ES2173982T3 - Hidrato de acido 8 - alcoxiquinoloncarboxilico con una estabilidad excelente y procedimiento para producir el mismo. - Google Patents

Hidrato de acido 8 - alcoxiquinoloncarboxilico con una estabilidad excelente y procedimiento para producir el mismo.

Info

Publication number
ES2173982T3
ES2173982T3 ES95938644T ES95938644T ES2173982T3 ES 2173982 T3 ES2173982 T3 ES 2173982T3 ES 95938644 T ES95938644 T ES 95938644T ES 95938644 T ES95938644 T ES 95938644T ES 2173982 T3 ES2173982 T3 ES 2173982T3
Authority
ES
Spain
Prior art keywords
same
excellent stability
alcoxychinoloncarboxyl
procedure
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95938644T
Other languages
English (en)
Inventor
Toyomi Matsumoto
Masamoto Hara
Kunio Miyashita
Yukihiro Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18290056&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2173982(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2173982T3 publication Critical patent/ES2173982T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

EN LA INVENCION SE PRESENTAN UN SESQUIHIDRATO DE ACIDO 1 CICLOPROPIL METIL UNA ESTABILIDAD EXCELENTE REPRESENTADO PRO LA FORMULA (1) SIGUIENTE, Y PROCESOS PARA LA PRODUCCION DEL MISMO.
ES95938644T 1994-12-21 1995-12-05 Hidrato de acido 8 - alcoxiquinoloncarboxilico con una estabilidad excelente y procedimiento para producir el mismo. Expired - Lifetime ES2173982T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33556994A JP3449658B2 (ja) 1994-12-21 1994-12-21 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法

Publications (1)

Publication Number Publication Date
ES2173982T3 true ES2173982T3 (es) 2002-11-01

Family

ID=18290056

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95938644T Expired - Lifetime ES2173982T3 (es) 1994-12-21 1995-12-05 Hidrato de acido 8 - alcoxiquinoloncarboxilico con una estabilidad excelente y procedimiento para producir el mismo.

Country Status (15)

