ES2173194T3 - Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos. - Google Patents

Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos.

Info

Publication number
ES2173194T3
ES2173194T3 ES95932092T ES95932092T ES2173194T3 ES 2173194 T3 ES2173194 T3 ES 2173194T3 ES 95932092 T ES95932092 T ES 95932092T ES 95932092 T ES95932092 T ES 95932092T ES 2173194 T3 ES2173194 T3 ES 2173194T3
Authority
ES
Spain
Prior art keywords
procedure
levobupivacaine
racemization
analogs
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95932092T
Other languages
English (en)
Inventor
Ulrich Conrad Dyer
Christopher James Lock
Martin Woods
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9504927.6A external-priority patent/GB9504927D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ES2173194T3 publication Critical patent/ES2173194T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measurement Of Radiation (AREA)

Abstract

UN PROCEDIMIENTO DE RACEMIZACION DE UN COMPUESTO DE PIPERIDINA2-CARBOXANILIDA, OPTICAMENTE ENRIQUECIDO, QUE CONSISTE EN EL CALENTAMIENTO DE DICHO COMPUESTO, EN PRESENCIA DE UN ACIDO ARILALCANOICO O ALCANOICO. UN PROCEDIMIENTO DE TRANSFORMACION ASIMETRICA DE DICHO COMPUESTO, QUE COMPRENDE EL CALENTAMIENTO DEL MISMO EN PRESENCIA DE UN ACIDO COMO EL DEFINIDO ANTERIORMENTE, UN AGENTE DE RESOLUCION DEL ACIDO QUIRAL Y UN COSOLVENTE INERTE.
ES95932092T 1994-09-23 1995-09-22 Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos. Expired - Lifetime ES2173194T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94306962 1994-09-23
GBGB9504927.6A GB9504927D0 (en) 1995-03-10 1995-03-10 Racemisation and asymmetric transformation

Publications (1)

Publication Number Publication Date
ES2173194T3 true ES2173194T3 (es) 2002-10-16

Family

ID=26137306

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95932092T Expired - Lifetime ES2173194T3 (es) 1994-09-23 1995-09-22 Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos.

Country Status (18)

Country Link
US (1) US5786484A (es)
EP (1) EP0782569B1 (es)
JP (1) JP3898220B2 (es)
KR (1) KR100393133B1 (es)
CN (1) CN1104416C (es)
AT (1) ATE214695T1 (es)
AU (1) AU695479B2 (es)
CA (1) CA2200490C (es)
DE (1) DE69525950T2 (es)
DK (1) DK0782569T3 (es)
ES (1) ES2173194T3 (es)
FI (1) FI117436B (es)
HU (1) HU216291B (es)
MX (1) MX9702210A (es)
NO (1) NO308074B1 (es)
PL (1) PL183204B1 (es)
PT (1) PT782569E (es)
WO (1) WO1996009290A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384227B2 (en) 1995-01-18 2002-05-07 Darwin Discovery Ltd. Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
JP2000256359A (ja) * 1999-03-11 2000-09-19 Japan Science & Technology Corp 面性キラリティーを有する分子群の高選択的不斉変換法
US6288280B1 (en) * 1999-07-09 2001-09-11 Hoffmann-La Roche Inc. Racemization of atropisomeric bis(phosphine oxide) compounds
BR0002246A (pt) 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
EP1295873A4 (en) * 2000-06-14 2004-05-19 METHODS OF PRODUCING RACEMIC PIPERIDINE DERIVATIVE AND PRODUCING OPTICALLY ACTIVE PIPERIDINE DERIVATIVE
DE10029851A1 (de) * 2000-06-16 2001-12-20 Boehringer Ingelheim Pharma Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
US6495694B2 (en) 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
EP2218448B1 (en) 2002-12-13 2015-09-23 Durect Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
DK2767292T3 (en) 2004-09-17 2016-12-19 Durect Corp RENEWABLE local anesthetic COMPOSITION CONTAINING SAIB
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
AU2007325918B2 (en) 2006-11-03 2013-10-17 Durect Corporation Transdermal delivery systems comprising bupivacaine
EP2067471B1 (en) * 2007-12-06 2018-02-14 Durect Corporation Oral pharmaceutical dosage forms
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
CA2905131A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
CN103664744B (zh) * 2013-11-30 2015-07-15 山东永泰化工有限公司 一种左布比卡因的制备方法
CN109475505A (zh) 2016-07-06 2019-03-15 度瑞公司 具有药物组成物、屏障层及药物层的口服剂型
WO2019222565A1 (en) 2018-05-18 2019-11-21 Kura Oncology, Inc. Synthesis of tipifarnib
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning

Also Published As

Publication number Publication date
KR100393133B1 (ko) 2003-11-17
FI117436B (fi) 2006-10-13
EP0782569B1 (en) 2002-03-20
DE69525950D1 (de) 2002-04-25
US5786484A (en) 1998-07-28
JPH10505855A (ja) 1998-06-09
PT782569E (pt) 2002-09-30
CA2200490A1 (en) 1996-03-28
FI971202A0 (fi) 1997-03-21
CN1159184A (zh) 1997-09-10
MX9702210A (es) 1998-05-31
CN1104416C (zh) 2003-04-02
DE69525950T2 (de) 2002-09-19
AU695479B2 (en) 1998-08-13
NO971358L (no) 1997-03-21
EP0782569A1 (en) 1997-07-09
DK0782569T3 (da) 2002-07-22
WO1996009290A1 (en) 1996-03-28
AU3527995A (en) 1996-04-09
PL319368A1 (en) 1997-08-04
HU216291B (hu) 1999-06-28
FI971202L (fi) 1997-03-21
JP3898220B2 (ja) 2007-03-28
NO971358D0 (no) 1997-03-21
CA2200490C (en) 2007-01-09
NO308074B1 (no) 2000-07-17
HUT77055A (hu) 1998-03-02
ATE214695T1 (de) 2002-04-15
PL183204B1 (pl) 2002-06-28

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