ES2158255T3 - Nuevos derivados del tiofeno, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados del tiofeno, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2158255T3
ES2158255T3 ES96400359T ES96400359T ES2158255T3 ES 2158255 T3 ES2158255 T3 ES 2158255T3 ES 96400359 T ES96400359 T ES 96400359T ES 96400359 T ES96400359 T ES 96400359T ES 2158255 T3 ES2158255 T3 ES 2158255T3
Authority
ES
Spain
Prior art keywords
sub
rent
thiophen
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96400359T
Other languages
English (en)
Inventor
Michel Wierzbicki
Frederic Sauveur
Jacqueline Bonnet
Charles Tordjman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2158255T3 publication Critical patent/ES2158255T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

NUEVOS COMPUESTOS DE TIOFENO DE FORMULA: EN LA QUE .X SUB,1}, X{SUB,2}, Y{SUB,1}, Y {SUB,2}, IDENTICOS O DIFERENTES, SON CADA UNO HIDROGENO O HALOGENO (C{SUB,1-5} ALQUILO O ALCOXI, O TRIFLUOROMETILO, R{SUB,1} ES HIDROGENO O C{SUB,1-5} ALQUILO, A ES UNA CADENA HIDROCARBONADA LINEAL DE C{SUB,1} A C{SUB,5} EN LA QUE CADA CARBONO ESTA EVENTUALMENTE MONO- O DI- SUSTITUIDO POR UN ALQUILO DE C{SUB,1} A C{SUB,5}, R{SUB,2} ES HIDROGENO, (C{SUB,1}-C{SUB,6}) ES ALQUILO, CICLOHEXILO O BENCILO; Y SUS SALES FISIOLOGICAMENTE TOLERABLES. LOS PRODUCTOS DE LA INVENCION PUEDEN UTILIZARSE EN TERAPIA PARTICULARMENTE COMO AGENTES ANTIINFLAMATORIOS.
ES96400359T 1995-02-23 1996-02-22 Nuevos derivados del tiofeno, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2158255T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502061A FR2730996B1 (fr) 1995-02-23 1995-02-23 Nouveaux composes du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ES2158255T3 true ES2158255T3 (es) 2001-09-01

Family

ID=9476411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96400359T Expired - Lifetime ES2158255T3 (es) 1995-02-23 1996-02-22 Nuevos derivados del tiofeno, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (18)

Country Link
US (2) US5705525A (es)
EP (1) EP0728755B1 (es)
JP (1) JPH08253470A (es)
CN (1) CN1058965C (es)
AT (1) ATE200488T1 (es)
AU (1) AU697832B2 (es)
CA (1) CA2170097C (es)
CY (1) CY2262B1 (es)
DE (1) DE69612416T2 (es)
DK (1) DK0728755T3 (es)
ES (1) ES2158255T3 (es)
FI (1) FI960795A7 (es)
FR (1) FR2730996B1 (es)
GR (1) GR3036192T3 (es)
NO (1) NO314997B1 (es)
NZ (1) NZ286045A (es)
PT (1) PT728755E (es)
ZA (1) ZA961472B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019399A1 (en) * 1997-10-03 2000-07-19 Merck Frosst Canada & Co. Aryl thiophene derivatives as pde iv inhibitors
AUPR283801A0 (en) * 2001-02-01 2001-03-01 Australian National University, The Chemical compounds and methods
FR2860792B1 (fr) 2003-10-10 2006-02-24 Sanofi Synthelabo Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique
WO2021083060A1 (zh) * 2019-10-28 2021-05-06 中国科学院上海药物研究所 五元杂环氧代羧酸类化合物及其医药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0055471A1 (en) * 1980-12-29 1982-07-07 E.I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-alpha,alpha-bis(polyhalomethyl)-2-thiophenemethanamines
GB8525716D0 (en) * 1985-10-18 1985-11-20 Roussel Lab Ltd Chemical compounds
FR2655043B1 (fr) * 1989-11-24 1992-02-07 Adir Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5571810A (en) * 1990-06-11 1996-11-05 Fujisawa Pharmaceutical Co., Ltd. Thiophene derivatives
GB9012936D0 (en) * 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
GR3036192T3 (en) 2001-10-31
FI960795A7 (fi) 1996-08-24
US5705525A (en) 1998-01-06
FR2730996B1 (fr) 1997-06-20
CN1058965C (zh) 2000-11-29
EP0728755A1 (fr) 1996-08-28
USRE37078E1 (en) 2001-02-27
FR2730996A1 (fr) 1996-08-30
CN1142496A (zh) 1997-02-12
EP0728755B1 (fr) 2001-04-11
AU697832B2 (en) 1998-10-15
AU4567596A (en) 1996-08-29
CA2170097A1 (fr) 1996-08-24
DE69612416T2 (de) 2001-11-22
JPH08253470A (ja) 1996-10-01
NO314997B1 (no) 2003-06-23
CA2170097C (fr) 2002-02-26
DK0728755T3 (da) 2001-07-30
ATE200488T1 (de) 2001-04-15
PT728755E (pt) 2001-09-28
CY2262B1 (en) 2003-07-04
NO960706D0 (no) 1996-02-22
FI960795A0 (fi) 1996-02-21
DE69612416D1 (de) 2001-05-17
NO960706L (no) 1996-08-26
NZ286045A (en) 1996-10-28
ZA961472B (en) 1996-08-28

