ES2157304T3 - Produccion de sucralosa sin aislamiento intermedio del 6-ester de sucralosa. - Google Patents

Produccion de sucralosa sin aislamiento intermedio del 6-ester de sucralosa.

Info

Publication number
ES2157304T3
ES2157304T3 ES95307329T ES95307329T ES2157304T3 ES 2157304 T3 ES2157304 T3 ES 2157304T3 ES 95307329 T ES95307329 T ES 95307329T ES 95307329 T ES95307329 T ES 95307329T ES 2157304 T3 ES2157304 T3 ES 2157304T3
Authority
ES
Spain
Prior art keywords
sucralose
ester
sucralosa
production
intermediate insulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95307329T
Other languages
English (en)
Inventor
Juan L Navia
Robert E Walkup
David S Neiditch
Nicholas M Vernon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kenvue Brands LLC
Original Assignee
McNeil PPC Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26984204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157304(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by McNeil PPC Inc filed Critical McNeil PPC Inc
Application granted granted Critical
Publication of ES2157304T3 publication Critical patent/ES2157304T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fish Paste Products (AREA)

Abstract

SE PRESENTA UN PROCESO PARA PRODUCIR SUCRALOSA A PARTIR DE SUCRALOSA-6-ESTER CON LO QUE LA SUCRALOSA-6-ESTER SE DESACILA DIRECTAMENTE BIEN ANTES O BIEN DESPUES DE LA RETIRADA DEL VEHICULO DE REACCION DE AMIDA TERCIARIA A PARTIR DE LA MEZCLA DE REACCION DE CLORACION NEUTRALIZADA, PARA PRODUCIR UNA SOLUCION ACUOSA DE SUCRALOSA MAS SALES E IMPUREZAS, A PARTIR DE LA CUAL SE RECUPERA LA SUCRALOSA POR EXTRACCION Y ENTONCES SE PURIFICA PREFERENTEMENTE POR CRISTALIZACION.
ES95307329T 1994-10-17 1995-10-16 Produccion de sucralosa sin aislamiento intermedio del 6-ester de sucralosa. Expired - Lifetime ES2157304T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32395494A 1994-10-17 1994-10-17
US08/448,710 US5498709A (en) 1994-10-17 1995-05-24 Production of sucralose without intermediate isolation of crystalline sucralose-6-ester

Publications (1)

Publication Number Publication Date
ES2157304T3 true ES2157304T3 (es) 2001-08-16

Family

ID=26984204

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95307329T Expired - Lifetime ES2157304T3 (es) 1994-10-17 1995-10-16 Produccion de sucralosa sin aislamiento intermedio del 6-ester de sucralosa.

Country Status (21)

