ES2170788T3 - Procedimiento para la obtencion de inmunoglobulinas a partir de fracciones que resultan de plasma sanguineo humano. - Google Patents

Procedimiento para la obtencion de inmunoglobulinas a partir de fracciones que resultan de plasma sanguineo humano.

Info

Publication number
ES2170788T3
ES2170788T3 ES95810596T ES95810596T ES2170788T3 ES 2170788 T3 ES2170788 T3 ES 2170788T3 ES 95810596 T ES95810596 T ES 95810596T ES 95810596 T ES95810596 T ES 95810596T ES 2170788 T3 ES2170788 T3 ES 2170788T3
Authority
ES
Spain
Prior art keywords
immunoglobulin
obtaining
procedure
blood plasma
plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95810596T
Other languages
English (en)
Inventor
Hanspeter Amstutz
Peter G Lerch
Jean-Jacques Morgenthaler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring AG
Original Assignee
ZLB Bioplasma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZLB Bioplasma AG filed Critical ZLB Bioplasma AG
Application granted granted Critical
Publication of ES2170788T3 publication Critical patent/ES2170788T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081DNA viruses
    • C07K16/082Hepadnaviridae (F), e.g. hepatitis B virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Gram-positive bacteria
    • C07K16/1282Clostridium (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE OBTIENEN PREPARADOS DE INMUNOGLOBULINA DE ALTA VALORACION, LLEVANDO A CABO SUCESIVAMENTE LOS SIGUIENTES PASOS: - FRACCIONAMIENTO DE PLASMA SANGUINEO A PARTIR DE UN CONJUNTO DE PLASMA, MEDIANTE EL CUAL SE SEPARA AL MENOS LA FRACCION DE VALOR INDUSTRIAL, QUE CONTIENE ESENCIALMENTE LA INMUNOGLOBULINA G POLICLONAL, OBTENIENDO AL MENOS UNA FRACCION RESIDUAL, - OBTENCION DE UNA SOLUCION PROTEINICA A PARTIR DE LOS COMPONENTES PROTEINICOS QUE ESTAN CONTENIDOS EN LA FRACCION RESIDUAL OBTENIDA EN EL PASO A) O EN SUBFRACCIONES DE ELLA, Y - AL MENOS UNA ETAPA DE CROMATOGRAFIA DE AFINIDAD CON LA SOLUCION PROTEINICA RESULTANTE CON LIGANDOS INMOVILIZADOS DE AL MENOS UN TIPO DE LIGANDO, DISOLVIENDO LAS PROTEINAS PLASMATICAS ESPECIFICAMENTE UNIDAS Y PASANDOLAS COMO COMPONENTES ACTIVOS A UN PREPARADO DE INMUNOGLOBULINA DE ALTA VALORACION. LAS INMUNOGLOBLINAS OBTENIDAS SE PUEDEN PROCESAR PARA DAR UN PRODUCTO ESTABLE. EL PROCEDIMIENTO, QUE OBTIENE UN PREPARADO VALIOSO DE INMUNOGLOBULINA, UTILIZA FRACCIONESPLASMATICAS HUMANAS, QUE SE DESECHABAN HASTA AHORA EN PROCEDIMIENTO CONVENCIONALES E INDUSTRIALES DE FRACCIONAMIENTO DE PLASMA.
ES95810596T 1995-09-22 1995-09-22 Procedimiento para la obtencion de inmunoglobulinas a partir de fracciones que resultan de plasma sanguineo humano. Expired - Lifetime ES2170788T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95810596A EP0764658B1 (de) 1995-09-22 1995-09-22 Verfahren zur Gewinnung von Immunglobulinen aus Fraktionen, die bei der Fraktionierung von menschlichem Blutplasma entstehen

Publications (1)

Publication Number Publication Date
ES2170788T3 true ES2170788T3 (es) 2002-08-16

Family

ID=8221797

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95810596T Expired - Lifetime ES2170788T3 (es) 1995-09-22 1995-09-22 Procedimiento para la obtencion de inmunoglobulinas a partir de fracciones que resultan de plasma sanguineo humano.

Country Status (21)

Country Link
EP (1) EP0764658B1 (es)
JP (1) JP2952572B2 (es)
KR (1) KR100236762B1 (es)
CN (1) CN1089609C (es)
AT (1) ATE211486T1 (es)
AU (1) AU715427B2 (es)
BR (1) BR9603826A (es)
CA (1) CA2185617A1 (es)
CZ (1) CZ286885B6 (es)
DE (1) DE59509979D1 (es)
DK (1) DK0764658T3 (es)
ES (1) ES2170788T3 (es)
FI (1) FI963719A7 (es)
HU (1) HUP9602570A3 (es)
MX (1) MX9604256A (es)
NO (1) NO963952L (es)
NZ (1) NZ299394A (es)
PL (1) PL316126A1 (es)
PT (1) PT764658E (es)
RO (1) RO117921B1 (es)
RU (1) RU2157240C2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2531459A1 (es) * 2013-06-10 2015-03-16 Antonio VILA SANJURJO Método para la separación física de "traductomas" convolucionados

