ES2170984T3 - Ensayo de dispersion de la luz intensificado por microparticulas y reactivos de microparticulas para el mismo. - Google Patents

Ensayo de dispersion de la luz intensificado por microparticulas y reactivos de microparticulas para el mismo.

Info

Publication number
ES2170984T3
ES2170984T3 ES98114621T ES98114621T ES2170984T3 ES 2170984 T3 ES2170984 T3 ES 2170984T3 ES 98114621 T ES98114621 T ES 98114621T ES 98114621 T ES98114621 T ES 98114621T ES 2170984 T3 ES2170984 T3 ES 2170984T3
Authority
ES
Spain
Prior art keywords
microparticles
reagents
light scattering
particles
intensified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98114621T
Other languages
English (en)
Inventor
Shinichi Eda
Jorg Heinrich Kaufmann
Stefan Pohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2170984T3 publication Critical patent/ES2170984T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO ENSAYO PERFECCIONADO DE AGLUTINACION POR DIFUSION LUMINOSA DE MICROPARTICULAS PARA DETERMINAR LA CANTIDAD DE UN ANALITO, Y UN REACTIVO DE MICROPARTICULAS PARA REALIZAR EL ENSAYO. LA INVENCION PROPONE: -UN ENSAYO MEJORADO DE AGLUTINACION POR DIFUSION LUMINOSA DE MICROPARTICULAS, PARA DETERMINAR LA CANTIDAD DE UN ANALITO, QUE COMPRENDE EL USO DE UNA MEZCLA DE PARTICULAS DE FUERTES PROPIEDADES DE DIFUSION LUMINOSA, QUE TRANSPORTAN AL MENOS UN MIEMBRO AGLUTINANTE DE ELEVADA REACTIVIDAD PARA EL ANALITO Y PARTICULAS CON PROPIEDADES DE DEBIL DIFUSION LUMINOSA QUE LLEVAN AL MENOS UN MIEMBRO DE AGLUTINACION DE BAJA REACTIVIDAD PARA EL ANALITO, Y - UN REACTIVO DE MICROPARTICULAS PARA UN INMUNOENSAYO MEJORADO DE DIFUSION LUMINOSA DE MICROPARTICULAS PARA DETERMINAR LA CANTIDAD DE UN ANALITO, QUE COMPRENDE UNA MEZCLA DE MICROPARTICULAS DE 30 A 600 NM DE DIAMETRO, INCLUIDAS PARTICULAS CON FUERTES PROPIEDADES DE DIFUSION LUMINOSA QUE TRANSPORTAN AL MENOS UN MIEMBRO AGLUTINANTE DE ELEVADA REACTIVIDAD PARA EL ANALITO Y PARTICULAS CON PROPIEDADES DE DEBIL DIFUSION DE LA LUZ QUE TRANSPORTAN AL MENOS UN MIEMBRO AGLUTINANTE DE BAJA REACTIVIDAD PARA EL ANALITO.
ES98114621T 1997-08-11 1998-08-04 Ensayo de dispersion de la luz intensificado por microparticulas y reactivos de microparticulas para el mismo. Expired - Lifetime ES2170984T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97113873 1997-08-11

Publications (1)

Publication Number Publication Date
ES2170984T3 true ES2170984T3 (es) 2002-08-16

Family

ID=8227200

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98114621T Expired - Lifetime ES2170984T3 (es) 1997-08-11 1998-08-04 Ensayo de dispersion de la luz intensificado por microparticulas y reactivos de microparticulas para el mismo.

Country Status (6)