Country Link
US (1) US5498709A (es)
EP (1) EP0708110B1 (es)
JP (1) JP4450436B2 (es)
KR (1) KR100390629B1 (es)
AT (1) ATE199723T1 (es)
AU (1) AU707557B2 (es)
BR (1) BR9504423A (es)
CA (1) CA2160641C (es)
DE (1) DE69520321T2 (es)
DK (1) DK0708110T3 (es)
ES (1) ES2157304T3 (es)
FI (1) FI954908L (es)
GR (1) GR3035878T3 (es)
IL (1) IL115562A (es)
MY (1) MY113405A (es)
NO (1) NO304950B1 (es)
NZ (1) NZ280208A (es)
PE (1) PE37196A1 (es)
PT (1) PT708110E (es)
TR (1) TR199501279A2 (es)
TW (1) TW331561B (es)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
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DE60133928D1 (de) 2000-11-17 2008-06-19 Tate & Lyle Technology Ltd Schmelzbare sucralosezusammensetzung
CA2429228C (en) 2000-11-17 2008-08-26 Mcneil-Ppc, Inc. Improved sucralose composition and process for the crystallization thereof
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US7049435B2 (en) * 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6998480B2 (en) * 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US6890581B2 (en) * 2002-04-05 2005-05-10 Tate & Lyle Public Limited Company Methods for buffer stabilized aqueous deacylation
US20040030124A1 (en) * 2002-08-06 2004-02-12 Catani Steven J. Process for recovering chlorosucrose compounds
US6984732B2 (en) * 2003-03-31 2006-01-10 Mcneil-Ppc, Inc. High-intensity sweetener composition and delivery of same
US6943248B2 (en) * 2003-04-30 2005-09-13 Tate & Lyle Public Limited Company Crystalline form of sucralose, and method for producing it
WO2005090376A1 (en) * 2004-03-19 2005-09-29 Pharmed Medicare Private Limited An improved process for producing chlorinated sucrose
DE602004032578D1 (de) * 2004-03-19 2011-06-16 Vb Medicare Pvt Ltd Verbessertes verfahren zur herstellung von chlorierter saccharose
US20050214425A1 (en) * 2004-03-23 2005-09-29 Roma Vazirani Sugar substitute prepared with nutritive and high-intensity sweeteners
US20060062811A1 (en) * 2004-09-21 2006-03-23 Szymczak Christopher E Medicinal cooling emulsions
WO2006061855A2 (en) * 2004-12-10 2006-06-15 Pharmed Medicare Private Limited Salts assisted selective extraction of 6-acetyl-4.1', 6' trichlorogalactosucrose and 4, 1 ', 6' trichlorogalactosucrose from aqueous reaction mixture
WO2006061854A2 (en) * 2004-12-10 2006-06-15 Pharmed Medicare Private Limited CONTROL OF pH BY DIRECT ADDITION OF CARBONATES AND BICARBONATES DURING CONCENTRATION OF ORGANIC SOLVENT EXTRACTS OF 6- ACETYL- 4,1 ‘, 6' TRICHLOROGALACTOSUCROSE AND 4,1 ‘, 6' TRICHLOROGALACTOSUCROSE
KR20070113194A (ko) * 2005-01-03 2007-11-28 팜드 메디케어 프리베이트 리미티드 염소화 시약의 동시 첨가에 의한 수크로스-6-에스테르염소화
US20060188629A1 (en) * 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
US7750146B2 (en) 2005-03-18 2010-07-06 Tate & Lyle Plc Granular sucralose
US20060247180A1 (en) * 2005-04-29 2006-11-02 Bergey James L Purgative composition and uses thereof
US20060276639A1 (en) * 2005-06-01 2006-12-07 Healthy Brands, Llc Conversion of sucralose-6-ester to sucralose
US20100190975A1 (en) * 2005-06-01 2010-07-29 Pharmed Medicare Private Limited Method for purification of chlorinated sucrose derivatives by solvent extraction
GB2443146A (en) * 2005-08-30 2008-04-23 Pharmed Medicare Pvt Ltd Novel method of exraction of 6-0-protected trichlorogalac tose from the chlorinated mass
CA2620875A1 (en) * 2005-08-30 2007-05-10 Pharmed Medicare Pvt. Ltd. A process for purification of trichlorogalactosucrose based on direct extraction in organic solvent from reaction mixture followed by evaporative removal of solvent
WO2007069269A1 (en) * 2005-10-20 2007-06-21 Pharmed Medicare Pvt. Ltd. Acid mediated deacylation of 6-0-trichlorogalactosucrose to trich-lorogalactosucrose.
US20070100139A1 (en) * 2005-10-31 2007-05-03 Healthy Brands, Llc Methods for chlorinating sucrose-6-ester
US20100184969A1 (en) * 2005-11-08 2010-07-22 Mangesh Rajadhyaksha Process to Prepare Sucralose
US7741477B2 (en) * 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
CN1814609B (zh) * 2006-03-06 2010-11-10 盐城捷康三氯蔗糖制造有限公司 一种提高三氯蔗糖合成收率的方法
GB2452870A (en) * 2006-04-27 2009-03-18 Vb Medicare Pvt Ltd Continuous neutralizer mixer reactor and a continuous process for quenching chlorination reaction mixture in production of chlorinated sucrose
WO2008004246A1 (en) * 2006-07-06 2008-01-10 Alembic Limited An improved process for the preparation of sucralose of high purity
US20080031927A1 (en) * 2006-07-11 2008-02-07 Catani Steven J Solid oral dosage vitamin and mineral compositions
