ES2161210T3 - Composiciones anti-patogenamente eficaces que comprenden peptidos liticos y enzimas hidroliticas. - Google Patents

Composiciones anti-patogenamente eficaces que comprenden peptidos liticos y enzimas hidroliticas.

Info

Publication number
ES2161210T3
ES2161210T3 ES91810144T ES91810144T ES2161210T3 ES 2161210 T3 ES2161210 T3 ES 2161210T3 ES 91810144 T ES91810144 T ES 91810144T ES 91810144 T ES91810144 T ES 91810144T ES 2161210 T3 ES2161210 T3 ES 2161210T3
Authority
ES
Spain
Prior art keywords
pathogenally
peptides
hydrolytic enzymes
effective compositions
lithic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91810144T
Other languages
English (en)
Inventor
John A Ryals
Philippe Bernard Dr Gay
Goy Patricia A Dr Ahl
Francisco Prof Garcia-Olmedo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Participations AG
Original Assignee
Syngenta Participations AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23953731&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2161210(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syngenta Participations AG filed Critical Syngenta Participations AG
Application granted granted Critical
Publication of ES2161210T3 publication Critical patent/ES2161210T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/244—Endo-1,3(4)-beta-glucanase (3.2.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2442—Chitinase (3.2.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01006—Endo-1,3(4)-beta-glucanase (3.2.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01014—Chitinase (3.2.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01058—Glucan 1,3-beta-glucosidase (3.2.1.58)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01073—Licheninase (3.2.1.73)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PRESENTAMOS LOS COMPUESTOS EFECTIVOS ANTIPATOGENICAMENTE, QUE FACILITAN UNA COMBINACION DE ENCIMAS HIDROLITICAS Y PEPTIDOS LITICOS COMO AGENTE ACTIVO. TAMBIEN PRESENTAMOS METODOS DE CONTROLAR EL CRECIMIENTO DE LOS PATOGENOS MEDIANTE LA UTILIZACION DE COMPUESTOS EFECTIVOS PATOGENICAMENTE Y PLANTAS TRANSGENICAS QUE CONTIENEN GENES CAPACES DE EXPRESAR PEPTIDOS LITICOS Y ENCIMAS HIDROLITICAS.
ES91810144T 1990-03-12 1991-03-04 Composiciones anti-patogenamente eficaces que comprenden peptidos liticos y enzimas hidroliticas. Expired - Lifetime ES2161210T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49180190A 1990-03-12 1990-03-12

Publications (1)

Publication Number Publication Date
ES2161210T3 true ES2161210T3 (es) 2001-12-01

Family

ID=23953731

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91810144T Expired - Lifetime ES2161210T3 (es) 1990-03-12 1991-03-04 Composiciones anti-patogenamente eficaces que comprenden peptidos liticos y enzimas hidroliticas.

Country Status (18)

Country Link
US (1) US5348743A (es)
EP (1) EP0448511B1 (es)
JP (1) JPH04217903A (es)
KR (1) KR910016255A (es)
AT (1) ATE203141T1 (es)
AU (1) AU655579B2 (es)
CA (1) CA2037806A1 (es)
DE (1) DE69132660T2 (es)
ES (1) ES2161210T3 (es)
HU (1) HUT56703A (es)
IE (1) IE910800A1 (es)
IL (1) IL97480A (es)
NO (1) NO910947L (es)
NZ (1) NZ237387A (es)
PH (1) PH30997A (es)
PT (1) PT96999B (es)
TR (1) TR26942A (es)
ZA (1) ZA911766B (es)

Families Citing this family (52)

