ES2179094T3 - Derivados de amidas ciclicas como antagonistas de la neuroquinina a. - Google Patents

Derivados de amidas ciclicas como antagonistas de la neuroquinina a.

Info

Publication number
ES2179094T3
ES2179094T3 ES95903415T ES95903415T ES2179094T3 ES 2179094 T3 ES2179094 T3 ES 2179094T3 ES 95903415 T ES95903415 T ES 95903415T ES 95903415 T ES95903415 T ES 95903415T ES 2179094 T3 ES2179094 T3 ES 2179094T3
Authority
ES
Spain
Prior art keywords
neuroquinina
antagonists
derivatives
cyclic amides
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95903415T
Other languages
English (en)
Inventor
Ashokkumar Bhikkappa Shenvi
Robert Toms Jacobs
Scott Carson Miller
Cyrus John Ohnmacht Jr
Chris Allan Veale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939325654A external-priority patent/GB9325654D0/en
Priority claimed from GB9423248A external-priority patent/GB9423248D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2179094T3 publication Critical patent/ES2179094T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I), EN LA QUE Q1, Q2, Q3 Y Q4 TIENEN CUALQUIERA DE LOS SIGNIFICADOS DADOS EN LAS ESPECIFICACIONES, SUS N-OXIDOS, Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES, LOS COMPUESTOS SON ANTAGONISTAS NO PEPTIDOS DE LA NEUROQUININA A Y POR LO TANTO SON UTILES PARA EL TRATAMIENTO DEL ASMA, ETC. TAMBIEN SE PRESENTAN COMPOSICIONES FARMACEUTICAS, PROCESOS PARA PREPARAR LOS COMPUESTOS DE LA FORMULA (I) Y PRODUCTOS INTERMEDIOS.
ES95903415T 1993-12-15 1994-12-13 Derivados de amidas ciclicas como antagonistas de la neuroquinina a. Expired - Lifetime ES2179094T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939325654A GB9325654D0 (en) 1993-12-15 1993-12-15 Cyclic amide derivatives
GB9423248A GB9423248D0 (en) 1994-11-17 1994-11-17 Cyclic amide derivatives

Publications (1)

Publication Number Publication Date
ES2179094T3 true ES2179094T3 (es) 2003-01-16

Family

ID=26304034

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95903415T Expired - Lifetime ES2179094T3 (es) 1993-12-15 1994-12-13 Derivados de amidas ciclicas como antagonistas de la neuroquinina a.

Country Status (22)

