ES2157297T3 - Granulos entericos de duloxetina. - Google Patents
Granulos entericos de duloxetina.Info
- Publication number
- ES2157297T3 ES2157297T3 ES95304977T ES95304977T ES2157297T3 ES 2157297 T3 ES2157297 T3 ES 2157297T3 ES 95304977 T ES95304977 T ES 95304977T ES 95304977 T ES95304977 T ES 95304977T ES 2157297 T3 ES2157297 T3 ES 2157297T3
- Authority
- ES
- Spain
- Prior art keywords
- enteric granules
- duloxetine
- duloxetine enteric
- enteric
- granules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title abstract 2
- 229960002866 duloxetine Drugs 0.000 title abstract 2
- 239000008187 granular material Substances 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229920002301 cellulose acetate Polymers 0.000 abstract 1
- 239000012055 enteric layer Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE PRESENTA UNA FORMULACION ENTERICA SUPERIOR DE LA DROGA ANTIDEPRESIVA, DULOXETINA, QUE TIENE FORMA DE TABLETAS ENTERICAS DE LAS CUALES LA CAPA ENTERICA COMPRENDE SUCCINATO DE ACETATO DE HIDROXIPROPILMETILCELULOSA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/276,232 US5508276A (en) | 1994-07-18 | 1994-07-18 | Duloxetine enteric pellets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2157297T3 true ES2157297T3 (es) | 2001-08-16 |
Family
ID=23055767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95304977T Expired - Lifetime ES2157297T3 (es) | 1994-07-18 | 1995-07-17 | Granulos entericos de duloxetina. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5508276A (es) |
| EP (1) | EP0693282B1 (es) |
| JP (1) | JP3707831B2 (es) |
| KR (1) | KR100356240B1 (es) |
| CN (1) | CN1106191C (es) |
| AT (1) | ATE200620T1 (es) |
| AU (1) | AU686384B2 (es) |
| BR (1) | BR9503346A (es) |
| CA (1) | CA2153856C (es) |
| CO (1) | CO4410177A1 (es) |
| CZ (1) | CZ288095B6 (es) |
| DE (1) | DE69520711T2 (es) |
| DK (1) | DK0693282T3 (es) |
| ES (1) | ES2157297T3 (es) |
| GE (1) | GEP20063944B (es) |
| GR (1) | GR3036185T3 (es) |
| HU (1) | HU221502B (es) |
| IL (1) | IL114584A (es) |
| MY (1) | MY116361A (es) |
| NO (2) | NO312397B1 (es) |
| NZ (1) | NZ272554A (es) |
| PE (1) | PE32196A1 (es) |
| PL (1) | PL181296B1 (es) |
| PT (1) | PT693282E (es) |
| RU (1) | RU2147231C1 (es) |
| SI (1) | SI0693282T1 (es) |
| TW (1) | TW382596B (es) |
| UA (1) | UA41344C2 (es) |
| YU (1) | YU49445B (es) |
| ZA (1) | ZA955799B (es) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ313076A (en) * | 1995-07-24 | 1999-11-29 | Lilly Co Eli | Medicament containing duloxetine for treating hyperactivity and attention deficiency disorders |
| US5910319A (en) * | 1997-05-29 | 1999-06-08 | Eli Lilly And Company | Fluoxetine enteric pellets and methods for their preparation and use |
| DK1113797T3 (da) | 1998-09-15 | 2010-02-01 | Lilly Co Eli | Anvendelse af duloxetin til behandling af fibromyalgi |
| ES2306646T3 (es) * | 1999-02-09 | 2008-11-16 | Pfizer Products Inc. | Composiciones de farmacos basicos con biodisponibilidad incrementada. |
| IL130602A0 (en) * | 1999-06-22 | 2000-06-01 | Dexcel Ltd | Stable benzimidazole formulation |
