ES2157259T3 - Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos. - Google Patents

Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos.

Info

Publication number
ES2157259T3
ES2157259T3 ES94917117T ES94917117T ES2157259T3 ES 2157259 T3 ES2157259 T3 ES 2157259T3 ES 94917117 T ES94917117 T ES 94917117T ES 94917117 T ES94917117 T ES 94917117T ES 2157259 T3 ES2157259 T3 ES 2157259T3
Authority
ES
Spain
Prior art keywords
esteres
prepare
procedure
amino acids
nucleosid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94917117T
Other languages
English (en)
Inventor
William Paul Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rolabo SL
Original Assignee
Rolabo SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939311952A external-priority patent/GB9311952D0/en
Priority claimed from GB939320645A external-priority patent/GB9320645D0/en
Application filed by Rolabo SL filed Critical Rolabo SL
Application granted granted Critical
Publication of ES2157259T3 publication Critical patent/ES2157259T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE UN AMINOACIDO ESTER DE UN ANALOGO DE NUCLEOSIDO, COMPRENDIENDO DICHO PROCESO LA REACCION DE UN ANALOGO NUCLEOSIDO QUE TIENE UN GRUPO HIDROXI ESTERIFICABLE EN SU ESTRUCTURA ETER LINEAL O CICLICA CON UN 2-OXA-4-AZACICLOALCANO-1,3-DIONA, SIENDO DICHO PROCESO ECONOMICO, RAPIDO Y SENCILLO DE REALIZAR.
ES94917117T 1993-06-10 1994-06-09 Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos. Expired - Lifetime ES2157259T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939311952A GB9311952D0 (en) 1993-06-10 1993-06-10 Process
GB939320645A GB9320645D0 (en) 1993-10-07 1993-10-07 Process

Publications (1)

Publication Number Publication Date
ES2157259T3 true ES2157259T3 (es) 2001-08-16

Family

ID=26303037

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94917117T Expired - Lifetime ES2157259T3 (es) 1993-06-10 1994-06-09 Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos.

Country Status (7)

Country Link
US (1) US5831075A (es)
EP (1) EP0702682B1 (es)
AT (1) ATE199719T1 (es)
AU (1) AU6854694A (es)
DE (1) DE69426880T2 (es)
ES (1) ES2157259T3 (es)
WO (1) WO1994029311A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
WO1997027194A1 (en) * 1996-01-26 1997-07-31 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
IT1283447B1 (it) * 1996-07-18 1998-04-21 Ind Chimica Srl Processo di preparazione del valaciclovir e relativi intermedi
HUP0500753A3 (en) * 2001-09-07 2006-05-29 Teva Pharma Crystalline forms of valacyclovir hydrochloride
CN1307177C (zh) * 2001-11-14 2007-03-28 特瓦制药工业有限公司 伐昔洛韦的合成与纯化
AU2003289995A1 (en) * 2002-12-09 2004-06-30 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
WO2004106338A1 (en) * 2003-05-30 2004-12-09 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Novel crystalline forms of valacyclovir hydrochloride
KR100871621B1 (ko) * 2003-06-02 2008-12-02 테바 파마슈티컬 인더스트리즈 리미티드 발라시클로비르 히드로클로라이드의 신규한 결정질 형태
JP2007505070A (ja) * 2003-09-11 2007-03-08 エフ．ホフマン−ラ　ロシュ　アーゲー 抗ウイルス性ヌクレオシド誘導体を製造する方法
US20070167353A1 (en) * 2003-10-24 2007-07-19 John Hilfinger Prodrug composition
US20050137141A1 (en) * 2003-10-24 2005-06-23 John Hilfinger Prodrug composition
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
EP1746098A1 (en) * 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
US20080281099A1 (en) * 2007-05-07 2008-11-13 Mayur Devjibhai Khunt Process for purifying valacyclovir hydrochloride and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.

Also Published As

Publication number Publication date
DE69426880T2 (de) 2001-10-31
AU6854694A (en) 1995-01-03
EP0702682B1 (en) 2001-03-14
ATE199719T1 (de) 2001-03-15
WO1994029311A1 (en) 1994-12-22
US5831075A (en) 1998-11-03
DE69426880D1 (de) 2001-04-19
EP0702682A1 (en) 1996-03-27

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