ES2156944T3 - Amidas naftalenicas con accion antagonista de los leucotrienos. - Google Patents
Amidas naftalenicas con accion antagonista de los leucotrienos.Info
- Publication number
- ES2156944T3 ES2156944T3 ES95929014T ES95929014T ES2156944T3 ES 2156944 T3 ES2156944 T3 ES 2156944T3 ES 95929014 T ES95929014 T ES 95929014T ES 95929014 T ES95929014 T ES 95929014T ES 2156944 T3 ES2156944 T3 ES 2156944T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- bound
- group
- naftalenic
- leucotriens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene-acid Natural products C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- JWAZRIHNYRIHIV-UHFFFAOYSA-N 2-naphthol Chemical group C1=CC=CC2=CC(O)=CC=C21 JWAZRIHNYRIHIV-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- -1 Naphthalene amides Chemical class 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 229950011260 betanaphthol Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002617 leukotrienes Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
AMIDAS DE NAFTALENO DE FORMULA (I), DONDE EL SUSTITUYENTE QUE CONTIENE A, ESTA UNIDO A LA POSICION -6 O -7 DEL SISTEMA NAFTOL; EL SUSTITUYENTE QUE CONTIENE B ESTA UNIDO AL ANILLO BENCENICO EN CUALQUIER POSICION LIBRE; R{SUP,1} ES HIDROGENO, FLUOR, CLORO, O BROMO; A- ES UN GRUPO -CO-NR{SUP,4}- O -NR{SUP,4}-CO-, DONDE R{SUP,4} ES HIDROGENO O METILO; B ES UN GRUPO 5-TETRAZOLIL O COOR{SUP,5}, DONDE R{SUP,5} ES HIDROGENO, UN GRUPO ALQUILO C{SUB,1-4} O FENILALQUILO DE MENOS DE 10 ATOMOS DE CARBONO; M ES 0 O 1; N Y P SON ENTEROS DE 0 A 6, CON LA CONDICION DE QUE N + P SEA MENOR O IGUAL A 6. DICHOS COMPUESTOS, ASI COMO LOS SOLVATOS Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, PRESENTAN ACCION ANTAGONISTA FRENTE A LOS LEUCOTRIENOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09401696A ES2103181B1 (es) | 1994-08-01 | 1994-08-01 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2156944T3 true ES2156944T3 (es) | 2001-08-01 |
Family
ID=8287122
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09401696A Expired - Lifetime ES2103181B1 (es) | 1994-01-31 | 1994-08-01 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
| ES95929014T Expired - Lifetime ES2156944T3 (es) | 1994-08-01 | 1995-07-27 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09401696A Expired - Lifetime ES2103181B1 (es) | 1994-01-31 | 1994-08-01 | Amidas naftalenicas con accion antagonista de los leucotrienos. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0775133B1 (es) |
| AT (1) | ATE201678T1 (es) |
| AU (1) | AU3253995A (es) |
| DE (1) | DE69521132T2 (es) |
| ES (2) | ES2103181B1 (es) |
| GR (1) | GR3036462T3 (es) |
| PT (1) | PT775133E (es) |
| WO (1) | WO1996004267A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2117551B1 (es) * | 1995-12-29 | 1999-04-01 | Menarini Lab | Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas. |
| ES2150848B1 (es) * | 1998-04-15 | 2001-07-01 | Menarini Lab | Heterociclos metiloxinaftil sustituidos con accion antagonista de los leucotrienos. |
| TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| PT1345900E (pt) | 2000-12-06 | 2007-03-30 | Sanofi Aventis Deutschland | Derivados amidina e guanidina como inibidores do factor xa |
| CA2430978C (en) * | 2000-12-28 | 2012-05-15 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
| TW591020B (en) * | 2001-06-20 | 2004-06-11 | Wyeth Corp | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| WO2003104178A1 (en) * | 2002-06-07 | 2003-12-18 | Cortical Pty Ltd | Napththalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (mif) |
| JP4676884B2 (ja) | 2003-07-24 | 2011-04-27 | 第一三共株式会社 | シクロヘキサンカルボン酸類 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
| US5084575A (en) * | 1987-07-31 | 1992-01-28 | American Home Products Corporation | Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
| US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
-
1994
- 1994-08-01 ES ES09401696A patent/ES2103181B1/es not_active Expired - Lifetime
-
1995
- 1995-07-27 AT AT95929014T patent/ATE201678T1/de not_active IP Right Cessation
- 1995-07-27 WO PCT/EP1995/002970 patent/WO1996004267A1/en not_active Ceased
- 1995-07-27 EP EP95929014A patent/EP0775133B1/en not_active Expired - Lifetime
- 1995-07-27 ES ES95929014T patent/ES2156944T3/es not_active Expired - Lifetime
- 1995-07-27 PT PT95929014T patent/PT775133E/pt unknown
- 1995-07-27 AU AU32539/95A patent/AU3253995A/en not_active Abandoned
- 1995-07-27 DE DE69521132T patent/DE69521132T2/de not_active Expired - Fee Related
-
2001
- 2001-08-29 GR GR20010401313T patent/GR3036462T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0775133A1 (en) | 1997-05-28 |
| AU3253995A (en) | 1996-03-04 |
| DE69521132T2 (de) | 2001-09-27 |
| GR3036462T3 (en) | 2001-11-30 |
| DE69521132D1 (de) | 2001-07-05 |
| PT775133E (pt) | 2001-10-30 |
| ES2103181B1 (es) | 1998-04-01 |
| ATE201678T1 (de) | 2001-06-15 |
| WO1996004267A1 (en) | 1996-02-15 |
| ES2103181A1 (es) | 1997-08-16 |
| EP0775133B1 (en) | 2001-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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