Country Link
US (1) US5880283A (es)
EP (1) EP0805156B1 (es)
JP (1) JP3449658B2 (es)
KR (1) KR100381644B1 (es)
CN (1) CN1137890C (es)
AT (1) ATE216381T1 (es)
AU (1) AU694946B2 (es)
CA (1) CA2208704C (es)
DE (1) DE69526453T2 (es)
DK (1) DK0805156T3 (es)
ES (1) ES2173982T3 (es)
HU (1) HU227795B1 (es)
PT (1) PT805156E (es)
TW (1) TW393479B (es)
WO (1) WO1996019472A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19820801A1 (de) * 1998-05-09 1999-11-25 Gruenenthal Gmbh Orale Arzneiformen mit reproduzierbarer Wirkstofffreisetzung von Gatifloxacin oder pharmazeutisch verwendbaren Salzen oder Hydraten
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
TWI287987B (en) * 2000-08-14 2007-10-11 Senju Pharma Co Cytokine inhibitor
US6413969B1 (en) * 2000-09-13 2002-07-02 Bristol-Myers Squibb Company Gatifloxacin pentahydrate
JP2002363172A (ja) * 2001-06-05 2002-12-18 Showa Denko Kk ５−アルキルオキサゾリジン−２，４−ジオンの製造方法
US6589955B2 (en) 2001-06-20 2003-07-08 Bristol-Myers Squibb Company Pediatric formulation of gatifloxacin
US20060142300A1 (en) * 2002-04-08 2006-06-29 Reddy Manne S Anhydrous crystalline forms of I and II of 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1- piperazinyl) 4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (gatifloxacin)
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
US7423153B2 (en) 2002-05-10 2008-09-09 Teva Pharmaceutical Industries Ltd. Crystalline forms of gatifloxacin
EP1645274A1 (en) * 2002-05-10 2006-04-12 Teva Pharmaceutical Industries Ltd. Process for making gatifloxacin form omega
CN1665504A (zh) * 2002-05-10 2005-09-07 特瓦制药工业有限公司 新晶型的加替沙星
JP2005532364A (ja) * 2002-06-14 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド ガチフロキサシンの新規結晶質形態
PL374993A1 (en) 2002-08-06 2005-11-14 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of gatifloxacin
WO2004069825A1 (en) * 2002-08-14 2004-08-19 Teva Pharmaceutical Industries Ltd. Synthesis of gatifloxacin
CA2510625A1 (en) * 2002-12-12 2004-07-01 Teva Pharmaceutical Industries Ltd. Crystalline forms of gatifloxacin and processes for preparation
WO2004087688A1 (en) * 2003-04-02 2004-10-14 Hetero Drugs Limited Novel crystalline forms of gatifloxacin
WO2004101547A1 (en) * 2003-05-19 2004-11-25 Hetero Drugs Limited Purification methods of gatifloxacin and a novel form of gatifloxacin
WO2005021000A1 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Solid oral dosage forms of gatifloxacin
ES2232311B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Forma cristalina de gatifloxacino.
ES2232310B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Formula cristalina no higroscopica de gatifloxacino.
WO2005118546A1 (en) 2004-06-04 2005-12-15 Matrix Laboratories Ltd Novel crystalline forms of gatifloxacin
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US20060247255A1 (en) * 2005-05-02 2006-11-02 Patel Satishkumar A Method for preparing a stable gatifloxacin composition
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
CA2621616A1 (en) * 2007-02-19 2008-08-19 Alcon Research, Ltd. Topical gatifloxacin formulations
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
WO2009064792A1 (en) * 2007-11-16 2009-05-22 Cumbre Pharmaceuticals Inc. Quinolone carboxylic acid-substituted rifamycin derivatives
CN102040644B (zh) * 2009-11-03 2014-05-14 刘力 丹参酮衍生物及其制备和用途
CN102757419B (zh) * 2012-08-08 2015-03-11 四川百利药业有限责任公司 一种加替沙星的纯化方法
KR102237887B1 (ko) 2013-03-15 2021-04-07 멜린타 서브시디어리 코프. 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
US11242367B2 (en) 2016-08-12 2022-02-08 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
AU2020419590A1 (en) 2019-11-15 2022-06-30 Silk Technologies, Ltd. Stable formulations of silk-derived protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
JPS57134482A (en) * 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
EP0241206A3 (en) * 1986-03-31 1989-05-10 Sankyo Company Limited Quinoline-3-carboxylic acid derivatives, their preparation and use
CA2128601C (en) * 1992-01-31 2003-07-15 Hiroyuki Nagano Quinolone carboxylic acid derivatives in crystalline hydrate form

Also Published As

Publication number Publication date
WO1996019472A1 (en) 1996-06-27
TW393479B (en) 2000-06-11
CN1137890C (zh) 2004-02-11
JPH08176143A (ja) 1996-07-09
EP0805156A1 (en) 1997-11-05
JP3449658B2 (ja) 2003-09-22
ATE216381T1 (de) 2002-05-15
AU3994695A (en) 1996-07-10
EP0805156A4 (en) 1998-04-15
CA2208704A1 (en) 1996-06-27
KR100381644B1 (ko) 2003-08-30
US5880283A (en) 1999-03-09
CN1171108A (zh) 1998-01-21
HU227795B1 (en) 2012-03-28
DE69526453D1 (de) 2002-05-23
EP0805156B1 (en) 2002-04-17
PT805156E (pt) 2002-09-30
DE69526453T2 (de) 2002-12-12
HUT77945A (hu) 1998-12-28
AU694946B2 (en) 1998-08-06
CA2208704C (en) 2005-05-03
DK0805156T3 (da) 2002-05-06

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