ES2178655T3 - Proceso ii. - Google Patents

Proceso ii.

Info

Publication number
ES2178655T3
ES2178655T3 ES94929077T ES94929077T ES2178655T3 ES 2178655 T3 ES2178655 T3 ES 2178655T3 ES 94929077 T ES94929077 T ES 94929077T ES 94929077 T ES94929077 T ES 94929077T ES 2178655 T3 ES2178655 T3 ES 2178655T3
Authority
ES
Spain
Prior art keywords
size
medicinal product
aglomerates
give
particulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929077T
Other languages
English (en)
Inventor
Eva Trofast
Magnus Olsson
Claes Ahlneck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9303215A external-priority patent/SE9303215D0/xx
Priority claimed from SE9304270A external-priority patent/SE9304270D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2178655T3 publication Critical patent/ES2178655T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Disintegrating Or Milling (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glanulating (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • External Artificial Organs (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

DE ACUERDO CON LA INVENCION, SE PROPORCIONA UN METODO DE TRATAMIENTO DE UN MEDICAMENTO EN POLVO FINAMENTE DIVIDIDO CON UN TAMAÑO DE PARTICULA MENOR A 10{MI}M Y POBRES PROPIEDADES DE FLUJO PARA FORMAR, DE MANERA CONTROLADA, AGLOMERADOS O BOLITAS QUE FLUYEN LIBREMENTE Y QUE SON CAPACES DE ROMPERSE PARA PROPORCIONAR UN MEDICAMENTO FINAMENTE DIVIDIDO, QUE INCLUYE LOS PASOS DE AGLOMERAR EL MEDICAMENTO EN POLVO CON UN TAMAÑO DE PARTICULA MENOR A 10{MI}M, ALIMENTANDOLO A UN TAMIZ, CAUSANDO QUE EL MEDICAMENTO PASE A TRAVES DE LAS ABERTURAS DEL MISMO, OBTENIENDO ASI AGLOMERADOS; DAR FORMA DE ESFERA A LOS AGLOMERADOS RESULTANTES PARA PROPORCIONAR AGLOMERADOS QUE SEAN MAS ESFERICOS, MAS DENSOS Y COMPACTOS QUE AQUELLOS QUE RESULTAN DEL PROCESO DE AGLOMERACION EN EL TAMIZ, Y DAR UN TAMAÑO A LOS MISMOS PARA OBTENER UN TAMAÑO UNIFORME DEL PRODUCTO FINAL. TAMBIEN SE PROPORCIONA UN APARATO PARA LLEVAR A CABO EL METODO.
ES94929077T 1993-10-01 1994-09-29 Proceso ii. Expired - Lifetime ES2178655T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9303215A SE9303215D0 (sv) 1993-10-01 1993-10-01 Process II
SE9304270A SE9304270D0 (sv) 1993-12-22 1993-12-22 Process II

Publications (1)

Publication Number Publication Date
ES2178655T3 true ES2178655T3 (es) 2003-01-01

Family

ID=26661852

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94929077T Expired - Lifetime ES2178655T3 (es) 1993-10-01 1994-09-29 Proceso ii.

Country Status (28)

Country Link
US (1) US6371171B1 (es)
EP (1) EP0721332B1 (es)
JP (1) JPH09504225A (es)
KR (1) KR100347497B1 (es)
CN (1) CN1119992C (es)
AT (1) ATE221371T1 (es)
AU (1) AU687896B2 (es)
BR (1) BR9407687A (es)
CA (1) CA2172055C (es)
CZ (1) CZ289394B6 (es)
DE (1) DE69431120T2 (es)
DK (1) DK0721332T3 (es)
EG (1) EG21071A (es)
ES (1) ES2178655T3 (es)
FI (1) FI117318B (es)
HU (1) HU226493B1 (es)
IL (1) IL111081A (es)
IS (1) IS1736B (es)
NO (1) NO316747B1 (es)
NZ (1) NZ274278A (es)
PL (1) PL175596B1 (es)
PT (1) PT721332E (es)
RU (1) RU2170083C2 (es)
SG (1) SG75091A1 (es)
SK (1) SK283554B6 (es)
TW (1) TW374728B (es)
UA (1) UA42736C2 (es)
WO (1) WO1995009616A1 (es)

