ES2159767T3 - Nuevos hidrogeles a base de copolimeros trisecuenciados, su preparacion y su aplicacion. - Google Patents

Nuevos hidrogeles a base de copolimeros trisecuenciados, su preparacion y su aplicacion.

Info

Publication number
ES2159767T3
ES2159767T3 ES96941085T ES96941085T ES2159767T3 ES 2159767 T3 ES2159767 T3 ES 2159767T3 ES 96941085 T ES96941085 T ES 96941085T ES 96941085 T ES96941085 T ES 96941085T ES 2159767 T3 ES2159767 T3 ES 2159767T3
Authority
ES
Spain
Prior art keywords
water
trisecuenced
copolymers
hydroxyled
copolimero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96941085T
Other languages
English (en)
Inventor
Michel Vert
Suming Li
Iliya Rashkov
Jose-Luis Espartero-Sanchez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of ES2159767T3 publication Critical patent/ES2159767T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/916—Hydrogel compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

LA INVENCION SE REFIERE A UN HIDROGEL SUAVE A BASE DE UN COPOLIMERO TRISECUENCIADO Y AGUA. EL COPOLIMERO RESPONDE A LA FORMULA (I): X - G - Y, DONDE: G ES UN BLOQUE POLIMERO LINEAL HIDROFILO NO HIDROXILADO QUE CONTIENE P MOTIVOS REPETITIVOS, SIENDO P UN NUMERO DE 10 A 150; X E Y REPRESENTAN UN BLOQUE POLIESTER QUE CONTIENE RESPECTIVAMENTE M Y N MOTIVOS REPETITIVOS, SIENDO LA RELACION (M + N)/P SUFICIENTEMENTE ALTA PARA QUE DICHO COPOLIMETO SEA INSOLUBLE EN AGUA, Y ELIGIENDOSE DICHA RELACION (M + N)/P DE MODO QUE LA ADICION DE AGUA A UNA SOLUCION DE COPOLIMERO EN UN DISOLVENTE ORGANICO MISCIBLE EN AGUA PROVOQUE LA FORMACION DE UN HIDROGEL SUAVE CAPAZ DE RETENER UNA CANTIDAD DE AGUA AL MENOS IGUAL AL PESO DE DICHO COPOLIMERO. ESTE HIDROGEL PUEDE RETENER Y LIBERAR PROGRESIVAMENTE SUSTANCIAS HIDROFOBAS Y/O MACROMOLECULAS HIDROFILAS, INCLUIDOS MEDICAMENTOS.
ES96941085T 1995-11-29 1996-11-29 Nuevos hidrogeles a base de copolimeros trisecuenciados, su preparacion y su aplicacion. Expired - Lifetime ES2159767T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9514144A FR2741628B1 (fr) 1995-11-29 1995-11-29 Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs

Publications (1)

Publication Number Publication Date
ES2159767T3 true ES2159767T3 (es) 2001-10-16

Family

ID=9485003

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96941085T Expired - Lifetime ES2159767T3 (es) 1995-11-29 1996-11-29 Nuevos hidrogeles a base de copolimeros trisecuenciados, su preparacion y su aplicacion.

Country Status (11)

Country Link
US (1) US6350812B1 (es)
EP (1) EP0863933B1 (es)
JP (2) JP4521067B2 (es)
AT (1) ATE202373T1 (es)
DE (1) DE69613481T2 (es)
DK (1) DK0863933T3 (es)
ES (1) ES2159767T3 (es)
FR (1) FR2741628B1 (es)
GR (1) GR3036586T3 (es)
PT (1) PT863933E (es)
WO (1) WO1997019973A1 (es)

