ES2098123T3 - Nuevos analogos de vitamina d. - Google Patents

Nuevos analogos de vitamina d.

Info

Publication number
ES2098123T3
ES2098123T3 ES94903741T ES94903741T ES2098123T3 ES 2098123 T3 ES2098123 T3 ES 2098123T3 ES 94903741 T ES94903741 T ES 94903741T ES 94903741 T ES94903741 T ES 94903741T ES 2098123 T3 ES2098123 T3 ES 2098123T3
Authority
ES
Spain
Prior art keywords
vitamin
formula
new analogs
compounds
proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94903741T
Other languages
English (en)
Inventor
Gunnar Grue-Sorensen
Erik Rytter Ottosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of ES2098123T3 publication Critical patent/ES2098123T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA (I) EN LA CUAL LA FORMULA Y ES AZUFRE, S(O), O S(O)2; R ES ALQUIL C1-C3, O (A) PUEDE FORMAR UN ANILLO CARBOCICLICO C3-C8, Q ES UN RADICAL DE HIDROCARBILENO C1-C8; Y DERIVADOS DE LOS MISMOS. LOS COMPUESTOS MUESTRAN EFECTOS ANTIINFLAMATORIOS E INMUNOMODULADORES ASI COMO UNA FUERTE ACTIVIDAD EN LA INDUCCION DE LA DIFERENCIACION E INHIBICION DE PROLIFERACION NO DESEADA DE CIERTOS CELULAS.
ES94903741T 1992-12-23 1993-12-17 Nuevos analogos de vitamina d. Expired - Lifetime ES2098123T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929226877A GB9226877D0 (en) 1992-12-23 1992-12-23 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2098123T3 true ES2098123T3 (es) 1997-04-16

Family

ID=10727157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94903741T Expired - Lifetime ES2098123T3 (es) 1992-12-23 1993-12-17 Nuevos analogos de vitamina d.

Country Status (15)

Country Link
US (1) US5554599A (es)
EP (1) EP0675878B1 (es)
KR (1) KR100295977B1 (es)
AT (1) ATE148454T1 (es)
AU (1) AU668638B2 (es)
CA (1) CA2146775C (es)
DE (1) DE69307929T2 (es)
DK (1) DK0675878T3 (es)
ES (1) ES2098123T3 (es)
FI (1) FI108225B (es)
GB (1) GB9226877D0 (es)
GR (1) GR3022774T3 (es)
NZ (1) NZ259317A (es)
RU (1) RU2136660C1 (es)
WO (1) WO1994014766A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830885A (en) * 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
KR100244060B1 (ko) * 1994-04-11 2000-02-01 나가야마 오사무 22-티아비타민 디3 유도체
US6869940B2 (en) 1995-12-28 2005-03-22 Chugai Seiyaku Kabushiki Kaisha Malignant tumor metastasis inhibitors
WO1997024126A1 (en) 1995-12-28 1997-07-10 Chugai Seiyaku Kabushiki Kaisha Malignant tumor metastasis inhibitors
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) * 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
ES2206758T3 (es) * 1996-12-20 2004-05-16 Chugai Seiyaku Kabushiki Kaisha Derivados de vitamina d 16-ene.
US6184398B1 (en) 1996-12-20 2001-02-06 Chugai Seiyaku Kabushiki Kaisha 16-ene-vitamin D derivatives
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ATE344039T1 (de) 1999-04-01 2006-11-15 Univ Johns Hopkins Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung
CA2385755C (en) 1999-09-29 2007-02-06 Colotech A/S Prevention of colorectal cancer
US6703380B2 (en) 1999-09-29 2004-03-09 Colotech A/S Prevention of cancer
WO2001030751A2 (en) * 1999-10-25 2001-05-03 Strakan Limited USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US7074777B2 (en) 2000-04-19 2006-07-11 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivatives
EP1295871B1 (en) * 2000-06-15 2011-05-18 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives possessing a 22-oxa or 22-thia atom, a c17-side chain substituted by an acid, ester or amide group and a 16(17)-double bond
EP1419143B1 (en) * 2001-08-22 2009-04-15 Johns Hopkins University 24-sulfur-substituted analogs of 1alpha,25-dihydroxy vitamin d3
BRPI0213658A8 (pt) 2001-10-19 2016-12-06 F Hoffmann La Roche Ltd Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
AU2003233735A1 (en) 2002-06-13 2003-12-31 Cytochroma Inc. 24-sulfoximine vitamin d3 compounds
WO2004054968A2 (en) 2002-12-18 2004-07-01 Johns Hopkins University 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
WO2010088304A1 (en) 2009-01-27 2010-08-05 Cytotech Labs, Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
KR101880032B1 (ko) 2009-08-14 2018-07-20 베르그 엘엘씨 탈모증 치료용 비타민 ｄ3 및 이의 유사체들
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749710A (en) * 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
SU1445729A1 (ru) * 1986-04-08 1988-12-23 Харьковский научно-исследовательский институт дерматологии и венерологии Способ лечени псориаза
FR2631025B1 (fr) * 1988-05-04 1991-04-12 Ire Medgenix Sa Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3
GB8904153D0 (en) * 1989-02-23 1989-04-05 Leo Pharm Prod Ltd Chemical compounds
KR100244060B1 (ko) * 1994-04-11 2000-02-01 나가야마 오사무 22-티아비타민 디3 유도체

