ES2071319T3 - Polipeptido antifungico, procedimiento para su preparacion. - Google Patents

Polipeptido antifungico, procedimiento para su preparacion.

Info

Publication number
ES2071319T3
ES2071319T3 ES91911239T ES91911239T ES2071319T3 ES 2071319 T3 ES2071319 T3 ES 2071319T3 ES 91911239 T ES91911239 T ES 91911239T ES 91911239 T ES91911239 T ES 91911239T ES 2071319 T3 ES2071319 T3 ES 2071319T3
Authority
ES
Spain
Prior art keywords
lys
cys
tyr
gly
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91911239T
Other languages
English (en)
Inventor
Norbert Ulbrich
Rolf Hilgenfeld
Heinz Hanel
Burkhard Sachse
Peter Braun
Joachim Wink
Peter Eckes
Jurgen Logemann
Jozef Schell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer CropScience AG
Original Assignee
Hoechst Schering Agrevo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Schering Agrevo GmbH filed Critical Hoechst Schering Agrevo GmbH
Application granted granted Critical
Publication of ES2071319T3 publication Critical patent/ES2071319T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S47/00—Plant husbandry
    • Y10S47/01—Methods of plant-breeding and including chromosome multiplication
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/823—Lower fungi, e.g. mold

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EL POLIPEPTIDO CON LA SECUENCIA : ALA-THR-TYR-ASN-GLY-LYS-CYSTYR-LYS-LYS-ASP-ASN-ILE-CYS-LYS-TYR-LYS-ALA-GLN-SER-GLY-LYS-THRALA-ILE-CYS-LYS-CYS-TYR-VAL-LYS-LYS-CYS-PRO-ARG-ASP-GLY-ALA-LYSCYS-GLU-PHE-ASP-SER-TYR-LYS-GLY-LYS-CYS-TYR-CYS PUEDE PRODUCIRSE MEDIANTE LA FERMENTACION DE ASPERGILLUS GIGANTEUS Y EMPLEARSE COMO AGENTE FUNGICIDA. MEDIANTE LA EXPRESION DE ESTE GEN DE POLIPEPTIDO EN PLANTAS SE CONSIGUE UNA FUERTE INHIBICION DEL CRECIMIENTO DE LOS HONGOS FITOPATOLOGICOS EN LA PLANTA.
ES91911239T 1990-06-15 1991-06-12 Polipeptido antifungico, procedimiento para su preparacion. Expired - Lifetime ES2071319T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4019105 1990-06-15
DE4107140 1991-03-06

Publications (1)

Publication Number Publication Date
ES2071319T3 true ES2071319T3 (es) 1995-06-16

Family

ID=25894160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91911239T Expired - Lifetime ES2071319T3 (es) 1990-06-15 1991-06-12 Polipeptido antifungico, procedimiento para su preparacion.

Country Status (9)

