ES2159231A1 - Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas. - Google Patents

Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.

Info

Publication number
ES2159231A1
ES2159231A1 ES009900729A ES9900729A ES2159231A1 ES 2159231 A1 ES2159231 A1 ES 2159231A1 ES 009900729 A ES009900729 A ES 009900729A ES 9900729 A ES9900729 A ES 9900729A ES 2159231 A1 ES2159231 A1 ES 2159231A1
Authority
ES
Spain
Prior art keywords
alcohols
enantiomeric mixtures
lipases
resolution
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009900729A
Other languages
English (en)
Other versions
ES2159231B1 (es
Inventor
Franco Fernando Cardenas
Castro Alvarez M Soledad De
Montero Jose Maria Sanchez
Gago Jose Maria Sinisterra
W Steve Elson
Ruiz Emilio Alvarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Haleon Alcala SA
Original Assignee
SmithKline Beecham SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham SA filed Critical SmithKline Beecham SA
Priority to ES009900729A priority Critical patent/ES2159231B1/es
Publication of ES2159231A1 publication Critical patent/ES2159231A1/es
Application granted granted Critical
Publication of ES2159231B1 publication Critical patent/ES2159231B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimiento de resolución de mezclas enantioméricas de alcoholes catalizada por lipasas. La presente invención se refiere a un procedimiento para la resolución de mezclas enantioméricas de alcoholes orgánicos que comprende la esterificación selectiva de los mismos. Dichos alcoholes pueden ser secundarios o primarios quirales en alfa. La invención se refiere también a procedimientos para la resolución de mezclas enantioméricas de alcoholes, que se llevan a cabo haciendo reaccionar en el seno de un disolvente orgánico apolar la mezcla a resolver con un éster en presencia de un biocatalizador, y la posterior separación del éster enantioméricamente enriquecido de los productos de partida. Dicho biocatalizador es una lipasa, o mezcla de lipasas, en diversos grados de purificación, producida por un microorganismo seleccionado del siguiente grupo: Fusarium oxysporum, Penicillium. chrysogenum, Arthroderma ciferrii Ovadendron sulphureo-ochraceum, Pseudomonas cepacia, Streptomyces halstedii Streptomyces fradiae y Streptomyces sp. Dichos procedimientos son de interés en la Industria Farmacéutica, Industria de aditivos alimentarios e Industria de Química Fina.
ES009900729A 1999-04-09 1999-04-09 Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas. Expired - Fee Related ES2159231B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES009900729A ES2159231B1 (es) 1999-04-09 1999-04-09 Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009900729A ES2159231B1 (es) 1999-04-09 1999-04-09 Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.

Publications (2)

Publication Number Publication Date
ES2159231A1 true ES2159231A1 (es) 2001-09-16
ES2159231B1 ES2159231B1 (es) 2002-05-16

Family

ID=8307962

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009900729A Expired - Fee Related ES2159231B1 (es) 1999-04-09 1999-04-09 Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.

Country Status (1)

Country Link
ES (1) ES2159231B1 (es)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130064A1 (en) * 1983-06-23 1985-01-02 Novo Nordisk A/S Improvements in and relating to an enzymatic detergent additive, a detergent, and a washing method
EP0328125A2 (en) * 1988-02-10 1989-08-16 ISTITUTO GUIDO DONEGANI S.p.A. Process for the enzymatic separation of the optical isomers of racemic alpha-alkyl-substituted primary alcohols
EP0357009A2 (en) * 1988-08-30 1990-03-07 G.D. Searle & Co. Method of resolution of hydroxy-cyclopentenones using a lipase and transacylation agents
US4963492A (en) * 1987-12-23 1990-10-16 Hoechst Aktiengesellschaft Method for the enzymatic racemate resolution of racemic alcohols with/in vinyl esters by transesterification
EP0454463A2 (en) * 1990-04-26 1991-10-30 ARCO Chemical Technology, L.P. Process for producing epoxyalcohols of high optical purity
JPH1057094A (ja) * 1996-06-14 1998-03-03 Yasuyuki Kita ケテンアセタール型アシル化剤を用いるアルコール類の酵素的光学分割法
JPH1084990A (ja) * 1996-09-18 1998-04-07 T Hasegawa Co Ltd 光学活性２，４，４−トリメチル−２−シクロヘキセン−１−オール及びそのエステル類の製造方法
ES2124605T3 (es) * 1995-02-20 1999-02-01 Hoechst Ag Procedimiento para la acilacion enzimatica de alcoholes con acetatos de alcoxi-vinilo por transesterificacion.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130064A1 (en) * 1983-06-23 1985-01-02 Novo Nordisk A/S Improvements in and relating to an enzymatic detergent additive, a detergent, and a washing method
US4963492A (en) * 1987-12-23 1990-10-16 Hoechst Aktiengesellschaft Method for the enzymatic racemate resolution of racemic alcohols with/in vinyl esters by transesterification
EP0328125A2 (en) * 1988-02-10 1989-08-16 ISTITUTO GUIDO DONEGANI S.p.A. Process for the enzymatic separation of the optical isomers of racemic alpha-alkyl-substituted primary alcohols
EP0357009A2 (en) * 1988-08-30 1990-03-07 G.D. Searle & Co. Method of resolution of hydroxy-cyclopentenones using a lipase and transacylation agents
EP0454463A2 (en) * 1990-04-26 1991-10-30 ARCO Chemical Technology, L.P. Process for producing epoxyalcohols of high optical purity
ES2124605T3 (es) * 1995-02-20 1999-02-01 Hoechst Ag Procedimiento para la acilacion enzimatica de alcoholes con acetatos de alcoxi-vinilo por transesterificacion.
JPH1057094A (ja) * 1996-06-14 1998-03-03 Yasuyuki Kita ケテンアセタール型アシル化剤を用いるアルコール類の酵素的光学分割法
JPH1084990A (ja) * 1996-09-18 1998-04-07 T Hasegawa Co Ltd 光学活性２，４，４−トリメチル−２−シクロヘキセン−１−オール及びそのエステル類の製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HOSHINO et al. Purification and some characteristics of extracellular lipase from Fusarium oxysporum f. sp. lini. Biosci. Biotech. Biochem., 1992, Vol. 56 (4), paginas 660-664. *

Also Published As

Publication number Publication date
ES2159231B1 (es) 2002-05-16

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