Country Link
US (2) US6248597B1 (es)
JP (1) JP3746902B2 (es)
AT (1) ATE213065T1 (es)
CA (1) CA2244326C (es)
DE (1) DE69803729T2 (es)
ES (1) ES2170984T3 (es)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
WO2001098781A1 (en) * 2000-06-20 2001-12-27 Mitsubishi Rayon Co., Ltd. Micro-array of organism-associated substance
US6764825B1 (en) * 2000-10-13 2004-07-20 Tang J. Wang Methods and device for detecting prostate specific antigen (PSA)
US20020127741A1 (en) * 2000-12-19 2002-09-12 Miquel Sales Amill Free Analyte detection system
JPWO2002079782A1 (ja) * 2001-03-30 2004-07-22 株式会社三菱化学ヤトロン エラスターゼ１の免疫分析用試薬及び免疫分析方法並びに膵疾患の検出方法
JP4577747B2 (ja) * 2001-06-05 2010-11-10 和光純薬工業株式会社 免疫学的測定法用凝集促進剤
US7790439B2 (en) * 2001-08-09 2010-09-07 Panasonic Corporation Biosensor and measurement method
US6551788B1 (en) * 2001-11-28 2003-04-22 Beckman Coulter, Inc. Particle-based ligand assay with extended dynamic range
US8257967B2 (en) * 2002-04-26 2012-09-04 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
AU2004225599B2 (en) * 2003-03-31 2008-09-04 Denka Company Limited Turbidimetric immunoassy for lipoprotein (a) and reagent therefor
US20040197841A1 (en) * 2003-04-02 2004-10-07 Apffel James Alexander Methods and reagents for multiplexed analyses
EP1496362B1 (en) * 2003-07-09 2006-12-13 Matsushita Electric Industrial Co., Ltd. Turbidimetric immunoassay and an apparatus therefor
WO2005049653A1 (en) * 2003-07-14 2005-06-02 Genway Biotech, Inc. Affinity separation composition and method
WO2005029031A2 (en) * 2003-08-01 2005-03-31 Biacore Ab Method and apparatus for quantitating surface-binding optical resonance profiles
JP4241301B2 (ja) * 2003-09-30 2009-03-18 和光純薬工業株式会社 免疫学的測定用試薬
EP1695082A2 (en) 2003-12-11 2006-08-30 Board of Regents, The University of Texas System Method and system for the analysis of saliva using a sensor array
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
DE102004023402A1 (de) * 2004-05-12 2005-12-08 Roche Diagnostics Gmbh Verfahren zur Erhöhung des dynamischen Messbereichs von auf spezifischen Bindereaktionen basierenden, insbesondere immunologischen Testelementen
JP4331073B2 (ja) * 2004-08-31 2009-09-16 デンカ生研株式会社 抗原の測定方法及びそのための試薬
US7638291B2 (en) 2004-10-25 2009-12-29 Seradyn, Inc. Immunoassays for topiramate
US20060115865A1 (en) * 2004-10-25 2006-06-01 Anlong Ouyang Lamotrigine analogs
US20060088886A1 (en) * 2004-10-25 2006-04-27 Anlong Ouyang Topiramate analogs
US7678551B2 (en) * 2004-10-25 2010-03-16 Seradyn, Inc. Immunoassays for lamotrigine
GB0426822D0 (en) * 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
US20060246522A1 (en) * 2005-04-28 2006-11-02 Bhullar Balwant S C-reactive protein immunoassay and method
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
EP1899450A4 (en) * 2005-06-24 2010-03-24 Univ Texas SYSTEMS AND METHODS INCLUDING INCLUDED CASSETTES WITH DEFINITION SYSTEMS AND LIQUIDITY SUPPLY SYSTEMS
US20070048795A1 (en) * 2005-08-26 2007-03-01 Xiangming Fang Immunoaffinity separation and analysis compositions and methods
EP1952154B1 (en) * 2005-11-24 2010-05-26 Gentian AS Turbidimetric immunoassay for assessing human cystatin c
CN101680890B (zh) * 2007-05-21 2014-05-07 根田股份有限公司 用于评估人抑半胱氨酸蛋白酶蛋白c的比浊免疫测定
JP2009085703A (ja) * 2007-09-28 2009-04-23 Fujifilm Corp 高感度免疫測定方法
JP5807300B2 (ja) * 2008-11-18 2015-11-10 株式会社シノテスト 試料中のｃ反応性蛋白質の測定方法及び測定試薬
CA2745610C (en) * 2008-12-04 2017-10-31 Sekisui Medical Co., Ltd. Method for measuring cystatin c in human body fluid
EP2241886A1 (en) * 2009-04-15 2010-10-20 Beckman Coulter Biomedical Limited Homogeneous agglutination immunoassay method and kit for such method
US9995688B2 (en) * 2009-09-21 2018-06-12 Arizona Board Of Regents Use of superhydrophobic surfaces for liquid agglutination assays
US20110151435A1 (en) * 2009-12-17 2011-06-23 Abaxis, Inc. Novel assays for detecting analytes in samples and kits and compositions related thereto
CN101833010B (zh) * 2010-03-29 2013-02-13 上海太阳生物技术有限公司 纤维蛋白(原)降解产物(fdp)测定试剂盒(胶乳免疫比浊法)
WO2012009760A1 (en) 2010-07-20 2012-01-26 Cephalon Australia Pty Ltd Anti-il-23 heterodimer specific antibodies
US20140106354A1 (en) 2011-04-18 2014-04-17 Garvan Institute Of Medical Research Method of Diagnosing Cancer