| AU4529101A (en) * | 2000-03-07 | 2001-09-17 | Eli Lilly And Company | Treatment of psoriasis |
| EP1383495A1 (en) * | 2001-03-29 | 2004-01-28 | Eli Lilly And Company | Duloxetine for treatment of hot flashes |
| KR20040011549A (ko) * | 2001-06-22 | 2004-02-05 | 화이자 프로덕츠 인크. | 저용해도 및(또는) 산-민감성 약물 및 중화된 산성중합체를 포함하는 제약 조성물 |
| WO2003000235A1 (en) * | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions of dispersions of drugs and neutral polymers |
| AU2003287499A1 (en) * | 2002-11-19 | 2004-06-15 | Eli Lilly And Company | Treatment of gastrointestinal disorders with duloxetine |
| EP1648421B1 (en) * | 2003-07-24 | 2017-10-18 | GlaxoSmithKline LLC | Orally dissolving films |
| US20070275853A1 (en) * | 2004-04-08 | 2007-11-29 | Kyowa Hakko Kogyo Co., Ltd. | Solid Products with Improved Stability and Method for Producing the Same |
| GB0410470D0 (en) * | 2004-05-11 | 2004-06-16 | Cipla Ltd | Pharmaceutical compound and polymorphs thereof |
| WO2006071868A2 (en) * | 2004-12-23 | 2006-07-06 | Teva Pharmaceutical Industries Ltd. | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
| EP1856087A1 (en) * | 2005-03-08 | 2007-11-21 | Teva Pharmaceutical Industries Limited | Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof |
| CA2599478A1 (en) * | 2005-03-14 | 2006-09-21 | Teva Pharmaceutical Industries Ltd. | Process for the purification of duloxetine hydrochloride |
| US20100285123A1 (en) * | 2005-06-20 | 2010-11-11 | Rudresha Korlakunte Virupakshalah Prasad | Controlled Release Dosage Formulation of Duloxetine |
| US8153824B2 (en) * | 2005-06-22 | 2012-04-10 | The Wockhardt Company | Antidepressant oral liquid compositions |
| EP1915137B8 (de) | 2005-08-10 | 2013-09-11 | ADD Advanced Drug Delivery Technologies, Ltd. | Orales präparat mit kontrollierter freisetzung |
| US20060165776A1 (en) * | 2005-08-31 | 2006-07-27 | Ramesh Sesha | Antidepressant oral pharmaceutical compositions |
| EP1838692A2 (en) * | 2005-09-22 | 2007-10-03 | Teva Pharmaceutical Industries Ltd | Dnt-maleate and methods of preparation thereof |
| US20080207923A1 (en) * | 2005-09-22 | 2008-08-28 | Santiago Ini | Pure DNT-maleate and methods of preparation thereof |
| AU2006318476A1 (en) * | 2005-11-23 | 2007-05-31 | Auspex Pharmaceuticals, Inc. | Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity |
| US7759500B2 (en) * | 2005-12-05 | 2010-07-20 | Teva Pharmaceutical Industries Ltd. | 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride |
| DE102005060393A1 (de) * | 2005-12-16 | 2007-06-21 | Add Advanced Drug Delivery Technologies Ltd. | Orales Präparat mit kontrollierter Freisetzung |
| MX2007011611A (es) * | 2006-01-23 | 2007-10-18 | Teva Pharma | Fumarato de dnt y metodos de preparacion de ellos. |
| EP1820800A1 (en) * | 2006-02-17 | 2007-08-22 | KRKA, tovarna zdravil, d.d., Novo mesto | Crystalline forms of duloxetine hydrochloride and processes for their preparation |
| KR200416582Y1 (ko) | 2006-03-07 | 2006-05-19 | 김정배 | 건강신발 |
| KR20090005237A (ko) * | 2006-05-22 | 2009-01-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 둘록세틴 염산염 지연 방출형 제제 |