Country Link
US (3) US5589489A (es)
EP (1) EP0734383B1 (es)
JP (1) JP3819934B2 (es)
CN (1) CN1142822A (es)
AT (1) ATE221064T1 (es)
AU (1) AU690951B2 (es)
BR (1) BR9408325A (es)
CA (1) CA2176036A1 (es)
CZ (1) CZ171796A3 (es)
DE (1) DE69431069T2 (es)
DK (1) DK0734383T3 (es)
ES (1) ES2179094T3 (es)
FI (1) FI962418A0 (es)
HU (1) HUT76275A (es)
IL (1) IL111970A (es)
NO (1) NO962543L (es)
NZ (1) NZ277291A (es)
PL (1) PL315035A1 (es)
PT (1) PT734383E (es)
SG (1) SG52667A1 (es)
SK (1) SK76396A3 (es)
WO (1) WO1995016682A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
GB9408872D0 (en) * 1994-05-03 1994-06-22 Zeneca Ltd Heterocyclic compounds
US5998444A (en) * 1995-10-24 1999-12-07 Zeneca Ltd. Piperidinyl compounds as NK1 or NK2 antagonists
DE69534213T2 (de) * 1994-10-25 2006-01-12 Astrazeneca Ab Therapeutisch wirksame Heterocyclen
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9508786D0 (en) 1995-04-29 1995-06-21 Zeneca Ltd Substituted heterocycles
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
GB9521781D0 (en) * 1995-10-24 1996-01-03 Merck Sharp & Dohme Therapeutic agents
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
US6124319A (en) * 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
JP2001508798A (ja) * 1997-01-21 2001-07-03 メルク エンド カンパニー インコーポレーテッド ケモカインレセプター活性のモジュレーターとしての３，３−二置換ピペリジン類
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US6281248B1 (en) 2000-02-16 2001-08-28 Magda Abdel Fattah Ahmed Composition for treating asthma
US6846814B2 (en) 2000-04-06 2005-01-25 Astra Zeneca Ab Neurokinin antagonists for use as medicaments
US7121402B2 (en) * 2003-04-09 2006-10-17 Reactive Nano Technologies, Inc Container hermetically sealed with crushable material and reactive multilayer material
US20050142495A1 (en) * 2003-10-09 2005-06-30 David Peter Van Heerden Methods of controlling multilayer foil ignition
US7441688B2 (en) * 2003-11-04 2008-10-28 Reactive Nanotechnologies Methods and device for controlling pressure in reactive multilayer joining and resulting product
DE60223904T2 (de) 2001-01-26 2008-11-27 Btg International Ltd. Benzylaminanalogen
AU2003213092A1 (en) 2002-02-15 2003-09-09 Smithkline Beecham Corporation Syntheses of quinazolinones
JP2005530785A (ja) 2002-05-09 2005-10-13 サイトキネティクス・インコーポレーテッド 化合物、組成物、及び方法
EP1503993A4 (en) 2002-05-09 2006-05-03 Cytokinetics Inc COMPOUNDS, METHODS AND COMPOSITIONS
EP1513820A4 (en) 2002-05-23 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
EP1556357A4 (en) 2002-06-14 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
US7211580B2 (en) 2002-07-23 2007-05-01 Cytokinetics, Incorporated Compounds, compositions, and methods
JP2006501306A (ja) 2002-09-30 2006-01-12 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
CA2525386A1 (en) * 2003-05-13 2005-01-20 Reactive Nanotechnologies, Inc. Method of controlling thermal waves in reactive multilayer joining and resulting product
JP2007513154A (ja) 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
CA2570800A1 (en) 2004-06-18 2006-01-26 Wyeth Processes for preparing 6-alkyl-5-arylsulfonyl- dihydrophenanthridines
IN2015MN00002A (es) 2012-07-09 2015-10-16 Lupin Ltd

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) * 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
AU680020B2 (en) * 1993-06-07 1997-07-17 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives

Also Published As

Publication number Publication date
HU9601568D0 (en) 1996-08-28
JP3819934B2 (ja) 2006-09-13
NZ277291A (en) 1997-12-19
IL111970A0 (en) 1995-03-15
EP0734383B1 (en) 2002-07-24
IL111970A (en) 1999-03-12
US5965576A (en) 1999-10-12
DK0734383T3 (da) 2002-10-14
US5705505A (en) 1998-01-06
BR9408325A (pt) 1997-08-19
JPH09506608A (ja) 1997-06-30
US5589489A (en) 1996-12-31
FI962418A7 (fi) 1996-06-11
NO962543D0 (no) 1996-06-14
SK76396A3 (en) 1996-12-04
PT734383E (pt) 2002-12-31
AU690951B2 (en) 1998-05-07
EP0734383A1 (en) 1996-10-02
DE69431069D1 (de) 2002-08-29
AU1247195A (en) 1995-07-03
CA2176036A1 (en) 1995-06-22
WO1995016682A1 (en) 1995-06-22
PL315035A1 (en) 1996-09-30
HUT76275A (en) 1997-07-28
FI962418L (fi) 1996-06-11
DE69431069T2 (de) 2003-05-08
ATE221064T1 (de) 2002-08-15
SG52667A1 (en) 1998-09-28
FI962418A0 (fi) 1996-06-11
CN1142822A (zh) 1997-02-12
CZ171796A3 (en) 1996-09-11
NO962543L (no) 1996-08-14

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