ES2071319T3 - Polipeptido antifungico, procedimiento para su preparacion. - Google Patents

Polipeptido antifungico, procedimiento para su preparacion.

Info

Publication number
ES2071319T3
ES2071319T3 ES91911239T ES91911239T ES2071319T3 ES 2071319 T3 ES2071319 T3 ES 2071319T3 ES 91911239 T ES91911239 T ES 91911239T ES 91911239 T ES91911239 T ES 91911239T ES 2071319 T3 ES2071319 T3 ES 2071319T3
Authority
ES
Spain
Prior art keywords
lys
cys
tyr
gly
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91911239T
Other languages
English (en)
Inventor
Norbert Ulbrich
Rolf Hilgenfeld
Heinz Hanel
Burkhard Sachse
Peter Braun
Joachim Wink
Peter Eckes
Jurgen Logemann
Jozef Schell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer CropScience AG
Original Assignee
Hoechst Schering Agrevo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Schering Agrevo GmbH filed Critical Hoechst Schering Agrevo GmbH
Application granted granted Critical
Publication of ES2071319T3 publication Critical patent/ES2071319T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S47/00—Plant husbandry
    • Y10S47/01—Methods of plant-breeding and including chromosome multiplication
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/823—Lower fungi, e.g. mold

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Agronomy & Crop Science (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EL POLIPEPTIDO CON LA SECUENCIA : ALA-THR-TYR-ASN-GLY-LYS-CYSTYR-LYS-LYS-ASP-ASN-ILE-CYS-LYS-TYR-LYS-ALA-GLN-SER-GLY-LYS-THRALA-ILE-CYS-LYS-CYS-TYR-VAL-LYS-LYS-CYS-PRO-ARG-ASP-GLY-ALA-LYSCYS-GLU-PHE-ASP-SER-TYR-LYS-GLY-LYS-CYS-TYR-CYS PUEDE PRODUCIRSE MEDIANTE LA FERMENTACION DE ASPERGILLUS GIGANTEUS Y EMPLEARSE COMO AGENTE FUNGICIDA. MEDIANTE LA EXPRESION DE ESTE GEN DE POLIPEPTIDO EN PLANTAS SE CONSIGUE UNA FUERTE INHIBICION DEL CRECIMIENTO DE LOS HONGOS FITOPATOLOGICOS EN LA PLANTA.
ES91911239T 1990-06-15 1991-06-12 Polipeptido antifungico, procedimiento para su preparacion. Expired - Lifetime ES2071319T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4019105 1990-06-15
DE4107140 1991-03-06

Publications (1)

Publication Number Publication Date
ES2071319T3 true ES2071319T3 (es) 1995-06-16

Family

ID=25894160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91911239T Expired - Lifetime ES2071319T3 (es) 1990-06-15 1991-06-12 Polipeptido antifungico, procedimiento para su preparacion.

Country Status (9)