| MX2008001079A (es) * | 2006-05-23 | 2008-03-19 | Teva Pharma | Polimorfos de hidrocloruro de duloxetina. |
| JP5052051B2 (ja) * | 2006-06-16 | 2012-10-17 | トーアエイヨー株式会社 | 腸溶性顆粒剤及びその製造方法 |
| WO2008020286A2 (en) * | 2006-08-14 | 2008-02-21 | Torrent Pharmaceuticals Limited | Pharmaceutical compositions of duloxetine |
| CN101190208B (zh) * | 2006-11-30 | 2011-11-02 | 石药集团中奇制药技术(石家庄)有限公司 | 一种含有盐酸度洛西汀的药物制剂及其制备方法 |
| WO2008077645A1 (en) | 2006-12-22 | 2008-07-03 | Synthon B.V. | Process for making duloxetine and related compounds |
| MX2009007057A (es) * | 2006-12-27 | 2009-09-23 | Lek Pharmaceuticals | Composicion de duloxetina. |
| EP2018860A1 (en) * | 2007-07-16 | 2009-01-28 | LEK Pharmaceuticals D.D. | Duloxetine composition |
| EP1938840A1 (en) * | 2006-12-27 | 2008-07-02 | LEK Pharmaceuticals D.D. | Duloxetine composition |
| US20080226711A1 (en) * | 2007-03-12 | 2008-09-18 | Torrent Pharmaceuticals Ltd. | Pharmaceutical compositions of duloxetine |
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| GB0712220D0 (en) * | 2007-06-23 | 2007-08-01 | Arrow Int Ltd | Duloxetine formulation |
| WO2009066181A2 (en) * | 2007-07-09 | 2009-05-28 | Combino Pharm, S.L. | Oral delayed-release duloxentine hydrochloride pellets |
| EP2182929A2 (en) * | 2007-07-13 | 2010-05-12 | Synthon B.V. | Duloxetine formulations |
| WO2009087657A2 (en) * | 2007-11-03 | 2009-07-16 | Alkem Laboratories Ltd. | Stable pharmaceutical composition of duloxetine and process for its preparation |
| WO2009073215A1 (en) * | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| US9233078B2 (en) | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
| EP2240173A4 (en) * | 2008-01-25 | 2013-07-17 | Alphapharm Pty Ltd | PHARMACEUTICAL COMPOSITION OF DULOXETINE WITH DELAYED RELEASE |
| US20090226517A1 (en) * | 2008-02-06 | 2009-09-10 | Vinita Umashankar Vyas | Pharmaceutical formulations comprising duloxetine |
| US20110020439A1 (en) * | 2008-03-24 | 2011-01-27 | Shrenik Annasaheb Kole | Delayed release compositions of duloxetine |
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| US20100040680A1 (en) * | 2008-08-15 | 2010-02-18 | Felix Lai | Multiparticulate selective serotonin and norepinephrine reuptake inhibitor formulation |
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| CN101756960B (zh) * | 2008-12-26 | 2012-06-27 | 上海中西制药有限公司 | 一种度洛西汀肠溶制剂及其芯材和制备方法 |
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Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS517116A (en) * | 1974-06-11 | 1976-01-21 | Shinetsu Chemical Co | Choyoseihifukuyakuzaino seizohoho |
| CH649216A5 (de) * | 1979-08-16 | 1985-05-15 | Sandoz Ag | Verfahren zur auftragung eines magensaftresistenten filmes auf einen heilmittelkern und feste einheitsdosierungsform mit magensaftresistentem film. |
| US5019302A (en) | 1986-03-12 | 1991-05-28 | Washington University Technology Associates, Inc. | Method for granulation |
| US5100592A (en) | 1986-03-12 | 1992-03-31 | Washington University Technology Associated, Inc. | Method and apparatus for granulation and granulated product |
| GB2189699A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
| JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| JPH04346930A (ja) * | 1991-05-25 | 1992-12-02 | Sumitomo Pharmaceut Co Ltd | 安定なアスピリン腸溶錠 |
| RU2024526C1 (ru) * | 1991-10-08 | 1994-12-15 | Институт органической химии Уральского отделения РАН | 5h- 3,4,6,7- тетрагидро-10- метокси-5-метил-6- (1',1'- диоксидо-3'- мета- хлоранилино-4'- метокси- бензо [в] тиофен -7'-ил) -фуро[4,3,2-q] [3]бензазоцин, обладающий антидепрессивным действием |
| RU2024520C1 (ru) * | 1991-10-08 | 1994-12-15 | Институт органической химии Уральского отделения РАН | 10-метокси-5- метил-6- (1',1'- диоксидо-2'- метахлорфенилазо -3'- гидрокси -4'-метоксибензо(в)тиофен- 7-ил) -5h-3,4,6,7- тетрагидрофуро [4.3.2-q] [3]бензазоцин, обладающий антидепрессивным действием |
| ZA93694B (en) * | 1993-02-01 | 1993-06-03 | Lilly Co Eli | Pharmaceutical treatments. |
| US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
-
1994
- 1994-07-18 US US08/276,232 patent/US5508276A/en not_active Expired - Lifetime
-
1995
- 1995-07-12 PL PL95309588A patent/PL181296B1/pl unknown
- 1995-07-12 ZA ZA955799A patent/ZA955799B/xx unknown
- 1995-07-12 NZ NZ272554A patent/NZ272554A/en not_active IP Right Cessation
- 1995-07-12 PE PE1995273613A patent/PE32196A1/es not_active IP Right Cessation
- 1995-07-12 TW TW084107228A patent/TW382596B/zh not_active IP Right Cessation
- 1995-07-12 CZ CZ19951805A patent/CZ288095B6/cs not_active IP Right Cessation
- 1995-07-13 IL IL11458495A patent/IL114584A/xx not_active IP Right Cessation
- 1995-07-13 MY MYPI95001986A patent/MY116361A/en unknown
- 1995-07-13 CA CA002153856A patent/CA2153856C/en not_active Expired - Lifetime
- 1995-07-13 NO NO19952786A patent/NO312397B1/no not_active IP Right Cessation
- 1995-07-13 UA UA95073317A patent/UA41344C2/uk unknown
- 1995-07-14 HU HU9502134A patent/HU221502B/hu unknown
- 1995-07-14 CO CO95031237A patent/CO4410177A1/es unknown
- 1995-07-15 KR KR1019950020885A patent/KR100356240B1/ko not_active Expired - Lifetime
- 1995-07-17 DK DK95304977T patent/DK0693282T3/da active
- 1995-07-17 CN CN95108414A patent/CN1106191C/zh not_active Expired - Lifetime
- 1995-07-17 JP JP18002695A patent/JP3707831B2/ja not_active Expired - Lifetime
- 1995-07-17 RU RU95113118A patent/RU2147231C1/ru active
- 1995-07-17 YU YU48095A patent/YU49445B/sh unknown
- 1995-07-17 DE DE69520711T patent/DE69520711T2/de not_active Expired - Lifetime
- 1995-07-17 AT AT95304977T patent/ATE200620T1/de active
- 1995-07-17 PT PT95304977T patent/PT693282E/pt unknown
- 1995-07-17 ES ES95304977T patent/ES2157297T3/es not_active Expired - Lifetime
- 1995-07-17 SI SI9530506T patent/SI0693282T1/xx unknown
- 1995-07-17 EP EP95304977A patent/EP0693282B1/en not_active Expired - Lifetime
- 1995-07-17 AU AU25051/95A patent/AU686384B2/en not_active Expired
- 1995-07-17 BR BR9503346A patent/BR9503346A/pt not_active IP Right Cessation
-
2001
- 2001-07-06 GR GR20010401033T patent/GR3036185T3/el unknown
-
2005
- 2005-02-01 NO NO2005002C patent/NO2005002I2/no unknown
-
2006
- 2006-03-23 GE GEAP20069310A patent/GEP20063944B/en unknown
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