ES2564518T3 (es) * 2006-09-14 2016-03-23 Bahram Memarzadeh Monolaurato de sucralosa y monomiristato de sucralosa, formulaciones farmacéuticas, estuches de diagnóstico y métodos de tratamiento
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
CN100591684C (zh) * 2006-12-27 2010-02-24 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖结晶方法
US20080227971A1 (en) * 2007-01-19 2008-09-18 Leinhos Duane A Deacylation of sucralose-6-acylates
GB0702857D0 (en) * 2007-01-19 2007-03-28 Tate & Lyle Plc Improved sucralose production method
CN101260126B (zh) * 2007-03-06 2010-12-22 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖的结晶方法
CN101386632B (zh) * 2007-09-12 2011-03-09 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖生产过程中回收叔酰胺溶剂的方法
CN101245085B (zh) * 2007-12-19 2012-02-01 上海同辰生物科技有限公司 一种三氯蔗糖的合成及纯化工艺
CA2710629C (en) * 2007-12-27 2016-06-21 Mcneil Nutritionals, Llc Synergistic sweetening compositions
US20110008508A1 (en) * 2007-12-27 2011-01-13 Catani Steven J Low calorie syrups
AR070082A1 (es) * 2008-01-04 2010-03-10 Tate & Lyle Technology Ltd Metodo para la produccion de sucralosa
US8557976B2 (en) * 2008-03-13 2013-10-15 Tate & Lyle Technology Limited Microbial consortia and methods for their use
WO2009117317A1 (en) 2008-03-20 2009-09-24 Tate & Lyle Technology Ltd Removal of acids from tertiary amide solvents
US8436157B2 (en) * 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
US20090259036A1 (en) * 2008-04-03 2009-10-15 Tate & Lyle Technology Limited Extraction of less polar impurities from sucralose containing aqueous feed streams
AR071134A1 (es) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd Cristalizacion de sucralosa a partir de chorros que contienen sucralosa
US8212022B2 (en) * 2008-04-03 2012-07-03 Tate & Lyle Technology Limited Effect of carbohydrate concentration on sucralose extraction efficiency
US20090299055A1 (en) * 2008-04-03 2009-12-03 Tate & Lyle Technology Limited Purification of Sucralose Containing Feed Streams for Sucralose Crystallization
US8497367B2 (en) * 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
US7862744B2 (en) * 2008-07-23 2011-01-04 Mamtek International Limited Methods and systems for preparing materials for sucralose production
EP2328558A2 (en) * 2008-08-08 2011-06-08 McNeil-PPC, Inc. Use of sucralose as a granulating agent
GB2468936B (en) 2009-03-27 2011-09-07 Mohamad Rami Radwan Jaber Chlorination of sucrose-6-esters
GB2469157B (en) * 2009-03-30 2011-07-06 John Kerr Process for removing dimethylamine during sucralose production
GB2469158B (en) 2009-03-31 2011-09-28 Peter J Seaberg Base-assisted formation of tin-sucrose adducts
GB2471348B (en) * 2009-06-22 2011-12-14 Tate & Lyle Technology Ltd A method for producing sucralose-6-acylate
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GB2474311B (en) 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
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GB201110520D0 (en) 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
CA2839385C (en) 2011-06-24 2018-10-30 Construction Research & Technology Gmbh Cementitious composition and admixture
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US8884004B2 (en) 2011-09-02 2014-11-11 Divi's Laboratories, Ltd. Process for the preparation of sucralose
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CN103087116A (zh) * 2011-11-07 2013-05-08 常茂生物化学工程股份有限公司 三氯蔗糖的制备方法
US9151747B1 (en) 2013-03-14 2015-10-06 Mercyhurst University Sucralose antibody and immunoassay
CN105829332B (zh) 2013-12-16 2018-10-02 塔特和莱利技术有限公司 蔗糖-6-酯的氯化
WO2016020635A1 (en) 2014-08-08 2016-02-11 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
CN104387427A (zh) * 2014-10-30 2015-03-04 安徽金禾实业股份有限公司 一种三氯蔗糖的生产方法
GB2536480B (en) 2015-03-17 2019-09-04 Tate & Lyle Tech Ltd DMF Distillation
GB2551591B (en) 2016-06-23 2019-08-07 Tate & Lyle Tech Ltd Liquid-liquid extraction of DMF
CN108191926A (zh) * 2018-01-10 2018-06-22 福建科宏生物工程股份有限公司 一种气相氯化剂制备三氯蔗糖-6-乙酸酯的方法
CN109180748B (zh) * 2018-10-12 2022-04-08 安徽金禾实业股份有限公司 一种三氯蔗糖氯化中和反应后溶剂的分离方法
CN111574394B (zh) * 2020-05-22 2022-08-19 安徽金禾实业股份有限公司 一种三氯蔗糖生产中含羧酸dmf的处理方法
EP4206211B1 (en) 2020-09-30 2025-12-31 Anhui Jinhe Industrial Co., Ltd. SUCRALOSE PURIFICATION PROCESS
CN112585151A (zh) * 2020-11-13 2021-03-30 安徽金禾实业股份有限公司 三氯蔗糖的提纯方法
CN112933635B (zh) * 2021-03-04 2022-04-12 安徽金禾实业股份有限公司 一种环绕离心式蔗糖-6-酯连续生产设备及生产方法
CN113767109A (zh) * 2021-08-04 2021-12-07 安徽金禾实业股份有限公司 三氯蔗糖的制备方法
WO2024082177A1 (zh) * 2022-10-19 2024-04-25 安徽金禾实业股份有限公司 一种利用水解体系制备三氯蔗糖粗品的方法