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US6566406B1 (en) 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US6316522B1 (en) * 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
AU736812B2 (en) * 1997-10-03 2001-08-02 Btg International Limited Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6222091B1 (en) * 1997-11-19 2001-04-24 Basf Aktiengesellschaft Multicomponent superabsorbent gel particles
US6072101A (en) * 1997-11-19 2000-06-06 Amcol International Corporation Multicomponent superabsorbent gel particles
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US7347850B2 (en) 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US7160931B2 (en) 2000-03-15 2007-01-09 Yu-Ling Cheng Thermally reversible implant and filler
AU2001242144A1 (en) * 2000-03-15 2001-09-24 Yu-Ling Cheng Environment responsive gelling copolymer
US7193007B2 (en) 2000-03-15 2007-03-20 Yu-Ling Cheng Environment responsive gelling copolymer
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US7347988B2 (en) * 2001-11-15 2008-03-25 University Of North Texas Synthesis, uses and compositions of crystal hydrogels
MXPA04005565A (es) * 2002-06-06 2004-12-06 Nippon Catalytic Chem Ind Composicion de agente de absorcion de agua y metodo para la produccion de la misma y material de absorcion y articulo absorbente.
EP1511792A1 (en) * 2002-06-10 2005-03-09 Rhodia Inc. Phase-separated composition comprising two miscible solvents, and use thereof in a process for making capsules
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20070054985A1 (en) * 2003-06-10 2007-03-08 Mathieu Joanicot Phase-separated composition comprising two miscible solvents, and use thereof in a process for making capsules
WO2006007402A2 (en) * 2004-06-16 2006-01-19 University Of Massachusets Poly (lactid acid) copolymer hydrogels and related methods of drug delivery
US8357391B2 (en) 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
JP2009507115A (ja) * 2005-09-07 2009-02-19 ディーエスエム アイピー アセッツ ビー．ブイ． チオエステル結合を含むポリマー
FR2891746B1 (fr) * 2005-10-11 2008-01-11 Centre Nat Rech Scient Matrice poreuse biocompatible et biodegradable notamment utile pour la construction cellulaire
FR2893943B1 (fr) * 2005-11-28 2011-08-19 Centre Nat Rech Scient Procede de preparation de copolymeres par polymerisation anionique sans solvant
JP5267121B2 (ja) * 2006-03-14 2013-08-21 株式会社ジェイ・エム・エス 生体吸収性材料製造用材料、生体吸収性材料およびそれらの製造方法
JP2008069324A (ja) * 2006-09-15 2008-03-27 Mitsui Chemicals Inc 生分解性を有する水環境応答型ポリマーを含む水崩壊性組成物および水崩壊性成形体
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
JP5171146B2 (ja) * 2007-07-27 2013-03-27 学校法人 関西大学 温度応答性を有する生分解性ポリマー及びその製造方法
US8246998B2 (en) * 2007-11-01 2012-08-21 Boston Scientific Scimed, Inc. Injectable biodegradable particles
JP5890182B2 (ja) 2009-02-12 2016-03-22 インセプト エルエルシー ヒドロゲルプラグによる薬物送達
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
MX347090B (es) 2010-12-29 2017-04-11 Medincell Composiciones de suministro de farmacos biodegradables.
US20130195946A1 (en) * 2012-01-31 2013-08-01 Aurora Stamper Insecticidal hydrogel feeding spheres
JP6134788B2 (ja) 2012-06-27 2017-05-24 メドインセルル 疎水性組成物のための生分解性薬物送達
FR3027522B1 (fr) 2014-10-27 2016-12-09 I Ceram Composition poreuse chargee en principe actif
KR101694228B1 (ko) * 2014-10-29 2017-01-10 인하대학교 산학협력단 장기간 보관이 가능한 폴리디아세틸렌 기반의 바이오센서
EP4374861A3 (en) 2015-11-16 2024-08-07 MedinCell S.A. A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
ES3015765T3 (en) 2017-07-17 2025-05-07 Medincell S A Pharmaceutical composition
US11884765B2 (en) 2018-04-04 2024-01-30 Board Of Regents, The University Of Texas System Biodegradable elastic hydrogels for bioprinting
GB201900258D0 (en) 2019-01-08 2019-02-27 Medincell Pharmaceutical composition
EP4014963A1 (en) 2020-12-16 2022-06-22 Medincell Pharmaceutical composition
GB202104224D0 (en) 2021-03-25 2021-05-12 Medincell Pharmaceutical composition
KR20240006032A (ko) 2021-04-30 2024-01-12 메딘셀 에스.에이. 새로운 제형
US20250009647A1 (en) 2021-08-05 2025-01-09 Medincell S.A. Pharmaceutical composition
PE20252752A1 (es) 2023-01-10 2025-12-05 Medincell Sa Composiciones de olanzapina y metodos de uso
WO2025104289A1 (en) 2023-11-17 2025-05-22 Medincell S.A. Antineoplastic combinations
WO2025224317A1 (en) 2024-04-25 2025-10-30 Medincell S.A. A method for targeting pharmaceutically active principle in total knee replacement

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JPH0678375B2 (ja) 1985-12-09 1994-10-05 三井東圧化学株式会社 高分子多孔体の製造方法
US4882168A (en) * 1986-09-05 1989-11-21 American Cyanamid Company Polyesters containing alkylene oxide blocks as drug delivery systems
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US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5019094A (en) * 1990-05-09 1991-05-28 Ethicon, Inc. Crystalline copolymers of p-dioxanone and poly(alkylene oxides)
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof

Also Published As

Publication number Publication date
FR2741628B1 (fr) 1998-02-06
WO1997019973A1 (fr) 1997-06-05
JP2008056935A (ja) 2008-03-13
EP0863933B1 (fr) 2001-06-20
EP0863933A1 (fr) 1998-09-16
ATE202373T1 (de) 2001-07-15
JP4521067B2 (ja) 2010-08-11
DE69613481T2 (de) 2002-04-25
DK0863933T3 (da) 2001-09-24
GR3036586T3 (en) 2001-12-31
US6350812B1 (en) 2002-02-26
FR2741628A1 (fr) 1997-05-30
JP2000500803A (ja) 2000-01-25
DE69613481D1 (de) 2001-07-26
PT863933E (pt) 2001-12-28

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