NO963952L - Fremgangsmåte for fremstilling av immunglobuliner - Google Patents

Fremgangsmåte for fremstilling av immunglobuliner

Info

Publication number
NO963952L
NO963952L NO963952A NO963952A NO963952L NO 963952 L NO963952 L NO 963952L NO 963952 A NO963952 A NO 963952A NO 963952 A NO963952 A NO 963952A NO 963952 L NO963952 L NO 963952L
Authority
NO
Norway
Prior art keywords
plasma
immunoglobulin
preparing
high titre
fractionation
Prior art date
Application number
NO963952A
Other languages
English (en)
Other versions
NO963952D0 (no
Inventor
Hanspeter Amstutz
Peter G Lerch
Jean-Jacques Morgenthaler
Original Assignee
Rotkreuzstiftung Zentrallab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotkreuzstiftung Zentrallab filed Critical Rotkreuzstiftung Zentrallab
Publication of NO963952D0 publication Critical patent/NO963952D0/no
Publication of NO963952L publication Critical patent/NO963952L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Fremgangsmåte for fremstilling av immunglobulinpreparater med høyt titer ved utførelse av de følgende trinn i rekkefølge: - fraksjonering av blodplasma fra et plasmaforråd, ved hvilken minst én industriell anvendelig fraksjon som vesentlig inneholder det polyklonale immunglobulin G, atskilles, hvorved det erholdes minst én restfraksjon, - fremstilling av en proteinløsning fra proteinkomponentene som er inneholdt i restfraksjonen fra trinn a) eller i underfraksjoner derav, og - minst én affinitetskromatografitrinn av den resulterende proteinløsning med immobiliserte ligander av minst én ligandtype, hvorved de bundne spesifikke plasmaproteiner frigjøres og overføres som aktive komponenter til et immunglobulinpreparat med høyt titer. De erholdte immunglobuliner kan bearbeides til et intravenøst forenlig lagringsstabilt produkt. Fremgangsmåten som fører til et verdifullt immunglobulinpreparat utnytter humane plasmafraksjoner som hittil ved konvensjonelle industrielle plasmafraksjoneringsfremgangsmåter er blitt kastet.
NO963952A 1995-09-22 1996-09-20 Fremgangsmåte for fremstilling av immunglobuliner NO963952L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95810596A EP0764658B1 (de) 1995-09-22 1995-09-22 Verfahren zur Gewinnung von Immunglobulinen aus Fraktionen, die bei der Fraktionierung von menschlichem Blutplasma entstehen

Publications (2)

Publication Number Publication Date
NO963952D0 NO963952D0 (no) 1996-09-20
NO963952L true NO963952L (no) 1997-03-24

Family

ID=8221797

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963952A NO963952L (no) 1995-09-22 1996-09-20 Fremgangsmåte for fremstilling av immunglobuliner

Country Status (21)

