ES2168357T3 - Agonistas del receptor ep2 como agentes para disminuir la presion intraocular. - Google Patents

Agonistas del receptor ep2 como agentes para disminuir la presion intraocular.

Info

Publication number
ES2168357T3
ES2168357T3 ES95909222T ES95909222T ES2168357T3 ES 2168357 T3 ES2168357 T3 ES 2168357T3 ES 95909222 T ES95909222 T ES 95909222T ES 95909222 T ES95909222 T ES 95909222T ES 2168357 T3 ES2168357 T3 ES 2168357T3
Authority
ES
Spain
Prior art keywords
around
sub
link
carbon atoms
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95909222T
Other languages
English (en)
Inventor
David F Woodward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Sales LLC
Original Assignee
Allergan Sales LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Sales LLC filed Critical Allergan Sales LLC
Application granted granted Critical
Publication of ES2168357T3 publication Critical patent/ES2168357T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A ( (MAS MENOS) ) TRANS- 2-[[]-4(()1HIDROXIHEXILO()) FENILO[]]-5-OXOCICLOPENTANOHEPTANOICACIDO, Y ESTER Y DERIVADOS INSATURADOS DEL MISMO, DERIVADOS DE PROSTAGLANDINA. EN CONCRETO, LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE LOS ENLACES ONDULADOS INDICAN LA CONFIGURACION {AL} O {BE}, EL ENLACE DISCONTINUO REPRESENTA O UN ENLACE UNICO O UNO DOBLE, EL CUAL PUEDE SER UN ENLACE DOBLE CIS O TRANS Y R ES UN GRUPO DE HIDROCARBURO SATURADO O INSATURADO ACICLICO QUE TIENE DE 1 A ALREDEDOR DE 20 ATOMOS DE CARBONO, O (()CH{SUB,2}()){SUB,M}R{SUB,1}- EN DONDE M ES DE 0-10, Y R{SUB,1} ES UN ANILLO ALIFATICO QUE TIENE DESDE ALREDEDOR DE 3 A ALREDEDOR DE 7 ATOMOS DE CARBONO, O UN ANILLO DE ARILO O HETEROARILO QUE TIENE DE ALREDEDOR DE 4 A ALREDEDOR DE 10 ATOMOS DE CARBONO Y EN DONDE EL HETEROATOMO SE SELECCIONA DEL GRUPO QUE CONSTA DE N, O Y S. LOS COMPUESTOS DE LA PRESENTE INVENCION SON POTENTES HIPOTENSORES OCULARES, Y SON PARTICULARMENTE UTILES PARA ELTRATAMIENTO DE GLAUCOMA.
ES95909222T 1994-01-19 1995-01-09 Agonistas del receptor ep2 como agentes para disminuir la presion intraocular. Expired - Lifetime ES2168357T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/183,682 US5462968A (en) 1994-01-19 1994-01-19 EP2 -receptor agonists as agents for lowering intraocular pressure

Publications (1)

Publication Number Publication Date
ES2168357T3 true ES2168357T3 (es) 2002-06-16

Family

ID=22673876

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95909222T Expired - Lifetime ES2168357T3 (es) 1994-01-19 1995-01-09 Agonistas del receptor ep2 como agentes para disminuir la presion intraocular.

Country Status (7)

Country Link
US (1) US5462968A (es)
EP (1) EP0789687B1 (es)
JP (2) JP4275194B2 (es)
AU (1) AU685591B2 (es)
DE (1) DE69524446T2 (es)
ES (1) ES2168357T3 (es)
WO (1) WO1995019964A1 (es)

