ES2158425T3 - Procedimiento para la preparacion de derivados de pirimidina. - Google Patents
Procedimiento para la preparacion de derivados de pirimidina.Info
- Publication number
- ES2158425T3 ES2158425T3 ES97119003T ES97119003T ES2158425T3 ES 2158425 T3 ES2158425 T3 ES 2158425T3 ES 97119003 T ES97119003 T ES 97119003T ES 97119003 T ES97119003 T ES 97119003T ES 2158425 T3 ES2158425 T3 ES 2158425T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- procedure
- preparation
- carbanionic
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH275796 | 1996-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2158425T3 true ES2158425T3 (es) | 2001-09-01 |
Family
ID=4240937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97119003T Expired - Lifetime ES2158425T3 (es) | 1996-11-08 | 1997-10-31 | Procedimiento para la preparacion de derivados de pirimidina. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5883254A (da) |
| EP (1) | EP0841326B1 (da) |
| JP (1) | JP3805502B2 (da) |
| KR (1) | KR100535450B1 (da) |
| CN (1) | CN1109023C (da) |
| AT (1) | ATE201201T1 (da) |
| DE (1) | DE69704832T2 (da) |
| DK (1) | DK0841326T3 (da) |
| ES (1) | ES2158425T3 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ542136A (en) | 2003-03-07 | 2008-07-31 | Sanofi Aventis | Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives |
| EP1454908B1 (en) * | 2003-03-07 | 2008-02-27 | Sanofi-Aventis | Substituted pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinone derivatives |
| EP1454910A1 (en) * | 2003-03-07 | 2004-09-08 | Sanofi-Synthelabo | Substituted pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidone derivatives |
| CL2004000545A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
| DE102004022897A1 (de) * | 2004-05-10 | 2005-12-08 | Bayer Cropscience Ag | Azinyl-imidazoazine |
| US20100022568A1 (en) * | 2006-04-13 | 2010-01-28 | Actelion Pharmaceeuticals Ltd. | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
| EP2072503B1 (en) * | 2007-12-18 | 2011-10-26 | Dipharma Francis S.r.l. | Process for the preparation of bosentan |
| EP2251001A4 (en) * | 2008-02-08 | 2013-01-09 | Shiseido Co Ltd | SKIN BLEACHING AND EXTERNAL PREPARATION FOR THE SKIN |
| WO2010118992A1 (en) | 2009-04-13 | 2010-10-21 | Sandoz Ag | Process for preparation of endothelial receptor antagonist (bosentan) |
| EP2509594A1 (en) | 2009-12-09 | 2012-10-17 | INSERM - Institut National de la Santé et de la Recherche Médicale | Endothelin inhibitors for the treatment of rapidly progressive glomerulonephritis |
| KR102004422B1 (ko) * | 2012-12-20 | 2019-07-26 | 제일약품주식회사 | 보센탄 일수화물의 제조방법, 이에 사용되는 신규 중간체 및 이의 제조방법 |
| WO2018185516A1 (en) | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cardiovascular toxicity induced by anti-cancer therapy |
| CN116410141A (zh) * | 2021-12-31 | 2023-07-11 | 南京艾德凯腾生物医药有限责任公司 | 一种阿伐那非中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH423708A (de) * | 1961-12-08 | 1966-06-30 | Ciba Geigy | Verfahren zum Färben und Bedrucken von Textilmaterialien |
| BE625803A (da) * | 1961-12-08 | |||
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| EP0726708A1 (en) * | 1993-11-05 | 1996-08-21 | Pathogenesis Corporation | Virus associated multiple sclerosis: treatments, prevention and diagnosis thereof |
-
1997
- 1997-10-16 US US08/951,700 patent/US5883254A/en not_active Expired - Lifetime
- 1997-10-28 KR KR1019970055491A patent/KR100535450B1/ko not_active Expired - Lifetime
- 1997-10-31 EP EP97119003A patent/EP0841326B1/en not_active Expired - Lifetime
- 1997-10-31 DE DE69704832T patent/DE69704832T2/de not_active Expired - Lifetime
- 1997-10-31 AT AT97119003T patent/ATE201201T1/de active
- 1997-10-31 DK DK97119003T patent/DK0841326T3/da active
- 1997-10-31 ES ES97119003T patent/ES2158425T3/es not_active Expired - Lifetime
- 1997-11-04 JP JP30148197A patent/JP3805502B2/ja not_active Expired - Lifetime
- 1997-11-07 CN CN97122238A patent/CN1109023C/zh not_active Expired - Lifetime
-
1998
- 1998-09-25 US US09/161,086 patent/US6121447A/en not_active Expired - Lifetime
-
2000
- 2000-03-16 US US09/526,252 patent/US6274734B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1109023C (zh) | 2003-05-21 |
| JP3805502B2 (ja) | 2006-08-02 |
| DK0841326T3 (da) | 2001-07-23 |
| EP0841326B1 (en) | 2001-05-16 |
| US6121447A (en) | 2000-09-19 |
| US6274734B1 (en) | 2001-08-14 |
| ATE201201T1 (de) | 2001-06-15 |
| KR19980041968A (ko) | 1998-08-17 |
| JPH10139765A (ja) | 1998-05-26 |
| EP0841326A1 (en) | 1998-05-13 |
| DE69704832D1 (de) | 2001-06-21 |
| US5883254A (en) | 1999-03-16 |
| KR100535450B1 (ko) | 2006-03-30 |
| DE69704832T2 (de) | 2001-11-29 |
| CN1182082A (zh) | 1998-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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