WO2012161226A1 (ja) * 2011-05-23 2012-11-29 積水メディカル株式会社 Pivka-ii測定試薬における非特異反応の抑制方法
JP5772425B2 (ja) * 2011-09-13 2015-09-02 ソニー株式会社 微小粒子測定装置
KR101982899B1 (ko) 2011-09-30 2019-05-27 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 ＴＬ1ａ에 대한 항체 및 그의 용도
CA2804843C (en) 2012-02-06 2021-02-02 Ortho-Clinical Diagnostics, Inc. Multiple time windows for extending the range of an assay
CN102608325B (zh) * 2012-02-24 2016-08-24 南京诺尔曼生物技术有限公司 心型脂肪酸结合蛋白(h-fabp)测定试剂盒(胶乳增强免疫比浊法)
EP2945942B1 (en) 2013-01-18 2018-05-09 ARK Diagnostics, Inc. Voriconazole immunoassays
WO2014117220A1 (en) 2013-02-01 2014-08-07 Transbio Ltd Anti-cd83 antibodies and use thereof
CN117843785A (zh) 2013-02-07 2024-04-09 Csl有限公司 Il-11r结合蛋白及其应用
EP2956444B1 (en) 2013-02-13 2018-05-30 ARK Diagnostics, Inc. Posaconazole immunoassays
FR3003353B1 (fr) * 2013-03-14 2015-03-06 Horiba Abx Sas Nouvelle methode de dosage en flux d'un objet d'interet
JPWO2014192963A1 (ja) 2013-05-31 2017-02-23 積水メディカル株式会社 免疫凝集測定法
EP2811300A1 (en) * 2013-06-07 2014-12-10 Roche Diagniostics GmbH Calibration for multi-component assays
EP3194624B1 (en) 2014-09-15 2022-02-16 Garvan Institute of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
EP3209695A4 (en) 2014-10-23 2018-05-30 DendroCyte BioTech Pty Ltd Cd83 binding proteins and uses thereof
EP3265074B1 (en) 2015-03-03 2020-08-12 ARK Diagnostics, Inc. Pregabalin immunoassays
AU2016258980B2 (en) 2015-05-05 2022-02-17 Mesoblast International Sàrl Potency assay
AU2016361462B2 (en) 2015-11-27 2023-09-21 Csl Limited CD131 binding proteins and uses thereof
SG11201909856XA (en) 2017-05-04 2019-11-28 Mesoblast Int Sarl Mesenchymal lineage precursor or stem cells with enhanced immunosuppression
CN109633167A (zh) * 2018-12-20 2019-04-16 北京贝尔生物工程股份有限公司 一种高灵敏度、宽检测范围的人血清淀粉样蛋白a测定试剂盒
JP2022515916A (ja) 2019-01-02 2022-02-22 メゾブラスト・インターナショナル・エスアーエールエル 腰痛を治療するための方法
US11578140B2 (en) 2019-03-26 2023-02-14 Microgenics Corporation Immunoassay for mitragynine
US10745492B1 (en) 2019-04-03 2020-08-18 Ark Diagnostics, Inc. Antibodies to symmetrically dimethylated arginine analytes and use thereof
CN113125699B (zh) * 2019-12-31 2024-03-26 科美博阳诊断技术(上海)有限公司 一种β-hCG均相化学发光检测试剂盒及其应用
CN113125415B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光检测方法及其应用
CN113125731B (zh) * 2019-12-31 2025-09-16 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光测定试剂盒及其应用
KR102924915B1 (ko) 2020-03-30 2026-02-10 덴카 주식회사 라텍스 응집법에 의한 목적 물질의 측정 방법 및 그 시약
AU2021323475A1 (en) 2020-08-10 2023-04-13 Mesoblast International Sarl A composition comprising mesenchymal precursor or stem cells and their use
CA3260880A1 (en) 2022-07-05 2024-01-11 Mesoblast International Sarl CRYOPROVERTED INTERMEDIATE AND BIOLOGICAL ACTIVITY TEST FOR IT
WO2025196663A1 (en) 2024-03-19 2025-09-25 Mesoblast International Sarl Potency assay and manufacturing method ii

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210723A (en) 1976-07-23 1980-07-01 The Dow Chemical Company Method of coupling a protein to an epoxylated latex
US4401765A (en) * 1981-09-01 1983-08-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
EP0101228B1 (en) * 1982-08-06 1986-10-08 International Institute Of Cellular And Molecular Pathology (Icp) Particle agglutination assay of antigens
US4590169A (en) 1983-11-18 1986-05-20 Beckman Instruments, Inc. Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations
US4595661A (en) 1983-11-18 1986-06-17 Beckman Instruments, Inc. Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
NO164622C (no) 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US5200315A (en) * 1990-07-25 1993-04-06 Eastman Kodak Company Particulate biologically active reagent containing polyoxyalkylene side chains, analytical element and methods for use of the reagent

Also Published As

Publication number Publication date
DE69803729T2 (de) 2002-09-05
JP3746902B2 (ja) 2006-02-22
DE69803729D1 (de) 2002-03-21
US6248597B1 (en) 2001-06-19
CA2244326A1 (en) 1999-02-11
ATE213065T1 (de) 2002-02-15
JPH11108929A (ja) 1999-04-23
US20010026945A1 (en) 2001-10-04
CA2244326C (en) 2006-03-28
US6828158B2 (en) 2004-12-07

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