ES2157066T3 - Procedimiento para la obtencion de acidos alfa-alcoxi-alfa-trifluormetil-arilaceticos y -arilacetatos. - Google Patents
Procedimiento para la obtencion de acidos alfa-alcoxi-alfa-trifluormetil-arilaceticos y -arilacetatos.Info
- Publication number
- ES2157066T3 ES2157066T3 ES97909373T ES97909373T ES2157066T3 ES 2157066 T3 ES2157066 T3 ES 2157066T3 ES 97909373 T ES97909373 T ES 97909373T ES 97909373 T ES97909373 T ES 97909373T ES 2157066 T3 ES2157066 T3 ES 2157066T3
- Authority
- ES
- Spain
- Prior art keywords
- alfa
- acids
- alcoxi
- trifluormethyl
- arylacetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 150000007513 acids Chemical class 0.000 title abstract 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- 150000001559 benzoic acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000005219 trimethyl ethers Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LOS ESTERES Y ACIDOS AL - ALCOXI - AL - TRIFUORMETIL - ARIL - ACETICOS SE OBTIENEN A PARTIR DE REACTIVOS FACILMENTE ACCESIBLES, SIN LA FORMACION DE ACIDOS BENZOICOS COMO COMPONENTES SECUNDARIOS, Y CON UN BUEN RENDIMIENTO Y PUREZA, EN BREVES TIEMPOS DE REACCION, HACIENDO QUE EL FENILCETOESTER REACCIONE, EN PRESENCIA DE UN DISOLVENTE, FORMADO POR UN FLUORURO AL MENOS LIGERAMENTE SOLUBLE EN LA MEZCLA DE REACCION, COMO CATALIZADOR, CON TRIFLUORMETIL - TRIMETILSILANO, HACIENDO QUE EL TRIMETILSILILETER ASI OBTENIDO REACCIONE CON UN ALCOHOLATO O UN ALCOHOL AJUSTADO EN SU VALOR ALCALINO, PROCEDIENDOSE FINALMENTE A LA DISOCIACION HIDROLITICA O CON UN ACIDO DEL ESTER, A FIN DE PRODUCIR LOS ACIDOS AL - ALCOXI - AL - TRIFUORMETIL - ARIL A CETICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19643592A DE19643592A1 (de) | 1996-10-22 | 1996-10-22 | Verfahren zur Herstellung von alpha-Alkoxy-alpha-trifluormethyl-arylessigsäureestern und -arylessigsäuren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2157066T3 true ES2157066T3 (es) | 2001-08-01 |
Family
ID=7809462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97909373T Expired - Lifetime ES2157066T3 (es) | 1996-10-22 | 1997-10-09 | Procedimiento para la obtencion de acidos alfa-alcoxi-alfa-trifluormetil-arilaceticos y -arilacetatos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6162943A (es) |
| EP (1) | EP0934246B1 (es) |
| JP (1) | JP2001502344A (es) |
| KR (1) | KR20000052684A (es) |
| AU (1) | AU4708297A (es) |
| CA (1) | CA2269133A1 (es) |
| CZ (1) | CZ142699A3 (es) |
| DE (2) | DE19643592A1 (es) |
| ES (1) | ES2157066T3 (es) |
| HU (1) | HUP0000237A3 (es) |
| PL (1) | PL332853A1 (es) |
| PT (1) | PT934246E (es) |
| WO (1) | WO1998017622A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6614587B1 (en) * | 2001-02-28 | 2003-09-02 | Avanex Corporation | Control methods for a metro optical amplifier |
| ES2714780T3 (es) * | 2003-05-30 | 2019-05-30 | Perkinelmer Las Inc | Reactivos químicamente estables marcados isotópicamente y proceso para su síntesis |
| US20070117497A1 (en) * | 2005-11-22 | 2007-05-24 | Cabot Microelectronics Corporation | Friction reducing aid for CMP |
| RU2470910C9 (ru) | 2007-06-29 | 2013-05-20 | Акьюсела, Инк. | Соединения, представляющие собой алкинилфенильные производные, для лечения офтальмических заболеваний и расстройств |
| CN103553945B (zh) | 2007-10-05 | 2015-01-07 | 奥克塞拉有限公司 | 用于治疗疾病的烷氧基化合物 |
| MY156662A (en) | 2007-11-01 | 2016-03-15 | Acucela Inc | Amine derivative compounds for treating ophthalmic diseases and disorders |
| JP5860398B2 (ja) * | 2009-07-02 | 2016-02-16 | アキュセラ インコーポレイテッド | 視覚サイクルモジュレーターの薬理 |
| EP2804605A4 (en) | 2012-01-20 | 2015-07-08 | Acucela Inc | SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASES |
-
1996
- 1996-10-22 DE DE19643592A patent/DE19643592A1/de not_active Withdrawn
-
1997
- 1997-10-09 US US09/284,689 patent/US6162943A/en not_active Expired - Fee Related
- 1997-10-09 EP EP97909373A patent/EP0934246B1/de not_active Expired - Lifetime
- 1997-10-09 CZ CZ991426A patent/CZ142699A3/cs unknown
- 1997-10-09 DE DE59703568T patent/DE59703568D1/de not_active Expired - Fee Related
- 1997-10-09 JP JP10518899A patent/JP2001502344A/ja active Pending
- 1997-10-09 PL PL97332853A patent/PL332853A1/xx unknown
- 1997-10-09 PT PT97909373T patent/PT934246E/pt unknown
- 1997-10-09 WO PCT/EP1997/005565 patent/WO1998017622A1/de not_active Ceased
- 1997-10-09 HU HU0000237A patent/HUP0000237A3/hu unknown
- 1997-10-09 AU AU47082/97A patent/AU4708297A/en not_active Abandoned
- 1997-10-09 KR KR1019990703470A patent/KR20000052684A/ko not_active Withdrawn
- 1997-10-09 ES ES97909373T patent/ES2157066T3/es not_active Expired - Lifetime
- 1997-10-09 CA CA002269133A patent/CA2269133A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0934246B1 (de) | 2001-05-16 |
| DE19643592A1 (de) | 1998-04-23 |
| CA2269133A1 (en) | 1998-04-30 |
| US6162943A (en) | 2000-12-19 |
| HUP0000237A2 (hu) | 2000-06-28 |
| DE59703568D1 (de) | 2001-06-21 |
| EP0934246A1 (de) | 1999-08-11 |
| AU4708297A (en) | 1998-05-15 |
| JP2001502344A (ja) | 2001-02-20 |
| HUP0000237A3 (en) | 2001-02-28 |
| PT934246E (pt) | 2001-10-30 |
| KR20000052684A (ko) | 2000-08-25 |
| WO1998017622A1 (de) | 1998-04-30 |
| CZ142699A3 (cs) | 1999-07-14 |
| PL332853A1 (en) | 1999-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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