de) 1996-07-11
AU4296196A (en) 1996-07-24
EP0801651A1 (de) 1997-10-22
FI972865L (fi) 1997-09-03
CN1168140A (zh) 1997-12-17
JP3001979B2 (ja) 2000-01-24
JPH10500998A (ja) 1998-01-27
DK0801651T3 (da) 2001-10-22
EP0801651B1 (de) 2001-07-11
PT801651E (pt) 2001-12-28
DE59607274D1 (de) 2001-08-16
GR3036867T3 (en) 2002-01-31

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