Country Link
US (3) US5421839A (es)
EP (1) EP0535060B1 (es)
JP (1) JP3370090B2 (es)
AT (1) ATE118788T1 (es)
DE (1) DE59104720D1 (es)
DK (1) DK0535060T3 (es)
ES (1) ES2071319T3 (es)
GR (1) GR3015741T3 (es)
WO (1) WO1991019738A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0535060T3 (da) * 1990-06-15 1995-07-17 Hoechst Schering Agrevo Gmbh Antifungisk polypeptid samt fremgangsmåde til dets fremstilling
JPH04234399A (ja) * 1990-12-28 1992-08-24 Kazuyasu Nakatani 抗真菌活性ペプチド
DK91192D0 (da) * 1992-07-10 1992-07-10 Novo Nordisk As Protein
DE4233337A1 (de) * 1992-10-05 1994-04-07 Bayer Ag Mikrobizide Mittel
USRE39238E1 (en) 1992-10-09 2006-08-15 Max-Planck-Gesellschaft zür Forderung der Wissenschaften e.V. Transgenic pathogen-resistant organism
DE4234131C2 (de) * 1992-10-09 1995-08-24 Max Planck Gesellschaft Transgener pathogen-resistenter Organismus
GB9310238D0 (en) * 1993-05-18 1993-07-14 Mini Agriculture & Fisheries Method,agents and kits for detection of organic agents
US6077995A (en) * 1996-03-21 2000-06-20 The United States Of America As Represented By The Secretary Of Agriculture Fungal gene encoding resistance to the phytotoxin cercosporin
US5773696A (en) 1996-03-29 1998-06-30 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
EP0979101B1 (en) 1996-07-03 2010-10-27 Merial, Inc. Recombinant canine adenovirus 2 (cav2) containing exogenous dna
US6121436A (en) 1996-12-13 2000-09-19 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
FR2766207B1 (fr) * 1997-07-11 2000-12-08 Rhone Poulenc Agrochimie Gene chimere codant pour la drosomycine, vecteur le contenant pour la transformation des cellules vegetales et plantes transformees obtenues resistantes aux maladies
FR2766206A1 (fr) * 1997-07-11 1999-01-22 Rhone Poulenc Agrochimie Gene chimere codant pour la drosomycine, vecteur le contenant pour la transformation des cellules vegetales et plantes transformees obtenues resistantes aux maladies
US6015941A (en) * 1997-10-31 2000-01-18 Pioneer Hi-Bred International, Inc. Peptide derivatives of tachyplesin having antimicrobial activity
AU772335B2 (en) * 1998-10-30 2004-04-22 Interlink Biotechnologies Llc Peptides with enhanced stability to protease degradation
BR9914922A (pt) * 1998-10-30 2001-07-10 Interlink Biotechnologies Llc Métodos para reduzir a extensão de degradação de protease de uma proteìna aplicada a ou produzida por uma planta, para inibir o crescimento de um patógeno vegetal e para produzir uma planta, peptìdeo, molécula de ácido nucleico, segmento de ácido nucleico, construção de ácido nucleico, planta transgênica, semente, célula vegetal, e, composição para o uso na proteção de um peptìdeo, polipeptìdeo ou proteìna da degradação da protease.
US6855865B2 (en) * 1999-05-07 2005-02-15 E.I. Du Pont De Nemours And Company Nucleic acids encoding plant defensins and methods of use thereof
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
EP1390081A2 (en) 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
WO2002090384A2 (en) * 2001-05-04 2002-11-14 Novozymes A/S Antimicrobial polypeptide from aspergillus niger
WO2003000863A2 (en) 2001-06-22 2003-01-03 Pioneer Hi-Bred International, Inc. Defensin polynucleotides and methods of use
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
CA2482995C (en) * 2002-04-22 2013-01-29 Dow Global Technologies Inc. Low-cost production of peptides
EP2999712B1 (en) 2013-04-30 2018-11-21 Donald Danforth Plant Science Center Antifungal plant proteins, peptides, and methods of use
WO2020146368A1 (en) 2019-01-07 2020-07-16 Donald Danforth Plant Science Center Antimicrobial peptides
WO2022266648A1 (en) 2021-06-16 2022-12-22 Donald Danforth Plant Science Center Modified antimicrobial peptides
CN120731217A (zh) 2022-12-21 2025-09-30 唐纳德丹福斯植物科学中心 抗微生物肽及其修饰
WO2025259861A2 (en) 2024-06-12 2025-12-18 Invaio Sciences, Inc. Antimicrobial peptides against citrus greening
WO2025259842A2 (en) 2024-06-12 2025-12-18 Invaio Sciences, Inc. Novel alpha-factor based peptides with antifungal activity
WO2026009000A1 (en) 2024-07-04 2026-01-08 Solasta Bio Limited Methods for production of insecticidal neuropeptides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3104204A (en) * 1960-07-11 1963-09-17 Michigan State Alpha sarcin
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
EP0590301A2 (en) * 1986-07-25 1994-04-06 Louisiana State University and Agricultural and Mechanical College Method for protecting plants from disease and infestation by gene insertion, and vectors and plant cells containing said genes
EP0275069A3 (en) * 1987-01-13 1990-04-25 DNA PLANT TECHNOLOGY CORPORATION (under the laws of the state of Delaware) Pollen-mediated gene transformation in plants
US5049500A (en) * 1987-01-13 1991-09-17 E. I. Du Pont De Nemours Pollen-mediated gene transformation in plants
ES2061720T3 (es) * 1987-05-05 1994-12-16 Sandoz Ag Transformacion de tejido vegetal.
ES2074999T3 (es) * 1987-05-20 1995-10-01 Ciba Geigy Ag Plantas de zea mays y plantas de zea mays transgenicas regeneradas de protoplastos o celulas derivadas de protoplastos.
AU2802989A (en) * 1987-11-02 1989-06-01 Louisiana State University Agricultural And Mechanical College Plants genetically enhanced for disease resistance
DK604687D0 (da) * 1987-11-17 1987-11-17 Novo Industri As Praeparater
FI890917A7 (fi) * 1988-03-02 1989-09-03 Schweizerische Eidgenossenschaft Menetelmä transgeenisten kasvien valmistamiseksi
DK0535060T3 (da) * 1990-06-15 1995-07-17 Hoechst Schering Agrevo Gmbh Antifungisk polypeptid samt fremgangsmåde til dets fremstilling

Also Published As

Publication number Publication date
ATE118788T1 (de) 1995-03-15
US5589624A (en) 1996-12-31
WO1991019738A1 (de) 1991-12-26
GR3015741T3 (en) 1995-07-31
EP0535060A1 (de) 1993-04-07
EP0535060B1 (de) 1995-02-22
DK0535060T3 (da) 1995-07-17
DE59104720D1 (de) 1995-03-30
US5421839A (en) 1995-06-06
JP3370090B2 (ja) 2003-01-27
JPH06500074A (ja) 1994-01-06
US5824874A (en) 1998-10-20

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