Similar Documents

Publication Publication Date Title
ES2108425T3 (es) Analogos de atp sustituidos con n-alquilo-2.
MX9300786A (es) Compuestos hipolipidaemicos.
ES2171109A1 (es) Derivados de 4-fenil-piridina.
ES2040838T3 (es) Compuestos piperazinil-heterociclicos.
ES2145638T3 (es) Nuevos compuestos azoicos, utilizacion para tincion, composiciones que los contienen y procedimientos de tincion.
CR9879A (es) Moduladores de ccr5 (divisional de la solicitud n° 6392)
CU23132A3 (es) Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
ES2011210T3 (es) Derivados de gem-difosfonato substituido, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2147230T3 (es) Derivados de aminoacidos, medicamentos que contienen a estos compuestos y procedimiento para su preparacion.
ES2179094T3 (es) Derivados de amidas ciclicas como antagonistas de la neuroquinina a.
ES2136037B1 (es) Inhibidores de sulfamida-metaloproteasa
ES2181803T3 (es) Acidos 4-biarilbutiricos o 5-biarilpentanoicos sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz.
ES2123810T3 (es) Heterociclos utiles como antagonistas de neuroquinina.
ES2151192T3 (es) Compuestos de quinolina y quinazolina utiles en terapia.
HUP0101999A2 (hu) 4-Hidroxi-kinolin-3-karboxamid- és -hidrazid-származékok, ezeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása
ES2161290T3 (es) Derivados de quinazolina.
ES2180945T3 (es) Agentes antimicrobianos derivados de azolilpiperazinilfeniloxazolidona.
GT199900008A (es) Compuestos 4-(2-ceto-1-benzilimidazolinil) piperidina como agonistas del receptor orl1
DOP2003000566A (es) Cicloalcanindoles con sustitución con fluor, composiciones que contienen estos compuestos y metodos de preparación para un medicamento
ES2164920T3 (es) Nuevos derivados heterociclicos y uso medicinal de los mismos.
ES2054844T3 (es) Nuevos esteroides que comprenden un ciclo espiranico con 3, 4 o 6 eslabones en posicion 17, su procedimiento, y productos intermedios de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
ES2181928T3 (es) Derivados de diester de acido fosfonico.
ES2159734T3 (es) Derivados 2-heteroarilalquenilicos del acido ciclopentano-heptan(en)oico como agentes terapeuticos para el tratamiento de la hipertension ocular.
ES2123652T3 (es) 7-(2-aminoetil)-benzotiazolonas.
UY27685A1 (es) Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 728755

Country of ref document: ES