ES2159488A1 - Procedimiento para la preparacion de derivados de pirimidona con actividad antifugica. - Google Patents

Procedimiento para la preparacion de derivados de pirimidona con actividad antifugica.

Info

Publication number
ES2159488A1
ES2159488A1 ES200000625A ES200000625A ES2159488A1 ES 2159488 A1 ES2159488 A1 ES 2159488A1 ES 200000625 A ES200000625 A ES 200000625A ES 200000625 A ES200000625 A ES 200000625A ES 2159488 A1 ES2159488 A1 ES 2159488A1
Authority
ES
Spain
Prior art keywords
pyrimidone derivatives
antifungal activity
formula
preparing
preparing pyrimidone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200000625A
Other languages
English (en)
Other versions
ES2159488B1 (es
Inventor
Javier Bartroli
Manuel Anguita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES200000625A priority Critical patent/ES2159488B1/es
Priority to ARP010101022A priority patent/AR027607A1/es
Priority to MXPA02008556A priority patent/MXPA02008556A/es
Priority to JP2001565337A priority patent/JP4772248B2/ja
Priority to CA002402390A priority patent/CA2402390C/en
Priority to PT01909840T priority patent/PT1282084E/pt
Priority to KR1020027011732A priority patent/KR100735583B1/ko
Priority to PCT/ES2001/000081 priority patent/WO2001066519A2/es
Priority to US10/221,099 priority patent/US6653475B2/en
Priority to ES01909840T priority patent/ES2207605T3/es
Priority to EP01909840A priority patent/EP1282084B9/en
Priority to HK03104472.6A priority patent/HK1052244B/en
Priority to DE60100810T priority patent/DE60100810T2/de
Priority to AT01909840T priority patent/ATE250256T1/de
Priority to AU2001237447A priority patent/AU2001237447A1/en
Priority to DK01909840T priority patent/DK1282084T3/da
Priority to BRPI0108990A priority patent/BRPI0108990B8/pt
Publication of ES2159488A1 publication Critical patent/ES2159488A1/es
Application granted granted Critical
Publication of ES2159488B1 publication Critical patent/ES2159488B1/es
Priority to NO20024256A priority patent/NO323314B1/no
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de derivados de pirimidona con actividad antifúngica. Procedimiento para la preparación de derivados de pirimidona de fórmula I, caracterizado porque comprende hacer reaccionar un compuesto de fórmula II con un compuesto de fórmula III en presencia de una base. Los derivados de pirimidona de fórmula I son útiles como agentes antifúngicos.
ES200000625A 2000-03-07 2000-03-07 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica. Expired - Fee Related ES2159488B1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
ES200000625A ES2159488B1 (es) 2000-03-07 2000-03-07 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
ARP010101022A AR027607A1 (es) 2000-03-07 2001-03-02 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica
AT01909840T ATE250256T1 (de) 2000-03-07 2001-03-05 Verfahren zur präparation von pyrimidonderivaten mit fungizidder aktivität
CA002402390A CA2402390C (en) 2000-03-07 2001-03-05 Process for the preparation of pyrimidone derivatives with antifungal activity
PT01909840T PT1282084E (pt) 2000-03-07 2001-03-05 Processo para a preparacao de derivados de pirimidona com actividade antifungica
KR1020027011732A KR100735583B1 (ko) 2000-03-07 2001-03-05 항진균 활성을 갖는 피리미돈 유도체의 제조 방법
PCT/ES2001/000081 WO2001066519A2 (es) 2000-03-07 2001-03-05 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica
US10/221,099 US6653475B2 (en) 2000-03-07 2001-03-05 Method for preparing pyrimidone derivatives with antifungal activity
ES01909840T ES2207605T3 (es) 2000-03-07 2001-03-05 Procedimiento para la preparacion de derivados de pirimidona con actividad angifungica.
EP01909840A EP1282084B9 (en) 2000-03-07 2001-03-05 Method for preparing pyrimidone derivatives with antifungal activity
MXPA02008556A MXPA02008556A (es) 2000-03-07 2001-03-05 Procedimiento para la preparacion de derivados de pirimidona con actividad anifungica.
DE60100810T DE60100810T2 (de) 2000-03-07 2001-03-05 Verfahren zur präparation von pyrimidonderivaten mit fungizidder aktivität
JP2001565337A JP4772248B2 (ja) 2000-03-07 2001-03-05 抗真菌活性を有するピリミドン誘導体の製造方法
AU2001237447A AU2001237447A1 (en) 2000-03-07 2001-03-05 Method for preparing pyrimidone derivatives with antifungal activity
DK01909840T DK1282084T3 (da) 2000-03-07 2001-03-05 Fremgangsmåde til fremstilling af pyrimidonderivater med antifungal aktivitet
BRPI0108990A BRPI0108990B8 (pt) 2000-03-07 2001-03-05 processo para preparação de derivados de pirimidona com atividade antifungos
HK03104472.6A HK1052244B (en) 2000-03-07 2001-03-05 Method for preparing pyrimidinone derivatives with antifungal activity
NO20024256A NO323314B1 (no) 2000-03-07 2002-09-06 Fremgangsmate for fremstilling av pyrimidonderivater med antifungal aktivitet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000625A ES2159488B1 (es) 2000-03-07 2000-03-07 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.

Publications (2)

Publication Number Publication Date
ES2159488A1 true ES2159488A1 (es) 2001-10-01
ES2159488B1 ES2159488B1 (es) 2002-04-16

Family

ID=8492714

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200000625A Expired - Fee Related ES2159488B1 (es) 2000-03-07 2000-03-07 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
ES01909840T Expired - Lifetime ES2207605T3 (es) 2000-03-07 2001-03-05 Procedimiento para la preparacion de derivados de pirimidona con actividad angifungica.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01909840T Expired - Lifetime ES2207605T3 (es) 2000-03-07 2001-03-05 Procedimiento para la preparacion de derivados de pirimidona con actividad angifungica.