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WO1998050024A1 (en) * 1997-05-09 1998-11-12 The Mount Sinai School Of Medicine Of The City University Of New York 8-iso-prostaglandins for glaucoma therapy
US6090847A (en) * 1997-11-21 2000-07-18 Allergan Sales, Inc. EP2 -receptor agonists as neuroprotective agents for the eye
US5877211A (en) * 1997-11-21 1999-03-02 Allergan EP2 receptor agonists as neuroprotective agents for the eye
EP1000619A3 (en) * 1998-06-23 2002-07-24 Pfizer Products Inc. Method for treating glaucoma
WO2000038667A2 (en) 1998-12-24 2000-07-06 Alcon Laboratories, Inc. Prostaglandin e agonists for treatment of glaucoma
ATE281432T1 (de) 1999-03-05 2004-11-15 Univ Duke C-16 ungesätigte fp-selektive prostaglandin analoge
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
BR0308493A (pt) * 2002-03-18 2005-01-11 Pfizer Prod Inc Uso de agonistas de receptor seletivo de ep4 para o tratamento da insuficiência hepática, perda de permeabilidade do canal arterial, glaucoma ou hipertensão ocular
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JP2006021998A (ja) * 2002-07-18 2006-01-26 Ono Pharmaceut Co Ltd Ｅｐ２アゴニストを有効成分とする月経困難症治療剤
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JP5319065B2 (ja) * 2003-02-11 2013-10-16 アラーガン インコーポレイテッド 眼圧降下剤としての１０，１０−ジアルキルプロスタン酸誘導体
EP2422814A1 (en) 2003-07-25 2012-02-29 Ono Pharmaceutical Co., Ltd. Remedy for cartilage-related diseases
DE602004013985D1 (de) 2003-08-05 2008-07-03 Oji Paper Co Wärmetransferaufnahmebogen, verfahren zur herstellung desselben und verfahren zur bilderzeugung damit
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
GB0329620D0 (en) * 2003-12-22 2004-01-28 Pharmagene Lab Ltd EP2 receptor agonists
JP4893999B2 (ja) 2004-10-22 2012-03-07 小野薬品工業株式会社 吸入用医薬組成物
US7091231B2 (en) * 2004-12-10 2006-08-15 Allergan, Inc. 12-Aryl prostaglandin analogs
EP1856042B1 (en) * 2005-03-10 2012-06-27 Allergan, Inc. Substituted gamma lactams as therapeutic agents
WO2006121822A1 (en) * 2005-05-06 2006-11-16 Allergan, Inc. USE OF β-LACTAMS FOR THE TREATMENTOF IBD AND GLAUCOMA
US7674786B2 (en) * 2005-05-06 2010-03-09 Allergan, Inc. Therapeutic β-lactams
RU2420316C2 (ru) 2005-06-03 2011-06-10 Оно Фармасьютикал Ко., Лтд. Агент для регенерации и/или защиты нервов
EP2027081B1 (en) * 2006-04-04 2017-05-03 Allergan, Inc. Therapeutic prostaglandin compounds for the treatment of glaucoma
US20090016981A1 (en) 2006-05-03 2009-01-15 Allergan, Inc. Therapeutic compounds
US7439372B2 (en) 2006-05-03 2008-10-21 Allergan, Inc. Therapeutic compounds
US7491844B2 (en) * 2006-05-04 2009-02-17 Allergan, Inc. Therapeutic cyclopentane derivatives
US7476755B2 (en) 2006-05-04 2009-01-13 Allergan, Inc. Therapeutic compounds
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US8722726B2 (en) 2007-01-25 2014-05-13 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
US9365485B2 (en) 2007-01-25 2016-06-14 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
US8063033B2 (en) * 2008-01-18 2011-11-22 Allergan, Inc. Therapeutic beta-lactams
US7956051B2 (en) * 2008-01-24 2011-06-07 Allergan, Inc. Therapeutic amides and related compounds
US8633310B2 (en) * 2008-02-19 2014-01-21 Allergan, Inc. Therapeutic substituted lactams
US7964596B2 (en) * 2008-03-07 2011-06-21 Allergan, Inc. Therapeutic compounds
US20090233921A1 (en) * 2008-03-11 2009-09-17 Allergan, Inc. Therapeutic cyclopentane derivatives
US7960379B2 (en) * 2008-03-14 2011-06-14 Allergan, Inc. Therapeutic compounds
US7732443B2 (en) * 2008-03-18 2010-06-08 Yariv Donde Therapeutic substituted cyclopentanes
US8198318B2 (en) * 2008-03-18 2012-06-12 Allergen, Inc. Therapeutic amides
US7956055B2 (en) * 2008-03-25 2011-06-07 Allergan, Inc. Substituted gamma lactams as therapeutic agents
BRPI0910741A2 (pt) * 2008-04-24 2015-09-29 Allergan Inc arilciclopentenos substituídos como agonistas de prostaglantina ep2
BRPI0911543A2 (pt) * 2008-04-24 2015-10-13 Allergan Inc arilciclopentenos substituídos como agentes terapêuticos
UA103616C2 (ru) 2008-04-24 2013-11-11 Аллерган, Инк. Замещенные гамма-лактамы как терапевтические агенты
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US7713967B2 (en) 2008-05-09 2010-05-11 Allergan, Inc. Therapeutic substituted hydantoins, and related compounds
CA2724605A1 (en) * 2008-05-27 2009-12-03 Allergan, Inc. Prostaglandin prodrugs as hypotensive agents
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US7985765B2 (en) 2008-08-20 2011-07-26 Allergan, Inc. Therapeutic substituted pyrroles
EP3828172A1 (en) 2009-05-01 2021-06-02 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
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ES2852377T3 (es) 2013-03-15 2021-09-13 Aerie Pharmaceuticals Inc Sales dimesilato de 4-(3-amino-1-(isoquinolin-6-ilamino)-1-oxopropan-2-il)bencilo, sus combinaciones con prostaglandinas y el uso de las mismas en el tratamiento de trastornos oculares
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Also Published As

Publication number Publication date
JP2008214351A (ja) 2008-09-18
EP0789687B1 (en) 2001-12-05
US5462968A (en) 1995-10-31
AU685591B2 (en) 1998-01-22
DE69524446T2 (de) 2002-06-27
EP0789687A1 (en) 1997-08-20
AU1725795A (en) 1995-08-08
JP4275194B2 (ja) 2009-06-10
JPH09509652A (ja) 1997-09-30
WO1995019964A1 (en) 1995-07-27
DE69524446D1 (de) 2002-01-17

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