ES2161602A1 - Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilinato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina. - Google Patents

Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilinato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.

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Publication number
ES2161602A1
ES2161602A1 ES009900717A ES9900717A ES2161602A1 ES 2161602 A1 ES2161602 A1 ES 2161602A1 ES 009900717 A ES009900717 A ES 009900717A ES 9900717 A ES9900717 A ES 9900717A ES 2161602 A1 ES2161602 A1 ES 2161602A1
Authority
ES
Spain
Prior art keywords
synthesis
sultamicillin
alpha
benzylideneaminophenylacetamido
dioxopenicillanoyloxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009900717A
Other languages
English (en)
Other versions
ES2161602B1 (es
Inventor
Jasanada Miguel Santos Bayod
Mari Felix Fernandez
Fernandez Francisco Gonzalez
Pozo Losada Carlos Del
Fernandez Eduardo Alonso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Priority to ES9900717A priority Critical patent/ES2161602B1/es
Priority to TR2000/00952A priority patent/TR200000952A2/xx
Priority to JP2000108544A priority patent/JP2000344783A/ja
Publication of ES2161602A1 publication Critical patent/ES2161602A1/es
Application granted granted Critical
Publication of ES2161602B1 publication Critical patent/ES2161602B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Síntesis de 6[D-alfa-(bencilidenaminofenilacetamido)] penicilanato de 1,1-dioxopenicilanoiloximetilo y análogos. Nuevos intermedios para la síntesis de sultamicilina. 6-[D-alfa- (bencilidenaminofenilacetamido)]penicilanato de 1,1- dioxopenicilanoiloximetilo y análogos del mismo (1), donde R1 es arilo opcionalmente sustituido por grupos nitro o halógeno, alquilo o heteroarilo, pueden obtenerse mediante un procedimiento que comprende hacer reaccionar ampicilina con un aldehído, generándose una ampicilina N-protegida, que se hace reaccionar con 1,1-dioxopenicilanato de iodemetilo. A partir de dichos iminoderivados (1) se puede obtener el antibiótico sultamicilina base o su correspondiente tosilato.
ES9900717A 1999-04-08 1999-04-08 Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina. Expired - Lifetime ES2161602B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9900717A ES2161602B1 (es) 1999-04-08 1999-04-08 Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.
TR2000/00952A TR200000952A2 (tr) 1999-04-08 2000-04-10 1,1-dioksopenisilanoiloksimetil 6-[D-alfa-(benzilidenamino-fenilasetamido)] penisilanat ve benzerlerinin sentezi. Sultamisilin sentezinde elverişli yeni ara maddeler.
JP2000108544A JP2000344783A (ja) 1999-04-08 2000-04-10 ６−［Ｄ−α−（ベンジリデンアミノフェニルアセタミド）］ペニシリン酸１，１−ジオキソペニシラノイルオキシメチルおよびその類似体の合成、スルタミシリンの合成における新規中間体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9900717A ES2161602B1 (es) 1999-04-08 1999-04-08 Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.

Publications (2)

Publication Number Publication Date
ES2161602A1 true ES2161602A1 (es) 2001-12-01
ES2161602B1 ES2161602B1 (es) 2003-02-16

Family

ID=8307946

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9900717A Expired - Lifetime ES2161602B1 (es) 1999-04-08 1999-04-08 Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.

Country Status (3)

Country Link
JP (1) JP2000344783A (es)
ES (1) ES2161602B1 (es)
TR (1) TR200000952A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100336816C (zh) * 2005-12-14 2007-09-12 广州大学 一种舒巴坦制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342772A (en) * 1979-02-13 1982-08-03 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) β-Lactam compounds, antibacterial compositions thereof and method of use
ES8206531A1 (es) * 1980-10-31 1982-08-16 Leo Pharm Prod Ltd Metodo para producir un 1,1-dioxopenicilanoiloximetil 6- (d-a-amino-a-fenilacetamido)penicilanato tosilato hidrato cristalino
ES8403133A1 (es) * 1981-03-23 1984-03-01 Pfizer Un procedimiento para la preparacion de bis-esteres de metanodiol.
EP0405316A2 (en) * 1989-06-20 1991-01-02 Yeong Sul Kim 1,1-dioxopenicillanoyloxymethyl D-6-[alpha(methyleneamino)-phenyl-acetamidol]-penicillanate and a process for the preparation thereof
ES2100125A1 (es) * 1995-06-02 1997-06-01 Asturpharma S A Procedimiento de preparacion de esteres de matanodiol de acido dioxopeneicilanico.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2052992A1 (en) * 1969-06-20 1971-04-16 Clin Midy Alpha aldimino benzyl penicillins
FR2230649A1 (en) * 1973-05-23 1974-12-20 Aries Robert Alkanoyloxymethyl esters of penicillins - with alpha-(methyleneimino)phenylacetamido side-chain with long duration of action
GB1461860A (en) * 1974-10-22 1977-01-19 Prodotti Antibiotici Spa Semi-synthetic penicillin
PH20068A (en) * 1982-12-06 1986-09-18 Pfizer Process and intermediates for sultamicillin and analogs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342772A (en) * 1979-02-13 1982-08-03 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) β-Lactam compounds, antibacterial compositions thereof and method of use
ES8206531A1 (es) * 1980-10-31 1982-08-16 Leo Pharm Prod Ltd Metodo para producir un 1,1-dioxopenicilanoiloximetil 6- (d-a-amino-a-fenilacetamido)penicilanato tosilato hidrato cristalino
ES8403133A1 (es) * 1981-03-23 1984-03-01 Pfizer Un procedimiento para la preparacion de bis-esteres de metanodiol.
EP0405316A2 (en) * 1989-06-20 1991-01-02 Yeong Sul Kim 1,1-dioxopenicillanoyloxymethyl D-6-[alpha(methyleneamino)-phenyl-acetamidol]-penicillanate and a process for the preparation thereof
ES2100125A1 (es) * 1995-06-02 1997-06-01 Asturpharma S A Procedimiento de preparacion de esteres de matanodiol de acido dioxopeneicilanico.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor

Also Published As

Publication number Publication date
TR200000952A3 (tr) 2000-11-21
TR200000952A2 (tr) 2000-11-21
ES2161602B1 (es) 2003-02-16
JP2000344783A (ja) 2000-12-12

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