ES2170841T3 - Procedimiento para la preparacion del 4,4,4-trifluoro-3(r)-hidroxi-butanoato de etilo. - Google Patents

Procedimiento para la preparacion del 4,4,4-trifluoro-3(r)-hidroxi-butanoato de etilo.

Info

Publication number: ES2170841T3
Authority: ES; Spain
Prior art keywords: trifluoro; butanoate; hydroxy; thyl; procedure
Prior art date: 1995-04-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES96400700T

Other languages

English (en)

Spanish (es)

Inventor

Arlette Tixidre

Lydia Zard

Guy Rossey

Andre Bourbon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Synthelabo SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-07

Filing date

1996-04-01

Publication date

2002-08-16

1996-04-01 Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA

2002-08-16 Application granted granted Critical

2002-08-16 Publication of ES2170841T3 publication Critical patent/ES2170841T3/es

2016-04-01 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
AFENDNXGAFYKQO-UHFFFAOYSA-N 2-hydroxybutyric acid Chemical compound CCC(O)C(O)=O AFENDNXGAFYKQO-UHFFFAOYSA-N 0.000 title 1
102000004882 Lipase Human genes 0.000 abstract 1
108090001060 Lipase Proteins 0.000 abstract 1
239000004367 Lipase Substances 0.000 abstract 1
150000002148 esters Chemical group 0.000 abstract 1
ZWEDFBKLJILTMC-UHFFFAOYSA-N ethyl 4,4,4-trifluoro-3-hydroxybutanoate Chemical compound CCOC(=O)CC(O)C(F)(F)F ZWEDFBKLJILTMC-UHFFFAOYSA-N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
235000019421 lipase Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

ES96400700T 1995-04-07 1996-04-01 Procedimiento para la preparacion del 4,4,4-trifluoro-3(r)-hidroxi-butanoato de etilo. Expired - Lifetime ES2170841T3 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9504141A FR2732679B1 (fr)	1995-04-07	1995-04-07	Procede de preparation enzymatique d'un intermediaire de synthese de la befloxatone

Publications (1)

Publication Number	Publication Date
ES2170841T3 true ES2170841T3 (es)	2002-08-16

Family

ID=9477856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES96400700T Expired - Lifetime ES2170841T3 (es)	1995-04-07	1996-04-01	Procedimiento para la preparacion del 4,4,4-trifluoro-3(r)-hidroxi-butanoato de etilo.

Country Status (7)

Country	Link
US (1)	US5716841A (de)
EP (1)	EP0736606B1 (de)
JP (1)	JP4017686B2 (de)
AT (1)	ATE211505T1 (de)
DE (1)	DE69618268T2 (de)
ES (1)	ES2170841T3 (de)
FR (1)	FR2732679B1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1054974B1 (de) *	1998-02-18	2007-03-28	Lonza AG	Verfahren zur herstellung von trifluor-3(r)-hydroxybuttersäurederivaten
US6642409B2 (en)	2000-01-27	2003-11-04	Central Glass Company, Limited	Process for producing 4,4,4-trifluoro-3-hydroxybutyric acid derivatives
JP4015450B2 (ja)	2001-05-18	2007-11-28	高砂香料工業株式会社	光学活性アルコールの製造方法
DE10164269A1 (de) *	2001-12-19	2003-07-03	Asca Gmbh Angewandte Synthesec	Verfahren zur kinetischen Racematspaltung von Alkoholen mit einem oder mehreren stereogenen Zentren

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0716437B2 (ja) *	1987-09-18	1995-03-01	日本碍子株式会社	光学活性体の合成法
EP0382767B1 (de) *	1987-09-28	1993-12-15	Novo Nordisk A/S	Verfahren zur immobilisierung von lipasen
JPH0240343A (ja) *	1988-07-29	1990-02-09	Meito Sangyo Kk	含フッ素ポリエステル及びその製造方法
FR2653017B1 (fr) *	1989-10-17	1995-05-05	Delalande Sa	Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.
JP2852545B2 (ja) *	1989-11-14	1999-02-03	チッソ株式会社	複数の不斉点を持つ光学活性化合物および製造法
JPH03254694A (ja) *	1990-03-01	1991-11-13	Kurita Water Ind Ltd	光学活性な含フッ素アルコールの製造方法
JP3171484B2 (ja) *	1991-05-31	2001-05-28	昭和シェル石油株式会社	光学活性フッ素含有アルコールの製法
EP0577446A3 (de) *	1992-05-28	1995-04-05	Showa Shell Sekiyu	Verfahren zur Herstellung von optisch-aktiven Halogen-enthaltenden Alkoholen.
WO1995034525A1 (fr) *	1994-06-13	1995-12-21	Mitsubishi Rayon Co., Ltd.	DERIVE D'ACIDE CARBOXYLIQUE OPTIQUEMENT ACTIF A SUBSTITUTION α ET PROCEDE DE PRODUCTION DUDIT DERIVE
EP0786012B1 (de) *	1994-10-12	1998-12-23	E.I. Du Pont De Nemours And Company	Enzymatisches verfahren zur herstellung von chiralen alpha-tertiären carbonsäureestern
US5696299A (en) *	1994-10-26	1997-12-09	The Nisshin Oil Mills, Ltd.	Optical resolution for producing optically active alcohol
JP2666890B2 (ja) *	1995-06-07	1997-10-22	工業技術院長	光学活性（＋）−４，４，４−トリフルオロ−３−（インドール−３−）酪酸の製造方法

1995
- 1995-04-07 FR FR9504141A patent/FR2732679B1/fr not_active Expired - Fee Related
1996
- 1996-04-01 EP EP96400700A patent/EP0736606B1/de not_active Expired - Lifetime
- 1996-04-01 ES ES96400700T patent/ES2170841T3/es not_active Expired - Lifetime
- 1996-04-01 DE DE69618268T patent/DE69618268T2/de not_active Expired - Lifetime
- 1996-04-01 AT AT96400700T patent/ATE211505T1/de not_active IP Right Cessation
- 1996-04-05 US US08/628,166 patent/US5716841A/en not_active Expired - Lifetime
- 1996-04-05 JP JP08375096A patent/JP4017686B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE211505T1 (de)	2002-01-15
US5716841A (en)	1998-02-10
DE69618268T2 (de)	2002-08-29
DE69618268D1 (de)	2002-02-07
EP0736606B1 (de)	2002-01-02
JP4017686B2 (ja)	2007-12-05
JPH08289799A (ja)	1996-11-05
EP0736606A1 (de)	1996-10-09
FR2732679A1 (fr)	1996-10-11
FR2732679B1 (fr)	1997-04-30

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2002-08-16

FG2A

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