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DE4425255A1 (de) 1994-07-16 1996-01-18 Asta Medica Ag Formulierung zur inhalativen Applikation
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
SE9700134D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
US5983956A (en) 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
US5826633A (en) 1996-04-26 1998-10-27 Inhale Therapeutic Systems Powder filling systems, apparatus and methods
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700135D0 (sv) † 1997-01-20 1997-01-20 Astra Ab New formulation
EP1393721B1 (en) 1997-03-20 2008-11-26 Schering Corporation Dosage form of powder agglomerates
US6495167B2 (en) 1997-03-20 2002-12-17 Schering Corporation Preparation of powder agglomerates
US6503537B2 (en) 1997-03-20 2003-01-07 Schering Corporation Preparation of powder agglomerates
US6182712B1 (en) 1997-07-21 2001-02-06 Inhale Therapeutic Systems Power filling apparatus and methods for their use
EP0938923B1 (en) * 1998-02-27 2005-03-16 Sandvik Aktiebolag Method and device for discharging free-flowing material in drop form onto a conveyor belt
US6623760B1 (en) 1999-01-28 2003-09-23 Schering Corporation Method of preparing particles for agglomeration
AU779869B2 (en) 1999-04-13 2005-02-17 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
DE60025019T2 (de) 1999-10-29 2006-08-24 Nektar Therapeutics, San Carlos Trockenpulverzusammensetzungen mit verbesserter dispersivität
WO2002096549A1 (en) * 2001-05-29 2002-12-05 Spheriform Pty Ltd Agglomeration of fine particulate material
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
PL1699434T3 (pl) 2003-09-02 2011-09-30 Norton Healthcare Ltd Sposób wytwarzania leku
WO2005067898A2 (en) 2004-01-07 2005-07-28 Nektar Therapeutics Improved sustained release compositions for pulmonary administration of insulin
DK1765288T3 (da) 2004-06-18 2013-02-11 Novartis Ag Tobramycinpræparater til behandling af endobronchiale infektioner
CN101239330B (zh) * 2007-02-09 2010-10-27 中国石油化工股份有限公司 微球形催化剂载体的制备方法
RU2517140C2 (ru) * 2007-10-25 2014-05-27 Новартис Аг Способ обработки упаковки с однократной дозой лекартвенного препарата
EP2350118B1 (en) 2008-09-19 2016-03-30 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
JP5668317B2 (ja) * 2009-04-24 2015-02-12 大正製薬株式会社 プソイドエフェドリン含有製剤粒子
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
MX2022003427A (es) 2019-09-24 2022-04-18 Chiesi Farm Spa Particulas portadoras novedosas para formulaciones de polvo seco para inhalacion.
CN113695054B (zh) * 2021-09-26 2024-08-30 常州市神工造粒设备有限公司 颗粒钾肥磨圆除粉装置
CN114917831B (zh) * 2022-05-23 2023-03-24 苏州易合医药有限公司 一种适用于微细粉末形成球形颗粒簇团的装置及使用方法