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EP0460753A3 (en) * 1990-06-07 1992-04-15 Mogen International N.V. New antifungal preparations, process for making such preparations, process for obtaining plants with decreased susceptibility to fungi
ES2235150T3 (es) * 1990-06-15 2005-07-01 Syngenta Participations Ag Nuevas secuencias de señales.
US6512166B1 (en) 1991-06-17 2003-01-28 Cornell Research Foundation, Inc. Combinations of fungal cell wall degrading enzyme and fungal cell membrane affecting compound
US6020540A (en) * 1993-04-14 2000-02-01 Cornell Research Foundation, Inc. Gene encoding endochitinase
GB9127250D0 (en) * 1991-12-23 1992-02-19 Unilever Plc Modification
WO1994001546A1 (en) 1992-07-01 1994-01-20 Cornell Research Foundation, Inc. Elicitor of the hypersensitive response in plants
NZ256788A (en) * 1992-09-30 1996-11-26 Cornell Res Foundation Inc Conferring resistance to fire blight in pomaceous fruit scion or cultivars through transformation with genes encoding lytic proteins
US5708139A (en) * 1993-05-17 1998-01-13 Cornell Research Foundation, Inc. Pseudomonas syringae pv syringae hrpZ gene
US5530187A (en) * 1993-07-16 1996-06-25 The Salk Institute For Biological Studies Transgenic plants containing multiple disease resistance genes
IL107080A0 (en) * 1993-09-23 1993-12-28 Yissum Res Dev Co A method for the biological control of pollen in plants
GB9509461D0 (en) * 1995-05-10 1995-07-05 Immunova DNA molecules and constructs and their use in the treatment of mastitis
JP3961023B2 (ja) * 1995-06-07 2007-08-15 コーネル・リサーチ・ファンデーション・インコーポレイテッド 植物における過敏応答誘導耐性
US5850015A (en) * 1995-06-07 1998-12-15 Cornell Research Foundation, Inc. Hypersensitive response elicitor from Erwinia chrysanthemi
HU219315B (en) * 1995-11-03 2001-03-28 Unilever Nv Natural composition for combatting fungi
US6750381B2 (en) * 1996-03-25 2004-06-15 National Institute Of Agrobiological Sciences Pathogen-resistant plants transformed with a DNA encoding sarcotoxin 1A linked to a signal peptide and a method for production thereof
US5773696A (en) 1996-03-29 1998-06-30 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
US6232528B1 (en) * 1996-06-26 2001-05-15 University Of Florida Research Foundation Incorporated Disease resistance in vitis
EP1138767B1 (en) * 1996-06-26 2006-02-01 University Of Florida Research Foundation, Inc. Disease resistance in vitis
AU759417B2 (en) * 1996-06-26 2003-04-17 United States Department Of Agriculture Disease resistance in vitis
US6235974B1 (en) 1996-12-05 2001-05-22 Cornell Research Foundation, Inc. Hypersensitive response induced resistance in plants by seed treatment with a hypersensitive response elicitor
US6121436A (en) 1996-12-13 2000-09-19 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
US6998515B1 (en) 1997-01-27 2006-02-14 Cornell Research Foundation, Inc. Use of a nucleic acid encoding a hypersensitive response elicitor polypeptide to enhance growth in plants
US6277814B1 (en) 1997-01-27 2001-08-21 Cornell Research Foundation, Inc. Enhancement of growth in plants
US5977060A (en) * 1997-02-28 1999-11-02 Cornell Research Foundation, Inc. Insect control with a hypersensitive response elicitor
US6635740B1 (en) 1997-03-27 2003-10-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ligand/lytic peptide compositions and methods of use
AU6587998A (en) * 1997-03-27 1998-10-20 Demeter Biotechnologies, Ltd. Ligand/lytic peptide compositions and methods of use
EP1878438B1 (en) * 1997-03-27 2017-11-29 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ligand/lytic peptide compositions and methods of use
BR9809699A (pt) 1997-05-30 2000-07-11 Cornell Res Foundation Inc Fragmento isolado de uma proteìna ou polipeptìdeo eliciador de resposta hipersensìvel de erwinia, molécula de dna isolada, sistema de expressão, célula hospedeira, planta transgênica, semente de planta transgênica, e, processos para conferir resistência a doença e intensificar crescimento de plantas e para controlar insetos para plantas
US6228644B1 (en) 1997-08-06 2001-05-08 Cornell Research Foundation, Inc. Hypersensitive response elicitor from Erwinia amylovora, its use, and encoding gene
US6262018B1 (en) 1997-08-06 2001-07-17 Cornell Research Foundation, Inc. Hypersensitive response elicitor from Erwinia amylovora and its use
US6172184B1 (en) 1997-08-06 2001-01-09 Cornell Research Foundation, Inc. Hypersensitive response elicitor from Pseudomonas syringae and its use
US6333302B1 (en) 1997-09-03 2001-12-25 Cornell Research Foundation, Inc. Use of hypersensitive response elicitor protein or polypeptide from Clavibacter michiganensis for disease resistance, growth enhancement and insect control
US6680058B1 (en) 1997-09-03 2004-01-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for contraception in or sterilization of mammals
JPH1175594A (ja) 1997-09-08 1999-03-23 Norin Suisansyo Nogyo Seibutsu Shigen Kenkyusho チオニン遺伝子を用いた複数病害抵抗性植物の作出方法
US6960705B2 (en) 1998-10-05 2005-11-01 Eden Bioscience Corporation Nucleic acid encoding a hypersensitive response elicitor from Xanthomonas campestris
US6858707B1 (en) 1998-10-05 2005-02-22 Eden Bioscience Corporation Hypersensitive response elicitor fragments which are active but do not elicit a hypersensitive response
US6624139B1 (en) 1998-11-05 2003-09-23 Eden Bioscience Corporation Hypersensitive response elicitor-induced stress resistance
CN103906840B (zh) * 2011-06-07 2018-01-30 艾比欧公司 重组蛋白通过与PNGase F共表达在活体内去糖基化
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
US9345741B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof
US9573980B2 (en) 2013-03-15 2017-02-21 Spogen Biotech Inc. Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots
US9345727B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component and uses thereof
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
IL315468A (en) 2014-09-17 2024-11-01 Spogen Biotech Inc Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria
EP3193619A1 (en) 2014-09-17 2017-07-26 Bayer Cropscience LP Compositions comprising recombinant bacillus cells and another biological control agent
AR101959A1 (es) 2014-09-17 2017-01-25 Bayer Cropscience Lp Composiciones que comprenden células recombinantes de bacillus y un insecticida
US11044915B2 (en) 2014-09-17 2021-06-29 Bayer Cropscience Lp Compositions comprising recombinant Bacillus cells and a fungicide
CA3221941A1 (en) * 2016-03-16 2017-09-21 Spogen Biotech Inc. Methods for promoting plant health using free enzymes and microorganisms that overexpress enzymes
CA3076491A1 (en) 2017-09-20 2019-03-28 Spogen Biotech Inc. Fusion proteins, recombinant bacteria, and exosporium fragments for plant health
KR102654962B1 (ko) * 2021-12-13 2024-04-05 대한민국 봉독을 포함하는 식물병 방제용 조성물