Country Status (17)

Country Link
US (1) US6653475B2 (es)
EP (1) EP1282084B9 (es)
JP (1) JP4772248B2 (es)
KR (1) KR100735583B1 (es)
AR (1) AR027607A1 (es)
AT (1) ATE250256T1 (es)
AU (1) AU2001237447A1 (es)
BR (1) BRPI0108990B8 (es)
CA (1) CA2402390C (es)
DE (1) DE60100810T2 (es)
DK (1) DK1282084T3 (es)
ES (2) ES2159488B1 (es)
HK (1) HK1052244B (es)
MX (1) MXPA02008556A (es)
NO (1) NO323314B1 (es)
PT (1) PT1282084E (es)
WO (1) WO2001066519A2 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
WO2003064399A1 (fr) * 2002-01-28 2003-08-07 Ube Industries, Ltd. Procede de production de derive de quinazolin-4-one
WO2003070701A2 (en) 2002-02-15 2003-08-28 Cytokinetics, Inc. Syntheses of quinazolinones
US7214800B2 (en) 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
CA2485148A1 (en) 2002-05-09 2003-11-20 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods
EP1513820A4 (en) 2002-05-23 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
WO2003106426A1 (en) 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
AU2003256805A1 (en) 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
WO2004034972A2 (en) 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
EP1692112A4 (en) 2003-12-08 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS, AND METHODS
EP1871766A4 (en) 2005-03-30 2010-07-21 Dae Woong Pharma TRIAZONE DERIVATIVES WITH ANTIPILY EFFECT
MX2009001208A (es) * 2006-08-07 2009-04-14 Stiefel Laboratories Compuestos cristalinos antifungicos.
EP1887004A1 (en) * 2006-08-07 2008-02-13 Palau Pharma, S.A. Crystalline forms of (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
EP2009009A1 (en) * 2007-06-26 2008-12-31 Palau Pharma, S.A. Crystalline antifungal compounds
TWI395728B (zh) 2006-12-06 2013-05-11 Du Pont 製備２-胺基-５-氰基苯甲酸衍生物之方法
TWI415827B (zh) 2006-12-21 2013-11-21 Du Pont 製備２-胺基-５-氰基苯甲酸衍生物之方法
US8324227B2 (en) 2008-03-03 2012-12-04 Fdc Limited Thieno[2,3-D]-pyrimidin-4(3H)-one compounds with antifungal properties and process thereof
SE532624C2 (sv) * 2008-06-19 2010-03-09 Andritz Technology And Asset Management Gmbh Kylning av en cellulosamassabana
CA2829785C (en) 2011-03-15 2019-02-26 Fdc Limited Enantiomers of fluconazole analogues containing thieno-[2,3-d]pyrimidin-4(3h)-one moiety as antifungal agents
CN106588889B (zh) * 2016-11-25 2019-01-22 江苏恒盛药业有限公司 一种伏立康唑的制备方法
CN111018839B (zh) * 2019-12-02 2022-12-23 中国人民解放军第二军医大学 三氮唑醇类衍生物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062009T3 (es) * 1988-08-13 1994-12-16 Pfizer Agentes antifungicos derivados de triazol.
ES2118160T3 (es) * 1992-04-28 1998-09-16 Takeda Chemical Industries Ltd Compuestos de azol, su produccion y su uso.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100423590B1 (ko) * 1995-08-02 2004-09-10 호따. 우리아치에씨아. 에세. 아. 항진균활성을갖는신규피리미돈유도체

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062009T3 (es) * 1988-08-13 1994-12-16 Pfizer Agentes antifungicos derivados de triazol.
ES2118160T3 (es) * 1992-04-28 1998-09-16 Takeda Chemical Industries Ltd Compuestos de azol, su produccion y su uso.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BARTROLI, J. et al. New azole antifungals. 3. Synthesis and antifungal activity the 3-substituted 4-(3H)-quinazolinones. J. Med. Chem., 1998, Volumen 41, paginas 1869-1882, ISSN 0022, 2623. Paginas 1869-1871. *

Also Published As

Publication number Publication date
JP2004500391A (ja) 2004-01-08
DE60100810D1 (de) 2003-10-23
US20030064986A1 (en) 2003-04-03
DE60100810T2 (de) 2004-07-01
HK1052244B (en) 2003-12-19
ES2207605T3 (es) 2004-06-01
HK1052244A1 (en) 2003-09-05
BR0108990A (pt) 2003-12-30
EP1282084B1 (en) 2003-09-17
AU2001237447A1 (en) 2001-09-17
NO20024256L (no) 2002-09-06
BR0108990B1 (pt) 2014-03-25
EP1282084A2 (en) 2003-02-05
ATE250256T1 (de) 2003-10-15
US6653475B2 (en) 2003-11-25
AR027607A1 (es) 2003-04-02
WO2001066519A3 (es) 2002-01-31
DK1282084T3 (da) 2004-02-02
BRPI0108990B8 (pt) 2021-05-25
KR20020075809A (ko) 2002-10-05
CA2402390C (en) 2009-09-15
PT1282084E (pt) 2004-02-27
MXPA02008556A (es) 2003-02-24
CA2402390A1 (en) 2001-09-13
NO20024256D0 (no) 2002-09-06
WO2001066519A2 (es) 2001-09-13
KR100735583B1 (ko) 2007-07-04
NO323314B1 (no) 2007-03-12
JP4772248B2 (ja) 2011-09-14
EP1282084B9 (en) 2005-03-02
ES2159488B1 (es) 2002-04-16

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