Country Link
US (3) US5421839A (es)
EP (1) EP0535060B1 (es)
JP (1) JP3370090B2 (es)
AT (1) ATE118788T1 (es)
DE (1) DE59104720D1 (es)
DK (1) DK0535060T3 (es)
ES (1) ES2071319T3 (es)
GR (1) GR3015741T3 (es)
WO (1) WO1991019738A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59104720D1 (de) * 1990-06-15 1995-03-30 Hoechst Ag Antifungisches polypeptid, verfahren zu seiner herstellung.
JPH04234399A (ja) * 1990-12-28 1992-08-24 Kazuyasu Nakatani 抗真菌活性ペプチド
DK91192D0 (da) * 1992-07-10 1992-07-10 Novo Nordisk As Protein
DE4233337A1 (de) * 1992-10-05 1994-04-07 Bayer Ag Mikrobizide Mittel
DE4234131C2 (de) * 1992-10-09 1995-08-24 Max Planck Gesellschaft Transgener pathogen-resistenter Organismus
USRE39238E1 (en) 1992-10-09 2006-08-15 Max-Planck-Gesellschaft zür Forderung der Wissenschaften e.V. Transgenic pathogen-resistant organism
GB9310238D0 (en) * 1993-05-18 1993-07-14 Mini Agriculture & Fisheries Method,agents and kits for detection of organic agents
US6077995A (en) * 1996-03-21 2000-06-20 The United States Of America As Represented By The Secretary Of Agriculture Fungal gene encoding resistance to the phytotoxin cercosporin
US5773696A (en) 1996-03-29 1998-06-30 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
EP0979101B1 (en) 1996-07-03 2010-10-27 Merial, Inc. Recombinant canine adenovirus 2 (cav2) containing exogenous dna
US6121436A (en) 1996-12-13 2000-09-19 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
FR2766207B1 (fr) * 1997-07-11 2000-12-08 Rhone Poulenc Agrochimie Gene chimere codant pour la drosomycine, vecteur le contenant pour la transformation des cellules vegetales et plantes transformees obtenues resistantes aux maladies
FR2766206A1 (fr) * 1997-07-11 1999-01-22 Rhone Poulenc Agrochimie Gene chimere codant pour la drosomycine, vecteur le contenant pour la transformation des cellules vegetales et plantes transformees obtenues resistantes aux maladies
US6015941A (en) * 1997-10-31 2000-01-18 Pioneer Hi-Bred International, Inc. Peptide derivatives of tachyplesin having antimicrobial activity
AU772335B2 (en) * 1998-10-30 2004-04-22 Interlink Biotechnologies Llc Peptides with enhanced stability to protease degradation
JP2002530274A (ja) * 1998-10-30 2002-09-17 インターリンク・バイオテクノロジーズ・リミテッド・ライアビリティ・カンパニー プロテアーゼ分解に対する安定性の高いペプチド
US6855865B2 (en) * 1999-05-07 2005-02-15 E.I. Du Pont De Nemours And Company Nucleic acids encoding plant defensins and methods of use thereof
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
JP2004536034A (ja) * 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
US7319087B2 (en) 2001-05-04 2008-01-15 Novozymes A/S Antimicrobial polypeptide from Aspergillus niger
US6911577B2 (en) 2001-06-22 2005-06-28 Pioneer Hi-Bred International, Inc. Defensin polynucleotides and methods of use
US7045116B2 (en) 2001-12-13 2006-05-16 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
DE60329382D1 (de) * 2002-04-22 2009-11-05 Dow Global Technologies Inc Kostengünstige herstellung von peptiden
AU2014260123B2 (en) 2013-04-30 2018-10-11 Donald Danforth Plant Science Center Antifungal plant proteins, peptides, and methods of use
US12492229B2 (en) 2019-01-07 2025-12-09 Donald Danforth Plant Science Center Antimicrobial peptides
JP2024528407A (ja) 2021-06-16 2024-07-30 ドナルド・ダンフォース・プラント・サイエンス・センター 修飾された抗微生物ペプチド
JP2026501185A (ja) 2022-12-21 2026-01-14 ドナルド・ダンフォース・プラント・サイエンス・センター 抗菌ペプチドおよびその改変体
US20250382332A1 (en) 2024-06-12 2025-12-18 Invaio Sciences, Inc. Novel alpha-factor based peptides with antifungal activity
WO2025259861A2 (en) 2024-06-12 2025-12-18 Invaio Sciences, Inc. Antimicrobial peptides against citrus greening
WO2026009000A1 (en) 2024-07-04 2026-01-08 Solasta Bio Limited Methods for production of insecticidal neuropeptides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3104204A (en) * 1960-07-11 1963-09-17 Michigan State Alpha sarcin
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
AU611859B2 (en) * 1986-07-25 1991-06-27 Louisiana State University And Agricultural And Mechanical College Method for introduction of disease and pest resistance into plants and novel genes incorporated into plants which code therefor
US5049500A (en) * 1987-01-13 1991-09-17 E. I. Du Pont De Nemours Pollen-mediated gene transformation in plants
EP0275069A3 (en) * 1987-01-13 1990-04-25 DNA PLANT TECHNOLOGY CORPORATION (under the laws of the state of Delaware) Pollen-mediated gene transformation in plants
DE3887375T2 (de) * 1987-05-05 1994-06-09 Sandoz Ag Pflanzengewebe-Transformation.
DE3856241T2 (de) * 1987-05-20 1999-03-25 Novartis Ag, Basel Verfahren zur Herstellug von transgene Zea mays-Pflanzen, die aus Protoplasten oder aus von Protopflasten erhaltenen Zellen regeneriert wurden
EP0675960A1 (en) * 1987-11-02 1995-10-11 Louisiana State University and Agricultural and Mechanical College Plants genetically enhanced for disease resistance
DK604687D0 (da) * 1987-11-17 1987-11-17 Novo Industri As Praeparater
FI890917L (fi) * 1988-03-02 1989-09-03 Eidgenoess Tech Hochschule Foerfarande foer framstaellning av transgena vaexter.
DE59104720D1 (de) * 1990-06-15 1995-03-30 Hoechst Ag Antifungisches polypeptid, verfahren zu seiner herstellung.

Also Published As

Publication number Publication date
JPH06500074A (ja) 1994-01-06
JP3370090B2 (ja) 2003-01-27
GR3015741T3 (en) 1995-07-31
DK0535060T3 (da) 1995-07-17
WO1991019738A1 (de) 1991-12-26
EP0535060B1 (de) 1995-02-22
DE59104720D1 (de) 1995-03-30
US5589624A (en) 1996-12-31
ATE118788T1 (de) 1995-03-15
EP0535060A1 (de) 1993-04-07
US5824874A (en) 1998-10-20
US5421839A (en) 1995-06-06

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