ES2148689T3 - Procedimiento para producir acido 2-hidroxi-4-arilbutirico opticamente activo, o su ester, e intermedio para su preparacion. - Google Patents

Procedimiento para producir acido 2-hidroxi-4-arilbutirico opticamente activo, o su ester, e intermedio para su preparacion.

Info

Publication number
ES2148689T3
ES2148689T3 ES96306057T ES96306057T ES2148689T3 ES 2148689 T3 ES2148689 T3 ES 2148689T3 ES 96306057 T ES96306057 T ES 96306057T ES 96306057 T ES96306057 T ES 96306057T ES 2148689 T3 ES2148689 T3 ES 2148689T3
Authority
ES
Spain
Prior art keywords
optically active
hydroxy
acid
ester
arylbutyric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96306057T
Other languages
English (en)
Inventor
Masahiko Kurauchi
Yoshimasa Hagiwara
Hiroyuki Matsueda
Takashi Nakano
Kunisuke Izawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of ES2148689T3 publication Critical patent/ES2148689T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE HACE REACCIONAR ANHIDRIDO ACICLOSUCCINICO OPTICAMENTE ACTIVO CON UN COMPUESTO AROMATICO, EN PRESENCIA DE UN ACIDO DE LEWIS, PARA PRODUCIR UN ACIDO 2-ACILOXI-4-OXO-4-ARILBUTIRICO OPTICAMENTE ACTIVO, QUE PUEDE CONVERTIRSE EN UN ACIDO 2-ACILOXI-4-ARILBUTIRICO OPTICAMENTE ACTIVO POR REDUCCION CATALITICA, Y ESTE ULTIMO COMPUESTO SE HIDROLIZA EN PRESENCIA DE UN ACIDO O UNA BASE, PARA PRODUCIR UN ACIDO 2-HIDROXI-4ARILBUTIRICO, QUE SE PUEDE OPCIONALMENTE HACER REACCIONAR CON UN ALCOHOL EN PRESENCIA DE UN ACIDO, PARA PRODUCIR UN ESTER DE ACIDO 2-HIDROXI-4-ARILBUTIRICO OPTICAMENTE ACTIVO.
ES96306057T 1995-08-22 1996-08-20 Procedimiento para producir acido 2-hidroxi-4-arilbutirico opticamente activo, o su ester, e intermedio para su preparacion. Expired - Lifetime ES2148689T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21343195 1995-08-22
JP19264896A JP3915015B2 (ja) 1995-08-22 1996-06-19 光学活性２−ヒドロキシ−４−アリール酪酸またはそのエステルの製造方法

Publications (1)

Publication Number Publication Date
ES2148689T3 true ES2148689T3 (es) 2000-10-16

Family

ID=26507445

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96306057T Expired - Lifetime ES2148689T3 (es) 1995-08-22 1996-08-20 Procedimiento para producir acido 2-hidroxi-4-arilbutirico opticamente activo, o su ester, e intermedio para su preparacion.

Country Status (6)

Country Link
US (3) US5959139A (es)
EP (1) EP0759424B1 (es)
JP (1) JP3915015B2 (es)
AT (1) ATE193882T1 (es)
DE (1) DE69608862T2 (es)
ES (1) ES2148689T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6508768B1 (en) * 2000-11-22 2003-01-21 University Of Kansas Medical Center Ultrasonic elasticity imaging
GB2375762B (en) 2001-05-21 2003-10-01 Fermenta Biotech Ltd Stereospecific synthesis of 2-hydroxy-4-phenyl-butyric acid esters
US20060293517A1 (en) * 2003-03-06 2006-12-28 Yatendra Kumar Enantiomerically pure cilazapril, process for preparation
CN100335457C (zh) * 2005-09-08 2007-09-05 上海交通大学 3－位手性羟基被保护的3，4－二羟基丁酸酯及其制备方法
US20090181723A1 (en) * 2008-01-11 2009-07-16 Koncelik Jr Lawrence J Apparatus and method for providing audio signal and/or visual indications of cell phone signal quality or signal strength
CN109929885B (zh) * 2019-03-06 2022-07-15 江苏惠利生物科技有限公司 一种利用酶膜反应器耦合萃取制备r-2-羟基-4-苯基丁酸乙酯的方法
EP4313986A1 (en) 2021-04-02 2024-02-07 Genentech, Inc. Processes for making bicyclic ketone compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US329156A (en) 1885-10-27 Combination square and gage
US4785089A (en) 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
KR950013082B1 (ko) * 1987-02-26 1995-10-24 메렐 다우 파마슈티칼스 인코포레이티드 (r)-2-하이드록시-4-페닐부티르산 및 에스테르의 제조 및 분리방법
GB2210364A (en) * 1987-09-29 1989-06-07 Ici Plc Cyclopropane ring-containing tertiary amine derivatives
US4904822A (en) * 1988-02-19 1990-02-27 Kuraray Co., Ltd. Process for the optical resolution of (+)-2-hydroxy-4-phenylbutanoic acid
JP2688528B2 (ja) * 1989-12-28 1997-12-10 ダイセル化学工業株式会社 光学活性２−ヒドロキシ−４−フェニル酪酸アルキルエステルの製造法
JPH0418050A (ja) 1990-05-10 1992-01-22 Yoshitomi Pharmaceut Ind Ltd （ｒ）―２―ヒドロキシ―４―フェニル―３―ブテン酸の製造法
US5225408A (en) 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
EP0564406B1 (de) 1992-04-02 1999-05-06 Novartis AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
JPH05286890A (ja) * 1992-04-07 1993-11-02 Toray Ind Inc ２−ヒドロキシ−４−フェニル酪酸またはそのエステルの製造法
AT401513B (de) * 1994-12-22 1996-09-25 Chemie Linz Gmbh Verfahren zur herstellung von 2-hydroxy-4-phenylbuttersäure

Also Published As

Publication number Publication date
EP0759424B1 (en) 2000-06-14
DE69608862D1 (de) 2000-07-20
ATE193882T1 (de) 2000-06-15
EP0759424A1 (en) 1997-02-26
JPH09118646A (ja) 1997-05-06
US6087526A (en) 2000-07-11
JP3915015B2 (ja) 2007-05-16
DE69608862T2 (de) 2001-02-22
US6258975B1 (en) 2001-07-10
US5959139A (en) 1999-09-28

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