ES2159554T3 - Nuevos derivados gangliosidos y liso-gangliosidos o-sulfatados. - Google Patents

Nuevos derivados gangliosidos y liso-gangliosidos o-sulfatados.

Info

Publication number
ES2159554T3
ES2159554T3 ES94910741T ES94910741T ES2159554T3 ES 2159554 T3 ES2159554 T3 ES 2159554T3 ES 94910741 T ES94910741 T ES 94910741T ES 94910741 T ES94910741 T ES 94910741T ES 2159554 T3 ES2159554 T3 ES 2159554T3
Authority
ES
Spain
Prior art keywords
sub
derivatives
gangliosid
liso
acil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94910741T
Other languages
English (en)
Inventor
Aurelio Romeo
Gunter Kirschner
Carlo Chizzolini
Hari Manev
Laura Facci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of ES2159554T3 publication Critical patent/ES2159554T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

DERIVADOS DE GANGLIOSIDOS Y N-ACIL-N-LISO-GANGLIOSIDOS, DE N''ACIL-N''-LISO-GANGLIOSIDOS Y N,N''-DI- O POLI-ACIL-N.N''-DI-LISOGANGLIOSIDOSM EN LOS QUE AL MENS UNO DE LOS GRUPOS HIDROXILO EN LOS RESIDUOS DE CERAMIDA, SIALICOS O DE SACARIDO ES ESTERIFICADO CON ACIDO SULFURICO, SUS DERIVADOS FUNCIONALES, Y SUS SALES CON SUS BASES ORGANICAS E INORGANICAS Y LAS SALES DE ADICION, EXCEPTO LOS DERIVADOS PERSULFATADOS Y SUS GRUPOS CERAMIDA, SILIACO E HIDROXILO DE LOS GANGLIOSIDOS GM{SUB,1}, GD{SUB,1A}, GD{SUB,1B} Y GB{SUB,1B}. TALES COMPUESTOS TIENE ACTIVIDAD ANTINUEROTOXICA Y NEURITOGENCA Y PUEDEN POR CONSIGUIENTE USARSE EN PREPARACIONES FARMACEUTICAS. TAMBIEN SE HA PRESENTADO UN EFECTO DE MODULACION MARCADO SOBRE LA EXPRESION DE LA MOLECULA CD{SUB,4} EN CELULAS DE SISTEMA INMUNOLOGICO.
ES94910741T 1993-03-04 1994-03-04 Nuevos derivados gangliosidos y liso-gangliosidos o-sulfatados. Expired - Lifetime ES2159554T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93PD000045A IT1267956B1 (it) 1993-03-04 1993-03-04 Derivati o-solfatati di gangliosidi e lisogangliosidi

Publications (1)

Publication Number Publication Date
ES2159554T3 true ES2159554T3 (es) 2001-10-16

Family

ID=11390210

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94910741T Expired - Lifetime ES2159554T3 (es) 1993-03-04 1994-03-04 Nuevos derivados gangliosidos y liso-gangliosidos o-sulfatados.

Country Status (10)

Country Link
EP (1) EP0688330B1 (es)
JP (1) JPH08507307A (es)
KR (1) KR960701073A (es)
AT (1) ATE204287T1 (es)
AU (1) AU694105B2 (es)
CA (1) CA2157359A1 (es)
DE (1) DE69427966T2 (es)
ES (1) ES2159554T3 (es)
IT (1) IT1267956B1 (es)
WO (1) WO1994020515A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1267955B1 (it) * 1993-03-04 1997-02-18 Fidia S P A In Amministrazione Derivati solfatati dei lisogangliosidi
WO2012004917A1 (ja) 2010-07-06 2012-01-12 Kaminishi Hidenori 神経突起伸長剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
JPH03246297A (ja) * 1990-02-22 1991-11-01 Nippon Koutai Kenkyusho:Kk ガングリオシド誘導体及びこれを含有する抗ｈｉｖ剤
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi

Also Published As

Publication number Publication date
EP0688330A1 (en) 1995-12-27
AU694105B2 (en) 1998-07-16
ITPD930045A0 (it) 1993-03-04
ITPD930045A1 (it) 1994-09-04
ATE204287T1 (de) 2001-09-15
AU6352194A (en) 1994-09-26
EP0688330B1 (en) 2001-08-16
DE69427966D1 (de) 2001-09-20
IT1267956B1 (it) 1997-02-18
JPH08507307A (ja) 1996-08-06
WO1994020515A1 (en) 1994-09-15
DE69427966T2 (de) 2002-04-04
CA2157359A1 (en) 1994-09-15
KR960701073A (ko) 1996-02-24

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