ES2170074T3 - Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales. - Google Patents

Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales.

Info

Publication number
ES2170074T3
ES2170074T3 ES93922174T ES93922174T ES2170074T3 ES 2170074 T3 ES2170074 T3 ES 2170074T3 ES 93922174 T ES93922174 T ES 93922174T ES 93922174 T ES93922174 T ES 93922174T ES 2170074 T3 ES2170074 T3 ES 2170074T3
Authority
ES
Spain
Prior art keywords
local anesthetic
biodegradable polymer
prolonged release
polymer matrices
anesthetic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93922174T
Other languages
English (en)
Inventor
Charles B Berde
Robert S Langer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Children's Hospital
Original Assignee
Boston Children's Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Children's Hospital filed Critical Boston Children's Hospital
Application granted granted Critical
Publication of ES2170074T3 publication Critical patent/ES2170074T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBE UN SISTEMA DE LIBERACION CONTROLADA BIODEGRADABLE MEJORADA, QUE CONSTA DE UNA MATRIZ POLIMERICA QUE INCORPORA UN ANESTESICO LOCAL PARA LA ADMINISTRACION PROLONGADA DEL AGENTE ANESTESICO LOCAL Y UN METODO PARA LA FABRICACION DEL MISMO. LOS POLIMEROS Y EL METODO DE FABRICACION USADOS PARA FORMAR LOS PLAM SON SELECCIONADOS SOBRE LA BASE DE SUS PERFILES DE DEGRADACION: LIBERACION DEL ANESTESICO TOPICO DE UNA MANERA LINEAL, CONTROLADA DURANTE UN PERIODO DE DOS SEMANAS CON PREFERENCIA Y DEGRADACION IN VIVO CON UNA VIDA MEDIA DE MENOS DE SEIS MESES, CON MAS PREFERENCIA DOS MESES, PARA EVITAR INFLAMACION LOCALIZADA. DE MODO ALTERNATIVO, PUEDE SER INCORPORADO UN ANTIINFLAMATORIO EN EL POLIMERO CON EL ANESTESICO LOCAL PARA PREVENIR LA INFLAMACION.
ES93922174T 1992-09-10 1993-09-10 Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales. Expired - Lifetime ES2170074T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94328792A 1992-09-10 1992-09-10

Publications (1)

Publication Number Publication Date
ES2170074T3 true ES2170074T3 (es) 2002-08-01

Family

ID=25479379

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93922174T Expired - Lifetime ES2170074T3 (es) 1992-09-10 1993-09-10 Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales.

Country Status (11)

Country Link
US (1) US5618563A (es)
EP (2) EP0659073B1 (es)
JP (1) JP3007687B2 (es)
AT (1) ATE210969T1 (es)
AU (1) AU683022B2 (es)
CA (1) CA2144407C (es)
DE (1) DE69331387T2 (es)
DK (1) DK0659073T3 (es)
ES (1) ES2170074T3 (es)
PT (1) PT659073E (es)
WO (1) WO1994005265A1 (es)

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JP3007687B2 (ja) 2000-02-07
ATE210969T1 (de) 2002-01-15
US5618563A (en) 1997-04-08
PT659073E (pt) 2002-06-28
DK0659073T3 (da) 2002-03-11
AU683022B2 (en) 1997-10-30
WO1994005265A1 (en) 1994-03-17
EP0659073A1 (en) 1995-06-28
EP0659073B1 (en) 2001-12-19
CA2144407A1 (en) 1994-03-17
AU5126993A (en) 1994-03-29
CA2144407C (en) 2000-05-30
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DE69331387T2 (de) 2002-08-22
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