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GB8617222D0 (en) * 1986-07-15 1986-08-20 Tate & Lyle Plc Sweetener
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US5089608A (en) * 1990-03-23 1992-02-18 Mcneil-Ppc, Inc. Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
US5034551A (en) * 1990-04-23 1991-07-23 Noramco, Inc. Process for recovery of organotin esters from reaction mixtures containing the same and re-use of the recovered organotin compounds
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Also Published As

Publication number Publication date
DK0708110T3 (da) 2001-04-17
FI954908A7 (fi) 1996-04-18
IL115562A (en) 2000-11-21
JPH08208679A (ja) 1996-08-13
NO304950B1 (no) 1999-03-08
NO954111L (no) 1996-04-18
CA2160641A1 (en) 1996-04-18
EP0708110A3 (en) 1996-08-07
MY113405A (en) 2002-02-28
BR9504423A (pt) 1997-05-27
AU707557B2 (en) 1999-07-15
DE69520321T2 (de) 2001-08-09
NO954111D0 (no) 1995-10-16
ATE199723T1 (de) 2001-03-15
GR3035878T3 (en) 2001-08-31
JP4450436B2 (ja) 2010-04-14
KR100390629B1 (ko) 2003-12-06
US5498709A (en) 1996-03-12
PE37196A1 (es) 1996-09-24
TR199501279A2 (tr) 1996-06-21
CA2160641C (en) 2007-03-20
EP0708110B1 (en) 2001-03-14
KR960014150A (ko) 1996-05-22
TW331561B (en) 1998-05-11
DE69520321D1 (de) 2001-04-19
IL115562A0 (en) 1996-01-19
FI954908A0 (fi) 1995-10-16
PT708110E (pt) 2001-06-29
FI954908L (fi) 1996-04-18
AU3420195A (en) 1996-05-02
NZ280208A (en) 1996-07-26
EP0708110A2 (en) 1996-04-24

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