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293119B1 (it) * 1997-06-12 1999-02-11 Mini Ricerca Scient Tecnolog Processo per la separazione di immunoglobuline specifiche da plasma standard e loro utilizzo per trattamenti terapeutici
US6159471A (en) * 1997-10-23 2000-12-12 Yoshitomi Pharmaceutical Industries, Ltd. Room temperature storable immunoglobulin preparation for intravenous injection
RU2239453C2 (ru) * 2002-12-03 2004-11-10 Федеральное государственное унитарное предприятие " Научно-производственное объединение по медицинским иммунобиологическим препаратам " Микроген" Препарат иммуноглобулина человека против цитомегаловируса и способ его получения
RU2252780C1 (ru) * 2004-04-30 2005-05-27 Аваков Анатолий Эдуардович Способ получения иммуноглобулинового препарата
MX2007002085A (es) * 2004-08-20 2007-07-19 Prometic Biosciences Ltd Esquemas de aislamiento y purificacion consecutivos de proteinas mediante cromatografia de afinidad.
DE102005023155A1 (de) * 2005-05-13 2006-11-16 Albutec Gmbh Albuminlösung
EP2233499A1 (en) 2009-03-26 2010-09-29 CSL Behring AG Antibody composition with altered Fab sialylation
US20100322943A1 (en) * 2009-06-17 2010-12-23 Thomas Cantor Therapeutic and diagnostic affinity purified specific polyclonal antibodies
ITRM20090558A1 (it) * 2009-11-03 2011-05-04 Michele Pitaro Procedimento per la produzione di immunoglobuline estratte da plasma umano ad uso terapeutico neutralizzanti il virus di epstein barr e farmaco contenente dette immunoglobuline
GB201006753D0 (en) 2010-04-22 2010-06-09 Biotest Ag Process for preparing an immunolobulin composition
SG187599A1 (en) * 2010-07-23 2013-03-28 Baxter Int Manufacture of inter -alpha - inhibitor proteins (iaip) from plasma
FR3018450B1 (fr) * 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
KR20150115639A (ko) * 2014-04-04 2015-10-14 전숙영 치료용 면역글로불린 제제 제조에 사용되는 산성 완충액, 이를 이용한 치료용 면역글로불린 제제 제조방법 및 이 제조방법으로 제조된 치료용 면역글로불린 제제
GB201413227D0 (en) * 2014-07-25 2014-09-10 Bioproducts Lab Ltd Process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232004A (en) * 1977-09-21 1980-11-04 American National Red Cross Antibody-specific solid phase immunoadsorbent, preparation thereof, and antibody purification therewith
US4617379A (en) * 1983-06-14 1986-10-14 Miles Laboratories, Inc. High titer cytomegalovirus immune serum globulin
DE3516119A1 (de) * 1985-05-04 1986-11-06 Biotest Pharma GmbH, 6000 Frankfurt Polyvalentes hyperimmunglobulin-praeparat
IL90281A (en) * 1988-06-06 1994-10-07 Miles Inc Preparations containing MGI antibodies

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2531459A1 (es) * 2013-06-10 2015-03-16 Antonio VILA SANJURJO Método para la separación física de "traductomas" convolucionados

Also Published As

Publication number Publication date
EP0764658A1 (de) 1997-03-26
CA2185617A1 (en) 1997-03-23
HU9602570D0 (en) 1996-11-28
NZ299394A (en) 1997-12-19
PL316126A1 (en) 1997-04-01
CN1153063A (zh) 1997-07-02
AU715427B2 (en) 2000-02-03
HUP9602570A2 (en) 1997-08-28
BR9603826A (pt) 1998-06-02
EP0764658B1 (de) 2002-01-02
JP2952572B2 (ja) 1999-09-27
HUP9602570A3 (en) 1998-01-28
ATE211486T1 (de) 2002-01-15
RU2157240C2 (ru) 2000-10-10
CZ274896A3 (en) 1997-04-16
JPH09124508A (ja) 1997-05-13
NO963952L (no) 1997-03-24
CZ286885B6 (en) 2000-07-12
CN1089609C (zh) 2002-08-28
NO963952D0 (no) 1996-09-20
FI963719A0 (fi) 1996-09-19
AU6572596A (en) 1997-04-10
MX9604256A (es) 1998-04-30
DE59509979D1 (de) 2002-02-07
RO117921B1 (ro) 2002-09-30
KR100236762B1 (ko) 2000-01-15
DK0764658T3 (da) 2002-04-22
KR970015745A (ko) 1997-04-28
FI963719A7 (fi) 1997-03-23
PT764658E (pt) 2002-06-28

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