ES2171364T1 - Procedimiento para la purificacion de diacereina. - Google Patents

Procedimiento para la purificacion de diacereina.

Info

Publication number
ES2171364T1
ES2171364T1 ES00931071T ES00931071T ES2171364T1 ES 2171364 T1 ES2171364 T1 ES 2171364T1 ES 00931071 T ES00931071 T ES 00931071T ES 00931071 T ES00931071 T ES 00931071T ES 2171364 T1 ES2171364 T1 ES 2171364T1
Authority
ES
Spain
Prior art keywords
purification
procedure
diacerein
diacereine
crystallized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES00931071T
Other languages
English (en)
Other versions
ES2171364T3 (es
Inventor
Monica Sinistri
Roberta Sinistri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SYNTECO SpA
Original Assignee
SYNTECO SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SYNTECO SpA filed Critical SYNTECO SpA
Publication of ES2171364T1 publication Critical patent/ES2171364T1/es
Application granted granted Critical
Publication of ES2171364T3 publication Critical patent/ES2171364T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/95—Esters of quinone carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para la purificación de diacereína bruta, caracterizado porque se cristaliza la diacereína en un disolvente compuesto por anhídrido acético y ácido acético o en únicamente anhídrido acético, después se disuelve la diacereína cristalizada en una mezcla de acetona / trietilamina y se vuelve a precipitar con una disolución acuosa de ácido fosfórico.
ES00931071T 1999-05-07 2000-04-25 Procedimiento para la purificacion de diacereina. Expired - Lifetime ES2171364T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000994A IT1312309B1 (it) 1999-05-07 1999-05-07 Procedimento per la purificazione di diacereina
ITMI990994 1999-05-07

Publications (2)

Publication Number Publication Date
ES2171364T1 true ES2171364T1 (es) 2002-09-16
ES2171364T3 ES2171364T3 (es) 2005-04-16

Family

ID=11382911

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00931071T Expired - Lifetime ES2171364T3 (es) 1999-05-07 2000-04-25 Procedimiento para la purificacion de diacereina.

Country Status (20)

Country Link
EP (1) EP1177164B1 (es)
JP (1) JP2002544183A (es)
KR (1) KR100700687B1 (es)
CN (1) CN1187311C (es)
AR (1) AR023853A1 (es)
AT (1) ATE277884T1 (es)
AU (1) AU772845B2 (es)
BR (1) BR0010697A (es)
DE (2) DE1177164T1 (es)
DK (1) DK1177164T3 (es)
ES (1) ES2171364T3 (es)
HK (1) HK1045498B (es)
IL (1) IL146171A0 (es)
IT (1) IT1312309B1 (es)
MX (1) MXPA01011317A (es)
PL (1) PL199648B1 (es)
PT (1) PT1177164E (es)
SI (1) SI1177164T1 (es)
TR (1) TR200103177T2 (es)
WO (1) WO2000068179A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318574B1 (it) * 2000-06-13 2003-08-27 Synteco Spa Procedimento per la purificazione di diacereina.
ITMI20022535A1 (it) * 2002-11-29 2004-05-30 Synteco Spa Procedimento per la purificazione della diacereina.
KR100885677B1 (ko) 2007-05-22 2009-02-25 주식회사 엔지켐 디아세레인의 정제 방법
BRPI0917627A2 (pt) * 2008-12-09 2015-11-17 Evultis Sa "processo para produzir diacereína não genotóxica, diacereína não genotíxica, cápsulas e formulações farmacêuticas"
WO2011030350A1 (en) 2009-09-08 2011-03-17 Lupin Limited Eco-friendly method for catalytic aerial oxidation of aloe-emodin to rheinal
ITTO20110120A1 (it) 2011-02-11 2012-08-12 Icrom Spa Un nuovo processo di purificazione per derivati antrachinonici

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264545B1 (it) * 1993-07-30 1996-10-02 Medidom Lab Procedimento per la preparazione della diacereina
CH689279A5 (fr) * 1995-02-07 1999-01-29 Steba Beheer Bv Procédé de purification de la diacétylrhéine.
IT1292132B1 (it) * 1997-06-11 1999-01-25 Synteco S R L Procedimento per la preparazione di diacereina

Also Published As

Publication number Publication date
IL146171A0 (en) 2002-07-25
ATE277884T1 (de) 2004-10-15
DE60014356D1 (de) 2004-11-04
DE60014356T2 (de) 2005-02-17
DE1177164T1 (de) 2003-03-06
ITMI990994A1 (it) 2000-11-07
HK1045498B (zh) 2005-07-29
MXPA01011317A (es) 2003-07-14
WO2000068179A1 (en) 2000-11-16
PT1177164E (pt) 2004-12-31
CN1349495A (zh) 2002-05-15
DK1177164T3 (da) 2005-01-31
BR0010697A (pt) 2002-02-05
AR023853A1 (es) 2002-09-04
EP1177164B1 (en) 2004-09-29
PL199648B1 (pl) 2008-10-31
SI1177164T1 (en) 2005-02-28
PL351547A1 (en) 2003-05-05
CN1187311C (zh) 2005-02-02
IT1312309B1 (it) 2002-04-15
HK1045498A1 (en) 2002-11-29
KR100700687B1 (ko) 2007-03-27
JP2002544183A (ja) 2002-12-24
ES2171364T3 (es) 2005-04-16
EP1177164A1 (en) 2002-02-06
KR20010113905A (ko) 2001-12-28
AU4913600A (en) 2000-11-21
AU772845B2 (en) 2004-05-06
TR200103177T2 (tr) 2002-02-21

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