Country Link
EP (1) EP0764658B1 (no)
JP (1) JP2952572B2 (no)
KR (1) KR100236762B1 (no)
CN (1) CN1089609C (no)
AT (1) ATE211486T1 (no)
AU (1) AU715427B2 (no)
BR (1) BR9603826A (no)
CA (1) CA2185617A1 (no)
CZ (1) CZ286885B6 (no)
DE (1) DE59509979D1 (no)
DK (1) DK0764658T3 (no)
ES (1) ES2170788T3 (no)
FI (1) FI963719A7 (no)
HU (1) HUP9602570A3 (no)
MX (1) MX9604256A (no)
NO (1) NO963952L (no)
NZ (1) NZ299394A (no)
PL (1) PL316126A1 (no)
PT (1) PT764658E (no)
RO (1) RO117921B1 (no)
RU (1) RU2157240C2 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293119B1 (it) * 1997-06-12 1999-02-11 Mini Ricerca Scient Tecnolog Processo per la separazione di immunoglobuline specifiche da plasma standard e loro utilizzo per trattamenti terapeutici
CN1149100C (zh) 1997-10-23 2004-05-12 三菱制药株式会社 可室温贮存的免疫球蛋白静脉注射制剂
RU2239453C2 (ru) * 2002-12-03 2004-11-10 Федеральное государственное унитарное предприятие " Научно-производственное объединение по медицинским иммунобиологическим препаратам " Микроген" Препарат иммуноглобулина человека против цитомегаловируса и способ его получения
RU2252780C1 (ru) * 2004-04-30 2005-05-27 Аваков Анатолий Эдуардович Способ получения иммуноглобулинового препарата
BRPI0514435B8 (pt) 2004-08-20 2021-05-25 American Nat Red Cross isolamento sequêncial de proteínas e esquemas de purificação através de cromatografia por afinidade
DE102005023155A1 (de) * 2005-05-13 2006-11-16 Albutec Gmbh Albuminlösung
EP2233499A1 (en) * 2009-03-26 2010-09-29 CSL Behring AG Antibody composition with altered Fab sialylation
US20100322943A1 (en) * 2009-06-17 2010-12-23 Thomas Cantor Therapeutic and diagnostic affinity purified specific polyclonal antibodies
ITRM20090558A1 (it) * 2009-11-03 2011-05-04 Michele Pitaro Procedimento per la produzione di immunoglobuline estratte da plasma umano ad uso terapeutico neutralizzanti il virus di epstein barr e farmaco contenente dette immunoglobuline
GB201006753D0 (en) 2010-04-22 2010-06-09 Biotest Ag Process for preparing an immunolobulin composition
ES2717177T3 (es) * 2010-07-23 2019-06-19 Baxalta GmbH Fabricación de proteínas inhibidoras inter-alfa (IaIp) a partir de plasma
ES2531459B1 (es) * 2013-06-10 2015-12-28 Antonio VILA SANJURJO Método para la separación física de "traductomas" convolucionados
FR3018450B1 (fr) * 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
KR20150115639A (ko) * 2014-04-04 2015-10-14 전숙영 치료용 면역글로불린 제제 제조에 사용되는 산성 완충액, 이를 이용한 치료용 면역글로불린 제제 제조방법 및 이 제조방법으로 제조된 치료용 면역글로불린 제제
GB201413227D0 (en) * 2014-07-25 2014-09-10 Bioproducts Lab Ltd Process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232004A (en) * 1977-09-21 1980-11-04 American National Red Cross Antibody-specific solid phase immunoadsorbent, preparation thereof, and antibody purification therewith
US4617379A (en) * 1983-06-14 1986-10-14 Miles Laboratories, Inc. High titer cytomegalovirus immune serum globulin
DE3516119A1 (de) * 1985-05-04 1986-11-06 Biotest Pharma GmbH, 6000 Frankfurt Polyvalentes hyperimmunglobulin-praeparat
IL90281A (en) * 1988-06-06 1994-10-07 Miles Inc Preparations containing MGI antibodies

Also Published As

Publication number Publication date
PT764658E (pt) 2002-06-28
JP2952572B2 (ja) 1999-09-27
NO963952D0 (no) 1996-09-20
FI963719A7 (fi) 1997-03-23
DK0764658T3 (da) 2002-04-22
HUP9602570A3 (en) 1998-01-28
JPH09124508A (ja) 1997-05-13
CN1089609C (zh) 2002-08-28
EP0764658A1 (de) 1997-03-26
ES2170788T3 (es) 2002-08-16
AU6572596A (en) 1997-04-10
EP0764658B1 (de) 2002-01-02
RO117921B1 (ro) 2002-09-30
AU715427B2 (en) 2000-02-03
CN1153063A (zh) 1997-07-02
HUP9602570A2 (en) 1997-08-28
DE59509979D1 (de) 2002-02-07
CZ286885B6 (en) 2000-07-12
PL316126A1 (en) 1997-04-01
HU9602570D0 (en) 1996-11-28
NZ299394A (en) 1997-12-19
FI963719A0 (fi) 1996-09-19
ATE211486T1 (de) 2002-01-15
KR100236762B1 (ko) 2000-01-15
RU2157240C2 (ru) 2000-10-10
KR970015745A (ko) 1997-04-28
CZ274896A3 (en) 1997-04-16
MX9604256A (es) 1998-04-30
BR9603826A (pt) 1998-06-02
CA2185617A1 (en) 1997-03-23

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