Also Published As

Publication number Publication date
RU95113480A (ru) 1997-03-20
FI952972L (fi) 1995-06-16
GR3022774T3 (en) 1997-06-30
NZ259317A (en) 1997-05-26
DE69307929T2 (de) 1997-09-04
FI108225B (fi) 2001-12-14
WO1994014766A1 (en) 1994-07-07
CA2146775C (en) 2005-06-28
EP0675878B1 (en) 1997-01-29
FI952972A0 (fi) 1995-06-16
AU668638B2 (en) 1996-05-09
CA2146775A1 (en) 1994-07-07
KR950703501A (ko) 1995-09-20
DE69307929D1 (de) 1997-03-13
DK0675878T3 (da) 1997-04-28
EP0675878A1 (en) 1995-10-11
KR100295977B1 (ko) 2001-11-14
RU2136660C1 (ru) 1999-09-10
GB9226877D0 (en) 1993-02-17
ATE148454T1 (de) 1997-02-15
US5554599A (en) 1996-09-10
AU5808794A (en) 1994-07-19

Similar Documents

Publication Publication Date Title
ES2098123T3 (es) Nuevos analogos de vitamina d.
UA26427A (uk) Похідhі ксаhтиhу у вигляді суміші ізомерів або іhдивідуальhих ізомерів, що мають властивість аhтагоhіста адеhозиhу
ES2111288T3 (es) Nuevos 3,4-diaril tiofenos y analogos de los mismos utiles como agentes antiinflamatorios.
CO5050332A1 (es) Composiciones fungicidas que comprenden 2-metoxibenzofenonas
ES2121896T3 (es) Derivados de acido hidroxamico como inhibidores de colagenasa.
ATE197710T1 (de) Chinazolin-derivate
ES538418A0 (es) Un derivado de indol-3-carboxamida
ES2101026T3 (es) Derivados sulfatados de glicosaminoglicanoides.
DE69728544D1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
DK0437030T3 (da) Anvendelse af 4-substituerede imidazoler til nedsættelse af det intraoculære tryk
ES2114619T3 (es) Nuevos analogos de la vitamina d.
NO943895L (no) Galantaminderivater, en fremgangsmåte for fremstilling samt deres anvendelse som medikamenter
ES2101073T3 (es) Nuevos aza-androstano-derivados 17-beta-substituidos.
ES8107199A1 (es) Un procedimiento para la preparacion de nuevos 1,2,4-triazo-les
ES8601957A1 (es) Un metodo para preparar derivados de 3-metilflavona
ATE153657T1 (de) Cyclische benzylamino-, benzylamido- und benzylimido derivate als antipsychotische wirkstoffe
ATE136307T1 (de) Trazodone alkyl derivate mit zns wirkung
DE3862791D1 (de) N-phenylethylaminoalkyl-benzamide als antiarrhythmische mittel.
DE69815380D1 (de) N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind
ATE195313T1 (de) 3-substituierte 1-arylindolverbindungen
ES2183500T3 (es) Nuevos compuestos y composiciones farmaceuticas que los contienen.
FI822706A0 (fi) Foerfarande foer framstaellning av farmakologiskt aktiva heteroaryloxipropanolaminer
DE69306278D1 (de) Tetrahydrothiophenederivate
ES2116522T3 (es) Compuestos citotoxicos.
ES2141134T3 (es) Derivados de carbamoil pirrolidona para el tratamiento de la depresion y de los trastornos cerebrovasculares.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 675878

Country of ref document: ES