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JPH082308B2 (ja) * 1985-01-28 1996-01-17 インタ−ナショナル・ジェネティック・エンジニアリング，インコ−ポレイテッド ａｒａＢプロモーターを含有する複製可能な発現ビヒクル
AU611859B2 (en) * 1986-07-25 1991-06-27 Louisiana State University And Agricultural And Mechanical College Method for introduction of disease and pest resistance into plants and novel genes incorporated into plants which code therefor
US4810777A (en) * 1987-03-04 1989-03-07 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial compounds
DE3850180T2 (de) * 1987-07-01 1995-03-02 Plant Genetic Systems Nv Bakteriozide und/oder bakteriostatische Peptide, Verfahren zu ihrer Isolierung, Herstellung und Verwendung.
WO1989004371A1 (en) * 1987-11-02 1989-05-18 Louisiana State University Agricultural And Mechan Plants genetically enhanced for disease resistance
US5032574A (en) * 1988-05-26 1991-07-16 Invitron Corporation Novel antimicrobial peptide
CA2005122A1 (en) * 1988-12-21 1991-05-16 Daniel J. Monticello Control of microbial growth with nisin/lysozyme formulations

Also Published As

Publication number Publication date
HUT56703A (en) 1991-10-28
DE69132660D1 (de) 2001-08-23
US5348743A (en) 1994-09-20
EP0448511B1 (en) 2001-07-18
NO910947D0 (no) 1991-03-11
NZ237387A (en) 1992-07-28
IL97480A (en) 1996-06-18
PT96999A (pt) 1991-10-31
KR910016255A (ko) 1991-11-05
CA2037806A1 (en) 1991-09-13
PT96999B (pt) 2002-02-28
NO910947L (no) 1991-09-13
TR26942A (tr) 1994-08-29
IL97480A0 (en) 1992-06-21
ATE203141T1 (de) 2001-08-15
PH30997A (en) 1997-12-23
ZA911766B (en) 1991-11-27
AU7279791A (en) 1991-09-19
EP0448511A1 (en) 1991-09-25
HU910788D0 (en) 1991-09-30
IE910800A1 (en) 1991-09-25
DE69132660T2 (de) 2002-05-23
AU655579B2 (en) 1995-01-05
JPH04217903A (ja) 1992-08-07

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