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US3335456A (en) * 1964-09-29 1967-08-15 Onoda Cement Co Ltd Pan-typed granulating machine
GB1242211A (en) 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
DE2350746C3 (de) * 1973-10-10 1978-08-31 Guenther Papenmeier Gmbh & Co Kg Maschinen- Und Apparatebau, 4930 Detmold Verfahren und Vorrichtungen zur Herstellung von Granulaten aus pulverformigem, körnigem oder teigigem Gut
GB1569611A (en) 1976-01-23 1980-06-18 Fisons Ltd Pelletised or granular medicament formulation
GB1520247A (en) 1974-08-10 1978-08-02 Fisons Ltd Pelletised medicament formulations
US4039480A (en) * 1975-03-21 1977-08-02 Reynolds Metals Company Hollow ceramic balls as automotive catalysts supports
US4161516A (en) * 1975-07-25 1979-07-17 Fisons Limited Composition for treating airway disease
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US4496376A (en) * 1978-01-26 1985-01-29 Litton Systems, Inc. Variable area molecular sieve container having a thermal control system
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AT366932B (de) * 1980-12-15 1982-05-25 Gergely Gerhard Vorrichtung zum mischen und granulieren von pulverfoermigen substanzen mit einer mittels eines ventilverschlusses angebrachten siebmaschine
DE3268533D1 (en) * 1981-07-24 1986-02-27 Fisons Plc Inhalation drugs, methods for their production and pharmaceutical formulations containing them
PL135587B1 (en) * 1982-08-16 1985-11-30 Zabrzanska Fabryka Maszyn Gorniczych "Powen" Centrifugal dewatering screen
US4495308A (en) * 1983-03-04 1985-01-22 Chevron Research Company Two-region spherical catalysts
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US4689297A (en) * 1985-03-05 1987-08-25 Miles Laboratories, Inc. Dust free particulate enzyme formulation
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US4655701A (en) * 1986-02-19 1987-04-07 Fuji Paudal Kabushiki Kaisha Granulating apparatus
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US5288500A (en) * 1987-03-13 1994-02-22 Benzon Pharma A/S Oral composition containing particles comprising an active substance
GB8711005D0 (en) * 1987-05-09 1987-06-10 British Petroleum Co Plc Chemical process
SU1762998A1 (ru) * 1989-10-17 1992-09-23 Белорусский Институт Инженеров Железнодорожного Транспорта Устройство дл уплотнени и гранулировани плохосыпучих материалов
EP0441740B1 (de) * 1990-01-29 1993-09-22 Ciba-Geigy Ag Verfahren und Vorrichtung zur Dosierung eines feinkörnigen Pulvers
US5547567A (en) * 1990-10-01 1996-08-20 Cps - Chemical Products & Services A/S Apparatus for washing-down serigraphical frames and filterpart for the apparatus
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DE4105984A1 (de) 1991-02-26 1992-08-27 Deutsche Forsch Luft Raumfahrt Verfahren zur aufbereitung pulverfoermiger rohstoffe
US5262172A (en) * 1992-06-19 1993-11-16 Digestive Care Inc. Compositions of gastric acid-resistant microspheres containing buffered bile acids
US5399358A (en) * 1993-11-12 1995-03-21 Edward Mendell Co., Inc. Sustained release formulations for 24 hour release of metroprolol

Also Published As

Publication number Publication date
JPH09504225A (ja) 1997-04-28
PT721332E (pt) 2002-10-31
KR100347497B1 (ko) 2002-12-26
CN1119992C (zh) 2003-09-03
EP0721332B1 (en) 2002-07-31
NO961291D0 (no) 1996-03-29
CA2172055C (en) 2005-11-08
IS1736B (is) 1999-12-30
TW374728B (en) 1999-11-21
UA42736C2 (uk) 2001-11-15
ATE221371T1 (de) 2002-08-15
SK39296A3 (en) 1997-06-04
AU7826294A (en) 1995-05-01
CZ289394B6 (cs) 2002-01-16
FI117318B (fi) 2006-09-15
PL313766A1 (en) 1996-07-22
BR9407687A (pt) 1997-02-04
RU2170083C2 (ru) 2001-07-10
FI961431A0 (fi) 1996-03-29
CA2172055A1 (en) 1995-04-13
CN1132477A (zh) 1996-10-02
IL111081A (en) 1998-12-06
DE69431120T2 (de) 2002-11-28
EP0721332A1 (en) 1996-07-17
PL175596B1 (pl) 1999-01-29
DE69431120D1 (de) 2002-09-05
NO961291L (no) 1996-03-29
CZ94196A3 (en) 1996-06-12
NO316747B1 (no) 2004-04-26
FI961431L (fi) 1996-03-29
HU9600823D0 (en) 1996-05-28
WO1995009616A1 (en) 1995-04-13
HUT74518A (en) 1997-01-28
NZ274278A (en) 1997-07-27
SK283554B6 (sk) 2003-09-11
US6371171B1 (en) 2002-04-16
SG75091A1 (en) 2000-09-19
EG21071A (en) 2000-10-31
IL111081A0 (en) 1994-11-28
HU226493B1 (en) 2009-03-02
IS4214A (is) 1995-04-02
DK0721332T3 (da) 2002-09-02
AU687896B2 (en) 1998-03-05

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